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A0R647

- BFRB_MYCS2

UniProt

A0R647 - BFRB_MYCS2

Protein

Ferritin BfrB

Gene

bfrB

Organism
Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 55 (01 Oct 2014)
      Sequence version 1 (09 Jan 2007)
      Previous versions | rss
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    Functioni

    Iron-storage protein that displays ferroxidase activity, catalyzing the oxidation of Fe2+ ions into Fe3+ ions, that can then be deposited as a ferric-oxide mineral core within the central cavity of the protein complex.By similarity

    Catalytic activityi

    4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi22 – 221Iron 1PROSITE-ProRule annotation
    Metal bindingi55 – 551Iron 1PROSITE-ProRule annotation
    Metal bindingi55 – 551Iron 2PROSITE-ProRule annotation
    Metal bindingi58 – 581Iron 1PROSITE-ProRule annotation
    Metal bindingi99 – 991Iron 2PROSITE-ProRule annotation
    Metal bindingi132 – 1321Iron 2PROSITE-ProRule annotation

    GO - Molecular functioni

    1. ferric iron binding Source: InterPro
    2. ferroxidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. cellular iron ion homeostasis Source: UniProtKB-KW
    2. iron ion transport Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Iron storage

    Keywords - Ligandi

    Iron, Metal-binding

    Enzyme and pathway databases

    BioCyciMSME246196:GJ4Y-6421-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ferritin BfrB (EC:1.16.3.1)
    Alternative name(s):
    Non-heme ferritin Ftn
    Gene namesi
    Name:bfrB
    Synonyms:ftn
    Ordered Locus Names:MSMEG_6422, MSMEI_6254
    OrganismiMycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
    Taxonomic identifieri246196 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
    ProteomesiUP000000757: Chromosome, UP000006158: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 181181Ferritin BfrBPRO_0000396101Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Cross-linki10 – 10Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-Cter in protein Pup)1 Publication

    Keywords - PTMi

    Isopeptide bond, Ubl conjugation

    Interactioni

    Subunit structurei

    Homooligomer of 24 subunits that are packed together to form an approximately spherical molecule with a central cavity, in which large amounts of iron can be stored.By similarity

    Protein-protein interaction databases

    STRINGi246196.MSMEG_6422.

    Structurei

    3D structure databases

    ProteinModelPortaliA0R647.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini5 – 150146Ferritin-like diironPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the ferritin family. Prokaryotic subfamily.Curated
    Contains 1 ferritin-like diiron domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG1528.
    HOGENOMiHOG000223382.
    OMAiHFYKQAV.
    OrthoDBiEOG6G4W12.

    Family and domain databases

    Gene3Di1.20.1260.10. 1 hit.
    InterProiIPR001519. Ferritin.
    IPR009040. Ferritin-like_diiron.
    IPR009078. Ferritin-like_SF.
    IPR012347. Ferritin-rel.
    IPR008331. Ferritin_DPS_dom.
    [Graphical view]
    PANTHERiPTHR11431. PTHR11431. 1 hit.
    PfamiPF00210. Ferritin. 1 hit.
    [Graphical view]
    SUPFAMiSSF47240. SSF47240. 1 hit.
    PROSITEiPS50905. FERRITIN_LIKE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A0R647-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTNSGALDTK FHALIQDQIR SEFTASQQYI AIAVFFDGAD LPQLAKHFYA    50
    QALEERNHAM MLVQYLLDRD VEVEIPGIDP VCNNFTTPRD ALALALDQER 100
    TVTEQISRLA SVARDEGDHL GEQFMQWFLK EQVEEVAAMT TLVRIADRAG 150
    SNLFHIEDFV AREMSAAGAD PTAPRAAGGA L 181
    Length:181
    Mass (Da):20,040
    Last modified:January 9, 2007 - v1
    Checksum:i521F00899CA34B8B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000480 Genomic DNA. Translation: ABK71142.1.
    CP001663 Genomic DNA. Translation: AFP42680.1.
    RefSeqiWP_003897831.1. NC_018289.1.
    YP_006570975.1. NC_018289.1.
    YP_890635.1. NC_008596.1.

    Genome annotation databases

    EnsemblBacteriaiABK71142; ABK71142; MSMEG_6422.
    AFP42680; AFP42680; MSMEI_6254.
    GeneIDi4532622.
    KEGGimsg:MSMEI_6254.
    msm:MSMEG_6422.
    PATRICi18085073. VBIMycSme59918_6249.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000480 Genomic DNA. Translation: ABK71142.1 .
    CP001663 Genomic DNA. Translation: AFP42680.1 .
    RefSeqi WP_003897831.1. NC_018289.1.
    YP_006570975.1. NC_018289.1.
    YP_890635.1. NC_008596.1.

    3D structure databases

    ProteinModelPortali A0R647.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 246196.MSMEG_6422.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABK71142 ; ABK71142 ; MSMEG_6422 .
    AFP42680 ; AFP42680 ; MSMEI_6254 .
    GeneIDi 4532622.
    KEGGi msg:MSMEI_6254.
    msm:MSMEG_6422.
    PATRICi 18085073. VBIMycSme59918_6249.

    Phylogenomic databases

    eggNOGi COG1528.
    HOGENOMi HOG000223382.
    OMAi HFYKQAV.
    OrthoDBi EOG6G4W12.

    Enzyme and pathway databases

    BioCyci MSME246196:GJ4Y-6421-MONOMER.

    Family and domain databases

    Gene3Di 1.20.1260.10. 1 hit.
    InterProi IPR001519. Ferritin.
    IPR009040. Ferritin-like_diiron.
    IPR009078. Ferritin-like_SF.
    IPR012347. Ferritin-rel.
    IPR008331. Ferritin_DPS_dom.
    [Graphical view ]
    PANTHERi PTHR11431. PTHR11431. 1 hit.
    Pfami PF00210. Ferritin. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47240. SSF47240. 1 hit.
    PROSITEi PS50905. FERRITIN_LIKE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Fleischmann R.D., Dodson R.J., Haft D.H., Merkel J.S., Nelson W.C., Fraser C.M.
      Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700084 / mc(2)155.
    2. "Interrupted coding sequences in Mycobacterium smegmatis: authentic mutations or sequencing errors?"
      Deshayes C., Perrodou E., Gallien S., Euphrasie D., Schaeffer C., Van-Dorsselaer A., Poch O., Lecompte O., Reyrat J.-M.
      Genome Biol. 8:R20.1-R20.9(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700084 / mc(2)155.
    3. "Ortho-proteogenomics: multiple proteomes investigation through orthology and a new MS-based protocol."
      Gallien S., Perrodou E., Carapito C., Deshayes C., Reyrat J.-M., Van Dorsselaer A., Poch O., Schaeffer C., Lecompte O.
      Genome Res. 19:128-135(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700084 / mc(2)155.
    4. Cited for: PUPYLATION AT LYS-10, IDENTIFICATION BY MASS SPECTROMETRY.

    Entry informationi

    Entry nameiBFRB_MYCS2
    AccessioniPrimary (citable) accession number: A0R647
    Secondary accession number(s): I7FMX7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 10, 2010
    Last sequence update: January 9, 2007
    Last modified: October 1, 2014
    This is version 55 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3