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Protein

ATP-dependent Clp protease ATP-binding subunit ClpC1

Gene

clpC1

Organism
Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity). Degrades anti-sigma-E factor RseA in the presence of ClpP2 (Probable).By similarityCurated1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi553 – 560ATPSequence analysis8
Nucleotide bindingi617 – 626ATPSequence analysis10

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-dependent Clp protease ATP-binding subunit ClpC1
Gene namesi
Name:clpC1
Ordered Locus Names:MSMEG_6091, MSMEI_5933
OrganismiMycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Taxonomic identifieri246196 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000006158 Componenti: Chromosome
  • UP000000757 Componenti: Chromosome

Pathology & Biotechi

Disruption phenotypei

Depletion experiments (using anti-sense RNA) stops degradation of anti-sigma-E factor RseA.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004229521 – 848ATP-dependent Clp protease ATP-binding subunit ClpC1Add BLAST848

Interactioni

Protein-protein interaction databases

STRINGi246196.MSMEG_6091.

Structurei

3D structure databases

ProteinModelPortaliA0R574.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini425 – 460UVRPROSITE-ProRule annotationAdd BLAST36

Sequence similaritiesi

Belongs to the ClpA/ClpB family. ClpC subfamily.Curated
Contains 1 UVR domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG4105C2Z. Bacteria.
COG0542. LUCA.
HOGENOMiHOG000218210.
KOiK03696.
OMAiENWDGEG.
OrthoDBiPOG091H019M.

Family and domain databases

Gene3Di1.10.1780.10. 1 hit.
3.40.50.300. 3 hits.
InterProiIPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR019489. Clp_ATPase_C.
IPR004176. Clp_N.
IPR001270. ClpA/B.
IPR018368. ClpA/B_CS1.
IPR027417. P-loop_NTPase.
IPR001943. UVR_dom.
[Graphical view]
PfamiPF00004. AAA. 1 hit.
PF07724. AAA_2. 1 hit.
PF02861. Clp_N. 2 hits.
PF10431. ClpB_D2-small. 1 hit.
PF02151. UVR. 1 hit.
[Graphical view]
PRINTSiPR00300. CLPPROTEASEA.
SMARTiSM00382. AAA. 2 hits.
SM01086. ClpB_D2-small. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF81923. SSF81923. 1 hit.
PROSITEiPS00870. CLPAB_1. 1 hit.
PS50151. UVR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A0R574-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFERFTDRAR RVVVLAQEEA RMLNHNYIGT EHILLGLIHE GEGVAAKSLE
60 70 80 90 100
SLGISLEGVR SQVEEIIGQG QQAPSGHIPF TPRAKKVLEL SLREALQLGH
110 120 130 140 150
NYIGTEHILL GLIREGEGVA AQVLVKLGAE LTRVRQQVIQ LLSGYQGKEA
160 170 180 190 200
AEAGTGGRGG ESGNPSTSLV LDQFGRNLTA AAMEGKLDPV IGREKEIERV
210 220 230 240 250
MQVLSRRTKN NPVLIGEPGV GKTAVVEGLA QAIVHGEVPE TLKDKQLYTL
260 270 280 290 300
DLGSLVAGSR YRGDFEERLK KVLKEINTRG DIILFIDELH TLVGAGAAEG
310 320 330 340 350
AIDAASILKP KLARGELQTI GATTLDEYRK YIEKDAALER RFQPVQVGEP
360 370 380 390 400
TVEHTIEILK GLRDRYEAHH RVSITDSAMV AAATLADRYI NDRFLPDKAI
410 420 430 440 450
DLIDEAGARM RIRRMTAPPD LREFDEKIAD ARREKESAID AQDFEKAAAL
460 470 480 490 500
RDKEKQLVAQ RAEREKQWRS GDLDVVAEVD DEQIAEVLGN WTGIPVFKLT
510 520 530 540 550
EEETTRLLRM EEELHKRIIG QEDAVKAVSK AIRRTRAGLK DPKRPSGSFI
560 570 580 590 600
FAGPSGVGKT ELSKALANFL FGDDDALIQI DMGEFHDRFT ASRLFGAPPG
610 620 630 640 650
YVGYEEGGQL TEKVRRKPFS VVLFDEIEKA HQEIYNSLLQ VLEDGRLTDG
660 670 680 690 700
QGRTVDFKNT VLIFTSNLGT SDISKAVGLG FSQGGSENNY ERMKQKVHDE
710 720 730 740 750
LKKHFRPEFL NRIDDIIVFH QLTQDEIIQM VDLMIGRVSN QLKTKDMALE
760 770 780 790 800
LSDKAKALLA KRGFDPVLGA RPLRRTIQRE IEDQLSEKIL FEEIGPGQLV
810 820 830 840
TVDVEGWDGE GQGEDAKFTF SGGPKRAETA EPDLAGAGAA GAPTAGTE
Length:848
Mass (Da):93,553
Last modified:January 9, 2007 - v1
Checksum:iFBC77898B659DA99
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000480 Genomic DNA. Translation: ABK74692.1.
CP001663 Genomic DNA. Translation: AFP42366.1.
RefSeqiWP_011731031.1. NZ_CP009494.1.
YP_890312.1. NC_008596.1.

Genome annotation databases

EnsemblBacteriaiABK74692; ABK74692; MSMEG_6091.
AFP42366; AFP42366; MSMEI_5933.
GeneIDi4533739.
KEGGimsb:LJ00_30125.
msg:MSMEI_5933.
msm:MSMEG_6091.
PATRICi18084421. VBIMycSme59918_5930.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000480 Genomic DNA. Translation: ABK74692.1.
CP001663 Genomic DNA. Translation: AFP42366.1.
RefSeqiWP_011731031.1. NZ_CP009494.1.
YP_890312.1. NC_008596.1.

3D structure databases

ProteinModelPortaliA0R574.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi246196.MSMEG_6091.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABK74692; ABK74692; MSMEG_6091.
AFP42366; AFP42366; MSMEI_5933.
GeneIDi4533739.
KEGGimsb:LJ00_30125.
msg:MSMEI_5933.
msm:MSMEG_6091.
PATRICi18084421. VBIMycSme59918_5930.

Phylogenomic databases

eggNOGiENOG4105C2Z. Bacteria.
COG0542. LUCA.
HOGENOMiHOG000218210.
KOiK03696.
OMAiENWDGEG.
OrthoDBiPOG091H019M.

Family and domain databases

Gene3Di1.10.1780.10. 1 hit.
3.40.50.300. 3 hits.
InterProiIPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR019489. Clp_ATPase_C.
IPR004176. Clp_N.
IPR001270. ClpA/B.
IPR018368. ClpA/B_CS1.
IPR027417. P-loop_NTPase.
IPR001943. UVR_dom.
[Graphical view]
PfamiPF00004. AAA. 1 hit.
PF07724. AAA_2. 1 hit.
PF02861. Clp_N. 2 hits.
PF10431. ClpB_D2-small. 1 hit.
PF02151. UVR. 1 hit.
[Graphical view]
PRINTSiPR00300. CLPPROTEASEA.
SMARTiSM00382. AAA. 2 hits.
SM01086. ClpB_D2-small. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF81923. SSF81923. 1 hit.
PROSITEiPS00870. CLPAB_1. 1 hit.
PS50151. UVR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCLPC1_MYCS2
AccessioniPrimary (citable) accession number: A0R574
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 24, 2013
Last sequence update: January 9, 2007
Last modified: November 2, 2016
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.