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A0R4Z6

- KSTR2_MYCS2

UniProt

A0R4Z6 - KSTR2_MYCS2

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Protein

HTH-type transcriptional repressor KstR2

Gene

kstR2

Organism
Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Controls the expression of a small regulon that may play a role in the utilization of cholesterol.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi33 – 5220H-T-H motifPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB
  2. protein homodimerization activity Source: UniProtKB

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciMSME246196:GJ4Y-6008-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
HTH-type transcriptional repressor KstR2
Gene namesi
Name:kstR2
Ordered Locus Names:MSMEG_6009, MSMEI_5849
OrganismiMycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Taxonomic identifieri246196 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
ProteomesiUP000000757: Chromosome, UP000006158: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 205205HTH-type transcriptional repressor KstR2PRO_0000405032Add
BLAST

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi246196.MSMEG_6009.

Structurei

3D structure databases

ProteinModelPortaliA0R4Z6.
SMRiA0R4Z6. Positions 10-198.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini10 – 7061HTH tetR-typePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 HTH tetR-type DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG1309.
HOGENOMiHOG000249907.
OMAiHESKYLQ.
OrthoDBiEOG69PQ6R.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
1.10.357.10. 1 hit.
InterProiIPR009057. Homeodomain-like.
IPR001647. HTH_TetR.
IPR015893. Tet_transcr_reg_TetR-like_C.
IPR011075. Tet_transcr_reg_TetR-rel_C.
[Graphical view]
PfamiPF00440. TetR_N. 1 hit.
[Graphical view]
PRINTSiPR00455. HTHTETR.
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF48498. SSF48498. 1 hit.
PROSITEiPS50977. HTH_TETR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A0R4Z6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAPDTPSQPA SRRDELLQLA ATMFADRGLK ATTVRDIADS AGILSGSLYH
60 70 80 90 100
HFKSKEQMVE EVLRDFLDWL FGRYQQILDT ATSPLEKLTG LFMASFEAIE
110 120 130 140 150
HRHAQVVIYQ DEAKRLSDLP QFDFVETRNK EQRKMWVDIL QEGVADGSFR
160 170 180 190 200
PDLDVDLVYR FIRDTTWVSV RWYKPGGPLS AEQVGQQYLA IVLGGITQSQ

GDKHA
Length:205
Mass (Da):23,306
Last modified:January 9, 2007 - v1
Checksum:i8300989F65E1868E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000480 Genomic DNA. Translation: ABK75778.1.
CP001663 Genomic DNA. Translation: AFP42282.1.
RefSeqiYP_006570577.1. NC_018289.1.
YP_890234.1. NC_008596.1.

Genome annotation databases

EnsemblBacteriaiABK75778; ABK75778; MSMEG_6009.
AFP42282; AFP42282; MSMEI_5849.
GeneIDi4534868.
KEGGimsg:MSMEI_5849.
msm:MSMEG_6009.
PATRICi18084253. VBIMycSme59918_5846.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000480 Genomic DNA. Translation: ABK75778.1 .
CP001663 Genomic DNA. Translation: AFP42282.1 .
RefSeqi YP_006570577.1. NC_018289.1.
YP_890234.1. NC_008596.1.

3D structure databases

ProteinModelPortali A0R4Z6.
SMRi A0R4Z6. Positions 10-198.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 246196.MSMEG_6009.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABK75778 ; ABK75778 ; MSMEG_6009 .
AFP42282 ; AFP42282 ; MSMEI_5849 .
GeneIDi 4534868.
KEGGi msg:MSMEI_5849.
msm:MSMEG_6009.
PATRICi 18084253. VBIMycSme59918_5846.

Phylogenomic databases

eggNOGi COG1309.
HOGENOMi HOG000249907.
OMAi HESKYLQ.
OrthoDBi EOG69PQ6R.

Enzyme and pathway databases

BioCyci MSME246196:GJ4Y-6008-MONOMER.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
1.10.357.10. 1 hit.
InterProi IPR009057. Homeodomain-like.
IPR001647. HTH_TetR.
IPR015893. Tet_transcr_reg_TetR-like_C.
IPR011075. Tet_transcr_reg_TetR-rel_C.
[Graphical view ]
Pfami PF00440. TetR_N. 1 hit.
[Graphical view ]
PRINTSi PR00455. HTHTETR.
SUPFAMi SSF46689. SSF46689. 1 hit.
SSF48498. SSF48498. 1 hit.
PROSITEi PS50977. HTH_TETR_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Fleischmann R.D., Dodson R.J., Haft D.H., Merkel J.S., Nelson W.C., Fraser C.M.
    Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700084 / mc(2)155.
  2. "Interrupted coding sequences in Mycobacterium smegmatis: authentic mutations or sequencing errors?"
    Deshayes C., Perrodou E., Gallien S., Euphrasie D., Schaeffer C., Van-Dorsselaer A., Poch O., Lecompte O., Reyrat J.-M.
    Genome Biol. 8:R20.1-R20.9(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700084 / mc(2)155.
  3. "Ortho-proteogenomics: multiple proteomes investigation through orthology and a new MS-based protocol."
    Gallien S., Perrodou E., Carapito C., Deshayes C., Reyrat J.-M., Van Dorsselaer A., Poch O., Schaeffer C., Lecompte O.
    Genome Res. 19:128-135(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700084 / mc(2)155.
  4. "Cholesterol utilization in mycobacteria is controlled by two TetR-type transcriptional regulators: kstR and kstR2."
    Kendall S.L., Burgess P., Balhana R., Withers M., Ten Bokum A., Lott J.S., Gao C., Uhia-Castro I., Stoker N.G.
    Microbiology 156:1362-1371(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION AS A TRANSCRIPTIONAL REPRESSOR.

Entry informationi

Entry nameiKSTR2_MYCS2
AccessioniPrimary (citable) accession number: A0R4Z6
Secondary accession number(s): I7G9M3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 8, 2011
Last sequence update: January 9, 2007
Last modified: October 29, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3