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A0R4Q0 (GABD2_MYCS2) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 39. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Putative succinate-semialdehyde dehydrogenase [NADP+]
Short name=SSADH
Short name=SSDH
EC=1.2.1.79
Gene names
Name:gabD2
Ordered Locus Names:MSMEG_5912
OrganismMycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Taxonomic identifier246196 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length517 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the NADP+-dependent oxidation of succinate semialdehyde to succinate. Although it has succinate semialdehyde dehydrogenase activity, is likely to act physiologically on a different aldehyde(s) By similarity.

Catalytic activity

Succinate semialdehyde + NADP+ + H2O = succinate + NADPH.

Sequence similarities

Belongs to the aldehyde dehydrogenase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 517517Putative succinate-semialdehyde dehydrogenase [NADP+]
PRO_0000310710

Regions

Nucleotide binding157 – 1582NADP By similarity
Nucleotide binding181 – 1844NADP By similarity
Nucleotide binding232 – 2332NADP By similarity

Sites

Active site2541Proton acceptor By similarity
Active site2881Nucleophile By similarity
Binding site2551NADP; via carbonyl oxygen By similarity
Binding site3861NADP By similarity

Sequences

Sequence LengthMass (Da)Tools
A0R4Q0 [UniParc].

Last modified January 9, 2007. Version 1.
Checksum: 8015E38D33E866C4

FASTA51754,992
        10         20         30         40         50         60 
MPAPSAADFA RLRSLVAIED LDARQSRPIE EVFTGRELTT IPVGTAEDVA AAFAKARAAQ 

        70         80         90        100        110        120 
RGWAHRPVAE RAAIMERFRD LVAKNRDFLM DVAQAETGKA RSAAQEEIVD MMLNARYYAR 

       130        140        150        160        170        180 
QAVKLLAPKR VQGLLPGVVK TVVNHHPKGV VGVISPWNYP MALSISDSIP ALLAGNAVVV 

       190        200        210        220        230        240 
KPDSQTPYCT LANAELLYEA GLPRDLFAVV PGPGSVVGTA IVENCDYLMF TGSTATGRTL 

       250        260        270        280        290        300 
AEQCGRRLIG FSAELGGKNP MIVTRGAKLD VAAKAATRAC FSNAGQLCIS IERIYVERAV 

       310        320        330        340        350        360 
ADEFTAKFGE QVRSMRLAAT YDFTADMGSL ISEDQIKTVS GHVDDAKAKG ATVIAGGNIR 

       370        380        390        400        410        420 
PDIGPRFYEP TVLTGVTDEM ECARNETFGP VVSIYPVESV AEAIEKANDT EYGLNASVWA 

       430        440        450        460        470        480 
GSKTEGEAIA AQLQAGTVNV DEGYALAFGS TAAPMGGMKA SGVGRRHGAD GILKYTESQT 

       490        500        510 
VATSRVLNLD PPLGISGTLW QKAMTPMIRA VQKLPGR

« Hide

References

[1]Fleischmann R.D., Dodson R.J., Haft D.H., Merkel J.S., Nelson W.C., Fraser C.M.
Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 700084 / mc(2)155.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000480 Genomic DNA. Translation: ABK69825.1.
RefSeqYP_890138.1. NC_008596.1.

3D structure databases

ProteinModelPortalA0R4Q0.
ModBaseSearch...

Protein-protein interaction databases

STRINGA0R4Q0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBMYCT00000043741; EBMYCP00000042078; EBMYCG00000043736.
GeneID4534217.
GenomeReviewsGene locus MSMEG_5912 in contig CP000480_GR.
KEGGmsm:MSMEG_5912.
NMPDRfig|246196.1.peg.5871.
PATRIC18084065. VBIMycSme59918_5752.
TIGRMSMEG_5912.

Phylogenomic databases

eggNOGCOG1012.
GeneTreeEBGT00050000015660.
HOGENOMHBG752218.
OMAGPLVSIY.
ProtClustDBPRK09407.

Enzyme and pathway databases

BioCycMSME246196:MSMEG_5912-MONOMER.

Family and domain databases

InterProIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
[Graphical view]
Gene3DG3DSA:3.40.309.10. Aldehyde_dehydrogenase_C. 1 hit.
G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
KOK00135.
PfamPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMSSF53720. Aldehyde_DH/Histidinol_DH. 1 hit.
PROSITEPS00070. ALDEHYDE_DEHYDR_CYS. False negative.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGABD2_MYCS2
AccessionPrimary (citable) accession number: A0R4Q0
Entry history
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: January 9, 2007
Last modified: December 14, 2011
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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