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A0R607

- A0R607_MYCS2

UniProt

A0R607 - A0R607_MYCS2

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Protein
Submitted name:

Oxidoreductase, FAD-binding

Gene

MSMEG_6382

Organism
Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei24 – 241FADImported
Binding sitei70 – 701FAD; via carbonyl oxygenImported
Binding sitei124 – 1241FAD; via amide nitrogenImported
Binding sitei185 – 1851FAD; via carbonyl oxygenImported
Binding sitei191 – 1911FAD; via amide nitrogen and carbonyl oxygenImported
Binding sitei422 – 4221FADImported

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi60 – 667FADImported
Nucleotide bindingi129 – 1324FADImported
Nucleotide bindingi136 – 1394FADImported

GO - Molecular functioni

  1. D-arabinono-1,4-lactone oxidase activity Source: InterPro
  2. flavin adenine dinucleotide binding Source: InterPro
  3. UDP-N-acetylmuramate dehydrogenase activity Source: InterPro
Complete GO annotation...

Keywords - Ligandi

FADImported, Flavoprotein, Nucleotide-bindingImported

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-17534.
MSME246196:GJ4Y-6381-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
Oxidoreductase, FAD-bindingImported
Gene namesi
Ordered Locus Names:MSMEG_6382Imported
OrganismiMycobacterium smegmatis (strain ATCC 700084 / mc(2)155)Imported
Taxonomic identifieri246196 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
ProteomesiUP000000757: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. membrane Source: InterPro
Complete GO annotation...

Interactioni

Protein-protein interaction databases

STRINGi246196.MSMEG_6382.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4AUTX-ray2.10A1-468[»]
4F4QX-ray2.62A1-468[»]
4G3TX-ray2.35A66-468[»]
4G3UX-ray2.69A/B66-468[»]
ProteinModelPortaliA0R607.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains FAD-binding PCMH-type domain.SAAS annotation

Phylogenomic databases

eggNOGiCOG0277.
HOGENOMiHOG000010204.
KOiK16653.
OMAiETIAFHS.
OrthoDBiEOG69WFG8.

Family and domain databases

Gene3Di3.30.465.10. 1 hit.
InterProiIPR007173. ALO.
IPR016169. CO_DH_flavot_FAD-bd_sub2.
IPR016166. FAD-bd_2.
IPR006094. Oxid_FAD_bind_N.
[Graphical view]
PfamiPF04030. ALO. 1 hit.
PF01565. FAD_binding_4. 1 hit.
[Graphical view]
SUPFAMiSSF56176. SSF56176. 1 hit.
PROSITEiPS51387. FAD_PCMH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A0R607-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGAVPSLTMS TTEFPTTTKR LMGWGRTAPT VASVLSTSDP EVIVRAVTRA
60 70 80 90 100
AEEGGRGVIA RGLGRSYGDN AQNGGGLVID MPALNRIHSI DSGTRLVDVD
110 120 130 140 150
AGVSLDQLMK AALPHGLWVP VLPGTRQVTV GGAIGCDIHG KNHHSAGSFG
160 170 180 190 200
NHVRSMELLT ANGEVRHLTP AGPDSDLFWA TVGGNGLTGI ILRATIEMTP
210 220 230 240 250
TETAYFIADG DVTGSLDETI AFHSDGSEAN YTYSSAWFDA ISKPPKLGRA
260 270 280 290 300
AISRGSLAKL DQLPSKLQKD PLKFDAPQLL TLPDIFPNGL ANKFTFMPIG
310 320 330 340 350
ELWYRKSGTY RNKVQNLTQF YHPLDMFGEW NRAYGSAGFL QYQFVVPTEA
360 370 380 390 400
VEEFKSIIVD IQRSGHYSFL NVFKLFGPGN QAPLSFPIPG WNVCVDFPIK
410 420 430 440 450
AGLHEFVTEL DRRVLEFGGR LYTAKDSRTT AETFHAMYPR IDEWIRIRRS
460
VDPDGVFASD MARRLQLL
Length:468
Mass (Da):51,134
Last modified:January 9, 2007 - v1
Checksum:iCF00458CEE7E6549
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000480 Genomic DNA. Translation: ABK72795.1.
RefSeqiWP_011731248.1. NC_008596.1.
YP_890595.1. NC_008596.1.

Genome annotation databases

EnsemblBacteriaiABK72795; ABK72795; MSMEG_6382.
GeneIDi4532115.
KEGGimsm:MSMEG_6382.
PATRICi18084993. VBIMycSme59918_6209.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000480 Genomic DNA. Translation: ABK72795.1 .
RefSeqi WP_011731248.1. NC_008596.1.
YP_890595.1. NC_008596.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4AUT X-ray 2.10 A 1-468 [» ]
4F4Q X-ray 2.62 A 1-468 [» ]
4G3T X-ray 2.35 A 66-468 [» ]
4G3U X-ray 2.69 A/B 66-468 [» ]
ProteinModelPortali A0R607.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 246196.MSMEG_6382.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABK72795 ; ABK72795 ; MSMEG_6382 .
GeneIDi 4532115.
KEGGi msm:MSMEG_6382.
PATRICi 18084993. VBIMycSme59918_6209.

Phylogenomic databases

eggNOGi COG0277.
HOGENOMi HOG000010204.
KOi K16653.
OMAi ETIAFHS.
OrthoDBi EOG69WFG8.

Enzyme and pathway databases

BioCyci MetaCyc:MONOMER-17534.
MSME246196:GJ4Y-6381-MONOMER.

Family and domain databases

Gene3Di 3.30.465.10. 1 hit.
InterProi IPR007173. ALO.
IPR016169. CO_DH_flavot_FAD-bd_sub2.
IPR016166. FAD-bd_2.
IPR006094. Oxid_FAD_bind_N.
[Graphical view ]
Pfami PF04030. ALO. 1 hit.
PF01565. FAD_binding_4. 1 hit.
[Graphical view ]
SUPFAMi SSF56176. SSF56176. 1 hit.
PROSITEi PS51387. FAD_PCMH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Fleischmann R.D., Dodson R.J., Haft D.H., Merkel J.S., Nelson W.C., Fraser C.M.
    Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700084 / mc(2)155Imported.
  2. "Structural basis for benzothiazinone-mediated killing of Mycobacterium tuberculosis."
    Neres J., Pojer F., Molteni E., Chiarelli L.R., Dhar N., Boy-Rottger S., Buroni S., Fullam E., Degiacomi G., Lucarelli A.P., Read R.J., Zanoni G., Edmondson D.E., De Rossi E., Pasca M.R., McKinney J.D., Dyson P.J., Riccardi G.
    , Mattevi A., Cole S.T., Binda C.
    Sci. Transl. Med. 4:150ra121-150ra121(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.10 ANGSTROMS) IN COMPLEX WITH FAD.
  3. "Crystal structure of decaprenylphosphoryl-?- D-ribose 2'-epimerase from Mycobacterium smegmatis."
    Li H., Jogl G.
    Proteins 81:538-543(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.35 ANGSTROMS) OF 66-468.

Entry informationi

Entry nameiA0R607_MYCS2
AccessioniPrimary (citable) accession number: A0R607
Entry historyi
Integrated into UniProtKB/TrEMBL: January 9, 2007
Last sequence update: January 9, 2007
Last modified: October 29, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported, Complete proteome, Reference proteomeImported

External Data

Dasty 3