A0R6M2 (A0R6M2_MYCS2) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
6,7-dimethyl-8-ribityllumazine synthase 2 HAMAP MF_00178
Short name=DMRL synthase 2 HAMAP MF_00178
Short name=Lumazine synthase 2 HAMAP MF_00178
EC=2.5.1.9 HAMAP MF_00178

Alternative name(s):
Riboflavin synthase beta chain 2 HAMAP MF_00178

Gene names

Name:	ribH2 HAMAP MF_00178
Ordered Locus Names:	MSMEG_6598

Organism

Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155) EMBL ABK71269.1

Taxonomic identifier

246196 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length	150 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Riboflavin synthase is a bifunctional enzyme complex catalyzing the formation of riboflavin from 5-amino-6-(1'-D)-ribityl-amino-2,4(1H,3H)-pyrimidinedione and L-3,4-dihydrohy-2-butanone-4-phosphate via 6,7-dimethyl-8-lumazine. The beta subunit catalyzes the condensation of 5-amino-6-(1'-D)-ribityl-amino-2,4(1H,3H)-pyrimidinedione with L-3,4-dihydrohy-2-butanone-4-phosphate yielding 6,7-dimethyl-8-lumazine By similarity. HAMAP MF_00178
Catalytic activity	2 6,7-dimethyl-8-(1-D-ribityl)lumazine = riboflavin + 4-(1-D-ribitylamino)-5-amino-2,6-dihydroxypyrimidine. HAMAP MF_00178
Pathway	Cofactor biosynthesis; riboflavin biosynthesis; riboflavin from 2-hydroxy-3-oxobutyl phosphate and 5-amino-6-(D-ribitylamino)uracil: step 2/2. HAMAP MF_00178
Sequence similarities	Belongs to the DMRL synthase family. HAMAP MF_00178

Ontologies

Keywords
Biological process	Riboflavin biosynthesis HAMAP MF_00178
Molecular function	Transferase HAMAP MF_00178
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	riboflavin biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	riboflavin synthase complex Inferred from electronic annotation. Source: InterPro
Molecular function	riboflavin synthase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	A0R6M2 [UniParc]. Last modified January 9, 2007. Version 1. Checksum: E52DAF3771204187	FASTA	150	16,458
	10 20 30 40 50 60 MSDVATQIAF VQATWHRNIV DQARAGFTDR INGLGFSSDT LEFFEVPGAF EIPLTAKRLA 70 80 90 100 110 120 KTGRYRAIVA AGLVVDGGIY RHEFVATAVI DGLMRVQLDT DVPVFSVVLT PHHFHEHDEH 130 140 150 VRYFAEHFVK KGAEAANAVA ATLELHASLG

References

[1]	Fleischmann R.D., Dodson R.J., Haft D.H., Merkel J.S., Nelson W.C., Fraser C.M. Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700084 / mc(2)155.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000480 Genomic DNA. Translation: ABK71269.1.
RefSeq	YP_890810.1. NC_008596.1.
3D structure databases
ProteinModelPortal	A0R6M2.
SMR	A0R6M2. Positions 7-138.
ModBase	Search...
Protein-protein interaction databases
STRING	A0R6M2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBMYCT00000045675; EBMYCP00000044012; EBMYCG00000045670.
GeneID	4537642.
GenomeReviews	Gene locus MSMEG_6598 in contig CP000480_GR.
KEGG	msm:MSMEG_6598.
NMPDR	fig|246196.1.peg.6559.
PATRIC	18085419. VBIMycSme59918_6422.
TIGR	MSMEG_6598.
Phylogenomic databases
eggNOG	COG0054.
GeneTree	EBGT00050000016935.
HOGENOM	HBG311126.
OMA	RRYTAIV.
ProtClustDB	PRK12419.
Family and domain databases
HAMAP	MF_00178. Lumazine_synth. [Tree]
InterPro	IPR002180. DMRL_synthase. [Graphical view]
Gene3D	G3DSA:3.40.50.960. DMRL_synthase. 1 hit.
KO	K00794.
PANTHER	PTHR21058. DMRL_synthase. 1 hit.
Pfam	PF00885. DMRL_synthase. 1 hit. [Graphical view]
SUPFAM	SSF52121. DMRL_synthase. 1 hit.
TIGRFAMs	TIGR00114. Lumazine-synth. 1 hit.
ProtoNet	Search...

Entry information

Entry name

A0R6M2_MYCS2

Accession

Primary (citable) accession number: A0R6M2

Entry history

Integrated into UniProtKB/TrEMBL:	January 9, 2007
Last sequence update:	January 9, 2007
Last modified:	December 14, 2011
This is version 41 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)