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A0R2T2 (A0R2T2_MYCS2) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 46. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
4-hydroxy-3-methylbut-2-enyl diphosphate reductase HAMAP MF_00191
EC=1.17.1.2 HAMAP MF_00191
Gene names
Name:ispH HAMAP MF_00191
Ordered Locus Names:MSMEG_5224
OrganismMycobacterium smegmatis (strain ATCC 700084 / mc(2)155) EMBL ABK75503.1
Taxonomic identifier246196 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length314 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) By similarity. HAMAP MF_00191

Catalytic activity

Dimethylallyl diphosphate + NAD(P)+ + H2O = (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + NAD(P)H. HAMAP MF_00191

Isopentenyl diphosphate + NAD(P)+ + H2O = (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + NAD(P)H. HAMAP MF_00191

Cofactor

Binds 1 3Fe-4S cluster By similarity. HAMAP MF_00191

Pathway

Isoprenoid biosynthesis; dimethylallyl diphosphate biosynthesis; dimethylallyl diphosphate from (2E)-4-hydroxy-3-methylbutenyl diphosphate: step 1/1. HAMAP MF_00191

Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 6/6. HAMAP MF_00191

Sequence similarities

Belongs to the IspH family. HAMAP MF_00191

Sequences

Sequence LengthMass (Da)Tools
A0R2T2 [UniParc].

Last modified January 9, 2007. Version 1.
Checksum: 568972EB98E9BEA1

FASTA31434,049
        10         20         30         40         50         60 
MSGKRVLLAE PRGYCAGVDR AVETVERALE KHGAPVYVRH EIVHNRHVVE TLAKAGAIFV 

        70         80         90        100        110        120 
DETDEVPEGA IVVFSAHGVA PTVHQSAAER NLKVIDATCP LVTKVHNEAK RFARDDYDIL 

       130        140        150        160        170        180 
LIGHEGHEEV VGTAGEAPDH VQLVDGPESV DAVTVRDESK VIWLSQTTLS VDETMETVRR 

       190        200        210        220        230        240 
LREKFPTLQD PPSDDICYAT QNRQVAVKAM APECELVIVV GSRNSSNSVR LVEVALNAGS 

       250        260        270        280        290        300 
DAAHLVDYAD DIDPAWLDGV TTIGVTSGAS VPEILVRGVL ERLAEHGYDT VQPVTTANET 

       310 
LVFALPREIR PPRG

« Hide

References

[1]Fleischmann R.D., Dodson R.J., Haft D.H., Merkel J.S., Nelson W.C., Fraser C.M.
Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 700084 / mc(2)155.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000480 Genomic DNA. Translation: ABK75503.1.
RefSeqYP_889470.1. NC_008596.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGA0R2T2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBMYCT00000045662; EBMYCP00000043999; EBMYCG00000045657.
GeneID4530979.
GenomeReviewsGene locus MSMEG_5224 in contig CP000480_GR.
KEGGmsm:MSMEG_5224.
NMPDRfig|246196.1.peg.5208.
PATRIC18082735. VBIMycSme59918_5096.
TIGRMSMEG_5224.

Phylogenomic databases

eggNOGCOG0761.
GeneTreeEBGT00050000016858.
HOGENOMHBG335228.
OMAAMAPECD.
PhylomeDBA0R2T2.
ProtClustDBPRK01045.

Family and domain databases

HAMAPMF_00191. IspH.
[Tree]
InterProIPR003451. LytB.
[Graphical view]
KOK03527.
PfamPF02401. LYTB. 1 hit.
[Graphical view]
TIGRFAMsTIGR00216. IspH_lytB. 1 hit.
ProtoNetSearch...

Entry information

Entry nameA0R2T2_MYCS2
AccessionPrimary (citable) accession number: A0R2T2
Entry history
Integrated into UniProtKB/TrEMBL: January 9, 2007
Last sequence update: January 9, 2007
Last modified: December 14, 2011
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry info