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A0R647

- BFRB_MYCS2

UniProt

A0R647 - BFRB_MYCS2

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Protein

Ferritin BfrB

Gene

bfrB

Organism
Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Iron-storage protein that displays ferroxidase activity, catalyzing the oxidation of Fe2+ ions into Fe3+ ions, that can then be deposited as a ferric-oxide mineral core within the central cavity of the protein complex.By similarity

Catalytic activityi

4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi22 – 221Iron 1PROSITE-ProRule annotation
Metal bindingi55 – 551Iron 1PROSITE-ProRule annotation
Metal bindingi55 – 551Iron 2PROSITE-ProRule annotation
Metal bindingi58 – 581Iron 1PROSITE-ProRule annotation
Metal bindingi99 – 991Iron 2PROSITE-ProRule annotation
Metal bindingi132 – 1321Iron 2PROSITE-ProRule annotation

GO - Molecular functioni

  1. ferric iron binding Source: InterPro
  2. ferroxidase activity Source: UniProtKB-EC

GO - Biological processi

  1. cellular iron ion homeostasis Source: UniProtKB-KW
  2. iron ion transport Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Iron storage

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

BioCyciMSME246196:GJ4Y-6421-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Ferritin BfrB (EC:1.16.3.1)
Alternative name(s):
Non-heme ferritin Ftn
Gene namesi
Name:bfrB
Synonyms:ftn
Ordered Locus Names:MSMEG_6422, MSMEI_6254
OrganismiMycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Taxonomic identifieri246196 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
ProteomesiUP000000757: Chromosome, UP000006158: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 181181Ferritin BfrBPRO_0000396101Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki10 – 10Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-Cter in protein Pup)1 Publication

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Interactioni

Subunit structurei

Homooligomer of 24 subunits that are packed together to form an approximately spherical molecule with a central cavity, in which large amounts of iron can be stored.By similarity

Protein-protein interaction databases

STRINGi246196.MSMEG_6422.

Structurei

3D structure databases

ProteinModelPortaliA0R647.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini5 – 150146Ferritin-like diironPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the ferritin family. Prokaryotic subfamily.Curated
Contains 1 ferritin-like diiron domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG1528.
HOGENOMiHOG000223382.
OMAiHFYKQAV.
OrthoDBiEOG6G4W12.

Family and domain databases

Gene3Di1.20.1260.10. 1 hit.
InterProiIPR001519. Ferritin.
IPR009040. Ferritin-like_diiron.
IPR009078. Ferritin-like_SF.
IPR012347. Ferritin-rel.
IPR008331. Ferritin_DPS_dom.
[Graphical view]
PANTHERiPTHR11431. PTHR11431. 1 hit.
PfamiPF00210. Ferritin. 1 hit.
[Graphical view]
SUPFAMiSSF47240. SSF47240. 1 hit.
PROSITEiPS50905. FERRITIN_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A0R647-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTNSGALDTK FHALIQDQIR SEFTASQQYI AIAVFFDGAD LPQLAKHFYA
60 70 80 90 100
QALEERNHAM MLVQYLLDRD VEVEIPGIDP VCNNFTTPRD ALALALDQER
110 120 130 140 150
TVTEQISRLA SVARDEGDHL GEQFMQWFLK EQVEEVAAMT TLVRIADRAG
160 170 180
SNLFHIEDFV AREMSAAGAD PTAPRAAGGA L
Length:181
Mass (Da):20,040
Last modified:January 9, 2007 - v1
Checksum:i521F00899CA34B8B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000480 Genomic DNA. Translation: ABK71142.1.
CP001663 Genomic DNA. Translation: AFP42680.1.
RefSeqiYP_006570975.1. NC_018289.1.
YP_890635.1. NC_008596.1.

Genome annotation databases

EnsemblBacteriaiABK71142; ABK71142; MSMEG_6422.
AFP42680; AFP42680; MSMEI_6254.
GeneIDi4532622.
KEGGimsm:MSMEG_6422.
PATRICi18085073. VBIMycSme59918_6249.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000480 Genomic DNA. Translation: ABK71142.1 .
CP001663 Genomic DNA. Translation: AFP42680.1 .
RefSeqi YP_006570975.1. NC_018289.1.
YP_890635.1. NC_008596.1.

3D structure databases

ProteinModelPortali A0R647.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 246196.MSMEG_6422.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABK71142 ; ABK71142 ; MSMEG_6422 .
AFP42680 ; AFP42680 ; MSMEI_6254 .
GeneIDi 4532622.
KEGGi msm:MSMEG_6422.
PATRICi 18085073. VBIMycSme59918_6249.

Phylogenomic databases

eggNOGi COG1528.
HOGENOMi HOG000223382.
OMAi HFYKQAV.
OrthoDBi EOG6G4W12.

Enzyme and pathway databases

BioCyci MSME246196:GJ4Y-6421-MONOMER.

Family and domain databases

Gene3Di 1.20.1260.10. 1 hit.
InterProi IPR001519. Ferritin.
IPR009040. Ferritin-like_diiron.
IPR009078. Ferritin-like_SF.
IPR012347. Ferritin-rel.
IPR008331. Ferritin_DPS_dom.
[Graphical view ]
PANTHERi PTHR11431. PTHR11431. 1 hit.
Pfami PF00210. Ferritin. 1 hit.
[Graphical view ]
SUPFAMi SSF47240. SSF47240. 1 hit.
PROSITEi PS50905. FERRITIN_LIKE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Fleischmann R.D., Dodson R.J., Haft D.H., Merkel J.S., Nelson W.C., Fraser C.M.
    Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700084 / mc(2)155.
  2. "Interrupted coding sequences in Mycobacterium smegmatis: authentic mutations or sequencing errors?"
    Deshayes C., Perrodou E., Gallien S., Euphrasie D., Schaeffer C., Van-Dorsselaer A., Poch O., Lecompte O., Reyrat J.-M.
    Genome Biol. 8:R20.1-R20.9(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700084 / mc(2)155.
  3. "Ortho-proteogenomics: multiple proteomes investigation through orthology and a new MS-based protocol."
    Gallien S., Perrodou E., Carapito C., Deshayes C., Reyrat J.-M., Van Dorsselaer A., Poch O., Schaeffer C., Lecompte O.
    Genome Res. 19:128-135(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700084 / mc(2)155.
  4. Cited for: PUPYLATION AT LYS-10, IDENTIFICATION BY MASS SPECTROMETRY.

Entry informationi

Entry nameiBFRB_MYCS2
AccessioniPrimary (citable) accession number: A0R647
Secondary accession number(s): I7FMX7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 10, 2010
Last sequence update: January 9, 2007
Last modified: November 26, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3