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UniProtKB - A0RD64 (3HAO_BACAH)

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Protein

3-hydroxyanthranilate 3,4-dioxygenase

Gene

nbaC

Organism
Bacillus thuringiensis (strain Al Hakam)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.UniRule annotation

Catalytic activityi

3-hydroxyanthranilate + O2 = 2-amino-3-carboxymuconate semialdehyde.UniRule annotation

Cofactori

Fe2+UniRule annotationNote: Binds 2 Fe2+ ions per subunit.UniRule annotation

Pathwayi: NAD(+) biosynthesis

This protein is involved in step 3 of the subpathway that synthesizes quinolinate from L-kynurenine.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Kynureninase (kynU), Kynureninase (kynU)
  3. 3-hydroxyanthranilate 3,4-dioxygenase (nbaC), 3-hydroxyanthranilate 3,4-dioxygenase (nbaC)
This subpathway is part of the pathway NAD(+) biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes quinolinate from L-kynurenine, the pathway NAD(+) biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei47DioxygenUniRule annotation1
Metal bindingi51Iron 1; catalyticUniRule annotation1
Metal bindingi57Iron 1; catalyticUniRule annotation1
Binding sitei57SubstrateUniRule annotation1
Metal bindingi96Iron 1; catalyticUniRule annotation1
Binding sitei100SubstrateUniRule annotation1
Binding sitei110SubstrateUniRule annotation1
Metal bindingi125Iron 2UniRule annotation1
Metal bindingi128Iron 2UniRule annotation1
Metal bindingi162Iron 2UniRule annotation1
Metal bindingi165Iron 2UniRule annotation1

GO - Molecular functioni

Complete GO annotation...

GO - Biological processi

Complete GO annotation...

Keywordsi

Molecular functionDioxygenase, Oxidoreductase
Biological processPyridine nucleotide biosynthesis
LigandIron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00253; UER00330.

Names & Taxonomyi

Protein namesi
Recommended name:
3-hydroxyanthranilate 3,4-dioxygenaseUniRule annotation (EC:1.13.11.6UniRule annotation)
Alternative name(s):
3-hydroxyanthranilate oxygenaseUniRule annotation
Short name:
3-HAOUniRule annotation
3-hydroxyanthranilic acid dioxygenaseUniRule annotation
Short name:
HADUniRule annotation
Gene namesi
Name:nbaCUniRule annotation
Ordered Locus Names:BALH_1838
OrganismiBacillus thuringiensis (strain Al Hakam)
Taxonomic identifieri412694 [NCBI]
Taxonomic lineageiBacteria › Firmicutes › Bacilli › Bacillales › Bacillaceae › Bacillus › Bacillus cereus group ›
Proteomesi
  • UP000000761 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003095751 – 1793-hydroxyanthranilate 3,4-dioxygenaseAdd BLAST179

Structurei

3D structure databases

ProteinModelPortaliA0RD64.
SMRiA0RD64.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the 3-HAO family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000218448.
KOiK00452.
OMAiNARKDYH.

Family and domain databases

Gene3Di2.60.120.10. 1 hit.
HAMAPiMF_00825. 3_HAO. 1 hit.
InterProiView protein in InterPro
IPR010329. 3hydroanth_dOase.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
PANTHERiPTHR15497. PTHR15497. 1 hit.
PfamiView protein in Pfam
PF06052. 3-HAO. 1 hit.
SUPFAMiSSF51182. SSF51182. 1 hit.
TIGRFAMsiTIGR03037. anthran_nbaC. 1 hit.

Sequencei

Sequence statusi: Complete.

A0RD64-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKTLQSFNL LKWIDENKEL LKPPVNNKVI WQDSEFIAMI LGGPNRRRDF 
        60         70         80         90        100
HVDPSDEFFY QIKGECYVEC ITEEGKREVV TVKEGDVFML PAMVPHSPHR 
       110        120        130        140        150
VANTYGLVIE RKRSQGELED FVWFCDECNH EMHRVRVQLS DIEKQVKEAI 
       160        170 
HSFNSNKEIR ACKNCGHIMP EEVGEWKCE
Length:179
Mass (Da):20,985
Last modified:January 9, 2007 - v1
Checksum:i1A5BF15A9B2302AC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000485 Genomic DNA. Translation: ABK85157.1.
RefSeqiWP_000047734.1. NC_008600.1.

Genome annotation databases

EnsemblBacteriaiABK85157; ABK85157; BALH_1838.
KEGGibtl:BALH_1838.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry namei3HAO_BACAH
AccessioniPrimary (citable) accession number: A0RD64
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: January 9, 2007
Last modified: June 7, 2017
This is version 69 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families