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A0R607

- A0R607_MYCS2

UniProt

A0R607 - A0R607_MYCS2

Protein
Submitted name:

Oxidoreductase, FAD-binding

Gene

MSMEG_6382

Organism
Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 57 (01 Oct 2014)
      Sequence version 1 (09 Jan 2007)
      Previous versions | rss
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    Functioni

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei24 – 241FADImported
    Binding sitei70 – 701FAD; via carbonyl oxygenImported
    Binding sitei124 – 1241FAD; via amide nitrogenImported
    Binding sitei185 – 1851FAD; via carbonyl oxygenImported
    Binding sitei191 – 1911FAD; via amide nitrogen and carbonyl oxygenImported
    Binding sitei422 – 4221FADImported

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi60 – 667FADImported
    Nucleotide bindingi129 – 1324FADImported
    Nucleotide bindingi136 – 1394FADImported

    GO - Molecular functioni

    1. D-arabinono-1,4-lactone oxidase activity Source: InterPro
    2. flavin adenine dinucleotide binding Source: InterPro
    3. UDP-N-acetylmuramate dehydrogenase activity Source: InterPro

    Keywords - Ligandi

    FADImported, Flavoprotein, Nucleotide-bindingImported

    Enzyme and pathway databases

    BioCyciMetaCyc:MONOMER-17534.
    MSME246196:GJ4Y-6381-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Oxidoreductase, FAD-bindingImported
    Gene namesi
    Ordered Locus Names:MSMEG_6382Imported
    OrganismiMycobacterium smegmatis (strain ATCC 700084 / mc(2)155)Imported
    Taxonomic identifieri246196 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
    ProteomesiUP000000757: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. membrane Source: InterPro

    Interactioni

    Protein-protein interaction databases

    STRINGi246196.MSMEG_6382.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4AUTX-ray2.10A1-468[»]
    4F4QX-ray2.62A1-468[»]
    4G3TX-ray2.35A66-468[»]
    4G3UX-ray2.69A/B66-468[»]
    ProteinModelPortaliA0R607.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Contains FAD-binding PCMH-type domain.SAAS annotation

    Phylogenomic databases

    eggNOGiCOG0277.
    HOGENOMiHOG000010204.
    KOiK16653.
    OMAiETIAFHS.
    OrthoDBiEOG69WFG8.

    Family and domain databases

    Gene3Di3.30.465.10. 1 hit.
    InterProiIPR007173. ALO.
    IPR016169. CO_DH_flavot_FAD-bd_sub2.
    IPR016166. FAD-bd_2.
    IPR006094. Oxid_FAD_bind_N.
    [Graphical view]
    PfamiPF04030. ALO. 1 hit.
    PF01565. FAD_binding_4. 1 hit.
    [Graphical view]
    SUPFAMiSSF56176. SSF56176. 1 hit.
    PROSITEiPS51387. FAD_PCMH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A0R607-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGAVPSLTMS TTEFPTTTKR LMGWGRTAPT VASVLSTSDP EVIVRAVTRA    50
    AEEGGRGVIA RGLGRSYGDN AQNGGGLVID MPALNRIHSI DSGTRLVDVD 100
    AGVSLDQLMK AALPHGLWVP VLPGTRQVTV GGAIGCDIHG KNHHSAGSFG 150
    NHVRSMELLT ANGEVRHLTP AGPDSDLFWA TVGGNGLTGI ILRATIEMTP 200
    TETAYFIADG DVTGSLDETI AFHSDGSEAN YTYSSAWFDA ISKPPKLGRA 250
    AISRGSLAKL DQLPSKLQKD PLKFDAPQLL TLPDIFPNGL ANKFTFMPIG 300
    ELWYRKSGTY RNKVQNLTQF YHPLDMFGEW NRAYGSAGFL QYQFVVPTEA 350
    VEEFKSIIVD IQRSGHYSFL NVFKLFGPGN QAPLSFPIPG WNVCVDFPIK 400
    AGLHEFVTEL DRRVLEFGGR LYTAKDSRTT AETFHAMYPR IDEWIRIRRS 450
    VDPDGVFASD MARRLQLL 468
    Length:468
    Mass (Da):51,134
    Last modified:January 9, 2007 - v1
    Checksum:iCF00458CEE7E6549
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000480 Genomic DNA. Translation: ABK72795.1.
    RefSeqiWP_011731248.1. NC_008596.1.
    YP_890595.1. NC_008596.1.

    Genome annotation databases

    EnsemblBacteriaiABK72795; ABK72795; MSMEG_6382.
    GeneIDi4532115.
    KEGGimsm:MSMEG_6382.
    PATRICi18084993. VBIMycSme59918_6209.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000480 Genomic DNA. Translation: ABK72795.1 .
    RefSeqi WP_011731248.1. NC_008596.1.
    YP_890595.1. NC_008596.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4AUT X-ray 2.10 A 1-468 [» ]
    4F4Q X-ray 2.62 A 1-468 [» ]
    4G3T X-ray 2.35 A 66-468 [» ]
    4G3U X-ray 2.69 A/B 66-468 [» ]
    ProteinModelPortali A0R607.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 246196.MSMEG_6382.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABK72795 ; ABK72795 ; MSMEG_6382 .
    GeneIDi 4532115.
    KEGGi msm:MSMEG_6382.
    PATRICi 18084993. VBIMycSme59918_6209.

    Phylogenomic databases

    eggNOGi COG0277.
    HOGENOMi HOG000010204.
    KOi K16653.
    OMAi ETIAFHS.
    OrthoDBi EOG69WFG8.

    Enzyme and pathway databases

    BioCyci MetaCyc:MONOMER-17534.
    MSME246196:GJ4Y-6381-MONOMER.

    Family and domain databases

    Gene3Di 3.30.465.10. 1 hit.
    InterProi IPR007173. ALO.
    IPR016169. CO_DH_flavot_FAD-bd_sub2.
    IPR016166. FAD-bd_2.
    IPR006094. Oxid_FAD_bind_N.
    [Graphical view ]
    Pfami PF04030. ALO. 1 hit.
    PF01565. FAD_binding_4. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56176. SSF56176. 1 hit.
    PROSITEi PS51387. FAD_PCMH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Fleischmann R.D., Dodson R.J., Haft D.H., Merkel J.S., Nelson W.C., Fraser C.M.
      Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700084 / mc(2)155Imported.
    2. "Structural basis for benzothiazinone-mediated killing of Mycobacterium tuberculosis."
      Neres J., Pojer F., Molteni E., Chiarelli L.R., Dhar N., Boy-Rottger S., Buroni S., Fullam E., Degiacomi G., Lucarelli A.P., Read R.J., Zanoni G., Edmondson D.E., De Rossi E., Pasca M.R., McKinney J.D., Dyson P.J., Riccardi G.
      , Mattevi A., Cole S.T., Binda C.
      Sci. Transl. Med. 4:150ra121-150ra121(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.10 ANGSTROMS) IN COMPLEX WITH FAD.
    3. "Crystal structure of decaprenylphosphoryl-?- D-ribose 2'-epimerase from Mycobacterium smegmatis."
      Li H., Jogl G.
      Proteins 81:538-543(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.35 ANGSTROMS) OF 66-468.

    Entry informationi

    Entry nameiA0R607_MYCS2
    AccessioniPrimary (citable) accession number: A0R607
    Entry historyi
    Integrated into UniProtKB/TrEMBL: January 9, 2007
    Last sequence update: January 9, 2007
    Last modified: October 1, 2014
    This is version 57 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported, Complete proteome, Reference proteomeImported

    External Data

    Dasty 3