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Protein

Intracellular chorismate mutase

Gene

MSMEG_5536

Organism
Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the Claisen rearrangement of chorismate to prephenate. Probably involved in the aromatic amino acid biosynthesis.1 Publication

Catalytic activityi

Chorismate = prephenate.

Pathwayi: prephenate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes prephenate from chorismate.
Proteins known to be involved in this subpathway in this organism are:
  1. Intracellular chorismate mutase (MSMEG_5536), Secreted chorismate mutase (MSMEG_2111)
This subpathway is part of the pathway prephenate biosynthesis, which is itself part of Metabolic intermediate biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes prephenate from chorismate, the pathway prephenate biosynthesis and in Metabolic intermediate biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei31SubstrateSequence analysis1
Binding sitei48SubstrateBy similarity1
Binding sitei52SubstrateBy similarity1
Binding sitei59SubstrateSequence analysis1
Sitei59Important for catalysisBy similarity1
Sitei100Important for activation via AroGBy similarity1
Sitei101Important for activation via AroGBy similarity1
Sitei102Important for activation via AroGBy similarity1

GO - Molecular functioni

  • chorismate mutase activity Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processAmino-acid biosynthesis, Aromatic amino acid biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00120; UER00203

Names & Taxonomyi

Protein namesi
Recommended name:
Intracellular chorismate mutase (EC:5.4.99.5)
Short name:
CM
Gene namesi
Ordered Locus Names:MSMEG_5536, MSMEI_5383
OrganismiMycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Taxonomic identifieri246196 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium fortuitum complex
Proteomesi
  • UP000006158 Componenti: Chromosome
  • UP000000757 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004149041 – 104Intracellular chorismate mutaseAdd BLAST104

Interactioni

Subunit structurei

Homodimer (By similarity). Probably interacts with MSMEG_4244.By similarity1 Publication

Protein-protein interaction databases

STRINGi246196.MSMEG_5536

Structurei

3D structure databases

SMRiA0R3N5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini23 – 104Chorismate mutasePROSITE-ProRule annotationAdd BLAST82

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni71 – 72Substrate bindingBy similarity2
Regioni99 – 100Substrate bindingSequence analysis2

Phylogenomic databases

eggNOGiENOG4106D2I Bacteria
ENOG410XW4G LUCA
HOGENOMiHOG000019826
KOiK04093
OrthoDBiPOG091H0AWL

Family and domain databases

Gene3Di1.20.59.10, 1 hit
InterProiView protein in InterPro
IPR036263 Chorismate_II_sf
IPR010958 Chorismate_mutase_highGC-bac
IPR036979 CM_dom_sf
IPR002701 CM_II_prokaryot
PfamiView protein in Pfam
PF01817 CM_2, 1 hit
SMARTiView protein in SMART
SM00830 CM_2, 1 hit
SUPFAMiSSF48600 SSF48600, 1 hit
TIGRFAMsiTIGR01808 CM_M_hiGC-arch, 1 hit
PROSITEiView protein in PROSITE
PS51168 CHORISMATE_MUT_2, 1 hit

Sequencei

Sequence statusi: Complete.

A0R3N5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRPDHRMGPP HDEEPHMPET IDAVPEIDDL RREIDELDAT IIAAIQRRTE
60 70 80 90 100
VSKTIGKARM ASGGTRLVHS REMKVIERYI DALGPEGKDL AMLLLRLGRG

RLGY
Length:104
Mass (Da):11,754
Last modified:January 25, 2012 - v2
Checksum:iFE8C0C16F012CF91
GO

Sequence cautioni

The sequence ABK71866 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AFP41824 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000480 Genomic DNA Translation: ABK71866.1 Different initiation.
CP001663 Genomic DNA Translation: AFP41824.1 Different initiation.
RefSeqiYP_889773.1, NC_008596.1

Genome annotation databases

EnsemblBacteriaiABK71866; ABK71866; MSMEG_5536
AFP41824; AFP41824; MSMEI_5383
GeneIDi4536816
KEGGimsg:MSMEI_5383
msm:MSMEG_5536
PATRICifig|246196.19.peg.5395

Similar proteinsi

Entry informationi

Entry nameiCHMU_MYCS2
AccessioniPrimary (citable) accession number: A0R3N5
Secondary accession number(s): I7GFF2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 25, 2012
Last sequence update: January 25, 2012
Last modified: May 23, 2018
This is version 66 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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