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A0R666

- ETHR_MYCS2

UniProt

A0R666 - ETHR_MYCS2

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Protein

HTH-type transcriptional regulator EthR

Gene

ethR

Organism
Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

Involved in the repression of teh monooxygenase EthA which is responsible of the formation of the active metabolite of ethionamide (ETH).1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei173 – 1731Inhibitor-bindingBy similarity
Sitei176 – 1761Inhibitor-bindingBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi44 – 6320H-T-H motifPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW

GO - Biological processi

  1. negative regulation of transcription, DNA-templated Source: UniProtKB
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciMSME246196:GJ4Y-6440-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
HTH-type transcriptional regulator EthR
Gene namesi
Name:ethR
Ordered Locus Names:MSMEG_6441, MSMEI_6273
OrganismiMycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Taxonomic identifieri246196 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
ProteomesiUP000000757: Chromosome, UP000006158: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 217217HTH-type transcriptional regulator EthRPRO_0000398580Add
BLAST

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi246196.MSMEG_6441.

Structurei

3D structure databases

ProteinModelPortaliA0R666.
SMRiA0R666. Positions 20-210.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini21 – 8161HTH tetR-typePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 HTH tetR-type DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG1309.
HOGENOMiHOG000054523.
OMAiFMQKWID.
OrthoDBiEOG67DPRF.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
1.10.357.10. 1 hit.
InterProiIPR009057. Homeodomain-like.
IPR001647. HTH_TetR.
IPR015893. Tet_transcr_reg_TetR-like_C.
IPR011075. Tet_transcr_reg_TetR-rel_C.
[Graphical view]
PfamiPF00440. TetR_N. 1 hit.
[Graphical view]
PRINTSiPR00455. HTHTETR.
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF48498. SSF48498. 1 hit.
PROSITEiPS50977. HTH_TETR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A0R666-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTTASQTRTP RGRRSARPSG DDREAAILAT AQRLLETKKF AEISVDDLAK
60 70 80 90 100
GAGISRPTFY FYFPSKEAVL LSLIDPLIKR ADSGFDNAVE SMPADPQRAI
110 120 130 140 150
RRGIEIFFNS FGSHPATARA GTEALKSSPE FKEFWSGLMQ KWIAATAALI
160 170 180 190 200
TAERERGAAP DTIPALDLAT SLNLMNERTM MAALADEQPG VAPEKVVATL
210
THIWLNSIYG TLPVGTA
Length:217
Mass (Da):23,512
Last modified:January 9, 2007 - v1
Checksum:i37BDD17023464AC5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000480 Genomic DNA. Translation: ABK70466.1.
CP001663 Genomic DNA. Translation: AFP42699.1.
RefSeqiWP_011731283.1. NC_018289.1.
YP_006570994.1. NC_018289.1.
YP_890654.1. NC_008596.1.

Genome annotation databases

EnsemblBacteriaiABK70466; ABK70466; MSMEG_6441.
AFP42699; AFP42699; MSMEI_6273.
GeneIDi4535770.
KEGGimsg:MSMEI_6273.
msm:MSMEG_6441.
PATRICi18085107. VBIMycSme59918_6266.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000480 Genomic DNA. Translation: ABK70466.1 .
CP001663 Genomic DNA. Translation: AFP42699.1 .
RefSeqi WP_011731283.1. NC_018289.1.
YP_006570994.1. NC_018289.1.
YP_890654.1. NC_008596.1.

3D structure databases

ProteinModelPortali A0R666.
SMRi A0R666. Positions 20-210.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 246196.MSMEG_6441.

Chemistry

ChEMBLi CHEMBL2163179.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABK70466 ; ABK70466 ; MSMEG_6441 .
AFP42699 ; AFP42699 ; MSMEI_6273 .
GeneIDi 4535770.
KEGGi msg:MSMEI_6273.
msm:MSMEG_6441.
PATRICi 18085107. VBIMycSme59918_6266.

Phylogenomic databases

eggNOGi COG1309.
HOGENOMi HOG000054523.
OMAi FMQKWID.
OrthoDBi EOG67DPRF.

Enzyme and pathway databases

BioCyci MSME246196:GJ4Y-6440-MONOMER.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
1.10.357.10. 1 hit.
InterProi IPR009057. Homeodomain-like.
IPR001647. HTH_TetR.
IPR015893. Tet_transcr_reg_TetR-like_C.
IPR011075. Tet_transcr_reg_TetR-rel_C.
[Graphical view ]
Pfami PF00440. TetR_N. 1 hit.
[Graphical view ]
PRINTSi PR00455. HTHTETR.
SUPFAMi SSF46689. SSF46689. 1 hit.
SSF48498. SSF48498. 1 hit.
PROSITEi PS50977. HTH_TETR_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Fleischmann R.D., Dodson R.J., Haft D.H., Merkel J.S., Nelson W.C., Fraser C.M.
    Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700084 / mc(2)155.
  2. "Interrupted coding sequences in Mycobacterium smegmatis: authentic mutations or sequencing errors?"
    Deshayes C., Perrodou E., Gallien S., Euphrasie D., Schaeffer C., Van-Dorsselaer A., Poch O., Lecompte O., Reyrat J.-M.
    Genome Biol. 8:R20.1-R20.9(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700084 / mc(2)155.
  3. "Ortho-proteogenomics: multiple proteomes investigation through orthology and a new MS-based protocol."
    Gallien S., Perrodou E., Carapito C., Deshayes C., Reyrat J.-M., Van Dorsselaer A., Poch O., Schaeffer C., Lecompte O.
    Genome Res. 19:128-135(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700084 / mc(2)155.
  4. Cited for: FUNCTION AS A REPRESSOR ETHA.

Entry informationi

Entry nameiETHR_MYCS2
AccessioniPrimary (citable) accession number: A0R666
Secondary accession number(s): I7GGF8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 5, 2010
Last sequence update: January 9, 2007
Last modified: October 1, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3