Reviewed, UniProtKB/Swiss-Prot A0RET0 (UPPP4_BACAH)

Names and origin

Protein names

Recommended name:
Undecaprenyl-diphosphatase 4
EC=3.6.1.27

Alternative name(s):
Undecaprenyl pyrophosphate phosphatase 4
Bacitracin resistance protein 4

Gene names

Name:	uppP4
Ordered Locus Names:	BALH_2434

Organism

Bacillus thuringiensis (strain Al Hakam) [Complete proteome] [HAMAP]

Taxonomic identifier

412694 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus › Bacillus cereus group

Protein attributes

Sequence length	259 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP MF_01006
Catalytic activity	Undecaprenyl diphosphate + H2O = undecaprenyl phosphate + phosphate. HAMAP MF_01006
Subcellular location	Cell membrane; Multi-pass membrane protein By similarity HAMAP MF_01006.
Miscellaneous	Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available. HAMAP MF_01006
Sequence similarities	Belongs to the uppP family.

Ontologies

Keywords
Biological process	Antibiotic resistance Cell shape Cell wall biogenesis/degradation Peptidoglycan synthesis
Cellular component	Cell membrane Membrane
Domain	Transmembrane
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cellular cell wall organization Inferred from electronic annotation. Source: UniProtKB-KW dephosphorylation Inferred from electronic annotation. Source: InterPro peptidoglycan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW regulation of cell shape Inferred from electronic annotation. Source: UniProtKB-KW response to antibiotic Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	undecaprenyl-diphosphatase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 259	259	Undecaprenyl-diphosphatase 4 HAMAP MF_01006		PRO_0000290687
Regions
	Transmembrane	1 – 21	21	Potential
	Transmembrane	39 – 59	21	Potential
	Transmembrane	71 – 91	21	Potential
	Transmembrane	99 – 119	21	Potential
	Transmembrane	133 – 153	21	Potential
	Transmembrane	173 – 193	21	Potential
	Transmembrane	208 – 228	21	Potential
	Transmembrane	239 – 259	21	Potential

Sequences

	Sequence		Length	Mass (Da)
	A0RET0-1 [UniParc]. Last modified January 9, 2007. Version 1. Checksum: 7E4301B612EB6332	FASTA	259	29,214
	10 20 30 40 50 60 MNWLEAFILG IIQGLTEFLP ISSTGHLYLG RHLFQLDEAG LFLDTMLHIG TLLAVFIYYK 70 80 90 100 110 120 KEFIYLIKNP FSKLMLLLIV GTIPAVVIGL LFKDFFEDIS KTGITIGWEF LVTGFFLYMA 130 140 150 160 170 180 DKQKNGRKKM DDITYKDAFI IGSFQAAAIF PAISRSGMTI VAALWRKLDR ETAAYFSFLL 190 200 210 220 230 240 STPAIVGAII LQFADVFQGK AESISNTSLI VGTLSAAFFG YIAVSWMIQY LKRHSLKVFA 250 YYVWGLGIII ITLQYTHVF

References

[1]

"The complete genome sequence of Bacillus thuringiensis Al Hakam." Challacombe J.F., Altherr M.R., Xie G., Bhotika S.S., Brown N., Bruce D., Campbell C.S., Campbell M.L., Chen J., Chertkov O., Cleland C., Dimitrijevic M., Doggett N.A., Fawcett J.J., Glavina T., Goodwin L.A., Green L.D., Han C.S. , Hill K.K., Hitchcock P., Jackson P.J., Keim P., Kewalramani A.R., Longmire J., Lucas S., Malfatti S., Martinez D., McMurry K., Meincke L.J., Misra M., Moseman B.L., Mundt M., Munk A.C., Okinaka R.T., Parson-Quintana B., Reilly L.P., Richardson P., Robinson D.L., Saunders E., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Ticknor L.O., Wills P.L., Gilna P., Brettin T.S. J. Bacteriol. 189:3680-3681(2007) [PubMed: 17337577] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000485 Genomic DNA. Translation: ABK85723.1.
RefSeq	YP_895230.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	A0RET0.
Genome annotation databases
GeneID	4542985.
GenomeReviews	Gene locus BALH_2434 in contig CP000485_GR.
KEGG	btl:BALH_2434.
NMPDR	fig|412694.5.peg.2367.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1968.
HOGENOM	HBG391969.
OMA	ITIGWEF.
ProtClustDB	PRK00281.
Family and domain databases
HAMAP	MF_01006. Undec_diphosphatase. [Tree]
InterPro	IPR003824. Bacitracin-R_BacA. [Graphical view]
Pfam	PF02673. BacA. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

UPPP4_BACAH

Accession

Primary (citable) accession number: A0RET0

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 12, 2007
Last sequence update:	January 9, 2007
Last modified:	March 2, 2010
This is version 30 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)