ID   GABD2_MYCS2             Reviewed;         517 AA.
AC   A0R4Q0;
DT   13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT   09-JAN-2007, sequence version 1.
DT   16-JUN-2009, entry version 20.
DE   RecName: Full=Putative succinate-semialdehyde dehydrogenase [NADP+];
DE            Short=SSADH;
DE            Short=SSDH;
DE            EC=1.2.1.16;
GN   Name=gabD2; OrderedLocusNames=MSMEG_5912;
OS   Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155).
OC   Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales;
OC   Corynebacterineae; Mycobacteriaceae; Mycobacterium.
OX   NCBI_TaxID=246196;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Fleischmann R.D., Dodson R.J., Haft D.H., Merkel J.S., Nelson W.C.,
RA   Fraser C.M.;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Catalyzes the NADP(+)-dependent oxidation of succinate
CC       semialdehyde to succinate. Although it has succinate semialdehyde
CC       dehydrogenase activity, is likely to act physiologically on a
CC       different aldehyde(s) (By similarity).
CC   -!- CATALYTIC ACTIVITY: Succinate semialdehyde + NAD(P)(+) + H(2)O =
CC       succinate + NAD(P)H.
CC   -!- SIMILARITY: Belongs to the aldehyde dehydrogenase family.
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DR   EMBL; CP000480; ABK69825.1; -; Genomic_DNA.
DR   RefSeq; YP_890138.1; -.
DR   GeneID; 4534217; -.
DR   GenomeReviews; CP000480_GR; MSMEG_5912.
DR   KEGG; msm:MSMEG_5912; -.
DR   NMPDR; fig|246196.1.peg.5871; -.
DR   TIGR; MSMEG_5912; -.
DR   OMA; A0R4Q0; DTEYGLN.
DR   GO; GO:0009013; F:succinate-semialdehyde dehydrogenase [NAD(P...; IEA:EC.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   InterPro; IPR016160; Ald_DH_CS.
DR   InterPro; IPR016162; Ald_DH_N.
DR   InterPro; IPR015590; Aldehyde_DH.
DR   Gene3D; G3DSA:3.40.605.10; Aldehyde_dehydrogenase_N; 1.
DR   PANTHER; PTHR11699; Aldehyde_dehyd; 1.
DR   Pfam; PF00171; Aldedh; 1.
DR   PROSITE; PS00070; ALDEHYDE_DEHYDR_CYS; FALSE_NEG.
DR   PROSITE; PS00687; ALDEHYDE_DEHYDR_GLU; 1.
PE   3: Inferred from homology;
KW   Complete proteome; NADP; Oxidoreductase.
FT   CHAIN         1    517       Putative succinate-semialdehyde
FT                                dehydrogenase [NADP+].
FT                                /FTId=PRO_0000310710.
FT   NP_BIND     232    237       NAD or NADP (By similarity).
FT   ACT_SITE    254    254       By similarity.
FT   ACT_SITE    288    288       By similarity.
SQ   SEQUENCE   517 AA;  54992 MW;  8015E38D33E866C4 CRC64;
     MPAPSAADFA RLRSLVAIED LDARQSRPIE EVFTGRELTT IPVGTAEDVA AAFAKARAAQ
     RGWAHRPVAE RAAIMERFRD LVAKNRDFLM DVAQAETGKA RSAAQEEIVD MMLNARYYAR
     QAVKLLAPKR VQGLLPGVVK TVVNHHPKGV VGVISPWNYP MALSISDSIP ALLAGNAVVV
     KPDSQTPYCT LANAELLYEA GLPRDLFAVV PGPGSVVGTA IVENCDYLMF TGSTATGRTL
     AEQCGRRLIG FSAELGGKNP MIVTRGAKLD VAAKAATRAC FSNAGQLCIS IERIYVERAV
     ADEFTAKFGE QVRSMRLAAT YDFTADMGSL ISEDQIKTVS GHVDDAKAKG ATVIAGGNIR
     PDIGPRFYEP TVLTGVTDEM ECARNETFGP VVSIYPVESV AEAIEKANDT EYGLNASVWA
     GSKTEGEAIA AQLQAGTVNV DEGYALAFGS TAAPMGGMKA SGVGRRHGAD GILKYTESQT
     VATSRVLNLD PPLGISGTLW QKAMTPMIRA VQKLPGR
//