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Protein

1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside deacetylase

Gene

mshB

Organism
Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the deacetylation of 1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway.1 Publication

Catalytic activityi

1-O-(2-acetamido-2-deoxy-alpha-D-glucopyranosyl)-1D-myo-inositol + H2O = 1-O-(2-amino-2-deoxy-alpha-D-glucopyranosyl)-1D-myo-inositol + acetate.

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi15ZincBy similarity1
Metal bindingi18ZincBy similarity1
Metal bindingi149ZincBy similarity1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase
LigandMetal-binding, Zinc

Enzyme and pathway databases

BioCyciMSME246196:G1H7P-5104-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside deacetylase (EC:3.5.1.103)
Short name:
GlcNAc-Ins deacetylase
Alternative name(s):
N-acetyl-1-D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside deacetylase
Gene namesi
Name:mshB
Ordered Locus Names:MSMEG_5129, MSMEI_5001
OrganismiMycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Taxonomic identifieri246196 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium fortuitum complex
Proteomesi
  • UP000006158 Componenti: Chromosome
  • UP000000757 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003998251 – 2901D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside deacetylaseAdd BLAST290

Interactioni

Protein-protein interaction databases

STRINGi246196.MSMEG_5129

Structurei

3D structure databases

ProteinModelPortaliA0R2I7
SMRiA0R2I7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MshB deacetylase family.Curated

Phylogenomic databases

eggNOGiENOG4108KZ5 Bacteria
COG2120 LUCA
HOGENOMiHOG000241173
KOiK15525
OMAiKFYWTVT
OrthoDBiPOG091H08W5

Family and domain databases

Gene3Di3.40.50.10320, 1 hit
HAMAPiMF_01696 MshB, 1 hit
InterProiView protein in InterPro
IPR003737 GlcNAc_PI_deacetylase-related
IPR024078 LmbE-like_dom_sf
IPR017810 Mycothiol_biosynthesis_MshB
PANTHERiPTHR12993 PTHR12993, 1 hit
PfamiView protein in Pfam
PF02585 PIG-L, 1 hit
SUPFAMiSSF102588 SSF102588, 1 hit
TIGRFAMsiTIGR03445 mycothiol_MshB, 1 hit

Sequencei

Sequence statusi: Complete.

A0R2I7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSHESPRLL FVHAHPDDET LTTGGTIAHY VARSAEVHVV TCTLGEEGEV
60 70 80 90 100
IGERYAQLAV DHADQLGGYR IAELTAALQS LGLRGPRYLG GAGHWRDSGM
110 120 130 140 150
AGTPSRGRQR WVDADLDEAV GALVAVIGEV RPHVVVTYDP NGGYGHPDHI
160 170 180 190 200
QTHVVTTRAV AAAPEAVGWT VPKFYWTVTA ISAMTAGLQA LGDVPSEWIR
210 220 230 240 250
VNAEDIPFGF GDDQIDAVVD VTAELPAKVG AMRAHATQIT VAPDGRAFAL
260 270 280 290
SNNIALPVLG EEHYVLVSGE AGPRDSRGWE TDLLAGLDLE
Length:290
Mass (Da):30,819
Last modified:January 9, 2007 - v1
Checksum:i3BCECBFB596A23BF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000480 Genomic DNA Translation: ABK71645.1
CP001663 Genomic DNA Translation: AFP41445.1
RefSeqiWP_011730335.1, NZ_CP009494.1
YP_889375.1, NC_008596.1

Genome annotation databases

EnsemblBacteriaiABK71645; ABK71645; MSMEG_5129
AFP41445; AFP41445; MSMEI_5001
GeneIDi4535725
KEGGimsb:LJ00_25370
msg:MSMEI_5001
msm:MSMEG_5129
PATRICifig|246196.19.peg.5005

Entry informationi

Entry nameiMSHB_MYCS2
AccessioniPrimary (citable) accession number: A0R2I7
Secondary accession number(s): I7FJE2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 5, 2010
Last sequence update: January 9, 2007
Last modified: May 23, 2018
This is version 74 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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