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A0R4Q6

- A0R4Q6_MYCS2

UniProt

A0R4Q6 - A0R4Q6_MYCS2

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Protein
Submitted name:

P450 heme-thiolate protein

Gene

MSMEG_5918

Organism
Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei239 – 2391Sulfate 2
Metal bindingi343 – 3431Iron (heme axial ligand)Imported
Binding sitei378 – 3781Sulfate 2

GO - Molecular functioni

  1. heme binding Source: InterPro
  2. iron ion binding Source: InterPro
  3. monooxygenase activity Source: UniProtKB-KW
  4. oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

MonooxygenaseUniRule annotationSAAS annotation, Oxidoreductase

Keywords - Ligandi

HemeUniRule annotationSAAS annotation, Iron, Metal-binding

Enzyme and pathway databases

BioCyciMSME246196:GJ4Y-5917-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
P450 heme-thiolate proteinImported
Gene namesi
Ordered Locus Names:MSMEG_5918Imported
OrganismiMycobacterium smegmatis (strain ATCC 700084 / mc(2)155)Imported
Taxonomic identifieri246196 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
ProteomesiUP000000757: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi246196.MSMEG_5918.

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2YOOX-ray1.69A/B/C/D4-401[»]
3ZBYX-ray1.93A/B/C/D/E/F1-401[»]
ProteinModelPortaliA0R4Q6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni4 – 74Sulfate 1 binding

Sequence similaritiesi

Belongs to the cytochrome P450 family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2124.
HOGENOMiHOG000243680.
KOiK16046.
OMAiRRRPANF.
OrthoDBiEOG6JB11P.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR002397. Cyt_P450_B.
IPR017972. Cyt_P450_CS.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00359. BP450.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A0R4Q6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTQMLTRPDV DLVNGMFYAD GGAREAYRWM RANEPVFRDR NGLAAATTYQ
60 70 80 90 100
AVLDAERNPE LFSSTGGIRP DQPGMPYMID MDDPQHLLRR KLVNAGFTRK
110 120 130 140 150
RVMDKVDSIG RLCDTLIDAV CERGECDFVR DIAAPLPMAV IGDMLGVLPT
160 170 180 190 200
ERDMLLKWSD DLVCGLSSHV DEAAIQKLMD TFAAYTEFTK DVITKRRAEP
210 220 230 240 250
TDDLFSVLVN SEVEGQRMSD DEIVFETLLI LIGGDETTRH TLSGGTEQLL
260 270 280 290 300
RHRDQWDALV ADVDLLPGAI EEMLRWTSPV KNMCRTLTAD TVFHGTELRA
310 320 330 340 350
GEKIMLMFES ANFDESVFGD PDNFRIDRNP NSHVAFGFGT HFCLGNQLAR
360 370 380 390 400
LELRLMTERV LRRLPDLRLA DDAPVPLRPA NFVSGPESMP VVFTPSAPVL

A
Length:401
Mass (Da):44,901
Last modified:January 9, 2007 - v1
Checksum:i9195ECA2F9D8D509
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000480 Genomic DNA. Translation: ABK74975.1.
RefSeqiYP_890144.1. NC_008596.1.

Genome annotation databases

EnsemblBacteriaiABK74975; ABK74975; MSMEG_5918.
GeneIDi4533135.
KEGGimsm:MSMEG_5918.
PATRICi18084077. VBIMycSme59918_5758.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000480 Genomic DNA. Translation: ABK74975.1 .
RefSeqi YP_890144.1. NC_008596.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2YOO X-ray 1.69 A/B/C/D 4-401 [» ]
3ZBY X-ray 1.93 A/B/C/D/E/F 1-401 [» ]
ProteinModelPortali A0R4Q6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 246196.MSMEG_5918.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABK74975 ; ABK74975 ; MSMEG_5918 .
GeneIDi 4533135.
KEGGi msm:MSMEG_5918.
PATRICi 18084077. VBIMycSme59918_5758.

Phylogenomic databases

eggNOGi COG2124.
HOGENOMi HOG000243680.
KOi K16046.
OMAi RRRPANF.
OrthoDBi EOG6JB11P.

Enzyme and pathway databases

BioCyci MSME246196:GJ4Y-5917-MONOMER.

Family and domain databases

Gene3Di 1.10.630.10. 1 hit.
InterProi IPR001128. Cyt_P450.
IPR002397. Cyt_P450_B.
IPR017972. Cyt_P450_CS.
[Graphical view ]
Pfami PF00067. p450. 1 hit.
[Graphical view ]
PRINTSi PR00359. BP450.
PR00385. P450.
SUPFAMi SSF48264. SSF48264. 1 hit.
PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Fleischmann R.D., Dodson R.J., Haft D.H., Merkel J.S., Nelson W.C., Fraser C.M.
    Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700084 / mc(2)155Imported.
  2. "A highly conserved mycobacterial cholesterol catabolic pathway."
    Garcia-Fernandez E., Frank D.J., Galan B., Kells P.M., Podust L.M., Garcia J.L., Ortiz de Montellano P.R.
    Environ. Microbiol. 15:2342-2359(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.69 ANGSTROMS) OF 4-401 IN COMPLEX WITH HEME.

Entry informationi

Entry nameiA0R4Q6_MYCS2
AccessioniPrimary (citable) accession number: A0R4Q6
Entry historyi
Integrated into UniProtKB/TrEMBL: January 9, 2007
Last sequence update: January 9, 2007
Last modified: October 29, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported, Complete proteome, Reference proteomeImported

External Data

Dasty 3