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A0R3I8

- MPRA_MYCS2

UniProt

A0R3I8 - MPRA_MYCS2

Protein

Response regulator MprA

Gene

mprA

Organism
Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 61 (01 Oct 2014)
      Sequence version 1 (09 Jan 2007)
      Previous versions | rss
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    Functioni

    Member of the two-component regulatory system MprB/MprA which contributes to maintaining a balance among several systems involved in stress resistance and is required for establishment and maintenance of persistent infection in the host. Functions as a transcriptional regulator that recognizes a 19-bp nucleotide motif comprizing two loosely conserved 8-bp direct DNA-binding motif repeats separated by a 3-bp spacer region By similarity.By similarity

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. phosphorelay response regulator activity Source: InterPro

    GO - Biological processi

    1. pathogenesis Source: UniProtKB-KW
    2. regulation of transcription, DNA-templated Source: UniProtKB-KW
    3. response to stress Source: UniProtKB-KW
    4. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Stress response, Transcription, Transcription regulation, Two-component regulatory system, Virulence

    Keywords - Ligandi

    DNA-binding

    Enzyme and pathway databases

    BioCyciMSME246196:GJ4Y-5487-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Response regulator MprA
    Alternative name(s):
    Mycobacterial persistence regulator A
    Gene namesi
    Name:mprA
    Ordered Locus Names:MSMEG_5488, MSMEI_5336
    OrganismiMycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
    Taxonomic identifieri246196 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
    ProteomesiUP000000757: Chromosome, UP000006158: Chromosome

    Subcellular locationi

    Cytoplasm Curated

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 230230Response regulator MprAPRO_0000308423Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei48 – 4814-aspartylphosphatePROSITE-ProRule annotation

    Post-translational modificationi

    Phosphorylated and dephosphorylated by MprB.By similarity

    Keywords - PTMi

    Phosphoprotein

    Interactioni

    Protein-protein interaction databases

    STRINGi246196.MSMEG_5488.

    Structurei

    3D structure databases

    ProteinModelPortaliA0R3I8.
    SMRiA0R3I8. Positions 3-227.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini4 – 118115Response regulatoryPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 response regulatory domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0745.
    HOGENOMiHOG000034815.
    KOiK07669.
    OMAiCKAIRSK.
    OrthoDBiEOG6G4VQG.

    Family and domain databases

    Gene3Di1.10.10.10. 1 hit.
    InterProiIPR011006. CheY-like_superfamily.
    IPR001867. Sig_transdc_resp-reg_C.
    IPR001789. Sig_transdc_resp-reg_receiver.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view]
    PfamiPF00072. Response_reg. 1 hit.
    PF00486. Trans_reg_C. 1 hit.
    [Graphical view]
    SMARTiSM00448. REC. 1 hit.
    SM00862. Trans_reg_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF52172. SSF52172. 1 hit.
    PROSITEiPS50110. RESPONSE_REGULATORY. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A0R3I8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAVRILVVDD DRAVRESLRR SLSFNGYSVE LAQDGVEALD AITNNRPDAL    50
    ILDVMMPRLD GLEVCRQLRS TGDDLPILVL TARDSVSERV AGLDAGADDY 100
    LPKPFALEEL LARMRALLRR TVSDDSGDSQ KMTFSDLTLD PVTREVTRGG 150
    RQISLTRTEF SLLEMLIANP RRVLTRSRIL EEVWGFDFPT SGNALEVYIG 200
    YLRRKTEAEG EPRLIHTVRG VGYVLRETPP 230
    Length:230
    Mass (Da):25,774
    Last modified:January 9, 2007 - v1
    Checksum:i7C967F0D16BD7301
    GO

    Sequence cautioni

    The sequence AFP41777.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000480 Genomic DNA. Translation: ABK75202.1.
    CP001663 Genomic DNA. Translation: AFP41777.1. Different initiation.
    RefSeqiWP_011730567.1. NC_008596.1.
    YP_006570072.1. NC_018289.1.
    YP_889726.1. NC_008596.1.

    Genome annotation databases

    EnsemblBacteriaiABK75202; ABK75202; MSMEG_5488.
    AFP41777; AFP41777; MSMEI_5336.
    GeneIDi4532340.
    KEGGimsg:MSMEI_5336.
    msm:MSMEG_5488.
    PATRICi18083245. VBIMycSme59918_5348.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000480 Genomic DNA. Translation: ABK75202.1 .
    CP001663 Genomic DNA. Translation: AFP41777.1 . Different initiation.
    RefSeqi WP_011730567.1. NC_008596.1.
    YP_006570072.1. NC_018289.1.
    YP_889726.1. NC_008596.1.

    3D structure databases

    ProteinModelPortali A0R3I8.
    SMRi A0R3I8. Positions 3-227.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 246196.MSMEG_5488.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABK75202 ; ABK75202 ; MSMEG_5488 .
    AFP41777 ; AFP41777 ; MSMEI_5336 .
    GeneIDi 4532340.
    KEGGi msg:MSMEI_5336.
    msm:MSMEG_5488.
    PATRICi 18083245. VBIMycSme59918_5348.

    Phylogenomic databases

    eggNOGi COG0745.
    HOGENOMi HOG000034815.
    KOi K07669.
    OMAi CKAIRSK.
    OrthoDBi EOG6G4VQG.

    Enzyme and pathway databases

    BioCyci MSME246196:GJ4Y-5487-MONOMER.

    Family and domain databases

    Gene3Di 1.10.10.10. 1 hit.
    InterProi IPR011006. CheY-like_superfamily.
    IPR001867. Sig_transdc_resp-reg_C.
    IPR001789. Sig_transdc_resp-reg_receiver.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view ]
    Pfami PF00072. Response_reg. 1 hit.
    PF00486. Trans_reg_C. 1 hit.
    [Graphical view ]
    SMARTi SM00448. REC. 1 hit.
    SM00862. Trans_reg_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52172. SSF52172. 1 hit.
    PROSITEi PS50110. RESPONSE_REGULATORY. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Fleischmann R.D., Dodson R.J., Haft D.H., Merkel J.S., Nelson W.C., Fraser C.M.
      Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700084 / mc(2)155.
    2. "Interrupted coding sequences in Mycobacterium smegmatis: authentic mutations or sequencing errors?"
      Deshayes C., Perrodou E., Gallien S., Euphrasie D., Schaeffer C., Van-Dorsselaer A., Poch O., Lecompte O., Reyrat J.-M.
      Genome Biol. 8:R20.1-R20.9(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700084 / mc(2)155.
    3. "Ortho-proteogenomics: multiple proteomes investigation through orthology and a new MS-based protocol."
      Gallien S., Perrodou E., Carapito C., Deshayes C., Reyrat J.-M., Van Dorsselaer A., Poch O., Schaeffer C., Lecompte O.
      Genome Res. 19:128-135(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Strain: ATCC 700084 / mc(2)155.

    Entry informationi

    Entry nameiMPRA_MYCS2
    AccessioniPrimary (citable) accession number: A0R3I8
    Secondary accession number(s): I7G7T7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 23, 2007
    Last sequence update: January 9, 2007
    Last modified: October 1, 2014
    This is version 61 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3