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Protein

D-erythrulose-4-phosphate isomerase 2

Gene

derI2

Organism
Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the isomerization of D-erythrulose-4P to D-erythrose-4P. Involved in the degradation pathways of L-threitol, D-threitol and erythritol, that allow M.smegmatis to grow on these compounds as the sole carbon source.1 Publication

Catalytic activityi

D-erythrulose 4-phosphate = D-erythrose 4-phosphate.1 Publication

Pathwayi: erythritol degradation

This protein is involved in the pathway erythritol degradation, which is part of Carbohydrate metabolism.1 Publication
View all proteins of this organism that are known to be involved in the pathway erythritol degradation and in Carbohydrate metabolism.

Pathwayi: D-threitol degradation

This protein is involved in the pathway D-threitol degradation, which is part of Carbohydrate metabolism.1 Publication
View all proteins of this organism that are known to be involved in the pathway D-threitol degradation and in Carbohydrate metabolism.

Pathwayi: L-threitol degradation

This protein is involved in the pathway L-threitol degradation, which is part of Carbohydrate metabolism.1 Publication
View all proteins of this organism that are known to be involved in the pathway L-threitol degradation and in Carbohydrate metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei70Proton acceptorBy similarity1

GO - Molecular functioni

GO - Biological processi

  • carbohydrate catabolic process Source: UniProtKB
  • carbohydrate utilization Source: UniProtKB
  • cellular response to carbohydrate stimulus Source: UniProtKB

Keywordsi

Molecular functionIsomerase
Biological processCarbohydrate metabolism

Enzyme and pathway databases

UniPathwayiUPA01065
UPA01066
UPA01067

Names & Taxonomyi

Protein namesi
Recommended name:
D-erythrulose-4-phosphate isomerase 21 Publication (EC:5.3.1.341 Publication)
Gene namesi
Name:derI21 Publication
Ordered Locus Names:MSMEG_6787Imported, MSMEI_6604Imported
OrganismiMycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Taxonomic identifieri246196 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium fortuitum complex
Proteomesi
  • UP000006158 Componenti: Chromosome
  • UP000000757 Componenti: Chromosome

Pathology & Biotechi

Disruption phenotypei

Cells lacking this gene are totally unable to grow on L-threitol. Cells lacking both derI1 and derI2 are totally unable to grow on D-threitol or on erythritol.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004355181 – 152D-erythrulose-4-phosphate isomerase 2Add BLAST152

Interactioni

Protein-protein interaction databases

STRINGi246196.MSMEG_6787

Structurei

3D structure databases

ProteinModelPortaliA0R757
SMRiA0R757
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LacAB/RpiB family.Curated

Phylogenomic databases

eggNOGiENOG4107YVI Bacteria
COG0698 LUCA
HOGENOMiHOG000226301
KOiK01808
OMAiSKQHNNT
OrthoDBiPOG091H00EO

Family and domain databases

Gene3Di3.40.1400.10, 1 hit
InterProiView protein in InterPro
IPR011860 Rib-5-P_Isoase
IPR003500 RpiB_LacA_LacB
IPR036569 RpiB_LacA_LacB_sf
PfamiView protein in Pfam
PF02502 LacAB_rpiB, 1 hit
PIRSFiPIRSF005384 RpiB_LacA_B, 1 hit
SUPFAMiSSF89623 SSF89623, 1 hit
TIGRFAMsiTIGR02133 RPI_actino, 1 hit
TIGR00689 rpiB_lacA_lacB, 1 hit

Sequencei

Sequence statusi: Complete.

A0R757-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALKIVIGGD NAGFNYKEAL RKDLEADDRV ASVEDVGVGG VDDTTSYPNV
60 70 80 90 100
AVAAAEKVAR GEADRALLIC GTGLGVAIAA NKVKGIRAVT AHDVYSVQRS
110 120 130 140 150
VLSNNAQVLC MGERVVGLEL ARALVKEWLG LEFDPQSASA AKVNDICAYE

GA
Length:152
Mass (Da):15,849
Last modified:January 9, 2007 - v1
Checksum:i9DAB1894937EC464
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000480 Genomic DNA Translation: ABK71442.1
CP001663 Genomic DNA Translation: AFP43030.1
RefSeqiWP_011731539.1, NZ_CP009494.1
YP_890995.1, NC_008596.1

Genome annotation databases

EnsemblBacteriaiABK71442; ABK71442; MSMEG_6787
AFP43030; AFP43030; MSMEI_6604
GeneIDi4531552
KEGGimsb:LJ00_33535
msg:MSMEI_6604
msm:MSMEG_6787
PATRICifig|246196.19.peg.6607

Similar proteinsi

Entry informationi

Entry nameiDERI2_MYCS2
AccessioniPrimary (citable) accession number: A0R757
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 17, 2016
Last sequence update: January 9, 2007
Last modified: May 23, 2018
This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
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