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Protein

Ferritin BfrB

Gene

bfrB

Organism
Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Iron-storage protein that displays ferroxidase activity, catalyzing the oxidation of Fe2+ ions into Fe3+ ions, that can then be deposited as a ferric-oxide mineral core within the central cavity of the protein complex.By similarity

Catalytic activityi

4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi22Iron 1PROSITE-ProRule annotation1
Metal bindingi55Iron 1PROSITE-ProRule annotation1
Metal bindingi55Iron 2PROSITE-ProRule annotation1
Metal bindingi58Iron 1PROSITE-ProRule annotation1
Metal bindingi99Iron 2PROSITE-ProRule annotation1
Metal bindingi132Iron 2PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processIron storage
LigandIron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ferritin BfrB (EC:1.16.3.1)
Alternative name(s):
Non-heme ferritin Ftn
Gene namesi
Name:bfrB
Synonyms:ftn
Ordered Locus Names:MSMEG_6422, MSMEI_6254
OrganismiMycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Taxonomic identifieri246196 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000006158 Componenti: Chromosome
  • UP000000757 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003961011 – 181Ferritin BfrBAdd BLAST181

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki10Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-Cter in protein Pup)1 Publication

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Interactioni

Subunit structurei

Homooligomer of 24 subunits that are packed together to form an approximately spherical molecule with a central cavity, in which large amounts of iron can be stored.By similarity

Protein-protein interaction databases

STRINGi246196.MSMEG_6422.

Structurei

3D structure databases

ProteinModelPortaliA0R647.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 150Ferritin-like diironPROSITE-ProRule annotationAdd BLAST146

Sequence similaritiesi

Belongs to the ferritin family. Prokaryotic subfamily.Curated

Phylogenomic databases

eggNOGiENOG4107YEV. Bacteria.
COG1528. LUCA.
HOGENOMiHOG000223382.
OMAiQYFLDRD.
OrthoDBiPOG093I04DD.

Family and domain databases

Gene3Di1.20.1260.10. 1 hit.
InterProiView protein in InterPro
IPR001519. Ferritin.
IPR009040. Ferritin-like_diiron.
IPR009078. Ferritin-like_SF.
IPR012347. Ferritin-rel.
IPR008331. Ferritin_DPS_dom.
PANTHERiPTHR11431. PTHR11431. 1 hit.
PfamiView protein in Pfam
PF00210. Ferritin. 1 hit.
SUPFAMiSSF47240. SSF47240. 1 hit.
PROSITEiView protein in PROSITE
PS50905. FERRITIN_LIKE. 1 hit.

Sequencei

Sequence statusi: Complete.

A0R647-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTNSGALDTK FHALIQDQIR SEFTASQQYI AIAVFFDGAD LPQLAKHFYA
60 70 80 90 100
QALEERNHAM MLVQYLLDRD VEVEIPGIDP VCNNFTTPRD ALALALDQER
110 120 130 140 150
TVTEQISRLA SVARDEGDHL GEQFMQWFLK EQVEEVAAMT TLVRIADRAG
160 170 180
SNLFHIEDFV AREMSAAGAD PTAPRAAGGA L
Length:181
Mass (Da):20,040
Last modified:January 9, 2007 - v1
Checksum:i521F00899CA34B8B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000480 Genomic DNA. Translation: ABK71142.1.
CP001663 Genomic DNA. Translation: AFP42680.1.
RefSeqiWP_003897831.1. NZ_CP009494.1.
YP_890635.1. NC_008596.1.

Genome annotation databases

EnsemblBacteriaiABK71142; ABK71142; MSMEG_6422.
AFP42680; AFP42680; MSMEI_6254.
GeneIDi4532622.
KEGGimsb:LJ00_31750.
msg:MSMEI_6254.
msm:MSMEG_6422.
PATRICi18085073. VBIMycSme59918_6249.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000480 Genomic DNA. Translation: ABK71142.1.
CP001663 Genomic DNA. Translation: AFP42680.1.
RefSeqiWP_003897831.1. NZ_CP009494.1.
YP_890635.1. NC_008596.1.

3D structure databases

ProteinModelPortaliA0R647.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi246196.MSMEG_6422.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABK71142; ABK71142; MSMEG_6422.
AFP42680; AFP42680; MSMEI_6254.
GeneIDi4532622.
KEGGimsb:LJ00_31750.
msg:MSMEI_6254.
msm:MSMEG_6422.
PATRICi18085073. VBIMycSme59918_6249.

Phylogenomic databases

eggNOGiENOG4107YEV. Bacteria.
COG1528. LUCA.
HOGENOMiHOG000223382.
OMAiQYFLDRD.
OrthoDBiPOG093I04DD.

Family and domain databases

Gene3Di1.20.1260.10. 1 hit.
InterProiView protein in InterPro
IPR001519. Ferritin.
IPR009040. Ferritin-like_diiron.
IPR009078. Ferritin-like_SF.
IPR012347. Ferritin-rel.
IPR008331. Ferritin_DPS_dom.
PANTHERiPTHR11431. PTHR11431. 1 hit.
PfamiView protein in Pfam
PF00210. Ferritin. 1 hit.
SUPFAMiSSF47240. SSF47240. 1 hit.
PROSITEiView protein in PROSITE
PS50905. FERRITIN_LIKE. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiBFRB_MYCS2
AccessioniPrimary (citable) accession number: A0R647
Secondary accession number(s): I7FMX7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 10, 2010
Last sequence update: January 9, 2007
Last modified: February 15, 2017
This is version 68 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.