NADPH dehydrogenase - Bacillus thuringiensis (strain Al Hakam)

Preferred order of sections

Names and origin

Protein names

Recommended name:
NADPH dehydrogenase
EC=1.6.99.1

Alternative name(s):
Xenobiotic reductase

Gene names

Name:	namA
Ordered Locus Names:	BALH_1798

Organism

Bacillus thuringiensis (strain Al Hakam) [Complete proteome] [HAMAP]

Taxonomic identifier

412694 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus › Bacillus cereus group

Protein attributes

Sequence length	345 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the reduction of the double bond of an array of alpha, beta-unsaturated aldehydes and ketones. It also reduces the nitro group of nitroester and nitroaromatic compounds. It could have a role in detoxification processes By similarity. HAMAP MF_01614
Catalytic activity	NADPH + acceptor = NADP⁺ + reduced acceptor. HAMAP MF_01614
Cofactor	FMN By similarity. HAMAP MF_01614
Subunit structure	Homotetramer By similarity. HAMAP MF_01614
Sequence similarities	Belongs to the NADH:flavin oxidoreductase/NADH oxidase family. NamA subfamily.

Ontologies

Keywords
Ligand	FMN Flavoprotein NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	FMN binding Inferred from electronic annotation. Source: InterPro NADPH dehydrogenase activity Inferred from electronic annotation. Source: EC pentaerythritol trinitrate reductase activity Inferred from electronic annotation. Source: EC trichloro-p-hydroquinone reductive dehalogenase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 345

345

NADPH dehydrogenase HAMAP MF_01614

PRO_1000069455

Regions

Nucleotide binding

23 – 27

5

FMN By similarity

Sites

Binding site

28

1

Substrate By similarity

Binding site

164

1

Substrate By similarity

Binding site

167

1

Substrate By similarity

Binding site

215

1

FMN By similarity

Binding site

308

1

FMN By similarity

Sequences

Sequence

Length

Mass (Da)

Tools

A0RD27 [UniParc].

Last modified January 9, 2007. Version 1.
Checksum: 98DEE9C8243CABB8
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FASTA

345

38,463

        10         20         30         40         50         60 
MNSELFSPYT IKDVTLKNRI VMSPMCMYSS ENEDGQVTNF HLIHYGTRAA GQVGLVMIEA 

        70         80         90        100        110        120 
TAVLPEGRIS NKDLGIWDDS LIEGLHKTTT FIHDNGAKAA IQLAHAGRKA ELETDALAPS 

       130        140        150        160        170        180 
AVPFNETMKI PVEMSIQQIK NTILAFQQAA VRSKQAGFDV IEIHGAHGYL INEFLSPLSN 

       190        200        210        220        230        240 
KRTDEYGGSP EKRYRFLREI IDSINEVWNG PLFVRISAND YHPDGLTVQD YVQYTKWMKE 

       250        260        270        280        290        300 
QGVDLIDCSS GAVVPARIDV YPGYQVQYAK HIKEHANIAT GAVGLITTGA QAEQILTNNE 

       310        320        330        340 
ADLIFIGREL LRNPYFPRIA ANELGFELEE PYQYERAPGK ISTNK

« Hide

References

[1]

"The complete genome sequence of Bacillus thuringiensis Al Hakam."
Challacombe J.F., Altherr M.R., Xie G., Bhotika S.S., Brown N., Bruce D., Campbell C.S., Campbell M.L., Chen J., Chertkov O., Cleland C., Dimitrijevic M., Doggett N.A., Fawcett J.J., Glavina T., Goodwin L.A., Green L.D., Han C.S.

Brettin T.S.
J. Bacteriol. 189:3680-3681(2007) [PubMed: 17337577] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Al Hakam.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000485 Genomic DNA. Translation: ABK85120.1.
RefSeq	YP_894627.1. NC_008600.1.
3D structure databases
ProteinModelPortal	A0RD27.
SMR	A0RD27. Positions 4-337.
ModBase	Search...
Protein-protein interaction databases
STRING	A0RD27.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBBACT00000066532; EBBACP00000064769; EBBACG00000066523.
GeneID	4545625.
GenomeReviews	Gene locus BALH_1798 in contig CP000485_GR.
KEGG	btl:BALH_1798.
NMPDR	fig\|412694.5.peg.1788.
PATRIC	18996050. VBIBacThu63319_2027.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1902.
GeneTree	EBGT00050000002219.
HOGENOM	HBG583461.
OMA	WVEDGWN.
ProtClustDB	PRK13523.
Enzyme and pathway databases
BioCyc	BTHU412694:BALH_1798-MONOMER.
Family and domain databases
HAMAP	MF_01614. NamA. [Tree]
InterPro	IPR013785. Aldolase_TIM. IPR023663. NADPH_DH. IPR001155. OxRdtase_FMN_N. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KO	K00356.
Pfam	PF00724. Oxidored_FMN. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

NAMA_BACAH

Accession

Primary (citable) accession number: A0RD27

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	January 9, 2007
Last modified:	December 14, 2011
This is version 37 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Sites

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Family and domain databases

Entry information

Relevant documents