Skip Header

Contribute Send feedback
Read comments (?) or add your own

A0R3D3 (PTH_MYCS2) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 39. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Peptidyl-tRNA hydrolase
Short name=PTH
EC=3.1.1.29
Gene names
Name:pth
Ordered Locus Names:MSMEG_5432
OrganismMycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Taxonomic identifier246196 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length191 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis By similarity. HAMAP MF_00083

Catalytic activity

N-substituted aminoacyl-tRNA + H2O = N-substituted amino acid + tRNA. HAMAP MF_00083

Subunit structure

Monomer By similarity. HAMAP MF_00083

Subcellular location

Cytoplasm By similarity HAMAP MF_00083.

Sequence similarities

Belongs to the PTH family.

Ontologies

Keywords
   Cellular componentCytoplasm
   Molecular functionHydrolase
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionaminoacyl-tRNA hydrolase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 191191Peptidyl-tRNA hydrolase HAMAP MF_00083
PRO_1000010613

Secondary structure

1 ................................ 191
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
A0R3D3 [UniParc].

Last modified January 9, 2007. Version 1.
Checksum: BA77A2644BDD6419

FASTA19120,278
        10         20         30         40         50         60 
MAEPLLVVGL GNPGPTYAKT RHNLGFMVAD VLAGRIGSAF KVHKKSGAEV VTGRLAGTSV 

        70         80         90        100        110        120 
VLAKPRCYMN ESGRQVGPLA KFYSVPPQQI VVIHDELDID FGRIRLKLGG GEGGHNGLRS 

       130        140        150        160        170        180 
VASALGTKNF HRVRIGVGRP PGRKDPAAFV LENFTAAERA EVPTIVEQAA DATELLIAQG 

       190 
LEPAQNTVHA W

« Hide

References

[1]Fleischmann R.D., Dodson R.J., Haft D.H., Merkel J.S., Nelson W.C., Fraser C.M.
Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 700084 / mc(2)155.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000480 Genomic DNA. Translation: ABK75581.1.
RefSeqYP_889671.1. NC_008596.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
3KJZX-ray2.40A1-191[»]
3KK0X-ray2.65A1-191[»]
3P2JX-ray2.22A1-191[»]
ProteinModelPortalA0R3D3.
SMRA0R3D3. Positions 1-191.
ModBaseSearch...

Protein-protein interaction databases

STRINGA0R3D3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBMYCT00000045680; EBMYCP00000044017; EBMYCG00000045675.
GeneID4537016.
GenomeReviewsGene locus MSMEG_5432 in contig CP000480_GR.
KEGGmsm:MSMEG_5432.
NMPDRfig|246196.1.peg.5413.
PATRIC18083133. VBIMycSme59918_5293.
TIGRMSMEG_5432.

Phylogenomic databases

eggNOGCOG0193.
GeneTreeEBGT00050000017462.
HOGENOMHBG610927.
OMAIKFKTGG.
PhylomeDBA0R3D3.
ProtClustDBPRK05426.

Enzyme and pathway databases

BioCycMSME246196:MSMEG_5432-MONOMER.

Family and domain databases

HAMAPMF_00083. Pept_tRNA_hydro_bact.
[Tree]
InterProIPR001328. Pept_tRNA_hydro.
IPR018171. Pept_tRNA_hydro_CS.
[Graphical view]
Gene3DG3DSA:3.40.50.1470. Pept_tRNA_hydro. 1 hit.
KOK01056.
PANTHERPTHR17224. Pept_tRNA_hydro. 1 hit.
PfamPF01195. Pept_tRNA_hydro. 1 hit.
[Graphical view]
SUPFAMSSF53178. Pept_tRNA_hydro. 1 hit.
TIGRFAMsTIGR00447. Pth. 1 hit.
PROSITEPS01195. PEPT_TRNA_HYDROL_1. 1 hit.
PS01196. PEPT_TRNA_HYDROL_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePTH_MYCS2
AccessionPrimary (citable) accession number: A0R3D3
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 9, 2007
Last modified: December 14, 2011
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents