ID   A0R6I8_MYCS2            Unreviewed;       189 AA.
AC   A0R6I8;
DT   09-JAN-2007, integrated into UniProtKB/TrEMBL.
DT   09-JAN-2007, sequence version 1.
DT   27-MAR-2024, entry version 118.
DE   SubName: Full=Transcriptional regulator, TetR family protein {ECO:0000313|EMBL:ABK75087.1};
GN   OrderedLocusNames=MSMEG_6564 {ECO:0000313|EMBL:ABK75087.1};
OS   Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) (Mycobacterium
OS   smegmatis).
OC   Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC   Mycolicibacterium.
OX   NCBI_TaxID=246196 {ECO:0000313|EMBL:ABK75087.1, ECO:0000313|Proteomes:UP000000757};
RN   [1] {ECO:0000313|EMBL:ABK75087.1, ECO:0000313|Proteomes:UP000000757}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700084 / mc(2)155 {ECO:0000313|Proteomes:UP000000757};
RA   Fleischmann R.D., Dodson R.J., Haft D.H., Merkel J.S., Nelson W.C.,
RA   Fraser C.M.;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0007829|PDB:4JKZ, ECO:0007829|PDB:4JL3}
RP   X-RAY CRYSTALLOGRAPHY (1.80 ANGSTROMS) OF 8-189.
RX   PubMed=23803605; DOI=10.1074/jbc.m113.468694;
RA   Yang S., Gao Z., Li T., Yang M., Zhang T., Dong Y., He Z.G.;
RT   "Structural basis for interaction between Mycobacterium smegmatis Ms6564, a
RT   TetR family master regulator, and its target DNA.";
RL   J. Biol. Chem. 288:23687-23695(2013).
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DR   EMBL; CP000480; ABK75087.1; -; Genomic_DNA.
DR   RefSeq; WP_011731364.1; NZ_SIJM01000054.1.
DR   RefSeq; YP_890776.1; NC_008596.1.
DR   PDB; 4JKZ; X-ray; 1.80 A; A=8-189.
DR   PDB; 4JL3; X-ray; 2.50 A; A/B/C/D=9-189.
DR   PDBsum; 4JKZ; -.
DR   PDBsum; 4JL3; -.
DR   AlphaFoldDB; A0R6I8; -.
DR   SMR; A0R6I8; -.
DR   STRING; 246196.MSMEG_6564; -.
DR   PaxDb; 246196-MSMEI_6387; -.
DR   GeneID; 66737831; -.
DR   KEGG; msm:MSMEG_6564; -.
DR   PATRIC; fig|246196.19.peg.6388; -.
DR   eggNOG; COG1309; Bacteria.
DR   OrthoDB; 9796019at2; -.
DR   Proteomes; UP000000757; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:UniProt.
DR   Gene3D; 1.10.357.10; Tetracycline Repressor, domain 2; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR001647; HTH_TetR.
DR   InterPro; IPR036271; Tet_transcr_reg_TetR-rel_C_sf.
DR   InterPro; IPR011075; TetR_C.
DR   PANTHER; PTHR30055; HTH-TYPE TRANSCRIPTIONAL REGULATOR RUTR; 1.
DR   PANTHER; PTHR30055:SF164; TRANSCRIPTIONAL REPRESSOR MCE3R; 1.
DR   Pfam; PF16859; TetR_C_11; 1.
DR   Pfam; PF00440; TetR_N; 1.
DR   PRINTS; PR00455; HTHTETR.
DR   SUPFAM; SSF46689; Homeodomain-like; 1.
DR   SUPFAM; SSF48498; Tetracyclin repressor-like, C-terminal domain; 1.
DR   PROSITE; PS50977; HTH_TETR_2; 1.
PE   1: Evidence at protein level;
KW   3D-structure {ECO:0007829|PDB:4JKZ, ECO:0007829|PDB:4JL3};
KW   DNA-binding {ECO:0000256|PROSITE-ProRule:PRU00335};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000757};
KW   Transcription {ECO:0000256|ARBA:ARBA00023163};
KW   Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT   DOMAIN          12..72
FT                   /note="HTH tetR-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50977"
FT   DNA_BIND        35..54
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00335"
SQ   SEQUENCE   189 AA;  20537 MW;  122895106954AF58 CRC64;
     MTTAEAPRRR SEKSRVAIVE ATRALLLERG FDGLSIEAVA AKAGVGKQTI YRWWPSRHAL
     VADVLLEDAD KILARMPKTD DVTADLASWA GTLAAALTTR RGHAMLKTLM AASLEHEDTA
     ARLREGFSRP LIESVRDRLR DEDIDADHAQ AAADALLGAV VNAVLSEGRS YSRQRAETSA
     RIIVAGLRP
//