A0R2V9 (COAA_MYCS2) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Pantothenate kinase
EC=2.7.1.33

Alternative name(s):
Pantothenic acid kinase

Gene names

Name:	coaA
Ordered Locus Names:	MSMEG_5252

Organism

Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)

Taxonomic identifier

246196 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length	312 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + (R)-pantothenate = ADP + (R)-4'-phosphopantothenate. HAMAP MF_00215
Pathway	Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 1/5. HAMAP MF_00215
Subcellular location	Cytoplasm Probable HAMAP MF_00215.
Sequence similarities	Belongs to the prokaryotic pantothenate kinase family.

Ontologies

Keywords
Biological process	Coenzyme A biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	coenzyme A biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW pantothenate kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 312	312	Pantothenate kinase HAMAP MF_00215		PRO_1000043228
Regions
	Nucleotide binding	97 – 104	8	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	A0R2V9 [UniParc]. Last modified January 9, 2007. Version 1. Checksum: 1FBAA5AEDA014E9B	FASTA	312	35,662
	10 20 30 40 50 60 MPRPSEPSPY VEFDRSQWRS LRMSTPLKLS EDELVRLRGM GEKLDLLEVE EVYLPLARLI 70 80 90 100 110 120 HLQVAARQRL FATTAEFLGE PQQNPDRPVP FIIGVAGSVA VGKSTTARVL QALLARWEHH 130 140 150 160 170 180 PRVDLVTTDG FLYPNAELAR RNLMHRKGFP ESYNRRALMR FVTAVKSGAD EAAAPVYSHL 190 200 210 220 230 240 LYDIVPGEYQ IVRHPDILIL EGLNVLQTGP ALMVSDLFDF SVYVDARIED IEQWYISRFL 250 260 270 280 290 300 TMRSTAFADP ASHFHSYSTL TDEQAVFAAR DIWHSINRPN LIENILPTRP RATLVLRKDA 310 DHSINRLRLR KL

References

[1]	Fleischmann R.D., Dodson R.J., Haft D.H., Merkel J.S., Nelson W.C., Fraser C.M. Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700084 / mc(2)155.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000480 Genomic DNA. Translation: ABK71855.1.
RefSeq	YP_889497.1. NC_008596.1.
3D structure databases
ProteinModelPortal	A0R2V9.
SMR	A0R2V9. Positions 5-312.
ModBase	Search...
Protein-protein interaction databases
STRING	A0R2V9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBMYCT00000046848; EBMYCP00000045185; EBMYCG00000046843.
GeneID	4535434.
GenomeReviews	Gene locus MSMEG_5252 in contig CP000480_GR.
KEGG	msm:MSMEG_5252.
NMPDR	fig|246196.1.peg.5236.
PATRIC	18082787. VBIMycSme59918_5122.
TIGR	MSMEG_5252.
Phylogenomic databases
eggNOG	COG1072.
GeneTree	EBGT00050000016369.
HOGENOM	HBG732538.
OMA	EVYLPLS.
PhylomeDB	A0R2V9.
ProtClustDB	PRK05439.
Enzyme and pathway databases
BioCyc	MSME246196:MSMEG_5252-MONOMER.
Family and domain databases
HAMAP	MF_00215. Pantothen_kinase_1. [Tree]
InterPro	IPR004566. PanK_bact. IPR006083. PRK/URK. [Graphical view]
KO	K00867.
PANTHER	PTHR10285:SF7. PanK_bact. 1 hit.
Pfam	PF00485. PRK. 1 hit. [Graphical view]
PIRSF	PIRSF000545. Pantothenate_kin. 1 hit.
TIGRFAMs	TIGR00554. PanK_bact. 1 hit.
ProtoNet	Search...

Entry information

Entry name

COAA_MYCS2

Accession

Primary (citable) accession number: A0R2V9

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	January 9, 2007
Last modified:	December 14, 2011
This is version 39 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program