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A0R9W6

- UPPP2_BACAH

UniProt

A0R9W6 - UPPP2_BACAH

Protein

Undecaprenyl-diphosphatase 2

Gene

uppP2

Organism
Bacillus thuringiensis (strain Al Hakam)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 52 (01 Oct 2014)
      Sequence version 1 (09 Jan 2007)
      Previous versions | rss
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    Functioni

    Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.UniRule annotation

    Catalytic activityi

    Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

    GO - Molecular functioni

    1. undecaprenyl-diphosphatase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. dephosphorylation Source: InterPro
    2. peptidoglycan biosynthetic process Source: UniProtKB-KW
    3. regulation of cell shape Source: UniProtKB-KW
    4. response to antibiotic Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

    Enzyme and pathway databases

    BioCyciBTHU412694:GH1W-677-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Undecaprenyl-diphosphatase 2UniRule annotation (EC:3.6.1.27UniRule annotation)
    Alternative name(s):
    Bacitracin resistance protein 2UniRule annotation
    Undecaprenyl pyrophosphate phosphatase 2UniRule annotation
    Gene namesi
    Name:uppP2UniRule annotation
    Ordered Locus Names:BALH_0623
    OrganismiBacillus thuringiensis (strain Al Hakam)
    Taxonomic identifieri412694 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
    ProteomesiUP000000761: Chromosome

    Subcellular locationi

    Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 270270Undecaprenyl-diphosphatase 2PRO_0000290685Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi412694.BALH_0623.

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei5 – 2521HelicalUniRule annotationAdd
    BLAST
    Transmembranei42 – 6221HelicalUniRule annotationAdd
    BLAST
    Transmembranei89 – 10921HelicalUniRule annotationAdd
    BLAST
    Transmembranei117 – 13721HelicalUniRule annotationAdd
    BLAST
    Transmembranei192 – 21221HelicalUniRule annotationAdd
    BLAST
    Transmembranei220 – 24021HelicalUniRule annotationAdd
    BLAST
    Transmembranei250 – 27021HelicalUniRule annotationAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the UppP family.UniRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1968.
    HOGENOMiHOG000218357.
    KOiK06153.
    OMAiNANEAVD.
    OrthoDBiEOG6QP13M.

    Family and domain databases

    HAMAPiMF_01006. Undec_diphosphatase.
    InterProiIPR003824. UppP.
    [Graphical view]
    PfamiPF02673. BacA. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A0R9W6-1 [UniParc]FASTAAdd to Basket

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    MEQFYYILKY LILGLFQGLT EPIPISSSGH LVLAQHLLGL KIEGFSFELL    50
    VNSASLLAVL LIYRNDLIRL TKNGLSYIFT RAEDAKSDFF FIIYLVIATI 100
    PAGVIGVLFK DYIDQYLKGV KMVGISLLIT AVGLWIIRNL RGRKNDGDLS 150
    MKDAIIVGLA QACALIPGIS RSGATIVAAM LLGMKQETAL RFSFLLYIPV 200
    SLGGLLLSIT DIAKDPNLDT LFVPYIVAFI ATFIMTYISL KWFMNIMAKG 250
    NLKYFSFYCI IVGVLTLIFL 270
    Length:270
    Mass (Da):29,976
    Last modified:January 9, 2007 - v1
    Checksum:iA7A6AA4C7262FCDC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000485 Genomic DNA. Translation: ABK84009.1.
    RefSeqiYP_893516.1. NC_008600.1.

    Genome annotation databases

    EnsemblBacteriaiABK84009; ABK84009; BALH_0623.
    GeneIDi4542492.
    KEGGibtl:BALH_0623.
    PATRICi18993412. VBIBacThu63319_0733.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000485 Genomic DNA. Translation: ABK84009.1 .
    RefSeqi YP_893516.1. NC_008600.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 412694.BALH_0623.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABK84009 ; ABK84009 ; BALH_0623 .
    GeneIDi 4542492.
    KEGGi btl:BALH_0623.
    PATRICi 18993412. VBIBacThu63319_0733.

    Phylogenomic databases

    eggNOGi COG1968.
    HOGENOMi HOG000218357.
    KOi K06153.
    OMAi NANEAVD.
    OrthoDBi EOG6QP13M.

    Enzyme and pathway databases

    BioCyci BTHU412694:GH1W-677-MONOMER.

    Family and domain databases

    HAMAPi MF_01006. Undec_diphosphatase.
    InterProi IPR003824. UppP.
    [Graphical view ]
    Pfami PF02673. BacA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Al Hakam.

    Entry informationi

    Entry nameiUPPP2_BACAH
    AccessioniPrimary (citable) accession number: A0R9W6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 12, 2007
    Last sequence update: January 9, 2007
    Last modified: October 1, 2014
    This is version 52 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3