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A0R4S7

- ACDH2_MYCS2

UniProt

A0R4S7 - ACDH2_MYCS2

Protein

Acetaldehyde dehydrogenase 2

Gene

mhpF

Organism
Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 58 (01 Oct 2014)
      Sequence version 2 (03 Nov 2009)
      Previous versions | rss
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    Functioni

    Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds.UniRule annotation

    Catalytic activityi

    Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei127 – 1271Acyl-thioester intermediateUniRule annotation
    Binding sitei277 – 2771NADUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi12 – 154NADUniRule annotation
    Nucleotide bindingi158 – 1669NADUniRule annotation

    GO - Molecular functioni

    1. acetaldehyde dehydrogenase (acetylating) activity Source: UniProtKB-HAMAP
    2. NAD binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. aromatic compound catabolic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Aromatic hydrocarbons catabolism

    Keywords - Ligandi

    NAD

    Enzyme and pathway databases

    BioCyciMSME246196:GJ4Y-5938-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Acetaldehyde dehydrogenase 2UniRule annotation (EC:1.2.1.10UniRule annotation)
    Alternative name(s):
    Acetaldehyde dehydrogenase [acetylating] 2UniRule annotation
    Gene namesi
    Name:mhpFUniRule annotation
    Ordered Locus Names:MSMEG_5939, MSMEI_5779
    OrganismiMycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
    Taxonomic identifieri246196 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
    ProteomesiUP000000757: Chromosome, UP000006158: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 307307Acetaldehyde dehydrogenase 2PRO_0000387681Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi246196.MSMEG_5939.

    Structurei

    3D structure databases

    ProteinModelPortaliA0R4S7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the acetaldehyde dehydrogenase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG4569.
    HOGENOMiHOG000052149.
    KOiK04073.
    OrthoDBiEOG6H1PXH.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    HAMAPiMF_01657. Ac_ald_DH_ac.
    InterProiIPR003361. Acetaldehyde_dehydrogenase.
    IPR015426. Acetylaldehyde_DH_C.
    IPR016040. NAD(P)-bd_dom.
    IPR000534. Semialdehyde_DH_NAD-bd.
    [Graphical view]
    PfamiPF09290. AcetDehyd-dimer. 1 hit.
    PF01118. Semialdhyde_dh. 1 hit.
    [Graphical view]
    PIRSFiPIRSF015689. Actaldh_dh_actl. 1 hit.
    SMARTiSM00859. Semialdhyde_dh. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR03215. ac_ald_DH_ac. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A0R4S7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPKKSSVAIV GSGNISTDLL YKLLRSEWLE PRWMIGIDPE SEGLARARKL    50
    GLETSAEGVD WLLAQSEKPD LVFEATSAYV HRDAAPRYEE AGIRAIDLTP 100
    AAVGPGVVPP ANLRDHLDAP NVNMVTCGGQ ATIPIVHAVS RVVDVPYAEI 150
    VASVSSASAG PGTRANIDEF TKTTSAGVQN IGGAQRGKAI IVLNPAEPPM 200
    IMRDTIFCAI PEGADHDAIT QSIKDVVAEV QTYVPGYRLL NEPQFDEPSV 250
    VNGGNHLVTT FVEVEGAGDY LPPYAGNLDI MTAAATKVGE EIAKKSAEAS 300
    LASGAQA 307
    Length:307
    Mass (Da):32,324
    Last modified:November 3, 2009 - v2
    Checksum:iA619D96D276AD6F5
    GO

    Sequence cautioni

    The sequence ABK73662.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000480 Genomic DNA. Translation: ABK73662.1. Different initiation.
    CP001663 Genomic DNA. Translation: AFP42212.1.
    RefSeqiYP_006570507.1. NC_018289.1.
    YP_890165.1. NC_008596.1.

    Genome annotation databases

    EnsemblBacteriaiABK73662; ABK73662; MSMEG_5939.
    AFP42212; AFP42212; MSMEI_5779.
    GeneIDi4531880.
    KEGGimsg:MSMEI_5779.
    msm:MSMEG_5939.
    PATRICi18084117. VBIMycSme59918_5778.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000480 Genomic DNA. Translation: ABK73662.1 . Different initiation.
    CP001663 Genomic DNA. Translation: AFP42212.1 .
    RefSeqi YP_006570507.1. NC_018289.1.
    YP_890165.1. NC_008596.1.

    3D structure databases

    ProteinModelPortali A0R4S7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 246196.MSMEG_5939.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABK73662 ; ABK73662 ; MSMEG_5939 .
    AFP42212 ; AFP42212 ; MSMEI_5779 .
    GeneIDi 4531880.
    KEGGi msg:MSMEI_5779.
    msm:MSMEG_5939.
    PATRICi 18084117. VBIMycSme59918_5778.

    Phylogenomic databases

    eggNOGi COG4569.
    HOGENOMi HOG000052149.
    KOi K04073.
    OrthoDBi EOG6H1PXH.

    Enzyme and pathway databases

    BioCyci MSME246196:GJ4Y-5938-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    HAMAPi MF_01657. Ac_ald_DH_ac.
    InterProi IPR003361. Acetaldehyde_dehydrogenase.
    IPR015426. Acetylaldehyde_DH_C.
    IPR016040. NAD(P)-bd_dom.
    IPR000534. Semialdehyde_DH_NAD-bd.
    [Graphical view ]
    Pfami PF09290. AcetDehyd-dimer. 1 hit.
    PF01118. Semialdhyde_dh. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF015689. Actaldh_dh_actl. 1 hit.
    SMARTi SM00859. Semialdhyde_dh. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR03215. ac_ald_DH_ac. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Fleischmann R.D., Dodson R.J., Haft D.H., Merkel J.S., Nelson W.C., Fraser C.M.
      Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700084 / mc(2)155.
    2. "Interrupted coding sequences in Mycobacterium smegmatis: authentic mutations or sequencing errors?"
      Deshayes C., Perrodou E., Gallien S., Euphrasie D., Schaeffer C., Van-Dorsselaer A., Poch O., Lecompte O., Reyrat J.-M.
      Genome Biol. 8:R20.1-R20.9(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700084 / mc(2)155.
    3. "Ortho-proteogenomics: multiple proteomes investigation through orthology and a new MS-based protocol."
      Gallien S., Perrodou E., Carapito C., Deshayes C., Reyrat J.-M., Van Dorsselaer A., Poch O., Schaeffer C., Lecompte O.
      Genome Res. 19:128-135(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700084 / mc(2)155.

    Entry informationi

    Entry nameiACDH2_MYCS2
    AccessioniPrimary (citable) accession number: A0R4S7
    Secondary accession number(s): I7G9C0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 3, 2009
    Last sequence update: November 3, 2009
    Last modified: October 1, 2014
    This is version 58 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3