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Protein

Inositol-3-phosphate synthase

Gene

ino1

Organism
Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the conversion of glucose 6-phosphate to 1D-myo-inositol 3-phosphate.By similarity

Catalytic activityi

D-glucose 6-phosphate = 1D-myo-inositol 3-phosphate.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Inositol biosynthesis

Enzyme and pathway databases

BioCyciMSME246196:GJ4Y-6903-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Inositol-3-phosphate synthase (EC:5.5.1.4)
Short name:
IPS
Alternative name(s):
Myo-inositol 1-phosphate synthase
Short name:
MI-1-P synthase
Short name:
MIP synthase
Gene namesi
Name:ino1
Ordered Locus Names:MSMEG_6904, MSMEI_6720
OrganismiMycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Taxonomic identifieri246196 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000006158 Componenti: Chromosome
  • UP000000757 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 363363Inositol-3-phosphate synthasePRO_0000383479Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki65 – 65Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-Cter in protein Pup)2 Publications

Post-translational modificationi

Pupylated at Lys-65 by the prokaryotic ubiquitin-like protein Pup, which leads to its degradation by the proteasome.2 Publications

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Interactioni

Protein-protein interaction databases

STRINGi246196.MSMEG_6904.

Structurei

3D structure databases

ProteinModelPortaliA0R7G6.
SMRiA0R7G6. Positions 7-363.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105CZA. Bacteria.
COG1260. LUCA.
HOGENOMiHOG000224236.
KOiK01858.
OMAiLVCYLPV.
OrthoDBiPOG091H08GX.

Family and domain databases

Gene3Di3.40.50.720. 2 hits.
InterProiIPR002587. Myo-inos-1-P_Synthase.
IPR017815. Myo-inos-1-P_Synthase_actino.
IPR013021. Myo-inos-1-P_Synthase_GAPDH.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11510. PTHR11510. 1 hit.
PfamiPF01658. Inos-1-P_synth. 1 hit.
[Graphical view]
PIRSFiPIRSF015578. Myoinos-ppht_syn. 1 hit.
SUPFAMiSSF51735. SSF51735. 2 hits.
TIGRFAMsiTIGR03450. mycothiol_INO1. 1 hit.

Sequencei

Sequence statusi: Complete.

A0R7G6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEHAGEIRV AIVGVGNCAS SLVQGVQYYR NADENTTVPG LMHVKFGPYH
60 70 80 90 100
VRDVNFVAAF DVDAKKVGFD LSEAIFASEN NTIKIADVPP TDVIVQRGPT
110 120 130 140 150
LDGIGKYYAD TIEVSDAEPV DVVKVLKEAE VDVLVSYLPV GSEEADKFYA
160 170 180 190 200
QCAIDAGVAF VNALPVFIAS DPVWAKKFED AGVPIVGDDI KSQVGATITH
210 220 230 240 250
RVMAKLFEDR GVTLDRTYQL NVGGNMDFLN MLERSRLESK KVSKTQAVTS
260 270 280 290 300
NLSGALAGKV EDKNVHIGPS DHVAWLDDRK WAYVRLEGRA FGDVPLNLEY
310 320 330 340 350
KLEVWDSPNS AGVIIDAVRA AKIAKDRGIG GPIEAASAYL MKSPPKQLAD
360
DVARAELETF IEG
Length:363
Mass (Da):39,300
Last modified:January 9, 2007 - v1
Checksum:i931F94699B6C8BD4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000480 Genomic DNA. Translation: ABK72827.1.
CP001663 Genomic DNA. Translation: AFP43146.1.
RefSeqiWP_011731620.1. NZ_CP009494.1.
YP_891104.1. NC_008596.1.

Genome annotation databases

EnsemblBacteriaiABK72827; ABK72827; MSMEG_6904.
AFP43146; AFP43146; MSMEI_6720.
GeneIDi4532403.
KEGGimsb:LJ00_34115.
msg:MSMEI_6720.
msm:MSMEG_6904.
PATRICi18086026. VBIMycSme59918_6725.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000480 Genomic DNA. Translation: ABK72827.1.
CP001663 Genomic DNA. Translation: AFP43146.1.
RefSeqiWP_011731620.1. NZ_CP009494.1.
YP_891104.1. NC_008596.1.

3D structure databases

ProteinModelPortaliA0R7G6.
SMRiA0R7G6. Positions 7-363.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi246196.MSMEG_6904.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABK72827; ABK72827; MSMEG_6904.
AFP43146; AFP43146; MSMEI_6720.
GeneIDi4532403.
KEGGimsb:LJ00_34115.
msg:MSMEI_6720.
msm:MSMEG_6904.
PATRICi18086026. VBIMycSme59918_6725.

Phylogenomic databases

eggNOGiENOG4105CZA. Bacteria.
COG1260. LUCA.
HOGENOMiHOG000224236.
KOiK01858.
OMAiLVCYLPV.
OrthoDBiPOG091H08GX.

Enzyme and pathway databases

BioCyciMSME246196:GJ4Y-6903-MONOMER.

Family and domain databases

Gene3Di3.40.50.720. 2 hits.
InterProiIPR002587. Myo-inos-1-P_Synthase.
IPR017815. Myo-inos-1-P_Synthase_actino.
IPR013021. Myo-inos-1-P_Synthase_GAPDH.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11510. PTHR11510. 1 hit.
PfamiPF01658. Inos-1-P_synth. 1 hit.
[Graphical view]
PIRSFiPIRSF015578. Myoinos-ppht_syn. 1 hit.
SUPFAMiSSF51735. SSF51735. 2 hits.
TIGRFAMsiTIGR03450. mycothiol_INO1. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiINO1_MYCS2
AccessioniPrimary (citable) accession number: A0R7G6
Secondary accession number(s): I7GGA1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: January 9, 2007
Last modified: September 7, 2016
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Was identified as a natural substrate of the M.smegmatis proteasome.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.