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Protein

HTH-type transcriptional regulator EthR

Gene

ethR

Organism
Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in the repression of teh monooxygenase EthA which is responsible of the formation of the active metabolite of ethionamide (ETH).1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei173Inhibitor-bindingBy similarity1
Sitei176Inhibitor-bindingBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi44 – 63H-T-H motifPROSITE-ProRule annotationAdd BLAST20

GO - Molecular functioni

GO - Biological processi

  • negative regulation of transcription, DNA-templated Source: UniProtKB
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
HTH-type transcriptional regulator EthR
Gene namesi
Name:ethR
Ordered Locus Names:MSMEG_6441, MSMEI_6273
OrganismiMycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Taxonomic identifieri246196 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium fortuitum complex
Proteomesi
  • UP000006158 Componenti: Chromosome
  • UP000000757 Componenti: Chromosome

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2163179

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003985801 – 217HTH-type transcriptional regulator EthRAdd BLAST217

Proteomic databases

PRIDEiA0R666

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi246196.MSMEG_6441

Chemistry databases

BindingDBiA0R666

Structurei

3D structure databases

ProteinModelPortaliA0R666
SMRiA0R666
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini21 – 81HTH tetR-typePROSITE-ProRule annotationAdd BLAST61

Phylogenomic databases

eggNOGiENOG41060BG Bacteria
ENOG41124PG LUCA
HOGENOMiHOG000054523
KOiK21961
OMAiNERTMMA
OrthoDBiPOG091H02BD

Family and domain databases

InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR001647 HTH_TetR
IPR036271 Tet_transcr_reg_TetR-rel_C_sf
PfamiView protein in Pfam
PF00440 TetR_N, 1 hit
PRINTSiPR00455 HTHTETR
SUPFAMiSSF46689 SSF46689, 1 hit
SSF48498 SSF48498, 1 hit
PROSITEiView protein in PROSITE
PS50977 HTH_TETR_2, 1 hit

Sequencei

Sequence statusi: Complete.

A0R666-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTASQTRTP RGRRSARPSG DDREAAILAT AQRLLETKKF AEISVDDLAK
60 70 80 90 100
GAGISRPTFY FYFPSKEAVL LSLIDPLIKR ADSGFDNAVE SMPADPQRAI
110 120 130 140 150
RRGIEIFFNS FGSHPATARA GTEALKSSPE FKEFWSGLMQ KWIAATAALI
160 170 180 190 200
TAERERGAAP DTIPALDLAT SLNLMNERTM MAALADEQPG VAPEKVVATL
210
THIWLNSIYG TLPVGTA
Length:217
Mass (Da):23,512
Last modified:January 9, 2007 - v1
Checksum:i37BDD17023464AC5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000480 Genomic DNA Translation: ABK70466.1
CP001663 Genomic DNA Translation: AFP42699.1
RefSeqiWP_011731283.1, NZ_CP009494.1
YP_890654.1, NC_008596.1

Genome annotation databases

EnsemblBacteriaiABK70466; ABK70466; MSMEG_6441
AFP42699; AFP42699; MSMEI_6273
GeneIDi4535770
KEGGimsb:LJ00_31845
msg:MSMEI_6273
msm:MSMEG_6441
PATRICifig|246196.19.peg.6266

Similar proteinsi

Entry informationi

Entry nameiETHR_MYCS2
AccessioniPrimary (citable) accession number: A0R666
Secondary accession number(s): I7GGF8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 5, 2010
Last sequence update: January 9, 2007
Last modified: May 23, 2018
This is version 81 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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