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A0R4Q6

- A0R4Q6_MYCS2

UniProt

A0R4Q6 - A0R4Q6_MYCS2

Protein
Submitted name:

P450 heme-thiolate protein

Gene

MSMEG_5918

Organism
Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 59 (01 Oct 2014)
      Sequence version 1 (09 Jan 2007)
      Previous versions | rss
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    Functioni

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei239 – 2391Sulfate 2
    Metal bindingi343 – 3431Iron (heme axial ligand)Imported
    Binding sitei378 – 3781Sulfate 2

    GO - Molecular functioni

    1. heme binding Source: InterPro
    2. iron ion binding Source: InterPro
    3. monooxygenase activity Source: UniProtKB-KW
    4. oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen Source: InterPro

    Keywords - Molecular functioni

    MonooxygenaseUniRule annotationSAAS annotation, Oxidoreductase

    Keywords - Ligandi

    HemeUniRule annotationSAAS annotationImported, Iron, Metal-binding

    Enzyme and pathway databases

    BioCyciMSME246196:GJ4Y-5917-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    P450 heme-thiolate proteinImported
    Gene namesi
    Ordered Locus Names:MSMEG_5918Imported
    OrganismiMycobacterium smegmatis (strain ATCC 700084 / mc(2)155)Imported
    Taxonomic identifieri246196 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
    ProteomesiUP000000757: Chromosome

    Interactioni

    Protein-protein interaction databases

    STRINGi246196.MSMEG_5918.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2YOOX-ray1.69A/B/C/D4-401[»]
    3ZBYX-ray1.93A/B/C/D/E/F1-401[»]
    ProteinModelPortaliA0R4Q6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni4 – 74Sulfate 1 binding

    Sequence similaritiesi

    Belongs to the cytochrome P450 family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2124.
    HOGENOMiHOG000243680.
    KOiK16046.
    OMAiRRRPANF.
    OrthoDBiEOG6JB11P.

    Family and domain databases

    Gene3Di1.10.630.10. 1 hit.
    InterProiIPR001128. Cyt_P450.
    IPR002397. Cyt_P450_B.
    IPR017972. Cyt_P450_CS.
    [Graphical view]
    PfamiPF00067. p450. 1 hit.
    [Graphical view]
    PRINTSiPR00359. BP450.
    PR00385. P450.
    SUPFAMiSSF48264. SSF48264. 1 hit.
    PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A0R4Q6-1 [UniParc]FASTAAdd to Basket

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    MTQMLTRPDV DLVNGMFYAD GGAREAYRWM RANEPVFRDR NGLAAATTYQ    50
    AVLDAERNPE LFSSTGGIRP DQPGMPYMID MDDPQHLLRR KLVNAGFTRK 100
    RVMDKVDSIG RLCDTLIDAV CERGECDFVR DIAAPLPMAV IGDMLGVLPT 150
    ERDMLLKWSD DLVCGLSSHV DEAAIQKLMD TFAAYTEFTK DVITKRRAEP 200
    TDDLFSVLVN SEVEGQRMSD DEIVFETLLI LIGGDETTRH TLSGGTEQLL 250
    RHRDQWDALV ADVDLLPGAI EEMLRWTSPV KNMCRTLTAD TVFHGTELRA 300
    GEKIMLMFES ANFDESVFGD PDNFRIDRNP NSHVAFGFGT HFCLGNQLAR 350
    LELRLMTERV LRRLPDLRLA DDAPVPLRPA NFVSGPESMP VVFTPSAPVL 400
    A 401
    Length:401
    Mass (Da):44,901
    Last modified:January 9, 2007 - v1
    Checksum:i9195ECA2F9D8D509
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000480 Genomic DNA. Translation: ABK74975.1.
    RefSeqiYP_890144.1. NC_008596.1.

    Genome annotation databases

    EnsemblBacteriaiABK74975; ABK74975; MSMEG_5918.
    GeneIDi4533135.
    KEGGimsm:MSMEG_5918.
    PATRICi18084077. VBIMycSme59918_5758.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000480 Genomic DNA. Translation: ABK74975.1 .
    RefSeqi YP_890144.1. NC_008596.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2YOO X-ray 1.69 A/B/C/D 4-401 [» ]
    3ZBY X-ray 1.93 A/B/C/D/E/F 1-401 [» ]
    ProteinModelPortali A0R4Q6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 246196.MSMEG_5918.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABK74975 ; ABK74975 ; MSMEG_5918 .
    GeneIDi 4533135.
    KEGGi msm:MSMEG_5918.
    PATRICi 18084077. VBIMycSme59918_5758.

    Phylogenomic databases

    eggNOGi COG2124.
    HOGENOMi HOG000243680.
    KOi K16046.
    OMAi RRRPANF.
    OrthoDBi EOG6JB11P.

    Enzyme and pathway databases

    BioCyci MSME246196:GJ4Y-5917-MONOMER.

    Family and domain databases

    Gene3Di 1.10.630.10. 1 hit.
    InterProi IPR001128. Cyt_P450.
    IPR002397. Cyt_P450_B.
    IPR017972. Cyt_P450_CS.
    [Graphical view ]
    Pfami PF00067. p450. 1 hit.
    [Graphical view ]
    PRINTSi PR00359. BP450.
    PR00385. P450.
    SUPFAMi SSF48264. SSF48264. 1 hit.
    PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Fleischmann R.D., Dodson R.J., Haft D.H., Merkel J.S., Nelson W.C., Fraser C.M.
      Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700084 / mc(2)155Imported.
    2. "A highly conserved mycobacterial cholesterol catabolic pathway."
      Garcia-Fernandez E., Frank D.J., Galan B., Kells P.M., Podust L.M., Garcia J.L., Ortiz de Montellano P.R.
      Environ. Microbiol. 15:2342-2359(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.69 ANGSTROMS) OF 4-401 IN COMPLEX WITH HEME.

    Entry informationi

    Entry nameiA0R4Q6_MYCS2
    AccessioniPrimary (citable) accession number: A0R4Q6
    Entry historyi
    Integrated into UniProtKB/TrEMBL: January 9, 2007
    Last sequence update: January 9, 2007
    Last modified: October 1, 2014
    This is version 59 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported, Complete proteome, Reference proteomeImported

    External Data

    Dasty 3