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Protein

Threonine synthase

Gene

thrC

Organism
Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine.By similarity

Catalytic activityi

O-phospho-L-homoserine + H2O = L-threonine + phosphate.

Cofactori

Pathwayi: L-threonine biosynthesis

This protein is involved in step 5 of the subpathway that synthesizes L-threonine from L-aspartate.
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Aspartokinase (MSMEG_6257), Aspartokinase (ask)
  2. Aspartate-semialdehyde dehydrogenase (asd), Aspartate-semialdehyde dehydrogenase (asd)
  3. Homoserine dehydrogenase (MSMEI_4830), Homoserine dehydrogenase (MSMEG_4957)
  4. Homoserine kinase (thrB)
  5. Threonine synthase (thrC)
This subpathway is part of the pathway L-threonine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-threonine from L-aspartate, the pathway L-threonine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei95Pyridoxal phosphateBy similarity1
Binding sitei326Pyridoxal phosphateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase
Biological processAmino-acid biosynthesis, Threonine biosynthesis
LigandPyridoxal phosphate

Enzyme and pathway databases

BioCyciMSME246196:G1H7P-4928-MONOMER
UniPathwayiUPA00050; UER00065

Names & Taxonomyi

Protein namesi
Recommended name:
Threonine synthase (EC:4.2.3.1)
Short name:
TS
Gene namesi
Name:thrC
Ordered Locus Names:MSMEG_4956, MSMEI_4829
OrganismiMycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Taxonomic identifieri246196 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium fortuitum complex
Proteomesi
  • UP000006158 Componenti: Chromosome
  • UP000000757 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003961391 – 360Threonine synthaseAdd BLAST360

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei69N6-(pyridoxal phosphate)lysineBy similarity1
Cross-linki151Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-Cter in protein Pup)1 Publication

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi246196.MSMEG_4956

Structurei

3D structure databases

ProteinModelPortaliA0R220
SMRiA0R220
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni196 – 200Pyridoxal phosphate bindingBy similarity5

Sequence similaritiesi

Belongs to the threonine synthase family.Curated

Phylogenomic databases

eggNOGiENOG4107R5I Bacteria
COG0498 LUCA
HOGENOMiHOG000076503
KOiK01733
OMAiCIPMGNA
OrthoDBiPOG091H02IR

Family and domain databases

InterProiView protein in InterPro
IPR001926 PLP-dep
IPR000634 Ser/Thr_deHydtase_PyrdxlP-BS
IPR004450 Thr_synthase-like
IPR026260 Thr_Synthase_bac/arc
IPR036052 Trypto_synt_PLP_dependent
PfamiView protein in Pfam
PF00291 PALP, 1 hit
PIRSFiPIRSF038945 Thr_synthase, 1 hit
SUPFAMiSSF53686 SSF53686, 1 hit
TIGRFAMsiTIGR00260 thrC, 1 hit
PROSITEiView protein in PROSITE
PS00165 DEHYDRATASE_SER_THR, 1 hit

Sequencei

Sequence statusi: Complete.

A0R220-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAAKAAVHQ PWPGLIEAYR DRLPIGDDWT TVTLLEGGTP LIHAKRISEL
60 70 80 90 100
TGCTVHLKVE GLNPTGSFKD RGMTVAVTES LARGQQAVLC ASTGNTSASA
110 120 130 140 150
AAYAARAGIT CAVLIPQGKI AMGKLAQAVM HGAKIIQVDG NFDDCLELAR
160 170 180 190 200
KLTADFPTIA LVNSVNPYRI EGQKTAAFEI VDALGTAPDV HALPVGNAGN
210 220 230 240 250
ITAYWKGYSE YHRDGVSDRL PRMLGTQAAG AAPLVTGAPV KDPETIATAI
260 270 280 290 300
RIGSPASWNS AVEAQQQSDG RFLAATDEEI LAAYHLVART EGVFVEPASA
310 320 330 340 350
ASIAGLLKSV EDGWVKRGST VVCTVTGNGL KDPDTALKGM PQVTPVPVDP
360
SAVVAELGLS
Length:360
Mass (Da):37,443
Last modified:January 9, 2007 - v1
Checksum:iC40EF7EED839FE94
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000480 Genomic DNA Translation: ABK71073.1
CP001663 Genomic DNA Translation: AFP41274.1
RefSeqiWP_011730211.1, NZ_CP009494.1
YP_889208.1, NC_008596.1

Genome annotation databases

EnsemblBacteriaiABK71073; ABK71073; MSMEG_4956
AFP41274; AFP41274; MSMEI_4829
GeneIDi4536683
KEGGimsb:LJ00_24505
msg:MSMEI_4829
msm:MSMEG_4956
PATRICifig|246196.19.peg.4835

Similar proteinsi

Entry informationi

Entry nameiTHRC_MYCS2
AccessioniPrimary (citable) accession number: A0R220
Secondary accession number(s): I7GEF5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 10, 2010
Last sequence update: January 9, 2007
Last modified: May 23, 2018
This is version 76 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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