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A0R528

- KSTR_MYCS2

UniProt

A0R528 - KSTR_MYCS2

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Protein

HTH-type transcriptional repressor KstR

Gene

kstR

Organism
Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

Controls the expression of genes used for utilizing diverse lipids as energy sources.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi41 – 6020H-T-H motifPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciMSME246196:GJ4Y-6041-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
HTH-type transcriptional repressor KstR
Gene namesi
Name:kstR
Ordered Locus Names:MSMEG_6042, MSMEI_5881
OrganismiMycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Taxonomic identifieri246196 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
ProteomesiUP000000757: Chromosome, UP000006158: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 204204HTH-type transcriptional repressor KstRPRO_0000405029Add
BLAST

Interactioni

Subunit structurei

Homodimer.Curated

Protein-protein interaction databases

STRINGi246196.MSMEG_6042.

Structurei

3D structure databases

ProteinModelPortaliA0R528.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini18 – 7861HTH tetR-typePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 HTH tetR-type DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG277692.
HOGENOMiHOG000052226.
OMAiMTRAFMF.
OrthoDBiEOG6NSGGJ.

Family and domain databases

Gene3Di1.10.357.10. 1 hit.
InterProiIPR009057. Homeodomain-like.
IPR001647. HTH_TetR.
IPR015893. Tet_transcr_reg_TetR-like_C.
[Graphical view]
PfamiPF00440. TetR_N. 1 hit.
[Graphical view]
PRINTSiPR00455. HTHTETR.
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS50977. HTH_TETR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A0R528-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTNVAVLSES ELGSEAQRER RKRILDATLA IASKGGYEAV QMRAVAERAD
60 70 80 90 100
VAVGTLYRYF PSKVHLLVSA LGREFERIDA KTDRAALAGG TPYQRLNFMV
110 120 130 140 150
GKLNRAMQRN PLLTEAMTRA FVFADASAAG EVDHVGKLMD SMFARAMSDG
160 170 180 190 200
EPTEDQYHIA RVISDVWLSN LLAWLTRRAS ATDVSKRLDL AVRLLIGTEE

QPKI
Length:204
Mass (Da):22,571
Last modified:January 9, 2007 - v1
Checksum:i1125BEBE034F88C2
GO

Sequence cautioni

The sequence AFP42314.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000480 Genomic DNA. Translation: ABK75291.1.
CP001663 Genomic DNA. Translation: AFP42314.1. Different initiation.
RefSeqiYP_006570609.1. NC_018289.1.
YP_890266.1. NC_008596.1.

Genome annotation databases

EnsemblBacteriaiABK75291; ABK75291; MSMEG_6042.
AFP42314; AFP42314; MSMEI_5881.
GeneIDi4531834.
KEGGimsm:MSMEG_6042.
PATRICi18084317. VBIMycSme59918_5878.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000480 Genomic DNA. Translation: ABK75291.1 .
CP001663 Genomic DNA. Translation: AFP42314.1 . Different initiation.
RefSeqi YP_006570609.1. NC_018289.1.
YP_890266.1. NC_008596.1.

3D structure databases

ProteinModelPortali A0R528.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 246196.MSMEG_6042.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABK75291 ; ABK75291 ; MSMEG_6042 .
AFP42314 ; AFP42314 ; MSMEI_5881 .
GeneIDi 4531834.
KEGGi msm:MSMEG_6042.
PATRICi 18084317. VBIMycSme59918_5878.

Phylogenomic databases

eggNOGi NOG277692.
HOGENOMi HOG000052226.
OMAi MTRAFMF.
OrthoDBi EOG6NSGGJ.

Enzyme and pathway databases

BioCyci MSME246196:GJ4Y-6041-MONOMER.

Family and domain databases

Gene3Di 1.10.357.10. 1 hit.
InterProi IPR009057. Homeodomain-like.
IPR001647. HTH_TetR.
IPR015893. Tet_transcr_reg_TetR-like_C.
[Graphical view ]
Pfami PF00440. TetR_N. 1 hit.
[Graphical view ]
PRINTSi PR00455. HTHTETR.
SUPFAMi SSF46689. SSF46689. 1 hit.
PROSITEi PS50977. HTH_TETR_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Fleischmann R.D., Dodson R.J., Haft D.H., Merkel J.S., Nelson W.C., Fraser C.M.
    Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700084 / mc(2)155.
  2. "Interrupted coding sequences in Mycobacterium smegmatis: authentic mutations or sequencing errors?"
    Deshayes C., Perrodou E., Gallien S., Euphrasie D., Schaeffer C., Van-Dorsselaer A., Poch O., Lecompte O., Reyrat J.-M.
    Genome Biol. 8:R20.1-R20.9(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700084 / mc(2)155.
  3. "Ortho-proteogenomics: multiple proteomes investigation through orthology and a new MS-based protocol."
    Gallien S., Perrodou E., Carapito C., Deshayes C., Reyrat J.-M., Van Dorsselaer A., Poch O., Schaeffer C., Lecompte O.
    Genome Res. 19:128-135(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700084 / mc(2)155.
  4. "A highly conserved transcriptional repressor controls a large regulon involved in lipid degradation in Mycobacterium smegmatis and Mycobacterium tuberculosis."
    Kendall S.L., Withers M., Soffair C.N., Moreland N.J., Gurcha S., Sidders B., Frita R., Ten Bokum A., Besra G.S., Lott J.S., Stoker N.G.
    Mol. Microbiol. 65:684-699(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION AS A TRANSCRIPTIONAL REPRESSOR.

Entry informationi

Entry nameiKSTR_MYCS2
AccessioniPrimary (citable) accession number: A0R528
Secondary accession number(s): I7GG00
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 8, 2011
Last sequence update: January 9, 2007
Last modified: November 26, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3