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A0R4Z6 (KSTR2_MYCS2) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 53. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
HTH-type transcriptional repressor KstR2
Gene names
Name:kstR2
Ordered Locus Names:MSMEG_6009, MSMEI_5849
OrganismMycobacterium smegmatis (strain ATCC 700084 / mc(2)155) [Reference proteome] [HAMAP]
Taxonomic identifier246196 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium

Protein attributes

Sequence length205 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Controls the expression of a small regulon that may play a role in the utilization of cholesterol. Ref.4

Subunit structure

Homodimer By similarity.

Sequence similarities

Contains 1 HTH tetR-type DNA-binding domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 205205HTH-type transcriptional repressor KstR2
PRO_0000405032

Regions

Domain10 – 7061HTH tetR-type
DNA binding33 – 5220H-T-H motif By similarity

Sequences

Sequence LengthMass (Da)Tools
A0R4Z6 [UniParc].

Last modified January 9, 2007. Version 1.
Checksum: 8300989F65E1868E

FASTA20523,306
        10         20         30         40         50         60 
MAPDTPSQPA SRRDELLQLA ATMFADRGLK ATTVRDIADS AGILSGSLYH HFKSKEQMVE 

        70         80         90        100        110        120 
EVLRDFLDWL FGRYQQILDT ATSPLEKLTG LFMASFEAIE HRHAQVVIYQ DEAKRLSDLP 

       130        140        150        160        170        180 
QFDFVETRNK EQRKMWVDIL QEGVADGSFR PDLDVDLVYR FIRDTTWVSV RWYKPGGPLS 

       190        200 
AEQVGQQYLA IVLGGITQSQ GDKHA 

« Hide

References

« Hide 'large scale' references
[1]Fleischmann R.D., Dodson R.J., Haft D.H., Merkel J.S., Nelson W.C., Fraser C.M.
Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 700084 / mc(2)155.
[2]"Interrupted coding sequences in Mycobacterium smegmatis: authentic mutations or sequencing errors?"
Deshayes C., Perrodou E., Gallien S., Euphrasie D., Schaeffer C., Van-Dorsselaer A., Poch O., Lecompte O., Reyrat J.-M.
Genome Biol. 8:R20.1-R20.9(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 700084 / mc(2)155.
[3]"Ortho-proteogenomics: multiple proteomes investigation through orthology and a new MS-based protocol."
Gallien S., Perrodou E., Carapito C., Deshayes C., Reyrat J.-M., Van Dorsselaer A., Poch O., Schaeffer C., Lecompte O.
Genome Res. 19:128-135(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 700084 / mc(2)155.
[4]"Cholesterol utilization in mycobacteria is controlled by two TetR-type transcriptional regulators: kstR and kstR2."
Kendall S.L., Burgess P., Balhana R., Withers M., Ten Bokum A., Lott J.S., Gao C., Uhia-Castro I., Stoker N.G.
Microbiology 156:1362-1371(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION AS A TRANSCRIPTIONAL REPRESSOR.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000480 Genomic DNA. Translation: ABK75778.1.
CP001663 Genomic DNA. Translation: AFP42282.1.
RefSeqYP_006570577.1. NC_018289.1.
YP_890234.1. NC_008596.1.

3D structure databases

ProteinModelPortalA0R4Z6.
SMRA0R4Z6. Positions 10-198.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING246196.MSMEG_6009.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABK75778; ABK75778; MSMEG_6009.
AFP42282; AFP42282; MSMEI_5849.
GeneID4534868.
KEGGmsg:MSMEI_5849.
msm:MSMEG_6009.
PATRIC18084253. VBIMycSme59918_5846.

Phylogenomic databases

eggNOGCOG1309.
HOGENOMHOG000249907.
OMAHESKYLQ.
OrthoDBEOG69PQ6R.

Enzyme and pathway databases

BioCycMSME246196:GJ4Y-6008-MONOMER.

Family and domain databases

Gene3D1.10.10.60. 1 hit.
1.10.357.10. 1 hit.
InterProIPR009057. Homeodomain-like.
IPR001647. HTH_TetR.
IPR015893. Tet_transcr_reg_TetR-like_C.
IPR011075. Tet_transcr_reg_TetR-rel_C.
[Graphical view]
PfamPF00440. TetR_N. 1 hit.
[Graphical view]
PRINTSPR00455. HTHTETR.
SUPFAMSSF46689. SSF46689. 1 hit.
SSF48498. SSF48498. 1 hit.
PROSITEPS50977. HTH_TETR_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameKSTR2_MYCS2
AccessionPrimary (citable) accession number: A0R4Z6
Secondary accession number(s): I7G9M3
Entry history
Integrated into UniProtKB/Swiss-Prot: February 8, 2011
Last sequence update: January 9, 2007
Last modified: July 9, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families