Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

A0R4Z6

- KSTR2_MYCS2

UniProt

A0R4Z6 - KSTR2_MYCS2

Protein

HTH-type transcriptional repressor KstR2

Gene

kstR2

Organism
Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 55 (01 Oct 2014)
      Sequence version 1 (09 Jan 2007)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Controls the expression of a small regulon that may play a role in the utilization of cholesterol.1 Publication

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi33 – 5220H-T-H motifPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB
    2. protein homodimerization activity Source: UniProtKB

    GO - Biological processi

    1. regulation of transcription, DNA-templated Source: UniProtKB
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Repressor

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Enzyme and pathway databases

    BioCyciMSME246196:GJ4Y-6008-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    HTH-type transcriptional repressor KstR2
    Gene namesi
    Name:kstR2
    Ordered Locus Names:MSMEG_6009, MSMEI_5849
    OrganismiMycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
    Taxonomic identifieri246196 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
    ProteomesiUP000000757: Chromosome, UP000006158: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 205205HTH-type transcriptional repressor KstR2PRO_0000405032Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Protein-protein interaction databases

    STRINGi246196.MSMEG_6009.

    Structurei

    3D structure databases

    ProteinModelPortaliA0R4Z6.
    SMRiA0R4Z6. Positions 10-198.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini10 – 7061HTH tetR-typePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 HTH tetR-type DNA-binding domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG1309.
    HOGENOMiHOG000249907.
    OMAiHESKYLQ.
    OrthoDBiEOG69PQ6R.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    1.10.357.10. 1 hit.
    InterProiIPR009057. Homeodomain-like.
    IPR001647. HTH_TetR.
    IPR015893. Tet_transcr_reg_TetR-like_C.
    IPR011075. Tet_transcr_reg_TetR-rel_C.
    [Graphical view]
    PfamiPF00440. TetR_N. 1 hit.
    [Graphical view]
    PRINTSiPR00455. HTHTETR.
    SUPFAMiSSF46689. SSF46689. 1 hit.
    SSF48498. SSF48498. 1 hit.
    PROSITEiPS50977. HTH_TETR_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A0R4Z6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAPDTPSQPA SRRDELLQLA ATMFADRGLK ATTVRDIADS AGILSGSLYH    50
    HFKSKEQMVE EVLRDFLDWL FGRYQQILDT ATSPLEKLTG LFMASFEAIE 100
    HRHAQVVIYQ DEAKRLSDLP QFDFVETRNK EQRKMWVDIL QEGVADGSFR 150
    PDLDVDLVYR FIRDTTWVSV RWYKPGGPLS AEQVGQQYLA IVLGGITQSQ 200
    GDKHA 205
    Length:205
    Mass (Da):23,306
    Last modified:January 9, 2007 - v1
    Checksum:i8300989F65E1868E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000480 Genomic DNA. Translation: ABK75778.1.
    CP001663 Genomic DNA. Translation: AFP42282.1.
    RefSeqiWP_003897410.1. NC_018289.1.
    YP_006570577.1. NC_018289.1.
    YP_890234.1. NC_008596.1.

    Genome annotation databases

    EnsemblBacteriaiABK75778; ABK75778; MSMEG_6009.
    AFP42282; AFP42282; MSMEI_5849.
    GeneIDi4534868.
    KEGGimsg:MSMEI_5849.
    msm:MSMEG_6009.
    PATRICi18084253. VBIMycSme59918_5846.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000480 Genomic DNA. Translation: ABK75778.1 .
    CP001663 Genomic DNA. Translation: AFP42282.1 .
    RefSeqi WP_003897410.1. NC_018289.1.
    YP_006570577.1. NC_018289.1.
    YP_890234.1. NC_008596.1.

    3D structure databases

    ProteinModelPortali A0R4Z6.
    SMRi A0R4Z6. Positions 10-198.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 246196.MSMEG_6009.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABK75778 ; ABK75778 ; MSMEG_6009 .
    AFP42282 ; AFP42282 ; MSMEI_5849 .
    GeneIDi 4534868.
    KEGGi msg:MSMEI_5849.
    msm:MSMEG_6009.
    PATRICi 18084253. VBIMycSme59918_5846.

    Phylogenomic databases

    eggNOGi COG1309.
    HOGENOMi HOG000249907.
    OMAi HESKYLQ.
    OrthoDBi EOG69PQ6R.

    Enzyme and pathway databases

    BioCyci MSME246196:GJ4Y-6008-MONOMER.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    1.10.357.10. 1 hit.
    InterProi IPR009057. Homeodomain-like.
    IPR001647. HTH_TetR.
    IPR015893. Tet_transcr_reg_TetR-like_C.
    IPR011075. Tet_transcr_reg_TetR-rel_C.
    [Graphical view ]
    Pfami PF00440. TetR_N. 1 hit.
    [Graphical view ]
    PRINTSi PR00455. HTHTETR.
    SUPFAMi SSF46689. SSF46689. 1 hit.
    SSF48498. SSF48498. 1 hit.
    PROSITEi PS50977. HTH_TETR_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Fleischmann R.D., Dodson R.J., Haft D.H., Merkel J.S., Nelson W.C., Fraser C.M.
      Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700084 / mc(2)155.
    2. "Interrupted coding sequences in Mycobacterium smegmatis: authentic mutations or sequencing errors?"
      Deshayes C., Perrodou E., Gallien S., Euphrasie D., Schaeffer C., Van-Dorsselaer A., Poch O., Lecompte O., Reyrat J.-M.
      Genome Biol. 8:R20.1-R20.9(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700084 / mc(2)155.
    3. "Ortho-proteogenomics: multiple proteomes investigation through orthology and a new MS-based protocol."
      Gallien S., Perrodou E., Carapito C., Deshayes C., Reyrat J.-M., Van Dorsselaer A., Poch O., Schaeffer C., Lecompte O.
      Genome Res. 19:128-135(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700084 / mc(2)155.
    4. "Cholesterol utilization in mycobacteria is controlled by two TetR-type transcriptional regulators: kstR and kstR2."
      Kendall S.L., Burgess P., Balhana R., Withers M., Ten Bokum A., Lott J.S., Gao C., Uhia-Castro I., Stoker N.G.
      Microbiology 156:1362-1371(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION AS A TRANSCRIPTIONAL REPRESSOR.

    Entry informationi

    Entry nameiKSTR2_MYCS2
    AccessioniPrimary (citable) accession number: A0R4Z6
    Secondary accession number(s): I7G9M3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 8, 2011
    Last sequence update: January 9, 2007
    Last modified: October 1, 2014
    This is version 55 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3