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A0R528

- KSTR_MYCS2

UniProt

A0R528 - KSTR_MYCS2

Protein

HTH-type transcriptional repressor KstR

Gene

kstR

Organism
Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 55 (01 Oct 2014)
      Sequence version 1 (09 Jan 2007)
      Previous versions | rss
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    Functioni

    Controls the expression of genes used for utilizing diverse lipids as energy sources.1 Publication

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi41 – 6020H-T-H motifPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW

    GO - Biological processi

    1. regulation of transcription, DNA-templated Source: UniProtKB
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Repressor

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Enzyme and pathway databases

    BioCyciMSME246196:GJ4Y-6041-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    HTH-type transcriptional repressor KstR
    Gene namesi
    Name:kstR
    Ordered Locus Names:MSMEG_6042, MSMEI_5881
    OrganismiMycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
    Taxonomic identifieri246196 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
    ProteomesiUP000000757: Chromosome, UP000006158: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 204204HTH-type transcriptional repressor KstRPRO_0000405029Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.Curated

    Protein-protein interaction databases

    STRINGi246196.MSMEG_6042.

    Structurei

    3D structure databases

    ProteinModelPortaliA0R528.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini18 – 7861HTH tetR-typePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 HTH tetR-type DNA-binding domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG277692.
    HOGENOMiHOG000052226.
    OMAiMTRAFMF.
    OrthoDBiEOG6NSGGJ.

    Family and domain databases

    Gene3Di1.10.357.10. 1 hit.
    InterProiIPR009057. Homeodomain-like.
    IPR001647. HTH_TetR.
    IPR015893. Tet_transcr_reg_TetR-like_C.
    [Graphical view]
    PfamiPF00440. TetR_N. 1 hit.
    [Graphical view]
    PRINTSiPR00455. HTHTETR.
    SUPFAMiSSF46689. SSF46689. 1 hit.
    PROSITEiPS50977. HTH_TETR_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A0R528-1 [UniParc]FASTAAdd to Basket

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    MTNVAVLSES ELGSEAQRER RKRILDATLA IASKGGYEAV QMRAVAERAD    50
    VAVGTLYRYF PSKVHLLVSA LGREFERIDA KTDRAALAGG TPYQRLNFMV 100
    GKLNRAMQRN PLLTEAMTRA FVFADASAAG EVDHVGKLMD SMFARAMSDG 150
    EPTEDQYHIA RVISDVWLSN LLAWLTRRAS ATDVSKRLDL AVRLLIGTEE 200
    QPKI 204
    Length:204
    Mass (Da):22,571
    Last modified:January 9, 2007 - v1
    Checksum:i1125BEBE034F88C2
    GO

    Sequence cautioni

    The sequence AFP42314.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000480 Genomic DNA. Translation: ABK75291.1.
    CP001663 Genomic DNA. Translation: AFP42314.1. Different initiation.
    RefSeqiYP_006570609.1. NC_018289.1.
    YP_890266.1. NC_008596.1.

    Genome annotation databases

    EnsemblBacteriaiABK75291; ABK75291; MSMEG_6042.
    AFP42314; AFP42314; MSMEI_5881.
    GeneIDi4531834.
    KEGGimsg:MSMEI_5881.
    msm:MSMEG_6042.
    PATRICi18084317. VBIMycSme59918_5878.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000480 Genomic DNA. Translation: ABK75291.1 .
    CP001663 Genomic DNA. Translation: AFP42314.1 . Different initiation.
    RefSeqi YP_006570609.1. NC_018289.1.
    YP_890266.1. NC_008596.1.

    3D structure databases

    ProteinModelPortali A0R528.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 246196.MSMEG_6042.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABK75291 ; ABK75291 ; MSMEG_6042 .
    AFP42314 ; AFP42314 ; MSMEI_5881 .
    GeneIDi 4531834.
    KEGGi msg:MSMEI_5881.
    msm:MSMEG_6042.
    PATRICi 18084317. VBIMycSme59918_5878.

    Phylogenomic databases

    eggNOGi NOG277692.
    HOGENOMi HOG000052226.
    OMAi MTRAFMF.
    OrthoDBi EOG6NSGGJ.

    Enzyme and pathway databases

    BioCyci MSME246196:GJ4Y-6041-MONOMER.

    Family and domain databases

    Gene3Di 1.10.357.10. 1 hit.
    InterProi IPR009057. Homeodomain-like.
    IPR001647. HTH_TetR.
    IPR015893. Tet_transcr_reg_TetR-like_C.
    [Graphical view ]
    Pfami PF00440. TetR_N. 1 hit.
    [Graphical view ]
    PRINTSi PR00455. HTHTETR.
    SUPFAMi SSF46689. SSF46689. 1 hit.
    PROSITEi PS50977. HTH_TETR_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Fleischmann R.D., Dodson R.J., Haft D.H., Merkel J.S., Nelson W.C., Fraser C.M.
      Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700084 / mc(2)155.
    2. "Interrupted coding sequences in Mycobacterium smegmatis: authentic mutations or sequencing errors?"
      Deshayes C., Perrodou E., Gallien S., Euphrasie D., Schaeffer C., Van-Dorsselaer A., Poch O., Lecompte O., Reyrat J.-M.
      Genome Biol. 8:R20.1-R20.9(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700084 / mc(2)155.
    3. "Ortho-proteogenomics: multiple proteomes investigation through orthology and a new MS-based protocol."
      Gallien S., Perrodou E., Carapito C., Deshayes C., Reyrat J.-M., Van Dorsselaer A., Poch O., Schaeffer C., Lecompte O.
      Genome Res. 19:128-135(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700084 / mc(2)155.
    4. "A highly conserved transcriptional repressor controls a large regulon involved in lipid degradation in Mycobacterium smegmatis and Mycobacterium tuberculosis."
      Kendall S.L., Withers M., Soffair C.N., Moreland N.J., Gurcha S., Sidders B., Frita R., Ten Bokum A., Besra G.S., Lott J.S., Stoker N.G.
      Mol. Microbiol. 65:684-699(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION AS A TRANSCRIPTIONAL REPRESSOR.

    Entry informationi

    Entry nameiKSTR_MYCS2
    AccessioniPrimary (citable) accession number: A0R528
    Secondary accession number(s): I7GG00
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 8, 2011
    Last sequence update: January 9, 2007
    Last modified: October 1, 2014
    This is version 55 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3