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A0R528 (KSTR_MYCS2) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 53. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
HTH-type transcriptional repressor KstR
Gene names
Name:kstR
Ordered Locus Names:MSMEG_6042, MSMEI_5881
OrganismMycobacterium smegmatis (strain ATCC 700084 / mc(2)155) [Reference proteome] [HAMAP]
Taxonomic identifier246196 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium

Protein attributes

Sequence length204 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Controls the expression of genes used for utilizing diverse lipids as energy sources. Ref.4

Subunit structure

Homodimer Probable.

Sequence similarities

Contains 1 HTH tetR-type DNA-binding domain.

Sequence caution

The sequence AFP42314.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   LigandDNA-binding
   Molecular functionRepressor
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processregulation of transcription, DNA-templated

Inferred from mutant phenotype Ref.4. Source: UniProtKB

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionDNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 204204HTH-type transcriptional repressor KstR
PRO_0000405029

Regions

Domain18 – 7861HTH tetR-type
DNA binding41 – 6020H-T-H motif By similarity

Sequences

Sequence LengthMass (Da)Tools
A0R528 [UniParc].

Last modified January 9, 2007. Version 1.
Checksum: 1125BEBE034F88C2

FASTA20422,571
        10         20         30         40         50         60 
MTNVAVLSES ELGSEAQRER RKRILDATLA IASKGGYEAV QMRAVAERAD VAVGTLYRYF 

        70         80         90        100        110        120 
PSKVHLLVSA LGREFERIDA KTDRAALAGG TPYQRLNFMV GKLNRAMQRN PLLTEAMTRA 

       130        140        150        160        170        180 
FVFADASAAG EVDHVGKLMD SMFARAMSDG EPTEDQYHIA RVISDVWLSN LLAWLTRRAS 

       190        200 
ATDVSKRLDL AVRLLIGTEE QPKI 

« Hide

References

« Hide 'large scale' references
[1]Fleischmann R.D., Dodson R.J., Haft D.H., Merkel J.S., Nelson W.C., Fraser C.M.
Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 700084 / mc(2)155.
[2]"Interrupted coding sequences in Mycobacterium smegmatis: authentic mutations or sequencing errors?"
Deshayes C., Perrodou E., Gallien S., Euphrasie D., Schaeffer C., Van-Dorsselaer A., Poch O., Lecompte O., Reyrat J.-M.
Genome Biol. 8:R20.1-R20.9(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 700084 / mc(2)155.
[3]"Ortho-proteogenomics: multiple proteomes investigation through orthology and a new MS-based protocol."
Gallien S., Perrodou E., Carapito C., Deshayes C., Reyrat J.-M., Van Dorsselaer A., Poch O., Schaeffer C., Lecompte O.
Genome Res. 19:128-135(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 700084 / mc(2)155.
[4]"A highly conserved transcriptional repressor controls a large regulon involved in lipid degradation in Mycobacterium smegmatis and Mycobacterium tuberculosis."
Kendall S.L., Withers M., Soffair C.N., Moreland N.J., Gurcha S., Sidders B., Frita R., Ten Bokum A., Besra G.S., Lott J.S., Stoker N.G.
Mol. Microbiol. 65:684-699(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION AS A TRANSCRIPTIONAL REPRESSOR.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000480 Genomic DNA. Translation: ABK75291.1.
CP001663 Genomic DNA. Translation: AFP42314.1. Different initiation.
RefSeqYP_006570609.1. NC_018289.1.
YP_890266.1. NC_008596.1.

3D structure databases

ProteinModelPortalA0R528.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING246196.MSMEG_6042.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABK75291; ABK75291; MSMEG_6042.
AFP42314; AFP42314; MSMEI_5881.
GeneID13427211.
4531834.
KEGGmsg:MSMEI_5881.
msm:MSMEG_6042.
PATRIC18084317. VBIMycSme59918_5878.

Phylogenomic databases

eggNOGNOG277692.
HOGENOMHOG000052226.
OMAMTRAFMF.
OrthoDBEOG6NSGGJ.

Enzyme and pathway databases

BioCycMSME246196:GJ4Y-6041-MONOMER.

Family and domain databases

Gene3D1.10.357.10. 1 hit.
InterProIPR009057. Homeodomain-like.
IPR001647. HTH_TetR.
IPR015893. Tet_transcr_reg_TetR-like_C.
[Graphical view]
PfamPF00440. TetR_N. 1 hit.
[Graphical view]
PRINTSPR00455. HTHTETR.
SUPFAMSSF46689. SSF46689. 1 hit.
PROSITEPS50977. HTH_TETR_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameKSTR_MYCS2
AccessionPrimary (citable) accession number: A0R528
Secondary accession number(s): I7GG00
Entry history
Integrated into UniProtKB/Swiss-Prot: February 8, 2011
Last sequence update: January 9, 2007
Last modified: February 19, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families