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A0R4Z6

- KSTR2_MYCS2

UniProt

A0R4Z6 - KSTR2_MYCS2

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Protein
HTH-type transcriptional repressor KstR2
Gene
kstR2, MSMEG_6009, MSMEI_5849
Organism
Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Controls the expression of a small regulon that may play a role in the utilization of cholesterol.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi33 – 5220H-T-H motif By similarity
Add
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB
  2. protein homodimerization activity Source: UniProtKB

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciMSME246196:GJ4Y-6008-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
HTH-type transcriptional repressor KstR2
Gene namesi
Name:kstR2
Ordered Locus Names:MSMEG_6009, MSMEI_5849
OrganismiMycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Taxonomic identifieri246196 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
ProteomesiUP000000757: Chromosome, UP000006158: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 205205HTH-type transcriptional repressor KstR2
PRO_0000405032Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.

Protein-protein interaction databases

STRINGi246196.MSMEG_6009.

Structurei

3D structure databases

ProteinModelPortaliA0R4Z6.
SMRiA0R4Z6. Positions 10-198.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini10 – 7061HTH tetR-type
Add
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1309.
HOGENOMiHOG000249907.
OMAiHESKYLQ.
OrthoDBiEOG69PQ6R.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
1.10.357.10. 1 hit.
InterProiIPR009057. Homeodomain-like.
IPR001647. HTH_TetR.
IPR015893. Tet_transcr_reg_TetR-like_C.
IPR011075. Tet_transcr_reg_TetR-rel_C.
[Graphical view]
PfamiPF00440. TetR_N. 1 hit.
[Graphical view]
PRINTSiPR00455. HTHTETR.
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF48498. SSF48498. 1 hit.
PROSITEiPS50977. HTH_TETR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A0R4Z6-1 [UniParc]FASTAAdd to Basket

« Hide

MAPDTPSQPA SRRDELLQLA ATMFADRGLK ATTVRDIADS AGILSGSLYH    50
HFKSKEQMVE EVLRDFLDWL FGRYQQILDT ATSPLEKLTG LFMASFEAIE 100
HRHAQVVIYQ DEAKRLSDLP QFDFVETRNK EQRKMWVDIL QEGVADGSFR 150
PDLDVDLVYR FIRDTTWVSV RWYKPGGPLS AEQVGQQYLA IVLGGITQSQ 200
GDKHA 205
Length:205
Mass (Da):23,306
Last modified:January 9, 2007 - v1
Checksum:i8300989F65E1868E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000480 Genomic DNA. Translation: ABK75778.1.
CP001663 Genomic DNA. Translation: AFP42282.1.
RefSeqiWP_003897410.1. NC_018289.1.
YP_006570577.1. NC_018289.1.
YP_890234.1. NC_008596.1.

Genome annotation databases

EnsemblBacteriaiABK75778; ABK75778; MSMEG_6009.
AFP42282; AFP42282; MSMEI_5849.
GeneIDi4534868.
KEGGimsg:MSMEI_5849.
msm:MSMEG_6009.
PATRICi18084253. VBIMycSme59918_5846.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000480 Genomic DNA. Translation: ABK75778.1 .
CP001663 Genomic DNA. Translation: AFP42282.1 .
RefSeqi WP_003897410.1. NC_018289.1.
YP_006570577.1. NC_018289.1.
YP_890234.1. NC_008596.1.

3D structure databases

ProteinModelPortali A0R4Z6.
SMRi A0R4Z6. Positions 10-198.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 246196.MSMEG_6009.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABK75778 ; ABK75778 ; MSMEG_6009 .
AFP42282 ; AFP42282 ; MSMEI_5849 .
GeneIDi 4534868.
KEGGi msg:MSMEI_5849.
msm:MSMEG_6009.
PATRICi 18084253. VBIMycSme59918_5846.

Phylogenomic databases

eggNOGi COG1309.
HOGENOMi HOG000249907.
OMAi HESKYLQ.
OrthoDBi EOG69PQ6R.

Enzyme and pathway databases

BioCyci MSME246196:GJ4Y-6008-MONOMER.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
1.10.357.10. 1 hit.
InterProi IPR009057. Homeodomain-like.
IPR001647. HTH_TetR.
IPR015893. Tet_transcr_reg_TetR-like_C.
IPR011075. Tet_transcr_reg_TetR-rel_C.
[Graphical view ]
Pfami PF00440. TetR_N. 1 hit.
[Graphical view ]
PRINTSi PR00455. HTHTETR.
SUPFAMi SSF46689. SSF46689. 1 hit.
SSF48498. SSF48498. 1 hit.
PROSITEi PS50977. HTH_TETR_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Fleischmann R.D., Dodson R.J., Haft D.H., Merkel J.S., Nelson W.C., Fraser C.M.
    Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700084 / mc(2)155.
  2. "Interrupted coding sequences in Mycobacterium smegmatis: authentic mutations or sequencing errors?"
    Deshayes C., Perrodou E., Gallien S., Euphrasie D., Schaeffer C., Van-Dorsselaer A., Poch O., Lecompte O., Reyrat J.-M.
    Genome Biol. 8:R20.1-R20.9(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700084 / mc(2)155.
  3. "Ortho-proteogenomics: multiple proteomes investigation through orthology and a new MS-based protocol."
    Gallien S., Perrodou E., Carapito C., Deshayes C., Reyrat J.-M., Van Dorsselaer A., Poch O., Schaeffer C., Lecompte O.
    Genome Res. 19:128-135(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700084 / mc(2)155.
  4. "Cholesterol utilization in mycobacteria is controlled by two TetR-type transcriptional regulators: kstR and kstR2."
    Kendall S.L., Burgess P., Balhana R., Withers M., Ten Bokum A., Lott J.S., Gao C., Uhia-Castro I., Stoker N.G.
    Microbiology 156:1362-1371(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION AS A TRANSCRIPTIONAL REPRESSOR.

Entry informationi

Entry nameiKSTR2_MYCS2
AccessioniPrimary (citable) accession number: A0R4Z6
Secondary accession number(s): I7G9M3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 8, 2011
Last sequence update: January 9, 2007
Last modified: September 3, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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