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A0RDW1 (IOLA1_BACAH) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 43. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Methylmalonate semialdehyde dehydrogenase [acylating] 1
Short name=MMSA dehydrogenase 1
Short name=MMSDH 1
Short name=MSDH 1
EC=1.2.1.27
Alternative name(s):
Malonate semialdehyde dehydrogenase [acetylating] 1
Short name=MSA dehydrogenase 1
EC=1.2.1.18
Gene names
Name:iolA1
Ordered Locus Names:BALH_2098
OrganismBacillus thuringiensis (strain Al Hakam) [Complete proteome] [HAMAP]
Taxonomic identifier412694 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus › Bacillus cereus group

Protein attributes

Sequence length486 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Converts malonate semialdehyde (MSA) and methylmalonate semialdehyde (MMSA) into acetyl-CoA and propanoyl-CoA, respectively By similarity. HAMAP MF_01670

Catalytic activity

3-oxopropanoate + CoA + NAD(P)+ = acetyl-CoA + CO2 + NAD(P)H. HAMAP MF_01670

2-methyl-3-oxopropanoate + CoA + H2O + NAD+ = propanoyl-CoA + HCO3- + NADH. HAMAP MF_01670

Pathway

Polyol metabolism; myo-inositol degradation into acetyl-CoA; acetyl-CoA from myo-inositol: step 7/7. HAMAP MF_01670

Subunit structure

Homotetramer By similarity. HAMAP MF_01670

Sequence similarities

Belongs to the aldehyde dehydrogenase family. IolA subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 486486Methylmalonate semialdehyde dehydrogenase [acylating] 1 HAMAP MF_01670
PRO_0000352333

Regions

Nucleotide binding178 – 1825NAD By similarity

Sites

Active site2861Nucleophile By similarity
Binding site3861NAD By similarity

Sequences

Sequence LengthMass (Da)Tools
A0RDW1 [UniParc].

Last modified January 9, 2007. Version 1.
Checksum: 37F24E5E70BE30D2

FASTA48653,005
        10         20         30         40         50         60 
MITTEIKRVK NHINGEWVES TGTEVEAVPN PATGKIIAYV PLSPKEDVEK AVEAAKAAYE 

        70         80         90        100        110        120 
TWSKVPVPNR SRQLYKYLQL LQENKEELAK IITLENGKTL TDATGEVQRG IEAVELATST 

       130        140        150        160        170        180 
PNLMMGQALP NIASGIDGSI WRYPIGVVAG ITPFNFPMMI PLWMFPLAIA CGNTFVLKTS 

       190        200        210        220        230        240 
ERTPLLAERL VELFYEAGFP KGVLNLVQGG KDVVNSILEN KDIQAVSFVG SEPVARYVYE 

       250        260        270        280        290        300 
TGTKHGKRVQ ALAGAKNHAI VMPDCNLEKT VQGVIGSAFA SSGERCMACS VVAVVDEIAD 

       310        320        330        340        350        360 
EFIDVLVAET KKLKVGDGFH EDNYVGPLIR ESHKERVLGY INSGVADGAT LLVDGRKIKE 

       370        380        390        400        410        420 
EVGEGYFVGA TIFDGVNQEM KIWQDEIFAP VLSIVRVKDL EEGIKLTNQS KFANGAVIYT 

       430        440        450        460        470        480 
SNGKHAQTFR DNIDAGMIGV NVNVPAPMAF FAFAGNKASF FGDLGTNGTD GVQFYTRKKV 


VTERWF

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000485 Genomic DNA. Translation: ABK85404.1.
RefSeqYP_894911.1. NC_008600.1.

3D structure databases

ProteinModelPortalA0RDW1.
SMRA0RDW1. Positions 5-485.
ModBaseSearch...

Protein-protein interaction databases

STRINGA0RDW1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBBACT00000068914; EBBACP00000067151; EBBACG00000068905.
GeneID4545461.
GenomeReviewsGene locus BALH_2098 in contig CP000485_GR.
KEGGbtl:BALH_2098.
PATRIC18996693. VBIBacThu63319_2347.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1012.
GeneTreeEBGT00070000031871.
HOGENOMHBG752218.
OMANGAGVDM.
ProtClustDBCLSK873284.

Enzyme and pathway databases

BioCycBTHU412694:BALH_2098-MONOMER.

Family and domain databases

HAMAPMF_01670. IolA.
[Tree]
InterProIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR010061. MeMal-semiAld_DH.
IPR023510. MeMal-semiAld_DH_GmP_bac.
[Graphical view]
Gene3DG3DSA:3.40.309.10. Aldehyde_dehydrogenase_C. 1 hit.
G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
KOK00140.
PANTHERPTHR11699:SF27. MMSDH. 1 hit.
PfamPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMSSF53720. Aldehyde_DH/Histidinol_DH. 1 hit.
TIGRFAMsTIGR01722. MMSDH. 1 hit.
PROSITEPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. False negative.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameIOLA1_BACAH
AccessionPrimary (citable) accession number: A0RDW1
Entry history
Integrated into UniProtKB/Swiss-Prot: October 14, 2008
Last sequence update: January 9, 2007
Last modified: December 14, 2011
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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