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A0RHT1 (MURG2_BACAH) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 44. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase 2
EC=2.4.1.227
Alternative name(s):
Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase 2
Gene names
Name:murG2
Ordered Locus Names:BALH_3540
OrganismBacillus thuringiensis (strain Al Hakam) [Complete proteome] [HAMAP]
Taxonomic identifier412694 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus › Bacillus cereus group

Protein attributes

Sequence length364 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II) By similarity. HAMAP MF_00033

Catalytic activity

UDP-N-acetylglucosamine + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol = UDP + GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol. HAMAP MF_00033

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP MF_00033

Subcellular location

Cell membrane; Peripheral membrane protein By similarity HAMAP MF_00033.

Sequence similarities

Belongs to the glycosyltransferase 28 family. MurG subfamily.

Sequence caution

The sequence ABK86774.1 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 364364UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase 2 HAMAP MF_00033
PRO_0000315067

Sequences

Sequence LengthMass (Da)Tools
A0RHT1 [UniParc].

Last modified January 15, 2008. Version 2.
Checksum: 2619A55B1E71F833

FASTA36439,600
        10         20         30         40         50         60 
MRVLVSGGGT GGHIYPALAL IREIKKLNPE ARFLYIGTEN GLESTIVPKA GIPFQSIVIS 

        70         80         90        100        110        120 
GFKRKISLDN VKTVMRFLKG VQDSKRYIRR FNPDIVIGTG GYVCGPVVYA AAKLGIPTIV 

       130        140        150        160        170        180 
HEQNSVPGVT NKFLSRYVDK VAVCFEAAAE HFPQSKVVMT GNPRASEVMD QNGMKGKRSV 

       190        200        210        220        230        240 
GLSLPKKSVL IFGGSRGARP INDAFVEAIE QFGNKSYEIL YVTGEVHYDK VMEAVKQKGN 

       250        260        270        280        290        300 
PNNVIIKPFI HNMPEVLTGV DLVVSRAGAT TLAELTALGK PSVLIPSPYV TNNHQEKNAR 

       310        320        330        340        350        360 
SVVDKGAAKM LLEKDLTAET LIRDIDEILL DAQTLQNMKL AAGQLGIPDA ANKLYEVMNK 


LVKK

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000485 Genomic DNA. Translation: ABK86774.1. Different initiation.
RefSeqYP_896281.1. NC_008600.1.

3D structure databases

ProteinModelPortalA0RHT1.
ModBaseSearch...

Protein-protein interaction databases

STRINGA0RHT1.

Protein family/group databases

CAZyGT28. Glycosyltransferase Family 28.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBBACT00000070827; EBBACP00000069064; EBBACG00000070818.
GeneID4543606.
GenomeReviewsGene locus BALH_3540 in contig CP000485_GR.
KEGGbtl:BALH_3540.
PATRIC18999837. VBIBacThu63319_3918.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0707.
GeneTreeEBGT00050000001194.
HOGENOMHBG617076.
ProtClustDBPRK00726.

Enzyme and pathway databases

BioCycBTHU412694:BALH_3540-MONOMER.

Family and domain databases

HAMAPMF_00033. MurG.
[Tree]
InterProIPR006009. GlcNAc_MurG.
IPR004276. Glyco_trans_28.
IPR007235. Glyco_trans_28_C.
[Graphical view]
KOK02563.
PANTHERPTHR21015:SF22. PTHR21015:SF22. 1 hit.
PfamPF04101. Glyco_tran_28_C. 1 hit.
PF03033. Glyco_transf_28. 1 hit.
[Graphical view]
TIGRFAMsTIGR01133. MurG. 1 hit.
ProtoNetSearch...

Entry information

Entry nameMURG2_BACAH
AccessionPrimary (citable) accession number: A0RHT1
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 15, 2008
Last modified: December 14, 2011
This is version 44 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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