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A0RHQ4 (A0RHQ4_BACAH) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 43. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Orotate phosphoribosyltransferase HAMAP MF_01208
Short name=OPRT HAMAP MF_01208
Short name=OPRTase HAMAP MF_01208
EC=2.4.2.10 HAMAP MF_01208
Gene names
Name:pyrE HAMAP MF_01208
Ordered Locus Names:BALH_3512
OrganismBacillus thuringiensis (strain Al Hakam) [Complete proteome] [HAMAP]
Taxonomic identifier412694 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus › Bacillus cereus group

Protein attributes

Sequence length216 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) By similarity. HAMAP MF_01208 SAAS SAAS004467

Catalytic activity

Orotidine 5'-phosphate + diphosphate = orotate + 5-phospho-alpha-D-ribose 1-diphosphate. HAMAP MF_01208 SAAS SAAS023031

Cofactor

Magnesium By similarity. HAMAP MF_01208

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 1/2. HAMAP MF_01208 SAAS SAAS023031

Subunit structure

Homodimer By similarity. HAMAP MF_01208 SAAS SAAS004467

Sequence similarities

Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily. HAMAP MF_01208

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Region126 – 13495-phosphoribose 1-diphosphate binding By similarity HAMAP MF_01208

Sites

Binding site10015-phosphoribose 1-diphosphate; shared with dimeric partner By similarity HAMAP MF_01208
Binding site10415-phosphoribose 1-diphosphate; shared with dimeric partner By similarity HAMAP MF_01208
Binding site10615-phosphoribose 1-diphosphate; shared with dimeric partner By similarity HAMAP MF_01208
Binding site1301Orotate By similarity HAMAP MF_01208

Sequences

Sequence LengthMass (Da)Tools
A0RHQ4 [UniParc].

Last modified January 9, 2007. Version 1.
Checksum: 0230E60F49D8EC63

FASTA21623,351
        10         20         30         40         50         60 
MGRCNSMKKE IASHLLEIGA VFLQPNDPFT WSSGMKSPIY CDNRLTLSYP KVRQAIAAGL 

        70         80         90        100        110        120 
EELIKEHFPT VEVIAGTATA GIAHAAWVSD RMDLPMCYVR SKAKGHGKGN QIEGKAEKGQ 

       130        140        150        160        170        180 
KVVVVEDLIS TGGSAITCVE ALREAGCEVL GIVSIFTYEL EAGKEKLEAA NVASYSLSDY 

       190        200        210 
SALTEVAAEK GMIGQAETKK LQEWRKNPAD EAWITA

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000485 Genomic DNA. Translation: ABK86747.1.
RefSeqYP_896254.1. NC_008600.1.

3D structure databases

ProteinModelPortalA0RHQ4.
ModBaseSearch...

Protein-protein interaction databases

STRINGA0RHQ4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBBACT00000070884; EBBACP00000069121; EBBACG00000070875.
GeneID4544120.
GenomeReviewsGene locus BALH_3512 in contig CP000485_GR.
KEGGbtl:BALH_3512.
NMPDRfig|412694.5.peg.3372.
PATRIC18999781. VBIBacThu63319_3890.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0461.
GeneTreeEBGT00050000002725.
HOGENOMHBG404341.
OMALPMTYVR.
ProtClustDBPRK00455.

Family and domain databases

HAMAPMF_01208. PyrE.
[Tree]
InterProIPR004467. Or_phspho_trans_clade-1.
IPR023031. Orotate_PribosylTferase.
IPR000836. PRibTrfase.
[Graphical view]
KOK00762.
PfamPF00156. Pribosyltran. 1 hit.
[Graphical view]
TIGRFAMsTIGR00336. PyrE. 1 hit.
ProtoNetSearch...

Entry information

Entry nameA0RHQ4_BACAH
AccessionPrimary (citable) accession number: A0RHQ4
Entry history
Integrated into UniProtKB/TrEMBL: January 9, 2007
Last sequence update: January 9, 2007
Last modified: December 14, 2011
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info