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A0R647

- BFRB_MYCS2

UniProt

A0R647 - BFRB_MYCS2

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Protein
Ferritin BfrB
Gene
bfrB, ftn, MSMEG_6422, MSMEI_6254
Organism
Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Iron-storage protein that displays ferroxidase activity, catalyzing the oxidation of Fe2+ ions into Fe3+ ions, that can then be deposited as a ferric-oxide mineral core within the central cavity of the protein complex By similarity.

Catalytic activityi

4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi22 – 221Iron 1 By similarity
Metal bindingi55 – 551Iron 1 By similarity
Metal bindingi55 – 551Iron 2 By similarity
Metal bindingi58 – 581Iron 1 By similarity
Metal bindingi99 – 991Iron 2 By similarity
Metal bindingi132 – 1321Iron 2 By similarity

GO - Molecular functioni

  1. ferric iron binding Source: InterPro
  2. ferroxidase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. cellular iron ion homeostasis Source: UniProtKB-KW
  2. iron ion transport Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Iron storage

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

BioCyciMSME246196:GJ4Y-6421-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Ferritin BfrB (EC:1.16.3.1)
Alternative name(s):
Non-heme ferritin Ftn
Gene namesi
Name:bfrB
Synonyms:ftn
Ordered Locus Names:MSMEG_6422, MSMEI_6254
OrganismiMycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Taxonomic identifieri246196 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
ProteomesiUP000000757: Chromosome, UP000006158: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 181181Ferritin BfrB
PRO_0000396101Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki10 – 10Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-Cter in protein Pup)

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Interactioni

Subunit structurei

Homooligomer of 24 subunits that are packed together to form an approximately spherical molecule with a central cavity, in which large amounts of iron can be stored By similarity.

Protein-protein interaction databases

STRINGi246196.MSMEG_6422.

Structurei

3D structure databases

ProteinModelPortaliA0R647.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini5 – 150146Ferritin-like diiron
Add
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1528.
HOGENOMiHOG000223382.
OMAiHFYKQAV.
OrthoDBiEOG6G4W12.

Family and domain databases

Gene3Di1.20.1260.10. 1 hit.
InterProiIPR001519. Ferritin.
IPR009040. Ferritin-like_diiron.
IPR009078. Ferritin-like_SF.
IPR012347. Ferritin-rel.
IPR008331. Ferritin_DPS_dom.
[Graphical view]
PANTHERiPTHR11431. PTHR11431. 1 hit.
PfamiPF00210. Ferritin. 1 hit.
[Graphical view]
SUPFAMiSSF47240. SSF47240. 1 hit.
PROSITEiPS50905. FERRITIN_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A0R647-1 [UniParc]FASTAAdd to Basket

« Hide

MTNSGALDTK FHALIQDQIR SEFTASQQYI AIAVFFDGAD LPQLAKHFYA    50
QALEERNHAM MLVQYLLDRD VEVEIPGIDP VCNNFTTPRD ALALALDQER 100
TVTEQISRLA SVARDEGDHL GEQFMQWFLK EQVEEVAAMT TLVRIADRAG 150
SNLFHIEDFV AREMSAAGAD PTAPRAAGGA L 181
Length:181
Mass (Da):20,040
Last modified:January 9, 2007 - v1
Checksum:i521F00899CA34B8B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000480 Genomic DNA. Translation: ABK71142.1.
CP001663 Genomic DNA. Translation: AFP42680.1.
RefSeqiWP_003897831.1. NC_018289.1.
YP_006570975.1. NC_018289.1.
YP_890635.1. NC_008596.1.

Genome annotation databases

EnsemblBacteriaiABK71142; ABK71142; MSMEG_6422.
AFP42680; AFP42680; MSMEI_6254.
GeneIDi4532622.
KEGGimsg:MSMEI_6254.
msm:MSMEG_6422.
PATRICi18085073. VBIMycSme59918_6249.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000480 Genomic DNA. Translation: ABK71142.1 .
CP001663 Genomic DNA. Translation: AFP42680.1 .
RefSeqi WP_003897831.1. NC_018289.1.
YP_006570975.1. NC_018289.1.
YP_890635.1. NC_008596.1.

3D structure databases

ProteinModelPortali A0R647.
ModBasei Search...

Protein-protein interaction databases

STRINGi 246196.MSMEG_6422.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABK71142 ; ABK71142 ; MSMEG_6422 .
AFP42680 ; AFP42680 ; MSMEI_6254 .
GeneIDi 4532622.
KEGGi msg:MSMEI_6254.
msm:MSMEG_6422.
PATRICi 18085073. VBIMycSme59918_6249.

Phylogenomic databases

eggNOGi COG1528.
HOGENOMi HOG000223382.
OMAi HFYKQAV.
OrthoDBi EOG6G4W12.

Enzyme and pathway databases

BioCyci MSME246196:GJ4Y-6421-MONOMER.

Family and domain databases

Gene3Di 1.20.1260.10. 1 hit.
InterProi IPR001519. Ferritin.
IPR009040. Ferritin-like_diiron.
IPR009078. Ferritin-like_SF.
IPR012347. Ferritin-rel.
IPR008331. Ferritin_DPS_dom.
[Graphical view ]
PANTHERi PTHR11431. PTHR11431. 1 hit.
Pfami PF00210. Ferritin. 1 hit.
[Graphical view ]
SUPFAMi SSF47240. SSF47240. 1 hit.
PROSITEi PS50905. FERRITIN_LIKE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Fleischmann R.D., Dodson R.J., Haft D.H., Merkel J.S., Nelson W.C., Fraser C.M.
    Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700084 / mc(2)155.
  2. "Interrupted coding sequences in Mycobacterium smegmatis: authentic mutations or sequencing errors?"
    Deshayes C., Perrodou E., Gallien S., Euphrasie D., Schaeffer C., Van-Dorsselaer A., Poch O., Lecompte O., Reyrat J.-M.
    Genome Biol. 8:R20.1-R20.9(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700084 / mc(2)155.
  3. "Ortho-proteogenomics: multiple proteomes investigation through orthology and a new MS-based protocol."
    Gallien S., Perrodou E., Carapito C., Deshayes C., Reyrat J.-M., Van Dorsselaer A., Poch O., Schaeffer C., Lecompte O.
    Genome Res. 19:128-135(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700084 / mc(2)155.
  4. Cited for: PUPYLATION AT LYS-10, IDENTIFICATION BY MASS SPECTROMETRY.

Entry informationi

Entry nameiBFRB_MYCS2
AccessioniPrimary (citable) accession number: A0R647
Secondary accession number(s): I7FMX7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 10, 2010
Last sequence update: January 9, 2007
Last modified: September 3, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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