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A0RIK9

- GCSPB_BACAH

UniProt

A0RIK9 - GCSPB_BACAH

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Protein

Probable glycine dehydrogenase (decarboxylating) subunit 2

Gene
gcvPB, BALH_3827
Organism
Bacillus thuringiensis (strain Al Hakam)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciBTHU412694:GH1W-3745-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 2 (EC:1.4.4.2)
Alternative name(s):
Glycine cleavage system P-protein subunit 2
Glycine decarboxylase subunit 2
Glycine dehydrogenase (aminomethyl-transferring) subunit 2
Gene namesi
Name:gcvPB
Ordered Locus Names:BALH_3827
OrganismiBacillus thuringiensis (strain Al Hakam)
Taxonomic identifieri412694 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
ProteomesiUP000000761: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 491491Probable glycine dehydrogenase (decarboxylating) subunit 2UniRule annotationPRO_1000045687Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei273 – 2731N6-(pyridoxal phosphate)lysine By similarity

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits By similarity.

Protein-protein interaction databases

STRINGi412694.BALH_3827.

Structurei

3D structure databases

ProteinModelPortaliA0RIK9.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239368.
KOiK00283.
OMAiWTGLMMI.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
HAMAPiMF_00713. GcvPB.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR023012. GDC_P_su2.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.

Sequencei

Sequence statusi: Complete.

A0RIK9-1 [UniParc]FASTAAdd to Basket

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MKNQDQALIF EVSKEGRIGY SLPKLDVEEV KLEDVFESDY IRVEDAELPE    50
VSELDIMRHY TALSNRNHGV DSGFYPLGSC TMKYNPKINE SVARFAGFAN 100
IHPLQDEETV QGAMELMYDL QEHLIEITGM DTVTLQPAAG AHGEWTGLML 150
IRAYHEANGD FNRTKVIVPD SAHGTNPASA TVAGFETITV KSNEHGLVDL 200
EDLKRVVNEE TAALMLTNPN TLGLFEENIL EMAEIVHNAG GKLYYDGANL 250
NAVLSQARPG DMGFDVVHLN LHKTFTGPHG GGGPGSGPVG VKADLIPYLP 300
KPILEKTENG YHFNYDRPEA IGRVKPFYGN FGINVRAYTY IRSMGPDGLR 350
AVTEYAVLNA NYMMRRLAPF YDLPFDRHCK HEFVLSGRRQ KKLGVRTLDI 400
AKRLLDFGYH PPTIYFPLNV EECIMIEPTE TESKETLDGF IDKMIQIAKE 450
VEENPEVVQE APHTTVIKRL DETMAARKPV LRYAKPAPVQ V 491
Length:491
Mass (Da):54,866
Last modified:January 9, 2007 - v1
Checksum:iC5F6266168C1FDAA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000485 Genomic DNA. Translation: ABK87052.1.
RefSeqiWP_000795694.1. NC_008600.1.
YP_896559.1. NC_008600.1.

Genome annotation databases

EnsemblBacteriaiABK87052; ABK87052; BALH_3827.
GeneIDi4544240.
KEGGibtl:BALH_3827.
PATRICi19000485. VBIBacThu63319_4242.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000485 Genomic DNA. Translation: ABK87052.1 .
RefSeqi WP_000795694.1. NC_008600.1.
YP_896559.1. NC_008600.1.

3D structure databases

ProteinModelPortali A0RIK9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 412694.BALH_3827.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABK87052 ; ABK87052 ; BALH_3827 .
GeneIDi 4544240.
KEGGi btl:BALH_3827.
PATRICi 19000485. VBIBacThu63319_4242.

Phylogenomic databases

eggNOGi COG1003.
HOGENOMi HOG000239368.
KOi K00283.
OMAi WTGLMMI.
OrthoDBi EOG6HMXDX.

Enzyme and pathway databases

BioCyci BTHU412694:GH1W-3745-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
HAMAPi MF_00713. GcvPB.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR023012. GDC_P_su2.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 1 hit.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Al Hakam.

Entry informationi

Entry nameiGCSPB_BACAH
AccessioniPrimary (citable) accession number: A0RIK9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 9, 2007
Last modified: September 3, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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