A0R5X8 (PATR_MYCS2) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative phenylalanine aminotransferase
EC=2.6.1.-

Gene names

Name:	pat
Ordered Locus Names:	MSMEG_6351

Organism

Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)

Taxonomic identifier

246196 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length	361 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May catalyze the transamination reaction in phenylalanine biosynthesis By similarity. HAMAP MF_01513
Cofactor	Pyridoxal phosphate By similarity. HAMAP MF_01513
Sequence similarities	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.

Ontologies

Keywords
Ligand	Pyridoxal phosphate
Molecular function	Aminotransferase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	histidine biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	histidinol-phosphate transaminase activity Inferred from electronic annotation. Source: InterPro pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 361	361	Putative phenylalanine aminotransferase HAMAP MF_01513		PRO_1000024496
Amino acid modifications
	Modified residue	215	1	N6-(pyridoxal phosphate)lysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	A0R5X8 [UniParc]. Last modified January 9, 2007. Version 1. Checksum: 1E1851D681D311E4	FASTA	361	38,871
	10 20 30 40 50 60 MSIRLRAEMA DLPAYAPGKT VPGAIKIASN ETVHGPLPSV REAILKATDL INRYPDNGYL 70 80 90 100 110 120 DLRERLAKHV NFAPENISVG CGSVSLCQQL IQITSSVGDE VLFAWRSFEI YPLQVRTAGA 130 140 150 160 170 180 TPVAVALRDH THDLDAMLAA ITDRTRLIFV CNPNNPTSTV VDPGELARFV AAVPPHILVV 190 200 210 220 230 240 LDEAYVEYIR DGLLPDSLGL VREHRNVVVL RTFSKAYGLA GLRVGYAVAD PEIVTALGKV 250 260 270 280 290 300 YVPFSATSVS QAAAIACLDA ADELLARTDA VVAERTRVSD ALRAAGYTLP PSQANFVWLP 310 320 330 340 350 360 LAERTLDFVA RAADNRIIVR PYGEDGVRVT IGAPHENDAF LDFAQRWIAP GGAGPRTGDS A

References

[1]	Fleischmann R.D., Dodson R.J., Haft D.H., Merkel J.S., Nelson W.C., Fraser C.M. Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700084 / mc(2)155.
[2]	"Ortho-proteogenomics: multiple proteomes investigation through orthology and a new MS-based protocol." Gallien S., Perrodou E., Carapito C., Deshayes C., Reyrat J.-M., Van Dorsselaer A., Poch O., Schaeffer C., Lecompte O. Genome Res. 19:128-135(2009) [PubMed: 18955433] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000480 Genomic DNA. Translation: ABK70318.1.
RefSeq	YP_890566.1. NC_008596.1.
3D structure databases
ProteinModelPortal	A0R5X8.
ModBase	Search...
Protein-protein interaction databases
STRING	A0R5X8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBMYCT00000043523; EBMYCP00000041860; EBMYCG00000043518.
GeneID	4535223.
GenomeReviews	Gene locus MSMEG_6351 in contig CP000480_GR.
KEGG	msm:MSMEG_6351.
NMPDR	fig|246196.1.peg.6314.
PATRIC	18084937. VBIMycSme59918_6182.
TIGR	MSMEG_6351.
Phylogenomic databases
eggNOG	COG0079.
GeneTree	EBGT00070000031717.
HOGENOM	HBG646350.
OMA	ASNESHY.
ProtClustDB	PRK03321.
Enzyme and pathway databases
BioCyc	MSME246196:MSMEG_6351-MONOMER.
Family and domain databases
HAMAP	MF_01513. Phe_aminotrans_2. [Tree]
InterPro	IPR001917. Aminotrans_II_pyridoxalP_BS. IPR004839. Aminotransferase_I/II. IPR024892. AroT. IPR005861. HisP_aminotrans. IPR015424. PyrdxlP-dep_Trfase_major_dom. IPR015421. PyrdxlP-dep_Trfase_major_sub1. IPR015422. PyrdxlP-dep_Trfase_major_sub2. [Graphical view]
Gene3D	G3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit. G3DSA:3.90.1150.10. PyrdxlP-dep_Trfase_major_sub2. 1 hit.
KO	K00817.
Pfam	PF00155. Aminotran_1_2. 1 hit. [Graphical view]
SUPFAM	SSF53383. PyrdxlP-dep_Trfase_major. 1 hit.
TIGRFAMs	TIGR01141. HisC. 1 hit.
PROSITE	PS00599. AA_TRANSFER_CLASS_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PATR_MYCS2

Accession

Primary (citable) accession number: A0R5X8

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	January 9, 2007
Last modified:	January 25, 2012
This is version 39 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program