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A0R3I8 (MPRA_MYCS2) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 57. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Response regulator MprA
Alternative name(s):
Mycobacterial persistence regulator A
Gene names
Name:mprA
Ordered Locus Names:MSMEG_5488, MSMEI_5336
OrganismMycobacterium smegmatis (strain ATCC 700084 / mc(2)155) [Reference proteome] [HAMAP]
Taxonomic identifier246196 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium

Protein attributes

Sequence length230 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Member of the two-component regulatory system MprB/MprA which contributes to maintaining a balance among several systems involved in stress resistance and is required for establishment and maintenance of persistent infection in the host. Functions as a transcriptional regulator that recognizes a 19-bp nucleotide motif comprizing two loosely conserved 8-bp direct DNA-binding motif repeats separated by a 3-bp spacer region By similarity.

Subcellular location

Cytoplasm Potential.

Post-translational modification

Phosphorylated and dephosphorylated by MprB By similarity.

Sequence similarities

Contains 1 response regulatory domain.

Sequence caution

The sequence AFP41777.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 230230Response regulator MprA
PRO_0000308423

Regions

Domain4 – 118115Response regulatory

Amino acid modifications

Modified residue4814-aspartylphosphate By similarity

Sequences

Sequence LengthMass (Da)Tools
A0R3I8 [UniParc].

Last modified January 9, 2007. Version 1.
Checksum: 7C967F0D16BD7301

FASTA23025,774
        10         20         30         40         50         60 
MAVRILVVDD DRAVRESLRR SLSFNGYSVE LAQDGVEALD AITNNRPDAL ILDVMMPRLD 

        70         80         90        100        110        120 
GLEVCRQLRS TGDDLPILVL TARDSVSERV AGLDAGADDY LPKPFALEEL LARMRALLRR 

       130        140        150        160        170        180 
TVSDDSGDSQ KMTFSDLTLD PVTREVTRGG RQISLTRTEF SLLEMLIANP RRVLTRSRIL 

       190        200        210        220        230 
EEVWGFDFPT SGNALEVYIG YLRRKTEAEG EPRLIHTVRG VGYVLRETPP 

« Hide

References

[1]Fleischmann R.D., Dodson R.J., Haft D.H., Merkel J.S., Nelson W.C., Fraser C.M.
Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 700084 / mc(2)155.
[2]"Interrupted coding sequences in Mycobacterium smegmatis: authentic mutations or sequencing errors?"
Deshayes C., Perrodou E., Gallien S., Euphrasie D., Schaeffer C., Van-Dorsselaer A., Poch O., Lecompte O., Reyrat J.-M.
Genome Biol. 8:R20.1-R20.9(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 700084 / mc(2)155.
[3]"Ortho-proteogenomics: multiple proteomes investigation through orthology and a new MS-based protocol."
Gallien S., Perrodou E., Carapito C., Deshayes C., Reyrat J.-M., Van Dorsselaer A., Poch O., Schaeffer C., Lecompte O.
Genome Res. 19:128-135(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Strain: ATCC 700084 / mc(2)155.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000480 Genomic DNA. Translation: ABK75202.1.
CP001663 Genomic DNA. Translation: AFP41777.1. Different initiation.
RefSeqYP_006570072.1. NC_018289.1.
YP_889726.1. NC_008596.1.

3D structure databases

ProteinModelPortalA0R3I8.
SMRA0R3I8. Positions 3-227.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING246196.MSMEG_5488.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABK75202; ABK75202; MSMEG_5488.
AFP41777; AFP41777; MSMEI_5336.
GeneID13426171.
4532340.
KEGGmsg:MSMEI_5336.
msm:MSMEG_5488.
PATRIC18083245. VBIMycSme59918_5348.

Phylogenomic databases

eggNOGCOG0745.
HOGENOMHOG000034815.
KOK07669.
OMADFMGDSN.
OrthoDBEOG6G4VQG.
ProtClustDBCLSK790869.

Enzyme and pathway databases

BioCycMSME246196:GJ4Y-5487-MONOMER.

Family and domain databases

Gene3D1.10.10.10. 1 hit.
InterProIPR011006. CheY-like_superfamily.
IPR001867. Sig_transdc_resp-reg_C.
IPR001789. Sig_transdc_resp-reg_receiver.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamPF00072. Response_reg. 1 hit.
PF00486. Trans_reg_C. 1 hit.
[Graphical view]
SMARTSM00448. REC. 1 hit.
SM00862. Trans_reg_C. 1 hit.
[Graphical view]
SUPFAMSSF52172. SSF52172. 1 hit.
PROSITEPS50110. RESPONSE_REGULATORY. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMPRA_MYCS2
AccessionPrimary (citable) accession number: A0R3I8
Secondary accession number(s): I7G7T7
Entry history
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: January 9, 2007
Last modified: April 16, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families