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Protein

Peptidyl-tRNA hydrolase

Gene

pth

Organism
Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.UniRule annotation

Catalytic activityi

N-substituted aminoacyl-tRNA + H2O = N-substituted amino acid + tRNA.UniRule annotation

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase

Enzyme and pathway databases

BioCyciMSME246196:G1H7P-5401-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidyl-tRNA hydrolaseUniRule annotation (EC:3.1.1.29UniRule annotation)
Short name:
PTHUniRule annotation
Gene namesi
Name:pthUniRule annotation
Ordered Locus Names:MSMEG_5432, MSMEI_5283
OrganismiMycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Taxonomic identifieri246196 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium fortuitum complex
Proteomesi
  • UP000006158 Componenti: Chromosome
  • UP000000757 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000106131 – 191Peptidyl-tRNA hydrolaseAdd BLAST191

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi246196.MSMEG_5432

Structurei

Secondary structure

1191
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi5 – 9Combined sources5
Turni15 – 19Combined sources5
Helixi21 – 23Combined sources3
Helixi24 – 36Combined sources13
Beta strandi41 – 43Combined sources3
Turni44 – 46Combined sources3
Beta strandi49 – 55Combined sources7
Beta strandi58 – 64Combined sources7
Beta strandi66 – 68Combined sources3
Helixi69 – 72Combined sources4
Helixi73 – 82Combined sources10
Helixi87 – 89Combined sources3
Beta strandi90 – 99Combined sources10
Beta strandi104 – 110Combined sources7
Helixi116 – 125Combined sources10
Beta strandi130 – 136Combined sources7
Beta strandi141 – 143Combined sources3
Helixi146 – 149Combined sources4
Helixi156 – 159Combined sources4
Helixi162 – 179Combined sources18
Helixi181 – 188Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2LGJNMR-A1-191[»]
2NAFNMR-A1-191[»]
3KJZX-ray2.40A1-191[»]
3KK0X-ray2.65A1-191[»]
3P2JX-ray2.22A1-191[»]
ProteinModelPortaliA0R3D3
SMRiA0R3D3
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiA0R3D3

Family & Domainsi

Sequence similaritiesi

Belongs to the PTH family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108ZPD Bacteria
COG0193 LUCA
HOGENOMiHOG000004796
KOiK01056
OMAiRYAHTRH
OrthoDBiPOG091H02CU

Family and domain databases

CDDicd00462 PTH, 1 hit
Gene3Di3.40.50.1470, 1 hit
HAMAPiMF_00083 Pept_tRNA_hydro_bact, 1 hit
InterProiView protein in InterPro
IPR001328 Pept_tRNA_hydro
IPR018171 Pept_tRNA_hydro_CS
IPR036416 Pept_tRNA_hydro_sf
PANTHERiPTHR17224 PTHR17224, 1 hit
PfamiView protein in Pfam
PF01195 Pept_tRNA_hydro, 1 hit
SUPFAMiSSF53178 SSF53178, 1 hit
TIGRFAMsiTIGR00447 pth, 1 hit
PROSITEiView protein in PROSITE
PS01195 PEPT_TRNA_HYDROL_1, 1 hit
PS01196 PEPT_TRNA_HYDROL_2, 1 hit

Sequencei

Sequence statusi: Complete.

A0R3D3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEPLLVVGL GNPGPTYAKT RHNLGFMVAD VLAGRIGSAF KVHKKSGAEV
60 70 80 90 100
VTGRLAGTSV VLAKPRCYMN ESGRQVGPLA KFYSVPPQQI VVIHDELDID
110 120 130 140 150
FGRIRLKLGG GEGGHNGLRS VASALGTKNF HRVRIGVGRP PGRKDPAAFV
160 170 180 190
LENFTAAERA EVPTIVEQAA DATELLIAQG LEPAQNTVHA W
Length:191
Mass (Da):20,278
Last modified:January 9, 2007 - v1
Checksum:iBA77A2644BDD6419
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000480 Genomic DNA Translation: ABK75581.1
CP001663 Genomic DNA Translation: AFP41725.1
RefSeqiWP_011730530.1, NZ_CP009494.1
YP_889671.1, NC_008596.1

Genome annotation databases

EnsemblBacteriaiABK75581; ABK75581; MSMEG_5432
AFP41725; AFP41725; MSMEI_5283
GeneIDi4537016
KEGGimsb:LJ00_26845
msg:MSMEI_5283
msm:MSMEG_5432
PATRICifig|246196.19.peg.5293

Similar proteinsi

Entry informationi

Entry nameiPTH_MYCS2
AccessioniPrimary (citable) accession number: A0R3D3
Secondary accession number(s): I7FK76
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 9, 2007
Last modified: May 23, 2018
This is version 80 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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