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Protein

1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside deacetylase

Gene

mshB

Organism
Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the deacetylation of 1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway.1 Publication

Catalytic activityi

1-O-(2-acetamido-2-deoxy-alpha-D-glucopyranosyl)-1D-myo-inositol + H2O = 1-O-(2-amino-2-deoxy-alpha-D-glucopyranosyl)-1D-myo-inositol + acetate.

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi15ZincBy similarity1
Metal bindingi18ZincBy similarity1
Metal bindingi149ZincBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside deacetylase (EC:3.5.1.103)
Short name:
GlcNAc-Ins deacetylase
Alternative name(s):
N-acetyl-1-D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside deacetylase
Gene namesi
Name:mshB
Ordered Locus Names:MSMEG_5129, MSMEI_5001
OrganismiMycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Taxonomic identifieri246196 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000006158 Componenti: Chromosome
  • UP000000757 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003998251 – 2901D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside deacetylaseAdd BLAST290

Interactioni

Protein-protein interaction databases

STRINGi246196.MSMEG_5129.

Structurei

3D structure databases

ProteinModelPortaliA0R2I7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MshB deacetylase family.Curated

Phylogenomic databases

eggNOGiENOG4108KZ5. Bacteria.
COG2120. LUCA.
HOGENOMiHOG000241173.
KOiK15525.
OMAiYAVCEAT.
OrthoDBiPOG091H08W5.

Family and domain databases

Gene3Di3.40.50.10320. 1 hit.
HAMAPiMF_01696. MshB. 1 hit.
InterProiIPR003737. GlcNAc_PI_deacetylase-related.
IPR024078. LmbE-like_dom.
IPR017810. Mycothiol_biosynthesis_MshB.
[Graphical view]
PANTHERiPTHR12993. PTHR12993. 1 hit.
PfamiPF02585. PIG-L. 1 hit.
[Graphical view]
SUPFAMiSSF102588. SSF102588. 1 hit.
TIGRFAMsiTIGR03445. mycothiol_MshB. 1 hit.

Sequencei

Sequence statusi: Complete.

A0R2I7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSHESPRLL FVHAHPDDET LTTGGTIAHY VARSAEVHVV TCTLGEEGEV
60 70 80 90 100
IGERYAQLAV DHADQLGGYR IAELTAALQS LGLRGPRYLG GAGHWRDSGM
110 120 130 140 150
AGTPSRGRQR WVDADLDEAV GALVAVIGEV RPHVVVTYDP NGGYGHPDHI
160 170 180 190 200
QTHVVTTRAV AAAPEAVGWT VPKFYWTVTA ISAMTAGLQA LGDVPSEWIR
210 220 230 240 250
VNAEDIPFGF GDDQIDAVVD VTAELPAKVG AMRAHATQIT VAPDGRAFAL
260 270 280 290
SNNIALPVLG EEHYVLVSGE AGPRDSRGWE TDLLAGLDLE
Length:290
Mass (Da):30,819
Last modified:January 9, 2007 - v1
Checksum:i3BCECBFB596A23BF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000480 Genomic DNA. Translation: ABK71645.1.
CP001663 Genomic DNA. Translation: AFP41445.1.
RefSeqiWP_011730335.1. NZ_CP009494.1.
YP_889375.1. NC_008596.1.

Genome annotation databases

EnsemblBacteriaiABK71645; ABK71645; MSMEG_5129.
AFP41445; AFP41445; MSMEI_5001.
GeneIDi4535725.
KEGGimsb:LJ00_25370.
msg:MSMEI_5001.
msm:MSMEG_5129.
PATRICi18082553. VBIMycSme59918_5005.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000480 Genomic DNA. Translation: ABK71645.1.
CP001663 Genomic DNA. Translation: AFP41445.1.
RefSeqiWP_011730335.1. NZ_CP009494.1.
YP_889375.1. NC_008596.1.

3D structure databases

ProteinModelPortaliA0R2I7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi246196.MSMEG_5129.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABK71645; ABK71645; MSMEG_5129.
AFP41445; AFP41445; MSMEI_5001.
GeneIDi4535725.
KEGGimsb:LJ00_25370.
msg:MSMEI_5001.
msm:MSMEG_5129.
PATRICi18082553. VBIMycSme59918_5005.

Phylogenomic databases

eggNOGiENOG4108KZ5. Bacteria.
COG2120. LUCA.
HOGENOMiHOG000241173.
KOiK15525.
OMAiYAVCEAT.
OrthoDBiPOG091H08W5.

Family and domain databases

Gene3Di3.40.50.10320. 1 hit.
HAMAPiMF_01696. MshB. 1 hit.
InterProiIPR003737. GlcNAc_PI_deacetylase-related.
IPR024078. LmbE-like_dom.
IPR017810. Mycothiol_biosynthesis_MshB.
[Graphical view]
PANTHERiPTHR12993. PTHR12993. 1 hit.
PfamiPF02585. PIG-L. 1 hit.
[Graphical view]
SUPFAMiSSF102588. SSF102588. 1 hit.
TIGRFAMsiTIGR03445. mycothiol_MshB. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiMSHB_MYCS2
AccessioniPrimary (citable) accession number: A0R2I7
Secondary accession number(s): I7FJE2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 5, 2010
Last sequence update: January 9, 2007
Last modified: November 2, 2016
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.