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A0RD69 (ACDH_BACAH) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 39. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Acetaldehyde dehydrogenase
EC=1.2.1.10
Alternative name(s):
Acetaldehyde dehydrogenase [acetylating]
Gene names
Ordered Locus Names:BALH_1843
OrganismBacillus thuringiensis (strain Al Hakam) [Complete proteome] [HAMAP]
Taxonomic identifier412694 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus › Bacillus cereus group

Protein attributes

Sequence length299 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds By similarity. HAMAP MF_01657

Catalytic activity

Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH. HAMAP MF_01657

Sequence similarities

Belongs to the acetaldehyde dehydrogenase family.

Ontologies

Keywords
   Biological processAromatic hydrocarbons catabolism
   LigandNAD
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processaromatic compound catabolic process

Inferred from electronic annotation. Source: UniProtKB-KW

cellular amino acid metabolic process

Inferred from electronic annotation. Source: InterPro

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: InterPro

   Molecular functionNAD binding

Inferred from electronic annotation. Source: InterPro

acetaldehyde dehydrogenase (acetylating) activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 299299Acetaldehyde dehydrogenase HAMAP MF_01657
PRO_0000387627

Regions

Nucleotide binding11 – 144NAD By similarity
Nucleotide binding157 – 1659NAD By similarity

Sites

Binding site2671NAD By similarity

Sequences

Sequence LengthMass (Da)Tools
A0RD69 [UniParc].

Last modified January 9, 2007. Version 1.
Checksum: 39C5F4B9E090C51D

FASTA29932,519
        10         20         30         40         50         60 
MQKVKAAIIG SGNIGTDLMY KLRKSEVIDL NAMIGIDVES DGLKRAKEAG YEVFDNGIQA 

        70         80         90        100        110        120 
IIDNPSLADI VFDATSAKAH RYHAKTLEEL EKIVIDLTPA AYGPFVCPAI RNNNFLDKQN 

       130        140        150        160        170        180 
VNMITCGGQA TIPIVHAING VANVTYAEIV ATISSLSAGP GTRANIDEFT ITTKRGIEEV 

       190        200        210        220        230        240 
GGADKGKAII ILNPAEPPIL MRDTIYCEVK DMDEVSIYEA IHKMVERVRT YVPGYSLKQE 

       250        260        270        280        290 
PMFDGNRVTV FLEVEGAGDY FPPYAGNLDI MTAAALKVGE EFATQIISEK KRGVMNEAK

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000485 Genomic DNA. Translation: ABK85162.1.
RefSeqYP_894669.1. NC_008600.1.

3D structure databases

ProteinModelPortalA0RD69.
SMRA0RD69. Positions 2-288.
ModBaseSearch...

Protein-protein interaction databases

STRINGA0RD69.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBBACT00000068498; EBBACP00000066735; EBBACG00000068489.
GeneID4545493.
GenomeReviewsGene locus BALH_1843 in contig CP000485_GR.
KEGGbtl:BALH_1843.
NMPDRfig|412694.5.peg.1829.
PATRIC18996140. VBIBacThu63319_2072.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG4569.
GeneTreeEBGT00050000005163.
HOGENOMHBG300125.
OMAHVKNDAF.
ProtClustDBPRK08300.

Enzyme and pathway databases

BioCycBTHU412694:BALH_1843-MONOMER.

Family and domain databases

HAMAPMF_01657. Ac_ald_DH_ac.
[Tree]
InterProIPR003361. Acetaldehyde_dehydrogenase.
IPR015426. Acetylaldehyde_DH_C.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
[Graphical view]
Gene3DG3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KOK04073.
PANTHERPTHR21123. Acetylald_dh. 1 hit.
PfamPF09290. AcetDehyd-dimer. 1 hit.
PF01118. Semialdhyde_dh. 1 hit.
[Graphical view]
PIRSFPIRSF015689. Actaldh_dh_actl. 1 hit.
SMARTSM00859. Semialdhyde_dh. 1 hit.
[Graphical view]
TIGRFAMsTIGR03215. Ac_ald_DH_ac. 1 hit.
ProtoNetSearch...

Entry information

Entry nameACDH_BACAH
AccessionPrimary (citable) accession number: A0RD69
Entry history
Integrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: January 9, 2007
Last modified: December 14, 2011
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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