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A0R666

- ETHR_MYCS2

UniProt

A0R666 - ETHR_MYCS2

Protein

HTH-type transcriptional regulator EthR

Gene

ethR

Organism
Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 57 (01 Oct 2014)
      Sequence version 1 (09 Jan 2007)
      Previous versions | rss
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    Functioni

    Involved in the repression of teh monooxygenase EthA which is responsible of the formation of the active metabolite of ethionamide (ETH).1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei173 – 1731Inhibitor-bindingBy similarity
    Sitei176 – 1761Inhibitor-bindingBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi44 – 6320H-T-H motifPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW

    GO - Biological processi

    1. negative regulation of transcription, DNA-templated Source: UniProtKB
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Repressor

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Enzyme and pathway databases

    BioCyciMSME246196:GJ4Y-6440-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    HTH-type transcriptional regulator EthR
    Gene namesi
    Name:ethR
    Ordered Locus Names:MSMEG_6441, MSMEI_6273
    OrganismiMycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
    Taxonomic identifieri246196 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
    ProteomesiUP000000757: Chromosome, UP000006158: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 217217HTH-type transcriptional regulator EthRPRO_0000398580Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Protein-protein interaction databases

    STRINGi246196.MSMEG_6441.

    Structurei

    3D structure databases

    ProteinModelPortaliA0R666.
    SMRiA0R666. Positions 20-210.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini21 – 8161HTH tetR-typePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 HTH tetR-type DNA-binding domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG1309.
    HOGENOMiHOG000054523.
    OMAiFMQKWID.
    OrthoDBiEOG67DPRF.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    1.10.357.10. 1 hit.
    InterProiIPR009057. Homeodomain-like.
    IPR001647. HTH_TetR.
    IPR015893. Tet_transcr_reg_TetR-like_C.
    IPR011075. Tet_transcr_reg_TetR-rel_C.
    [Graphical view]
    PfamiPF00440. TetR_N. 1 hit.
    [Graphical view]
    PRINTSiPR00455. HTHTETR.
    SUPFAMiSSF46689. SSF46689. 1 hit.
    SSF48498. SSF48498. 1 hit.
    PROSITEiPS50977. HTH_TETR_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A0R666-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTTASQTRTP RGRRSARPSG DDREAAILAT AQRLLETKKF AEISVDDLAK    50
    GAGISRPTFY FYFPSKEAVL LSLIDPLIKR ADSGFDNAVE SMPADPQRAI 100
    RRGIEIFFNS FGSHPATARA GTEALKSSPE FKEFWSGLMQ KWIAATAALI 150
    TAERERGAAP DTIPALDLAT SLNLMNERTM MAALADEQPG VAPEKVVATL 200
    THIWLNSIYG TLPVGTA 217
    Length:217
    Mass (Da):23,512
    Last modified:January 9, 2007 - v1
    Checksum:i37BDD17023464AC5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000480 Genomic DNA. Translation: ABK70466.1.
    CP001663 Genomic DNA. Translation: AFP42699.1.
    RefSeqiWP_011731283.1. NC_018289.1.
    YP_006570994.1. NC_018289.1.
    YP_890654.1. NC_008596.1.

    Genome annotation databases

    EnsemblBacteriaiABK70466; ABK70466; MSMEG_6441.
    AFP42699; AFP42699; MSMEI_6273.
    GeneIDi4535770.
    KEGGimsg:MSMEI_6273.
    msm:MSMEG_6441.
    PATRICi18085107. VBIMycSme59918_6266.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000480 Genomic DNA. Translation: ABK70466.1 .
    CP001663 Genomic DNA. Translation: AFP42699.1 .
    RefSeqi WP_011731283.1. NC_018289.1.
    YP_006570994.1. NC_018289.1.
    YP_890654.1. NC_008596.1.

    3D structure databases

    ProteinModelPortali A0R666.
    SMRi A0R666. Positions 20-210.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 246196.MSMEG_6441.

    Chemistry

    ChEMBLi CHEMBL2163179.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABK70466 ; ABK70466 ; MSMEG_6441 .
    AFP42699 ; AFP42699 ; MSMEI_6273 .
    GeneIDi 4535770.
    KEGGi msg:MSMEI_6273.
    msm:MSMEG_6441.
    PATRICi 18085107. VBIMycSme59918_6266.

    Phylogenomic databases

    eggNOGi COG1309.
    HOGENOMi HOG000054523.
    OMAi FMQKWID.
    OrthoDBi EOG67DPRF.

    Enzyme and pathway databases

    BioCyci MSME246196:GJ4Y-6440-MONOMER.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    1.10.357.10. 1 hit.
    InterProi IPR009057. Homeodomain-like.
    IPR001647. HTH_TetR.
    IPR015893. Tet_transcr_reg_TetR-like_C.
    IPR011075. Tet_transcr_reg_TetR-rel_C.
    [Graphical view ]
    Pfami PF00440. TetR_N. 1 hit.
    [Graphical view ]
    PRINTSi PR00455. HTHTETR.
    SUPFAMi SSF46689. SSF46689. 1 hit.
    SSF48498. SSF48498. 1 hit.
    PROSITEi PS50977. HTH_TETR_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Fleischmann R.D., Dodson R.J., Haft D.H., Merkel J.S., Nelson W.C., Fraser C.M.
      Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700084 / mc(2)155.
    2. "Interrupted coding sequences in Mycobacterium smegmatis: authentic mutations or sequencing errors?"
      Deshayes C., Perrodou E., Gallien S., Euphrasie D., Schaeffer C., Van-Dorsselaer A., Poch O., Lecompte O., Reyrat J.-M.
      Genome Biol. 8:R20.1-R20.9(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700084 / mc(2)155.
    3. "Ortho-proteogenomics: multiple proteomes investigation through orthology and a new MS-based protocol."
      Gallien S., Perrodou E., Carapito C., Deshayes C., Reyrat J.-M., Van Dorsselaer A., Poch O., Schaeffer C., Lecompte O.
      Genome Res. 19:128-135(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700084 / mc(2)155.
    4. Cited for: FUNCTION AS A REPRESSOR ETHA.

    Entry informationi

    Entry nameiETHR_MYCS2
    AccessioniPrimary (citable) accession number: A0R666
    Secondary accession number(s): I7GGF8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 5, 2010
    Last sequence update: January 9, 2007
    Last modified: October 1, 2014
    This is version 57 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3