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A0R8Y3 (UPPP1_BACAH) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 58. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Undecaprenyl-diphosphatase 1

EC=3.6.1.27
Alternative name(s):
Bacitracin resistance protein 1
Undecaprenyl pyrophosphate phosphatase 1
Gene names
Name:uppP1
Synonyms:bacA
Ordered Locus Names:BALH_0274
OrganismBacillus thuringiensis (strain Al Hakam) [Complete proteome] [HAMAP]
Taxonomic identifier412694 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group

Protein attributes

Sequence length265 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006

Catalytic activity

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006

Subcellular location

Cell membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Sequence similarities

Belongs to the UppP family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 265265Undecaprenyl-diphosphatase 1 HAMAP-Rule MF_01006
PRO_0000290684

Regions

Transmembrane4 – 2421Helical; Potential
Transmembrane42 – 6221Helical; Potential
Transmembrane84 – 10421Helical; Potential
Transmembrane108 – 12821Helical; Potential
Transmembrane184 – 20421Helical; Potential
Transmembrane217 – 23721Helical; Potential
Transmembrane245 – 26521Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
A0R8Y3 [UniParc].

Last modified January 9, 2007. Version 1.
Checksum: ADC7A773B82E6053

FASTA26529,044
        10         20         30         40         50         60 
MSDIIIAFIL GIVEGLAEFL PISSTGHLIL VGHLLGFEGE RAKTFEIVIQ LGAILAIAIL 

        70         80         90        100        110        120 
YHKRLVSLCN IKPLLRKEKK FNAFHVFLGV FPAVVAGLLL HDVIKTYLFQ PYTVVIGLVA 

       130        140        150        160        170        180 
GAILMIFAEV KKQEATSYSL DDLTYRQALT IGLFQCLAVY PGFSRAGSTI SGGLLAKVNY 

       190        200        210        220        230        240 
KTASEFSFLI ALPVMVGATG LDLLKSWTYL SVDDIPMFAV GFITSFIVAM LAVVTFLKLL 

       250        260 
EKIGLKPFAY YRILLAILFT VFVLL 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000485 Genomic DNA. Translation: ABK83676.1.
RefSeqYP_893183.1. NC_008600.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING412694.BALH_0274.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABK83676; ABK83676; BALH_0274.
GeneID4544189.
KEGGbtl:BALH_0274.
PATRIC18992633. VBIBacThu63319_0369.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1968.
HOGENOMHOG000218356.
KOK06153.
OMADSITFTQ.
OrthoDBEOG6QP13M.
ProtClustDBPRK00281.

Enzyme and pathway databases

BioCycBTHU412694:GH1W-319-MONOMER.

Family and domain databases

HAMAPMF_01006. Undec_diphosphatase.
InterProIPR003824. UppP.
[Graphical view]
PfamPF02673. BacA. 1 hit.
[Graphical view]
TIGRFAMsTIGR00753. undec_PP_bacA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameUPPP1_BACAH
AccessionPrimary (citable) accession number: A0R8Y3
Entry history
Integrated into UniProtKB/Swiss-Prot: June 12, 2007
Last sequence update: January 9, 2007
Last modified: February 19, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families