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Protein

HTH-type transcriptional regulator EthR

Gene

ethR

Organism
Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the repression of teh monooxygenase EthA which is responsible of the formation of the active metabolite of ethionamide (ETH).1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei173 – 1731Inhibitor-bindingBy similarity
Sitei176 – 1761Inhibitor-bindingBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi44 – 6320H-T-H motifPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • negative regulation of transcription, DNA-templated Source: UniProtKB
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciMSME246196:GJ4Y-6440-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
HTH-type transcriptional regulator EthR
Gene namesi
Name:ethR
Ordered Locus Names:MSMEG_6441, MSMEI_6273
OrganismiMycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Taxonomic identifieri246196 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
ProteomesiUP000006158 Componenti: Chromosome UP000000757 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 217217HTH-type transcriptional regulator EthRPRO_0000398580Add
BLAST

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi246196.MSMEG_6441.

Structurei

3D structure databases

ProteinModelPortaliA0R666.
SMRiA0R666. Positions 20-210.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini21 – 8161HTH tetR-typePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 HTH tetR-type DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG1309.
HOGENOMiHOG000054523.
OMAiATSEDVW.
OrthoDBiEOG67DPRF.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
1.10.357.10. 1 hit.
InterProiIPR009057. Homeodomain-like.
IPR001647. HTH_TetR.
IPR015893. Tet_transcr_reg_TetR-like_C.
IPR011075. Tet_transcr_reg_TetR-rel_C.
[Graphical view]
PfamiPF00440. TetR_N. 1 hit.
[Graphical view]
PRINTSiPR00455. HTHTETR.
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF48498. SSF48498. 1 hit.
PROSITEiPS50977. HTH_TETR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A0R666-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTASQTRTP RGRRSARPSG DDREAAILAT AQRLLETKKF AEISVDDLAK
60 70 80 90 100
GAGISRPTFY FYFPSKEAVL LSLIDPLIKR ADSGFDNAVE SMPADPQRAI
110 120 130 140 150
RRGIEIFFNS FGSHPATARA GTEALKSSPE FKEFWSGLMQ KWIAATAALI
160 170 180 190 200
TAERERGAAP DTIPALDLAT SLNLMNERTM MAALADEQPG VAPEKVVATL
210
THIWLNSIYG TLPVGTA
Length:217
Mass (Da):23,512
Last modified:January 9, 2007 - v1
Checksum:i37BDD17023464AC5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000480 Genomic DNA. Translation: ABK70466.1.
CP001663 Genomic DNA. Translation: AFP42699.1.
RefSeqiWP_011731283.1. NC_018289.1.
YP_006570994.1. NC_018289.1.
YP_890654.1. NC_008596.1.

Genome annotation databases

EnsemblBacteriaiABK70466; ABK70466; MSMEG_6441.
AFP42699; AFP42699; MSMEI_6273.
GeneIDi4535770.
KEGGimsm:MSMEG_6441.
PATRICi18085107. VBIMycSme59918_6266.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000480 Genomic DNA. Translation: ABK70466.1.
CP001663 Genomic DNA. Translation: AFP42699.1.
RefSeqiWP_011731283.1. NC_018289.1.
YP_006570994.1. NC_018289.1.
YP_890654.1. NC_008596.1.

3D structure databases

ProteinModelPortaliA0R666.
SMRiA0R666. Positions 20-210.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi246196.MSMEG_6441.

Chemistry

BindingDBiA0R666.
ChEMBLiCHEMBL2163179.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABK70466; ABK70466; MSMEG_6441.
AFP42699; AFP42699; MSMEI_6273.
GeneIDi4535770.
KEGGimsm:MSMEG_6441.
PATRICi18085107. VBIMycSme59918_6266.

Phylogenomic databases

eggNOGiCOG1309.
HOGENOMiHOG000054523.
OMAiATSEDVW.
OrthoDBiEOG67DPRF.

Enzyme and pathway databases

BioCyciMSME246196:GJ4Y-6440-MONOMER.

Miscellaneous databases

PROiA0R666.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
1.10.357.10. 1 hit.
InterProiIPR009057. Homeodomain-like.
IPR001647. HTH_TetR.
IPR015893. Tet_transcr_reg_TetR-like_C.
IPR011075. Tet_transcr_reg_TetR-rel_C.
[Graphical view]
PfamiPF00440. TetR_N. 1 hit.
[Graphical view]
PRINTSiPR00455. HTHTETR.
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF48498. SSF48498. 1 hit.
PROSITEiPS50977. HTH_TETR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Fleischmann R.D., Dodson R.J., Haft D.H., Merkel J.S., Nelson W.C., Fraser C.M.
    Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700084 / mc(2)155.
  2. "Interrupted coding sequences in Mycobacterium smegmatis: authentic mutations or sequencing errors?"
    Deshayes C., Perrodou E., Gallien S., Euphrasie D., Schaeffer C., Van-Dorsselaer A., Poch O., Lecompte O., Reyrat J.-M.
    Genome Biol. 8:R20.1-R20.9(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700084 / mc(2)155.
  3. "Ortho-proteogenomics: multiple proteomes investigation through orthology and a new MS-based protocol."
    Gallien S., Perrodou E., Carapito C., Deshayes C., Reyrat J.-M., Van Dorsselaer A., Poch O., Schaeffer C., Lecompte O.
    Genome Res. 19:128-135(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700084 / mc(2)155.
  4. Cited for: FUNCTION AS A REPRESSOR ETHA.

Entry informationi

Entry nameiETHR_MYCS2
AccessioniPrimary (citable) accession number: A0R666
Secondary accession number(s): I7GGF8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 5, 2010
Last sequence update: January 9, 2007
Last modified: May 27, 2015
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.