A0RIU9 (NADD_BACAH) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable nicotinate-nucleotide adenylyltransferase
EC=2.7.7.18

Alternative name(s):
Deamido-NAD(+) diphosphorylase
Deamido-NAD(+) pyrophosphorylase
Nicotinate mononucleotide adenylyltransferase
Short name=NaMN adenylyltransferase

Gene names

Name:	nadD
Ordered Locus Names:	BALH_3920

Organism

Bacillus thuringiensis (strain Al Hakam) [Complete proteome] [HAMAP]

Taxonomic identifier

412694 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Bacilli › Bacillales › Bacillaceae › Bacillus › Bacillus cereus group › Bacillus thuringiensis

Protein attributes

Sequence length	189 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) By similarity. HAMAP-Rule MF_00244
Catalytic activity	ATP + beta-nicotinate-D-ribonucleotide = diphosphate + deamido-NAD+. HAMAP-Rule MF_00244
Pathway	Cofactor biosynthesis; NAD(+) biosynthesis; deamido-NAD(+) from nicotinate D-ribonucleotide: step 1/1. HAMAP-Rule MF_00244
Sequence similarities	Belongs to the NadD family.

Ontologies

Keywords
Biological process	Pyridine nucleotide biosynthesis
Ligand	ATP-binding NAD Nucleotide-binding
Molecular function	Nucleotidyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	NAD biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW nicotinate-nucleotide adenylyltransferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 189	189	Probable nicotinate-nucleotide adenylyltransferase HAMAP-Rule MF_00244		PRO_0000310097

Sequences

	Sequence		Length	Mass (Da)
	A0RIU9 [UniParc]. Last modified January 9, 2007. Version 1. Checksum: 0F2A7DAEB42391F2	FASTA	189	21,899
	10 20 30 40 50 60 MRKIGIIGGT FDPPHYGHLL IANEVYHALN LEEVWFLPNQ IPPHKQGRNI TSVESRLQML 70 80 90 100 110 120 ELATEAEEHF SICLEELSRK GPSYTYDTML QLTKKYPDVQ FHFIIGGDMV EYLPKWYNIE 130 140 150 160 170 180 ALLDLVTFVG VARPGYTLHT SYPITTVEIP EFAVSSSLLR ERYKEKKTCK YLLPEKVQVY IERNGLYES

References

[1]

"The complete genome sequence of Bacillus thuringiensis Al Hakam." Challacombe J.F., Altherr M.R., Xie G., Bhotika S.S., Brown N., Bruce D., Campbell C.S., Campbell M.L., Chen J., Chertkov O., Cleland C., Dimitrijevic M., Doggett N.A., Fawcett J.J., Glavina T., Goodwin L.A., Green L.D., Han C.S. , Hill K.K., Hitchcock P., Jackson P.J., Keim P., Kewalramani A.R., Longmire J., Lucas S., Malfatti S., Martinez D., McMurry K., Meincke L.J., Misra M., Moseman B.L., Mundt M., Munk A.C., Okinaka R.T., Parson-Quintana B., Reilly L.P., Richardson P., Robinson D.L., Saunders E., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Ticknor L.O., Wills P.L., Gilna P., Brettin T.S. J. Bacteriol. 189:3680-3681(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Al Hakam.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000485 Genomic DNA. Translation: ABK87142.1.
RefSeq	YP_896649.1. NC_008600.1.
3D structure databases
ProteinModelPortal	A0RIU9.
SMR	A0RIU9. Positions 1-189.
ModBase	Search...
Protein-protein interaction databases
STRING	412694.BALH_3920.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABK87142; ABK87142; BALH_3920.
GeneID	4545069.
KEGG	btl:BALH_3920.
PATRIC	19000704. VBIBacThu63319_4350.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1057.
HOGENOM	HOG000262780.
KO	K00969.
OMA	HLLMANE.
ProtClustDB	PRK00071.
Enzyme and pathway databases
BioCyc	BTHU412694:GH1W-3682-MONOMER.
UniPathway	UPA00253; UER00332.
Family and domain databases
Gene3D	3.40.50.620. 1 hit.
HAMAP	MF_00244. NaMN_adenylyltr.
InterPro	IPR004821. Cyt_trans-like. IPR005248. NAMN_adtrnsfrase. IPR014729. Rossmann-like_a/b/a_fold. [Graphical view]
PANTHER	PTHR12039. PTHR12039. 1 hit.
Pfam	PF01467. CTP_transf_2. 1 hit. [Graphical view]
TIGRFAMs	TIGR00125. cyt_tran_rel. 1 hit. TIGR00482. TIGR00482. 1 hit.
ProtoNet	Search...

Entry information

Entry name

NADD_BACAH

Accession

Primary (citable) accession number: A0RIU9

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 13, 2007
Last sequence update:	January 9, 2007
Last modified:	May 1, 2013
This is version 48 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program