A0R2K7 (PHS_MYCS2) Reviewed, UniProtKB/Swiss-Prot
Last modified
December 14, 2011.
Version 35.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Putative pterin-4-alpha-carbinolamine dehydratase Short name=PHS EC=4.2.1.96 Alternative name(s): 4-alpha-hydroxy-tetrahydropterin dehydratase Pterin carbinolamine dehydratase Short name=PCD | ||
| Gene names |
| ||
| Organism | Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155) | ||
| Taxonomic identifier | 246196 [NCBI] | ||
| Taxonomic lineage | Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium |
Protein attributes
| Sequence length | 94 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level |
General annotation (Comments)
| Catalytic activity | (6R)-6-(L-erythro-1,2-dihydroxypropyl)-5,6,7,8-tetrahydro-4a-hydroxypterin = (6R)-6-(L-erythro-1,2-dihydroxypropyl)-7,8-dihydro-6H-pterin + H2O. HAMAP MF_00434 |
| Sequence similarities | Belongs to the pterin-4-alpha-carbinolamine dehydratase family. |
Ontologies
| Keywords | |
|---|---|
| Molecular function | Lyase |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Biological process | tetrahydrobiopterin biosynthetic process Inferred from electronic annotation. Source: InterPro |
| Molecular function | 4-alpha-hydroxytetrahydrobiopterin dehydratase activity Inferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | |||
Molecule processing | ||||||||
|---|---|---|---|---|---|---|---|---|
| Initiator methionine | 1 | 1 | Removed Ref.2 | |||||
| Chain | 2 – 94 | 93 | Putative pterin-4-alpha-carbinolamine dehydratase HAMAP MF_00434 | PRO_1000050422 | ||||
Sequences
References
| [1] | Fleischmann R.D., Dodson R.J., Haft D.H., Merkel J.S., Nelson W.C., Fraser C.M. Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700084 / mc(2)155. |
| [2] | "Ortho-proteogenomics: multiple proteomes investigation through orthology and a new MS-based protocol." Gallien S., Perrodou E., Carapito C., Deshayes C., Reyrat J.-M., Van Dorsselaer A., Poch O., Schaeffer C., Lecompte O. Genome Res. 19:128-135(2009) [PubMed: 18955433] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | CP000480 Genomic DNA. Translation: ABK72204.1. |
| RefSeq | YP_889395.1. NC_008596.1. |
3D structure databases | |
| ProteinModelPortal | A0R2K7. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | A0R2K7. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| EnsemblBacteria | EBMYCT00000045473; EBMYCP00000043810; EBMYCG00000045468. |
| GeneID | 4531636. |
| GenomeReviews | Gene locus MSMEG_5150 in contig CP000480_GR. |
| KEGG | msm:MSMEG_5150. |
| NMPDR | fig|246196.1.peg.5135. |
| PATRIC | 18082591. VBIMycSme59918_5024. |
| TIGR | MSMEG_5150. |
Phylogenomic databases | |
| eggNOG | COG2154. |
| GeneTree | EBGT00050000016936. |
| HOGENOM | HBG705804. |
| OMA | EHAESKD. |
| ProtClustDB | PRK00823. |
Enzyme and pathway databases | |
| BioCyc | MSME246196:MSMEG_5150-MONOMER. |
Family and domain databases | |
| HAMAP | MF_00434. Pterin_4_alpha. [Tree] |
| InterPro | IPR001533. Trans/pterin_deHydtase. [Graphical view] |
| Gene3D | G3DSA:3.30.1360.20. Trans_pterinDh. 1 hit. |
| KO | K01724. |
| PANTHER | PTHR12599. Trans_pterinDh. 1 hit. |
| Pfam | PF01329. Pterin_4a. 1 hit. [Graphical view] |
| SUPFAM | SSF55248. Trans_pterinDh. 1 hit. |
| ProtoNet | Search... |
Entry information
| Entry name | PHS_MYCS2 | ||||||||
| Accession | Primary (citable) accession number: A0R2K7 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Prokaryotic Protein Annotation Program | ||||||||
Relevant documents
| SIMILARITY comments Index of protein domains and families |

Clusters with