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Protein

DNA topoisomerase

Gene

topB

Organism
Bacillus thuringiensis (strain Al Hakam)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.SAAS annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase, TopoisomeraseSAAS annotation

Keywords - Ligandi

DNA-bindingSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
DNA topoisomeraseSAAS annotation (EC:5.99.1.2SAAS annotation)
Gene namesi
Name:topBImported
Ordered Locus Names:BALH_1686Imported
OrganismiBacillus thuringiensis (strain Al Hakam)Imported
Taxonomic identifieri412694 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
Proteomesi
  • UP000000761 Componenti: Chromosome

Structurei

3D structure databases

ProteinModelPortaliA0RCR8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 140ToprimInterPro annotationAdd BLAST140

Sequence similaritiesi

Belongs to the type IA topoisomerase family.SAAS annotation

Phylogenomic databases

HOGENOMiHOG000086847.
KOiK03169.
OMAiMSRACAD.

Family and domain databases

CDDicd00186. TOP1Ac. 1 hit.
Gene3Di1.10.460.10. 2 hits.
2.70.20.10. 2 hits.
3.40.50.140. 1 hit.
InterProiIPR000380. Topo_IA.
IPR003601. Topo_IA_2.
IPR023406. Topo_IA_AS.
IPR013497. Topo_IA_cen.
IPR013824. Topo_IA_cen_sub1.
IPR013825. Topo_IA_cen_sub2.
IPR023405. Topo_IA_core_domain.
IPR003602. Topo_IA_DNA-bd_dom.
IPR005738. TopoIII.
IPR025589. Toprim_C_rpt.
IPR006171. Toprim_domain.
[Graphical view]
PANTHERiPTHR11390. PTHR11390. 2 hits.
PfamiPF01131. Topoisom_bac. 1 hit.
PF01751. Toprim. 1 hit.
PF13342. Toprim_Crpt. 1 hit.
[Graphical view]
PRINTSiPR00417. PRTPISMRASEI.
SMARTiSM00437. TOP1Ac. 1 hit.
SM00436. TOP1Bc. 1 hit.
SM00493. TOPRIM. 1 hit.
[Graphical view]
SUPFAMiSSF56712. SSF56712. 1 hit.
TIGRFAMsiTIGR01056. topB. 1 hit.
PROSITEiPS00396. TOPOISOMERASE_I_PROK. 1 hit.
PS50880. TOPRIM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A0RCR8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLIIAEKPD QGLALVSQFK YRRKDGYLEV EANELFPNGA YCTWAIGHLT
60 70 80 90 100
QLCNPEHYHA EWKKWSLNTL PMIPERFQFE VTKSKYKQFN VVKQLLHNPQ
110 120 130 140 150
VTEIIHAGDA GREGELIVRN IINLCNVQKP MKRLWISSLT KQAIYQGFKN
160 170 180 190 200
LLDESDTINT YYEAYTRSCA DWVVGMNASR VFSILLKKKG MNDVFSAGRV
210 220 230 240 250
QTPTLALIVK REKEIENFKS EPFWEVFATF NIEGKKYEGK WEKDNESRLK
260 270 280 290 300
DPDMANKIAA FCQGKPAEVK EMKTERKEFQ PPLLFNLSSL QATANKAFKF
310 320 330 340 350
SPKKTLDITQ ALYQKGIVSY PRSDSNYVTQ GEAATFPDIL QKLSQFDEYK
360 370 380 390 400
GLLPAPVESI MNNKRYVNEK KVTDHYAIIP TEQVTNPSRL SGDEKKIYDM
410 420 430 440 450
IVRRLIAAHY EVAIFDYTTI ITLVDERAEF ISKGKQQIQE GWRKVIFQDD
460 470 480 490 500
KDDETILPIV VEGEQGKVVK VKVKEGKTQP PKRYTEGQLI TLMKTAGKYL
510 520 530 540 550
ENEELEKVLK KTEGLGTEAT RAGIITMLKD RKYIDVKKNQ VYATDKGKVL
560 570 580 590 600
ITAIGDKILA SPEMTAKWEQ RLAEIGEGTA SPATFMEQTK KLSAKIIEDA
610 620 630 640 650
VEMSEKWDFT GLHVESIERK GSKFTTGKKV GSCKKCDGDV IDKSTFYGCS
660 670 680 690 700
NYNTTQCDFT ISKKILSKTI SQKNMTKLLK GEKTDLIKGF KKGEKTFDAK
710
LEWKDNKINF VFEN
Length:714
Mass (Da):81,587
Last modified:January 9, 2007 - v1
Checksum:iF87F63F292CC7039
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000485 Genomic DNA. Translation: ABK85011.1.
RefSeqiWP_000766776.1. NC_008600.1.

Genome annotation databases

EnsemblBacteriaiABK85011; ABK85011; BALH_1686.
KEGGibtl:BALH_1686.
PATRICi18995814. VBIBacThu63319_1909.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000485 Genomic DNA. Translation: ABK85011.1.
RefSeqiWP_000766776.1. NC_008600.1.

3D structure databases

ProteinModelPortaliA0RCR8.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABK85011; ABK85011; BALH_1686.
KEGGibtl:BALH_1686.
PATRICi18995814. VBIBacThu63319_1909.

Phylogenomic databases

HOGENOMiHOG000086847.
KOiK03169.
OMAiMSRACAD.

Family and domain databases

CDDicd00186. TOP1Ac. 1 hit.
Gene3Di1.10.460.10. 2 hits.
2.70.20.10. 2 hits.
3.40.50.140. 1 hit.
InterProiIPR000380. Topo_IA.
IPR003601. Topo_IA_2.
IPR023406. Topo_IA_AS.
IPR013497. Topo_IA_cen.
IPR013824. Topo_IA_cen_sub1.
IPR013825. Topo_IA_cen_sub2.
IPR023405. Topo_IA_core_domain.
IPR003602. Topo_IA_DNA-bd_dom.
IPR005738. TopoIII.
IPR025589. Toprim_C_rpt.
IPR006171. Toprim_domain.
[Graphical view]
PANTHERiPTHR11390. PTHR11390. 2 hits.
PfamiPF01131. Topoisom_bac. 1 hit.
PF01751. Toprim. 1 hit.
PF13342. Toprim_Crpt. 1 hit.
[Graphical view]
PRINTSiPR00417. PRTPISMRASEI.
SMARTiSM00437. TOP1Ac. 1 hit.
SM00436. TOP1Bc. 1 hit.
SM00493. TOPRIM. 1 hit.
[Graphical view]
SUPFAMiSSF56712. SSF56712. 1 hit.
TIGRFAMsiTIGR01056. topB. 1 hit.
PROSITEiPS00396. TOPOISOMERASE_I_PROK. 1 hit.
PS50880. TOPRIM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiA0RCR8_BACAH
AccessioniPrimary (citable) accession number: A0RCR8
Entry historyi
Integrated into UniProtKB/TrEMBL: January 9, 2007
Last sequence update: January 9, 2007
Last modified: November 30, 2016
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.