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Protein

HTH-type transcriptional repressor KstR2

Gene

kstR2

Organism
Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Controls the expression of a small regulon that may play a role in the utilization of cholesterol.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi33 – 52H-T-H motifPROSITE-ProRule annotationAdd BLAST20

GO - Molecular functioni

  • DNA binding Source: UniProtKB
  • protein homodimerization activity Source: UniProtKB

GO - Biological processi

  • regulation of transcription, DNA-templated Source: UniProtKB
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
HTH-type transcriptional repressor KstR2
Gene namesi
Name:kstR2
Ordered Locus Names:MSMEG_6009, MSMEI_5849
OrganismiMycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Taxonomic identifieri246196 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000006158 Componenti: Chromosome
  • UP000000757 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004050321 – 205HTH-type transcriptional repressor KstR2Add BLAST205

Interactioni

Subunit structurei

Homodimer.By similarity

GO - Molecular functioni

  • protein homodimerization activity Source: UniProtKB

Protein-protein interaction databases

STRINGi246196.MSMEG_6009.

Structurei

3D structure databases

ProteinModelPortaliA0R4Z6.
SMRiA0R4Z6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini10 – 70HTH tetR-typePROSITE-ProRule annotationAdd BLAST61

Phylogenomic databases

eggNOGiENOG4108RZE. Bacteria.
ENOG4111HHS. LUCA.
HOGENOMiHOG000249907.
OMAiATVFFHE.
OrthoDBiPOG091H02BD.

Family and domain databases

InterProiView protein in InterPro
IPR009057. Homeobox-like.
IPR001647. HTH_TetR.
IPR011075. Tet_transcr_reg_TetR-rel_C.
PfamiView protein in Pfam
PF00440. TetR_N. 1 hit.
PRINTSiPR00455. HTHTETR.
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF48498. SSF48498. 1 hit.
PROSITEiView protein in PROSITE
PS50977. HTH_TETR_2. 1 hit.

Sequencei

Sequence statusi: Complete.

A0R4Z6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPDTPSQPA SRRDELLQLA ATMFADRGLK ATTVRDIADS AGILSGSLYH
60 70 80 90 100
HFKSKEQMVE EVLRDFLDWL FGRYQQILDT ATSPLEKLTG LFMASFEAIE
110 120 130 140 150
HRHAQVVIYQ DEAKRLSDLP QFDFVETRNK EQRKMWVDIL QEGVADGSFR
160 170 180 190 200
PDLDVDLVYR FIRDTTWVSV RWYKPGGPLS AEQVGQQYLA IVLGGITQSQ

GDKHA
Length:205
Mass (Da):23,306
Last modified:January 9, 2007 - v1
Checksum:i8300989F65E1868E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000480 Genomic DNA. Translation: ABK75778.1.
CP001663 Genomic DNA. Translation: AFP42282.1.
RefSeqiWP_003897410.1. NZ_CP009494.1.
YP_890234.1. NC_008596.1.

Genome annotation databases

EnsemblBacteriaiABK75778; ABK75778; MSMEG_6009.
AFP42282; AFP42282; MSMEI_5849.
GeneIDi4534868.
KEGGimsb:LJ00_29710.
msg:MSMEI_5849.
msm:MSMEG_6009.
PATRICifig|246196.19.peg.5846.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiKSTR2_MYCS2
AccessioniPrimary (citable) accession number: A0R4Z6
Secondary accession number(s): I7G9M3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 8, 2011
Last sequence update: January 9, 2007
Last modified: June 7, 2017
This is version 72 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome