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Reviewed, UniProtKB/Swiss-Prot A0R4Q0 (GABD2_MYCS2)

Last modified June 16, 2009. Version 20. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Putative succinate-semialdehyde dehydrogenase [NADP+]
      Short name=SSADH
      Short name=SSDH
    EC=1.2.1.16
Gene names
Name: gabD2
Ordered Locus Names: MSMEG_5912
OrganismMycobacterium smegmatis (strain ATCC 700084 / mc(2)155) [Complete proteome] [HAMAP]
Taxonomic identifier246196 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

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Protein attributes

Sequence length517 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

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General annotation (Comments)

Function

Catalyzes the NADP+-dependent oxidation of succinate semialdehyde to succinate. Although it has succinate semialdehyde dehydrogenase activity, is likely to act physiologically on a different aldehyde(s) By similarity.

Catalytic activity

Succinate semialdehyde + NAD(P)+ + H2O = succinate + NAD(P)H.

Sequence similarities

Belongs to the aldehyde dehydrogenase family.

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Ontologies

Keywords
   LigandNADP
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processoxidation reduction

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionsuccinate-semialdehyde dehydrogenase [NAD(P)+] activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 517517Putative succinate-semialdehyde dehydrogenase [NADP+]
PRO_0000310710

Regions

Nucleotide binding232 – 2376NAD or NADP By similarity

Sites

Active site2541 By similarity
Active site2881 By similarity

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Sequences

Sequence LengthMass (Da)Tools
A0R4Q0-1 [UniParc].

Last modified January 9, 2007. Version 1.
Checksum: 8015E38D33E866C4

FASTA51754,992
        10         20         30         40         50         60 
MPAPSAADFA RLRSLVAIED LDARQSRPIE EVFTGRELTT IPVGTAEDVA AAFAKARAAQ 

        70         80         90        100        110        120 
RGWAHRPVAE RAAIMERFRD LVAKNRDFLM DVAQAETGKA RSAAQEEIVD MMLNARYYAR 

       130        140        150        160        170        180 
QAVKLLAPKR VQGLLPGVVK TVVNHHPKGV VGVISPWNYP MALSISDSIP ALLAGNAVVV 

       190        200        210        220        230        240 
KPDSQTPYCT LANAELLYEA GLPRDLFAVV PGPGSVVGTA IVENCDYLMF TGSTATGRTL 

       250        260        270        280        290        300 
AEQCGRRLIG FSAELGGKNP MIVTRGAKLD VAAKAATRAC FSNAGQLCIS IERIYVERAV 

       310        320        330        340        350        360 
ADEFTAKFGE QVRSMRLAAT YDFTADMGSL ISEDQIKTVS GHVDDAKAKG ATVIAGGNIR 

       370        380        390        400        410        420 
PDIGPRFYEP TVLTGVTDEM ECARNETFGP VVSIYPVESV AEAIEKANDT EYGLNASVWA 

       430        440        450        460        470        480 
GSKTEGEAIA AQLQAGTVNV DEGYALAFGS TAAPMGGMKA SGVGRRHGAD GILKYTESQT 

       490        500        510 
VATSRVLNLD PPLGISGTLW QKAMTPMIRA VQKLPGR

« Hide

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References

[1]Fleischmann R.D., Dodson R.J., Haft D.H., Merkel J.S., Nelson W.C., Fraser C.M.
Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

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Cross-references

Sequence databases

CP000480 Genomic DNA. Translation: ABK69825.1.
RefSeqYP_890138.1.

3D structure databases

ModBaseSearch...

Genome annotation databases

GeneID4534217.
GenomeReviewsGene locus MSMEG_5912 in contig CP000480_GR.
KEGGmsm:MSMEG_5912.
NMPDRfig|246196.1.peg.5871.
TIGRMSMEG_5912.

Phylogenomic databases

OMAA0R4Q0. DTEYGLN.

Family and domain databases

InterProIPR016160. Ald_DH_CS.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH.
[Graphical view]
Gene3DG3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
PANTHERPTHR11699. Aldehyde_dehyd. 1 hit.
PfamPF00171. Aldedh. 1 hit.
[Graphical view]
PROSITEPS00070. ALDEHYDE_DEHYDR_CYS. False negative.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameGABD2_MYCS2
AccessionPrimary (citable) accession number: A0R4Q0
Entry history
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: January 9, 2007
Last modified: June 16, 2009
This is version 20 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents