Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

A0R4S7

- ACDH2_MYCS2

UniProt

A0R4S7 - ACDH2_MYCS2

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Acetaldehyde dehydrogenase 2

Gene

mhpF

Organism
Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds.UniRule annotation

Catalytic activityi

Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei127 – 1271Acyl-thioester intermediateUniRule annotation
Binding sitei277 – 2771NADUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi12 – 154NADUniRule annotation
Nucleotide bindingi158 – 1669NADUniRule annotation

GO - Molecular functioni

  1. acetaldehyde dehydrogenase (acetylating) activity Source: UniProtKB-HAMAP
  2. NAD binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. aromatic compound catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Aromatic hydrocarbons catabolism

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciMSME246196:GJ4Y-5938-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetaldehyde dehydrogenase 2UniRule annotation (EC:1.2.1.10UniRule annotation)
Alternative name(s):
Acetaldehyde dehydrogenase [acetylating] 2UniRule annotation
Gene namesi
Name:mhpFUniRule annotation
Ordered Locus Names:MSMEG_5939, MSMEI_5779
OrganismiMycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Taxonomic identifieri246196 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
ProteomesiUP000000757: Chromosome, UP000006158: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 307307Acetaldehyde dehydrogenase 2PRO_0000387681Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi246196.MSMEG_5939.

Structurei

3D structure databases

ProteinModelPortaliA0R4S7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the acetaldehyde dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG4569.
HOGENOMiHOG000052149.
KOiK04073.
OrthoDBiEOG6H1PXH.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_01657. Ac_ald_DH_ac.
InterProiIPR003361. Acetaldehyde_dehydrogenase.
IPR015426. Acetylaldehyde_DH_C.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
[Graphical view]
PfamiPF09290. AcetDehyd-dimer. 1 hit.
PF01118. Semialdhyde_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF015689. Actaldh_dh_actl. 1 hit.
SMARTiSM00859. Semialdhyde_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03215. ac_ald_DH_ac. 1 hit.

Sequencei

Sequence statusi: Complete.

A0R4S7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPKKSSVAIV GSGNISTDLL YKLLRSEWLE PRWMIGIDPE SEGLARARKL
60 70 80 90 100
GLETSAEGVD WLLAQSEKPD LVFEATSAYV HRDAAPRYEE AGIRAIDLTP
110 120 130 140 150
AAVGPGVVPP ANLRDHLDAP NVNMVTCGGQ ATIPIVHAVS RVVDVPYAEI
160 170 180 190 200
VASVSSASAG PGTRANIDEF TKTTSAGVQN IGGAQRGKAI IVLNPAEPPM
210 220 230 240 250
IMRDTIFCAI PEGADHDAIT QSIKDVVAEV QTYVPGYRLL NEPQFDEPSV
260 270 280 290 300
VNGGNHLVTT FVEVEGAGDY LPPYAGNLDI MTAAATKVGE EIAKKSAEAS

LASGAQA
Length:307
Mass (Da):32,324
Last modified:November 3, 2009 - v2
Checksum:iA619D96D276AD6F5
GO

Sequence cautioni

The sequence ABK73662.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000480 Genomic DNA. Translation: ABK73662.1. Different initiation.
CP001663 Genomic DNA. Translation: AFP42212.1.
RefSeqiWP_014878495.1. NC_018289.1.
YP_006570507.1. NC_018289.1.
YP_890165.1. NC_008596.1.

Genome annotation databases

EnsemblBacteriaiABK73662; ABK73662; MSMEG_5939.
AFP42212; AFP42212; MSMEI_5779.
GeneIDi4531880.
KEGGimsm:MSMEG_5939.
PATRICi18084117. VBIMycSme59918_5778.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000480 Genomic DNA. Translation: ABK73662.1 . Different initiation.
CP001663 Genomic DNA. Translation: AFP42212.1 .
RefSeqi WP_014878495.1. NC_018289.1.
YP_006570507.1. NC_018289.1.
YP_890165.1. NC_008596.1.

3D structure databases

ProteinModelPortali A0R4S7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 246196.MSMEG_5939.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABK73662 ; ABK73662 ; MSMEG_5939 .
AFP42212 ; AFP42212 ; MSMEI_5779 .
GeneIDi 4531880.
KEGGi msm:MSMEG_5939.
PATRICi 18084117. VBIMycSme59918_5778.

Phylogenomic databases

eggNOGi COG4569.
HOGENOMi HOG000052149.
KOi K04073.
OrthoDBi EOG6H1PXH.

Enzyme and pathway databases

BioCyci MSME246196:GJ4Y-5938-MONOMER.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
HAMAPi MF_01657. Ac_ald_DH_ac.
InterProi IPR003361. Acetaldehyde_dehydrogenase.
IPR015426. Acetylaldehyde_DH_C.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
[Graphical view ]
Pfami PF09290. AcetDehyd-dimer. 1 hit.
PF01118. Semialdhyde_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF015689. Actaldh_dh_actl. 1 hit.
SMARTi SM00859. Semialdhyde_dh. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR03215. ac_ald_DH_ac. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Fleischmann R.D., Dodson R.J., Haft D.H., Merkel J.S., Nelson W.C., Fraser C.M.
    Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700084 / mc(2)155.
  2. "Interrupted coding sequences in Mycobacterium smegmatis: authentic mutations or sequencing errors?"
    Deshayes C., Perrodou E., Gallien S., Euphrasie D., Schaeffer C., Van-Dorsselaer A., Poch O., Lecompte O., Reyrat J.-M.
    Genome Biol. 8:R20.1-R20.9(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700084 / mc(2)155.
  3. "Ortho-proteogenomics: multiple proteomes investigation through orthology and a new MS-based protocol."
    Gallien S., Perrodou E., Carapito C., Deshayes C., Reyrat J.-M., Van Dorsselaer A., Poch O., Schaeffer C., Lecompte O.
    Genome Res. 19:128-135(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700084 / mc(2)155.

Entry informationi

Entry nameiACDH2_MYCS2
AccessioniPrimary (citable) accession number: A0R4S7
Secondary accession number(s): I7G9C0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: November 3, 2009
Last modified: November 26, 2014
This is version 59 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3