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A0R8Z7

- A0R8Z7_BACAH

UniProt

A0R8Z7 - A0R8Z7_BACAH

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Protein
Amidophosphoribosyltransferase
Gene
purF, BALH_0289
Organism
Bacillus thuringiensis (strain Al Hakam)
Status
Unreviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

5-phospho-beta-D-ribosylamine + diphosphate + L-glutamate = L-glutamine + 5-phospho-alpha-D-ribose 1-diphosphate + H2O.UniRule annotation

Cofactori

Binds 1 magnesium ion per subunit By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei18 – 181For GATase activity By similarityUniRule annotation

GO - Molecular functioni

  1. amidophosphoribosyltransferase activity Source: UniProtKB-EC
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
  2. nucleoside metabolic process Source: InterPro
  3. purine nucleobase biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

GlycosyltransferaseUniRule annotationImported, Transferase

Keywords - Biological processi

Purine biosynthesisUniRule annotation

Keywords - Ligandi

MagnesiumUniRule annotation, Metal-bindingUniRule annotation

Enzyme and pathway databases

BioCyciBTHU412694:GH1W-339-MONOMER.
UniPathwayiUPA00074; UER00124.

Protein family/group databases

MEROPSiC44.001.

Names & Taxonomyi

Protein namesi
Recommended name:
AmidophosphoribosyltransferaseUniRule annotation (EC:2.4.2.14UniRule annotation)
Short name:
ATaseUniRule annotation
Alternative name(s):
Glutamine phosphoribosylpyrophosphate amidotransferase
Gene namesi
Name:purFImported
Ordered Locus Names:BALH_0289Imported
OrganismiBacillus thuringiensis (strain Al Hakam)Imported
Taxonomic identifieri412694 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
ProteomesiUP000000761: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi412694.BALH_0289.

Structurei

3D structure databases

ProteinModelPortaliA0R8Z7.
SMRiA0R8Z7. Positions 18-466.

Family & Domainsi

Sequence similaritiesi

In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0034.
HOGENOMiHOG000033688.
KOiK00764.
OMAiSGIPYEM.
OrthoDBiEOG6KT2Q1.

Family and domain databases

Gene3Di3.40.50.2020. 1 hit.
3.60.20.10. 1 hit.
InterProiIPR005854. Amd_phspho_trans.
IPR017932. GATase_2_dom.
IPR029055. Ntn_hydrolases_N.
IPR000836. PRibTrfase_dom.
IPR029057. PRTase-like.
[Graphical view]
PfamiPF00156. Pribosyltran. 1 hit.
[Graphical view]
PIRSFiPIRSF000485. Amd_phspho_trans. 1 hit.
SUPFAMiSSF53271. SSF53271. 1 hit.
SSF56235. SSF56235. 1 hit.
TIGRFAMsiTIGR01134. purF. 1 hit.
PROSITEiPS51278. GATASE_TYPE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A0R8Z7-1 [UniParc]FASTAAdd to Basket

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MERGNPMLAE IKGLNEECGV FGIWGHENAA QVSYYGLHSL QHRGQEGAGI    50
VVNNGEKIVG HKGLGLISEV FSRGELEGLN GKSAIGHVRY ATAGGSEVAN 100
VQPLLFRFSD HSMALAHNGN LINAKMLRRE LEAEGSIFQT SSDTEVLLHL 150
IKRSTKDSLI ESVKEALNKV KGAFAYLLLT GNEMIVALDP NGFRPLSIGK 200
MGDAYVVASE TCAFDVVGAT YIRDVEPGEL LIINDEGIHV DRFTNEVDHA 250
ICSMEYIYFA RPDSNIAGIN VHAARKNMGK RLAAEAPIEA DVVTGVPDSS 300
ISAAIGYAEA TGIPYELGLI KNRYVGRTFI QPSQELREQG VKMKLSAVRG 350
VVEGKRVVMI DDSIVRGTTS KRIVRMLREA GATEVHVRIA SPPLKYPCFY 400
GIDIQTRKEL IAANHTVEEI REMIGADSLT FLSEDGLVDA IGRPYEGKYG 450
GLCMAYFNGD YPTALYDYEQ ELLESMK 477
Length:477
Mass (Da):52,089
Last modified:January 9, 2007 - v1
Checksum:iE92AA1B798521BB8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000485 Genomic DNA. Translation: ABK83690.1.
RefSeqiWP_011732424.1. NC_008600.1.
YP_893197.1. NC_008600.1.

Genome annotation databases

EnsemblBacteriaiABK83690; ABK83690; BALH_0289.
GeneIDi4544203.
KEGGibtl:BALH_0289.
PATRICi18992677. VBIBacThu63319_0385.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000485 Genomic DNA. Translation: ABK83690.1 .
RefSeqi WP_011732424.1. NC_008600.1.
YP_893197.1. NC_008600.1.

3D structure databases

ProteinModelPortali A0R8Z7.
SMRi A0R8Z7. Positions 18-466.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 412694.BALH_0289.

Protein family/group databases

MEROPSi C44.001.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABK83690 ; ABK83690 ; BALH_0289 .
GeneIDi 4544203.
KEGGi btl:BALH_0289.
PATRICi 18992677. VBIBacThu63319_0385.

Phylogenomic databases

eggNOGi COG0034.
HOGENOMi HOG000033688.
KOi K00764.
OMAi SGIPYEM.
OrthoDBi EOG6KT2Q1.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00124 .
BioCyci BTHU412694:GH1W-339-MONOMER.

Family and domain databases

Gene3Di 3.40.50.2020. 1 hit.
3.60.20.10. 1 hit.
InterProi IPR005854. Amd_phspho_trans.
IPR017932. GATase_2_dom.
IPR029055. Ntn_hydrolases_N.
IPR000836. PRibTrfase_dom.
IPR029057. PRTase-like.
[Graphical view ]
Pfami PF00156. Pribosyltran. 1 hit.
[Graphical view ]
PIRSFi PIRSF000485. Amd_phspho_trans. 1 hit.
SUPFAMi SSF53271. SSF53271. 1 hit.
SSF56235. SSF56235. 1 hit.
TIGRFAMsi TIGR01134. purF. 1 hit.
PROSITEi PS51278. GATASE_TYPE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Al HakamImported.

Entry informationi

Entry nameiA0R8Z7_BACAH
AccessioniPrimary (citable) accession number: A0R8Z7
Entry historyi
Integrated into UniProtKB/TrEMBL: January 9, 2007
Last sequence update: January 9, 2007
Last modified: September 3, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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