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Protein
Submitted name:

Malate dehydrogenase

Gene

mdh

Organism
Bacillus thuringiensis (strain Al Hakam)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Cofactori

Mg2+UniRule annotation, Mn2+UniRule annotationNote: Divalent metal cations. Prefers magnesium or manganese.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei59 – 591Proton donorUniRule annotation
Active sitei114 – 1141Proton acceptorUniRule annotation
Metal bindingi156 – 1561Divalent metal cationUniRule annotation
Metal bindingi157 – 1571Divalent metal cationUniRule annotation
Metal bindingi182 – 1821Divalent metal cationUniRule annotation

GO - Molecular functioni

  1. L-malate dehydrogenase activity Source: UniProtKB-EC
  2. malate dehydrogenase (decarboxylating) (NAD+) activity Source: InterPro
  3. metal ion binding Source: UniProtKB-KW
  4. NAD binding Source: InterPro

GO - Biological processi

  1. malate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotationImported

Keywords - Ligandi

Metal-bindingUniRule annotation

Enzyme and pathway databases

BioCyciBTHU412694:GH1W-4088-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
Malate dehydrogenaseImported (EC:1.1.1.37Imported)
Gene namesi
Name:mdhImported
Ordered Locus Names:BALH_4186Imported
OrganismiBacillus thuringiensis (strain Al Hakam)Imported
Taxonomic identifieri412694 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
ProteomesiUP000000761: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi412694.BALH_4186.

Structurei

3D structure databases

ProteinModelPortaliA0RJK0.
SMRiA0RJK0. Positions 24-407.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the malic enzymes family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0281.
HOGENOMiHOG000132447.
KOiK00027.
OMAiFGGVDAW.
OrthoDBiEOG6QCD9W.

Family and domain databases

Gene3Di3.40.50.10380. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR015884. Malic_enzyme_CS.
IPR012301. Malic_N_dom.
IPR012302. Malic_NAD-bd.
IPR001891. Malic_OxRdtase.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF00390. malic. 1 hit.
PF03949. Malic_M. 1 hit.
[Graphical view]
PIRSFiPIRSF000106. ME. 1 hit.
PRINTSiPR00072. MALOXRDTASE.
SMARTiSM00919. Malic_M. 1 hit.
[Graphical view]
PROSITEiPS00331. MALIC_ENZYMES. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A0RJK0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MFVVRPLGEI DISKNNLRRV DSLSTLREEA LHMHKVHQGK LETVSKVKVE
60 70 80 90 100
NAKDLSLAYS PGVAEPCKEI YDDKSKVYEY TMKGNMVAVV TDGTAVLGLG
110 120 130 140 150
NIGPEASLPV MEGKAVLFKS FAGVDAFPIA LNTNDVDKIV ETVKLMEPTF
160 170 180 190 200
GGVNLEDIAA PNCFIIEERL KKETNIPIFH DDQHGTAIVT VAGLVNALKL
210 220 230 240 250
VGKKMSDIKV VANGAGAAGI AIIKLLYRYG VRDIIMCDRK GAIYEGRPTG
260 270 280 290 300
MNPVKDEVAK YTNKNRIEGS LADVVQGADV FIGVSAEGAL TEEMVRTMND
310 320 330 340 350
NAIIFAMANP VPEIMPELAK AAGAAVVGTG RSDFANQVNN VLAFPGIFRG
360 370 380 390 400
ALDVHATQIN EEMKMAAVQA IAELVAEDEL NADYIIPAPF DARVAPQVAA
410 420 430
YVAKAAMETG VARRQVDPNE VAEKTKQLAL IGKE
Length:434
Mass (Da):46,606
Last modified:January 9, 2007 - v1
Checksum:iADD10F9721690612
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000485 Genomic DNA. Translation: ABK87393.1.
RefSeqiYP_896900.1. NC_008600.1.

Genome annotation databases

EnsemblBacteriaiABK87393; ABK87393; BALH_4186.
GeneIDi4544288.
KEGGibtl:BALH_4186.
PATRICi19001282. VBIBacThu63319_4637.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000485 Genomic DNA. Translation: ABK87393.1.
RefSeqiYP_896900.1. NC_008600.1.

3D structure databases

ProteinModelPortaliA0RJK0.
SMRiA0RJK0. Positions 24-407.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi412694.BALH_4186.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABK87393; ABK87393; BALH_4186.
GeneIDi4544288.
KEGGibtl:BALH_4186.
PATRICi19001282. VBIBacThu63319_4637.

Phylogenomic databases

eggNOGiCOG0281.
HOGENOMiHOG000132447.
KOiK00027.
OMAiFGGVDAW.
OrthoDBiEOG6QCD9W.

Enzyme and pathway databases

BioCyciBTHU412694:GH1W-4088-MONOMER.

Family and domain databases

Gene3Di3.40.50.10380. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR015884. Malic_enzyme_CS.
IPR012301. Malic_N_dom.
IPR012302. Malic_NAD-bd.
IPR001891. Malic_OxRdtase.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF00390. malic. 1 hit.
PF03949. Malic_M. 1 hit.
[Graphical view]
PIRSFiPIRSF000106. ME. 1 hit.
PRINTSiPR00072. MALOXRDTASE.
SMARTiSM00919. Malic_M. 1 hit.
[Graphical view]
PROSITEiPS00331. MALIC_ENZYMES. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Al HakamImported.

Entry informationi

Entry nameiA0RJK0_BACAH
AccessioniPrimary (citable) accession number: A0RJK0
Entry historyi
Integrated into UniProtKB/TrEMBL: January 9, 2007
Last sequence update: January 9, 2007
Last modified: February 4, 2015
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.