UniProtKB - A0RD64 (3HAO_BACAH)
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Protein
3-hydroxyanthranilate 3,4-dioxygenase
Gene
nbaC
Organism
Bacillus thuringiensis (strain Al Hakam)
Status
Functioni
Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.UniRule annotation
Catalytic activityi
3-hydroxyanthranilate + O2 = 2-amino-3-carboxymuconate semialdehyde.UniRule annotation
Cofactori
Fe2+UniRule annotationNote: Binds 2 Fe2+ ions per subunit.UniRule annotation
: NAD(+) biosynthesis Pathwayi
This protein is involved in step 3 of the subpathway that synthesizes quinolinate from L-kynurenine.UniRule annotationProteins known to be involved in the 3 steps of the subpathway in this organism are:
- no protein annotated in this organism
- Kynureninase (kynU)
- 3-hydroxyanthranilate 3,4-dioxygenase (nbaC)
View all proteins of this organism that are known to be involved in the subpathway that synthesizes quinolinate from L-kynurenine, the pathway NAD(+) biosynthesis and in Cofactor biosynthesis.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 47 | DioxygenUniRule annotation | 1 | |
Metal bindingi | 51 | Iron 1; catalyticUniRule annotation | 1 | |
Metal bindingi | 57 | Iron 1; catalyticUniRule annotation | 1 | |
Binding sitei | 57 | SubstrateUniRule annotation | 1 | |
Metal bindingi | 96 | Iron 1; catalyticUniRule annotation | 1 | |
Binding sitei | 100 | SubstrateUniRule annotation | 1 | |
Binding sitei | 110 | SubstrateUniRule annotation | 1 | |
Metal bindingi | 125 | Iron 2UniRule annotation | 1 | |
Metal bindingi | 128 | Iron 2UniRule annotation | 1 | |
Metal bindingi | 162 | Iron 2UniRule annotation | 1 | |
Metal bindingi | 165 | Iron 2UniRule annotation | 1 |
GO - Molecular functioni
- 3-hydroxyanthranilate 3,4-dioxygenase activity Source: UniProtKB-EC
- iron ion binding Source: InterPro
GO - Biological processi
- NAD biosynthetic process Source: UniProtKB-UniPathway
Keywordsi
Molecular function | Dioxygenase, Oxidoreductase |
Biological process | Pyridine nucleotide biosynthesis |
Ligand | Iron, Metal-binding |
Enzyme and pathway databases
UniPathwayi | UPA00253; UER00330. |
Names & Taxonomyi
Protein namesi | Recommended name: 3-hydroxyanthranilate 3,4-dioxygenaseUniRule annotation (EC:1.13.11.6UniRule annotation)Alternative name(s): 3-hydroxyanthranilate oxygenaseUniRule annotation Short name: 3-HAOUniRule annotation 3-hydroxyanthranilic acid dioxygenaseUniRule annotation Short name: HADUniRule annotation |
Gene namesi | Name:nbaCUniRule annotation Ordered Locus Names:BALH_1838 |
Organismi | Bacillus thuringiensis (strain Al Hakam) |
Taxonomic identifieri | 412694 [NCBI] |
Taxonomic lineagei | Bacteria › Firmicutes › Bacilli › Bacillales › Bacillaceae › Bacillus › Bacillus cereus group › |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000309575 | 1 – 179 | 3-hydroxyanthranilate 3,4-dioxygenaseAdd BLAST | 179 |
Structurei
3D structure databases
ProteinModelPortali | A0RD64. |
SMRi | A0RD64. |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Sequence similaritiesi
Belongs to the 3-HAO family.UniRule annotation
Phylogenomic databases
HOGENOMi | HOG000218448. |
KOi | K00452. |
OMAi | NARKDYH. |
Family and domain databases
Gene3Di | 2.60.120.10. 1 hit. |
HAMAPi | MF_00825. 3_HAO. 1 hit. |
InterProi | View protein in InterPro IPR010329. 3hydroanth_dOase. IPR014710. RmlC-like_jellyroll. IPR011051. RmlC_Cupin_sf. |
PANTHERi | PTHR15497. PTHR15497. 1 hit. |
Pfami | View protein in Pfam PF06052. 3-HAO. 1 hit. |
SUPFAMi | SSF51182. SSF51182. 1 hit. |
TIGRFAMsi | TIGR03037. anthran_nbaC. 1 hit. |
i Sequence
Sequence statusi: Complete.
A0RD64-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSKTLQSFNL LKWIDENKEL LKPPVNNKVI WQDSEFIAMI LGGPNRRRDF
60 70 80 90 100
HVDPSDEFFY QIKGECYVEC ITEEGKREVV TVKEGDVFML PAMVPHSPHR
110 120 130 140 150
VANTYGLVIE RKRSQGELED FVWFCDECNH EMHRVRVQLS DIEKQVKEAI
160 170
HSFNSNKEIR ACKNCGHIMP EEVGEWKCE
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CP000485 Genomic DNA. Translation: ABK85157.1. |
RefSeqi | WP_000047734.1. NC_008600.1. |
Genome annotation databases
EnsemblBacteriai | ABK85157; ABK85157; BALH_1838. |
KEGGi | btl:BALH_1838. |
Similar proteinsi
Entry informationi
Entry namei | 3HAO_BACAH | |
Accessioni | A0RD64Primary (citable) accession number: A0RD64 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 13, 2007 |
Last sequence update: | January 9, 2007 | |
Last modified: | November 22, 2017 | |
This is version 70 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |