Skip Header

Contribute Send feedback
Read comments (?) or add your own

A0R2B1 (KGD_MYCS2) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 45. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
2-oxoglutarate decarboxylase
EC=4.1.1.71
Alternative name(s):
2-oxoglutarate carboxy-lyase
Alpha-ketoglutarate decarboxylase
Gene names
Name:kgd
Ordered Locus Names:MSMEG_5049
OrganismMycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Taxonomic identifier246196 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length1227 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Catalyzes an oxidative decarboxylation from five-carbon 2-oxoglutarate (alpha-ketoglutarate) to four-carbon succinate semialdehyde By similarity.

Catalytic activity

2-oxoglutarate = succinate semialdehyde + CO2.

Cofactor

Magnesium By similarity.

Thiamine pyrophosphate By similarity.

Sequence similarities

Belongs to the 2-oxoacid dehydrogenase family. Kgd subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 122712272-oxoglutarate decarboxylase
PRO_0000310718

Regions

Coiled coil783 – 81432 Potential

Secondary structure

1 ..................................................................................................................................... 1227
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
A0R2B1 [UniParc].

Last modified January 9, 2007. Version 1.
Checksum: 76C5BFFD1638A391

FASTA1,227135,944
        10         20         30         40         50         60 
MSSSPSPFGQ NEWLVEEMYR KFRDDPSSVD PSWHEFLVDY SPEPTTDSAS NGRTTTAAPV 

        70         80         90        100        110        120 
TPPTPAPAPA PEPKAAPKPA AKTEAKPAKP AKSATPAKGD ESQILRGAAA AVVKNMNASL 

       130        140        150        160        170        180 
EVPTATSVRA IPAKLMIDNR VVINNHLKRT RGGKISFTHL LGYAIVQAVK KFPNMNRHFA 

       190        200        210        220        230        240 
VVDGKPTAIT PAHTNLGLAI DLQGKDGNRS LVVAAIKRCE TMRFGQFIAA YEDIVRRARD 

       250        260        270        280        290        300 
GKLTAEDFSG VTISLTNPGT LGTVHSVPRL MQGQGAIIGA GAMEYPAEFQ GASEERIADL 

       310        320        330        340        350        360 
GIGKLITLTS TYDHRIIQGA ESGDFLRTIH QLLLDDDFFD EIFRELGIPY EPVRWRTDNP 

       370        380        390        400        410        420 
DSIEDKNARV IELIAAYRNR GHLMADIDPL RLDNTRFRSH PDLDVNSHGL TLWDLDREFK 

       430        440        450        460        470        480 
VDGFAGVQRK KLRDILSVLR DAYCRHVGVE YTHILEPEQQ RWIQERVETK HDKPTVAEQK 

       490        500        510        520        530        540 
YILSKLNAAE AFETFLQTKY VGQKRFSLEG AETVIPMMDA VIDQCAEHGL DEVVIAMPHR 

       550        560        570        580        590        600 
GRLNVLANIV GKPYSQIFSE FEGNLNPSQA HGSGDVKYHL GATGTYIQMF GDNDIEVSLT 

       610        620        630        640        650        660 
ANPSHLEAVD PVLEGLVRAK QDLLDTGEEG SDNRFSVVPL MLHGDAAFAG QGVVAETLNL 

       670        680        690        700        710        720 
ALLRGYRTGG TIHIVVNNQI GFTTAPTDSR SSEYCTDVAK MIGAPIFHVN GDDPEACAWV 

       730        740        750        760        770        780 
ARLAVDFRQA FKKDVVIDML CYRRRGHNEG DDPSMTQPYM YDVIDTKRGS RKAYTEALIG 

       790        800        810        820        830        840 
RGDISMKEAE DALRDYQGQL ERVFNEVREL EKHEIEPSES VEADQQIPSK LATAVDKAML 

       850        860        870        880        890        900 
QRIGDAHLAL PEGFTVHPRV RPVLEKRREM AYEGRIDWAF AELLALGSLI AEGKLVRLSG 

       910        920        930        940        950        960 
QDTQRGTFTQ RHAVIVDRKT GEEFTPLQLL ATNPDGTPTG GKFLVYNSAL SEFAAVGFEY 

       970        980        990       1000       1010       1020 
GYSVGNPDAM VLWEAQFGDF VNGAQSIIDE FISSGEAKWG QLSDVVLLLP HGHEGQGPDH 

      1030       1040       1050       1060       1070       1080 
TSGRIERFLQ LWAEGSMTIA MPSTPANYFH LLRRHGKDGI QRPLIVFTPK SMLRNKAAVS 

      1090       1100       1110       1120       1130       1140 
DIRDFTESKF RSVLEEPMYT DGEGDRNKVT RLLLTSGKIY YELAARKAKE NREDVAIVRI 

      1150       1160       1170       1180       1190       1200 
EQLAPLPRRR LAETLDRYPN VKEKFWVQEE PANQGAWPSF GLTLPEILPD HFTGLKRISR 

      1210       1220 
RAMSAPSSGS SKVHAVEQQE ILDTAFG

« Hide

References

[1]Fleischmann R.D., Dodson R.J., Haft D.H., Merkel J.S., Nelson W.C., Fraser C.M.
Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 700084 / mc(2)155.
[2]"Ortho-proteogenomics: multiple proteomes investigation through orthology and a new MS-based protocol."
Gallien S., Perrodou E., Carapito C., Deshayes C., Reyrat J.-M., Van Dorsselaer A., Poch O., Schaeffer C., Lecompte O.
Genome Res. 19:128-135(2009) [PubMed: 18955433] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000480 Genomic DNA. Translation: ABK74238.1.
RefSeqYP_889299.1. NC_008596.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2XT6X-ray2.74A/B116-1227[»]
2XT9X-ray2.20A361-1227[»]
2XTAX-ray2.20A/B/C/D361-1227[»]
2Y0PX-ray2.40A/B/C/D361-1227[»]
2YICX-ray1.96A/B/C/D361-1227[»]
2YIDX-ray2.25A/B/C/D361-1227[»]
ProteinModelPortalA0R2B1.
ModBaseSearch...

Protein-protein interaction databases

STRINGA0R2B1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBMYCT00000047233; EBMYCP00000045570; EBMYCG00000047228.
GeneID4535402.
GenomeReviewsGene locus MSMEG_5049 in contig CP000480_GR.
KEGGmsm:MSMEG_5049.
NMPDRfig|246196.1.peg.5037.
PATRIC18082397. VBIMycSme59918_4927.
TIGRMSMEG_5049.

Phylogenomic databases

eggNOGCOG0567.
GeneTreeEBGT00050000014858.
HOGENOMHBG289950.
OMAEGDEPAF.
PhylomeDBA0R2B1.
ProtClustDBPRK12270.

Enzyme and pathway databases

BioCycMSME246196:MSMEG_5049-MONOMER.

Family and domain databases

InterProIPR001078. 2-oxoacid_DH_actylTfrase.
IPR011603. 2oxoglutarate_DH_E1.
IPR023213. CAT-like_dom.
IPR001017. DH_E1.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view]
Gene3DG3DSA:3.30.559.10. CAT-like_dom. 1 hit.
KOK01616.
PANTHERPTHR23152. 2oxoglutarate_DH_E1. 1 hit.
PfamPF00198. 2-oxoacid_dh. 1 hit.
PF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view]
PIRSFPIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTSM00861. Transket_pyr. 1 hit.
[Graphical view]
TIGRFAMsTIGR00239. 2oxo_dh_E1. 1 hit.
ProtoNetSearch...

Entry information

Entry nameKGD_MYCS2
AccessionPrimary (citable) accession number: A0R2B1
Entry history
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: January 9, 2007
Last modified: December 14, 2011
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents