Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Pantothenate synthetase

Gene

panC

Organism
Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.UniRule annotation

Miscellaneous

The reaction proceeds by a bi uni uni bi ping pong mechanism.UniRule annotation

Catalytic activityi

ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate.UniRule annotation

Pathwayi: (R)-pantothenate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes (R)-pantothenate from (R)-pantoate and beta-alanine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Pantothenate synthetase (panC)
This subpathway is part of the pathway (R)-pantothenate biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (R)-pantothenate from (R)-pantoate and beta-alanine, the pathway (R)-pantothenate biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei50Proton donorUniRule annotation1
Binding sitei75Beta-alanineUniRule annotation1
Binding sitei75PantoateUniRule annotation1
Binding sitei167PantoateUniRule annotation1
Binding sitei190ATP; via amide nitrogen and carbonyl oxygenUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi43 – 50ATPUniRule annotation8
Nucleotide bindingi161 – 164ATPUniRule annotation4
Nucleotide bindingi198 – 201ATPUniRule annotation4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processPantothenate biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMSME246196:G1H7P-6063-MONOMER
UniPathwayiUPA00028; UER00005

Names & Taxonomyi

Protein namesi
Recommended name:
Pantothenate synthetaseUniRule annotation (EC:6.3.2.1UniRule annotation)
Short name:
PSUniRule annotation
Alternative name(s):
Pantoate--beta-alanine ligaseUniRule annotation
Pantoate-activating enzymeUniRule annotation
Gene namesi
Name:panCUniRule annotation
Ordered Locus Names:MSMEG_6097, MSMEI_5938
OrganismiMycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Taxonomic identifieri246196 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium fortuitum complex
Proteomesi
  • UP000006158 Componenti: Chromosome
  • UP000000757 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003054871 – 314Pantothenate synthetaseAdd BLAST314

Proteomic databases

PRIDEiA0R580

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi246196.MSMEG_6097

Structurei

3D structure databases

ProteinModelPortaliA0R580
SMRiA0R580
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the pantothenate synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108IAA Bacteria
COG0414 LUCA
HOGENOMiHOG000175516
KOiK01918
OMAiLFNMVQP
OrthoDBiPOG091H00FM

Family and domain databases

CDDicd00560 PanC, 1 hit
Gene3Di3.40.50.620, 1 hit
HAMAPiMF_00158 PanC, 1 hit
InterProiView protein in InterPro
IPR003721 Pantoate_ligase
IPR014729 Rossmann-like_a/b/a_fold
PANTHERiPTHR21299:SF1 PTHR21299:SF1, 1 hit
PfamiView protein in Pfam
PF02569 Pantoate_ligase, 1 hit
TIGRFAMsiTIGR00018 panC, 1 hit

Sequencei

Sequence statusi: Complete.

A0R580-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTISRTPKFS AGELNVYSAP ADVAAVTRAL RTAGRRIVLV PTMGALHEGH
60 70 80 90 100
LTLVRAAKRT PGAVVVVSIF VNPLQFGPNE DLNAYPRTLE DDLTALRAEG
110 120 130 140 150
VEIVFTPTGS DMYPDGTRTS VHPGPLGDDL EGSSRPGHFA GVLTVVLKLF
160 170 180 190 200
SIVRPDRAYF GEKDYQQLTL LRQMVADLNV DVQIVGVPTV RESDGLALSS
210 220 230 240 250
RNRYLDKDQR EQAGALSAAL LAGKYAAAGG AEAALDAARA VLDEVPALEV
260 270 280 290 300
DYLQVRDPML GPAPAEGQAR LLVAARLGRT RLIDNIAIDV GASAGIDGHP
310
RVGNDQNHEL PWRN
Length:314
Mass (Da):33,525
Last modified:January 9, 2007 - v1
Checksum:iAABE76E46E7E96AF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000480 Genomic DNA Translation: ABK70073.1
CP001663 Genomic DNA Translation: AFP42371.1
RefSeqiWP_011731036.1, NZ_CP009494.1
YP_890318.1, NC_008596.1

Genome annotation databases

EnsemblBacteriaiABK70073; ABK70073; MSMEG_6097
AFP42371; AFP42371; MSMEI_5938
GeneIDi4531246
KEGGimsb:LJ00_30150
msg:MSMEI_5938
msm:MSMEG_6097
PATRICifig|246196.19.peg.5936

Similar proteinsi

Entry informationi

Entry nameiPANC_MYCS2
AccessioniPrimary (citable) accession number: A0R580
Secondary accession number(s): I7GFF1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: January 9, 2007
Last modified: May 23, 2018
This is version 76 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health