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Protein
Submitted name:

P450 heme-thiolate protein

Gene

MSMEG_5918

Organism
Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi343 – 3431Iron (heme axial ligand)Combined sources

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

HemeCombined sources, Iron, Metal-binding

Enzyme and pathway databases

BioCyciMSME246196:GJ4Y-5917-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
P450 heme-thiolate proteinImported
Gene namesi
Ordered Locus Names:MSMEG_5918Imported
OrganismiMycobacterium smegmatis (strain ATCC 700084 / mc(2)155)Imported
Taxonomic identifieri246196 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
ProteomesiUP000000757 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi246196.MSMEG_5918.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2YOOX-ray1.69A/B/C/D4-401[»]
3ZBYX-ray1.93A/B/C/D/E/F1-401[»]
4TRIX-ray2.00A/B1-401[»]
4UAXX-ray1.78A1-401[»]
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiCOG2124.
HOGENOMiHOG000243680.
KOiK16046.
OMAiSHVAFGF.
OrthoDBiEOG6JB11P.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR002397. Cyt_P450_B.
IPR017972. Cyt_P450_CS.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00359. BP450.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A0R4Q6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTQMLTRPDV DLVNGMFYAD GGAREAYRWM RANEPVFRDR NGLAAATTYQ
60 70 80 90 100
AVLDAERNPE LFSSTGGIRP DQPGMPYMID MDDPQHLLRR KLVNAGFTRK
110 120 130 140 150
RVMDKVDSIG RLCDTLIDAV CERGECDFVR DIAAPLPMAV IGDMLGVLPT
160 170 180 190 200
ERDMLLKWSD DLVCGLSSHV DEAAIQKLMD TFAAYTEFTK DVITKRRAEP
210 220 230 240 250
TDDLFSVLVN SEVEGQRMSD DEIVFETLLI LIGGDETTRH TLSGGTEQLL
260 270 280 290 300
RHRDQWDALV ADVDLLPGAI EEMLRWTSPV KNMCRTLTAD TVFHGTELRA
310 320 330 340 350
GEKIMLMFES ANFDESVFGD PDNFRIDRNP NSHVAFGFGT HFCLGNQLAR
360 370 380 390 400
LELRLMTERV LRRLPDLRLA DDAPVPLRPA NFVSGPESMP VVFTPSAPVL

A
Length:401
Mass (Da):44,901
Last modified:January 9, 2007 - v1
Checksum:i9195ECA2F9D8D509
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000480 Genomic DNA. Translation: ABK74975.1.
RefSeqiWP_011730892.1. NZ_CP009494.1.
YP_890144.1. NC_008596.1.

Genome annotation databases

EnsemblBacteriaiABK74975; ABK74975; MSMEG_5918.
AIU10920; AIU10920; LJ00_29265.
GeneIDi4533135.
KEGGimsb:LJ00_29265.
msm:MSMEG_5918.
PATRICi18084077. VBIMycSme59918_5758.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000480 Genomic DNA. Translation: ABK74975.1.
RefSeqiWP_011730892.1. NZ_CP009494.1.
YP_890144.1. NC_008596.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2YOOX-ray1.69A/B/C/D4-401[»]
3ZBYX-ray1.93A/B/C/D/E/F1-401[»]
4TRIX-ray2.00A/B1-401[»]
4UAXX-ray1.78A1-401[»]
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi246196.MSMEG_5918.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABK74975; ABK74975; MSMEG_5918.
AIU10920; AIU10920; LJ00_29265.
GeneIDi4533135.
KEGGimsb:LJ00_29265.
msm:MSMEG_5918.
PATRICi18084077. VBIMycSme59918_5758.

Phylogenomic databases

eggNOGiCOG2124.
HOGENOMiHOG000243680.
KOiK16046.
OMAiSHVAFGF.
OrthoDBiEOG6JB11P.

Enzyme and pathway databases

BioCyciMSME246196:GJ4Y-5917-MONOMER.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR002397. Cyt_P450_B.
IPR017972. Cyt_P450_CS.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00359. BP450.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Fleischmann R.D., Dodson R.J., Haft D.H., Merkel J.S., Nelson W.C., Fraser C.M.
    Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700084 / mc(2)155Imported.
  2. "A highly conserved mycobacterial cholesterol catabolic pathway."
    Garcia-Fernandez E., Frank D.J., Galan B., Kells P.M., Podust L.M., Garcia J.L., Ortiz de Montellano P.R.
    Environ. Microbiol. 15:2342-2359(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.69 ANGSTROMS) OF 4-401 IN COMPLEX WITH HEME.
  3. "Cholesterol ester oxidation by mycobacterial cytochrome P450."
    Frank D.J., Madrona Y., Ortiz de Montellano P.R.
    J. Biol. Chem. 289:30417-30425(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.78 ANGSTROMS) IN COMPLEX WITH HEME.

Entry informationi

Entry nameiA0R4Q6_MYCS2
AccessioniPrimary (citable) accession number: A0R4Q6
Entry historyi
Integrated into UniProtKB/TrEMBL: January 9, 2007
Last sequence update: January 9, 2007
Last modified: July 22, 2015
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.