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Protein

Inositol-3-phosphate synthase

Gene

ino1

Organism
Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the conversion of glucose 6-phosphate to 1D-myo-inositol 3-phosphate.By similarity

Miscellaneous

Was identified as a natural substrate of the M.smegmatis proteasome.

Catalytic activityi

D-glucose 6-phosphate = 1D-myo-inositol 3-phosphate.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processInositol biosynthesis

Enzyme and pathway databases

BioCyciMSME246196:G1H7P-6867-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Inositol-3-phosphate synthase (EC:5.5.1.4)
Short name:
IPS
Alternative name(s):
Myo-inositol 1-phosphate synthase
Short name:
MI-1-P synthase
Short name:
MIP synthase
Gene namesi
Name:ino1
Ordered Locus Names:MSMEG_6904, MSMEI_6720
OrganismiMycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Taxonomic identifieri246196 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium fortuitum complex
Proteomesi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003834791 – 363Inositol-3-phosphate synthaseAdd BLAST363

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki65Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-Cter in protein Pup)2 Publications

Post-translational modificationi

Pupylated at Lys-65 by the prokaryotic ubiquitin-like protein Pup, which leads to its degradation by the proteasome.2 Publications

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Interactioni

Protein-protein interaction databases

STRINGi246196.MSMEG_6904

Structurei

3D structure databases

ProteinModelPortaliA0R7G6
SMRiA0R7G6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105CZA Bacteria
COG1260 LUCA
HOGENOMiHOG000224236
KOiK01858
OMAiCFLRMEG
OrthoDBiPOG091H08GX

Family and domain databases

InterProiView protein in InterPro
IPR002587 Myo-inos-1-P_Synthase
IPR017815 Myo-inos-1-P_Synthase_actino
IPR013021 Myo-inos-1-P_Synthase_GAPDH
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF01658 Inos-1-P_synth, 1 hit
PIRSFiPIRSF015578 Myoinos-ppht_syn, 1 hit
SUPFAMiSSF51735 SSF51735, 2 hits
TIGRFAMsiTIGR03450 mycothiol_INO1, 1 hit

Sequencei

Sequence statusi: Complete.

A0R7G6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEHAGEIRV AIVGVGNCAS SLVQGVQYYR NADENTTVPG LMHVKFGPYH
60 70 80 90 100
VRDVNFVAAF DVDAKKVGFD LSEAIFASEN NTIKIADVPP TDVIVQRGPT
110 120 130 140 150
LDGIGKYYAD TIEVSDAEPV DVVKVLKEAE VDVLVSYLPV GSEEADKFYA
160 170 180 190 200
QCAIDAGVAF VNALPVFIAS DPVWAKKFED AGVPIVGDDI KSQVGATITH
210 220 230 240 250
RVMAKLFEDR GVTLDRTYQL NVGGNMDFLN MLERSRLESK KVSKTQAVTS
260 270 280 290 300
NLSGALAGKV EDKNVHIGPS DHVAWLDDRK WAYVRLEGRA FGDVPLNLEY
310 320 330 340 350
KLEVWDSPNS AGVIIDAVRA AKIAKDRGIG GPIEAASAYL MKSPPKQLAD
360
DVARAELETF IEG
Length:363
Mass (Da):39,300
Last modified:January 9, 2007 - v1
Checksum:i931F94699B6C8BD4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000480 Genomic DNA Translation: ABK72827.1
CP001663 Genomic DNA Translation: AFP43146.1
RefSeqiWP_011731620.1, NZ_CP009494.1
YP_891104.1, NC_008596.1

Genome annotation databases

EnsemblBacteriaiABK72827; ABK72827; MSMEG_6904
AFP43146; AFP43146; MSMEI_6720
GeneIDi4532403
KEGGimsb:LJ00_34115
msg:MSMEI_6720
msm:MSMEG_6904
PATRICifig|246196.19.peg.6725

Similar proteinsi

Entry informationi

Entry nameiINO1_MYCS2
AccessioniPrimary (citable) accession number: A0R7G6
Secondary accession number(s): I7GGA1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: January 9, 2007
Last modified: May 23, 2018
This is version 77 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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