A0R1X0 (MURI_MYCS2) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Glutamate racemase
EC=5.1.1.3

Gene names

Name:	murI
Ordered Locus Names:	MSMEG_4903

Organism

Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)

Taxonomic identifier

246196 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length	277 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Provides the (R)-glutamate required for cell wall biosynthesis By similarity. HAMAP MF_00258
Catalytic activity	L-glutamate = D-glutamate. HAMAP MF_00258
Pathway	Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP MF_00258
Sequence similarities	Belongs to the aspartate/glutamate racemases family.

Ontologies

Keywords
Biological process	Cell shape Cell wall biogenesis/degradation Peptidoglycan synthesis
Molecular function	Isomerase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	cellular cell wall organization Inferred from electronic annotation. Source: UniProtKB-KW peptidoglycan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW regulation of cell shape Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	glutamate racemase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 277	277	Glutamate racemase HAMAP MF_00258		PRO_1000047586

Sequences

	Sequence		Length	Mass (Da)
	A0R1X0 [UniParc]. Last modified January 9, 2007. Version 1. Checksum: 6E4BD345B82C8F62	FASTA	277	29,283
	10 20 30 40 50 60 MSDRLAPIGI FDSGVGGLTV ARAIIDQLPD EDIVYVGDTG NGPYGPLTIP QIRAHSLAIG 70 80 90 100 110 120 DDLVSRGVKA LVIACNTASS ACLRDARERY SPVPVVEVIL PAVRRAVAAT RNGRIGVIGT 130 140 150 160 170 180 QATIASGAYQ DAFAAARDTE VFTVACPRFV DFVERGVTSG RQVLGLAEGY LEPLQLAEVD 190 200 210 220 230 240 TLVLGCTHYP MLSGLIQLAM GDNVTLVSSA EETAKDLLRV LTELDLLRPH PDDPSVTAVR 250 260 270 RFEATGDPEA FTALAARFLG PTLDGVRPVR RHAGAGR

References

[1]	Fleischmann R.D., Dodson R.J., Haft D.H., Merkel J.S., Nelson W.C., Fraser C.M. Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700084 / mc(2)155.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000480 Genomic DNA. Translation: ABK72762.1.
RefSeq	YP_889158.1. NC_008596.1.
3D structure databases
ProteinModelPortal	A0R1X0.
ModBase	Search...
Protein-protein interaction databases
STRING	A0R1X0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBMYCT00000045129; EBMYCP00000043466; EBMYCG00000045124.
GeneID	4531366.
GenomeReviews	Gene locus MSMEG_4903 in contig CP000480_GR.
KEGG	msm:MSMEG_4903.
NMPDR	fig|246196.1.peg.4888.
PATRIC	18082103. VBIMycSme59918_4784.
TIGR	MSMEG_4903.
Phylogenomic databases
eggNOG	COG0796.
GeneTree	EBGT00050000016063.
HOGENOM	HBG645102.
OMA	PQEDTIY.
PhylomeDB	A0R1X0.
ProtClustDB	PRK00865.
Enzyme and pathway databases
BioCyc	MSME246196:MSMEG_4903-MONOMER.
Family and domain databases
HAMAP	MF_00258. Glu_racemase. [Tree]
InterPro	IPR015942. Asp/Glu/hydantoin_racemase. IPR001920. Asp/Glu_race. IPR018187. Asp/Glu_racemase_AS. IPR004391. Glu_race. [Graphical view]
Gene3D	G3DSA:3.40.50.1860. Asp/Glu_race. 1 hit.
KO	K01776.
PANTHER	PTHR21198. PTHR21198. 1 hit.
Pfam	PF01177. Asp_Glu_race. 1 hit. [Graphical view]
SUPFAM	SSF53681. Asp/Glu_race. 2 hits.
TIGRFAMs	TIGR00067. Glut_race. 1 hit.
PROSITE	PS00923. ASP_GLU_RACEMASE_1. 1 hit. PS00924. ASP_GLU_RACEMASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MURI_MYCS2

Accession

Primary (citable) accession number: A0R1X0

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	January 9, 2007
Last modified:	December 14, 2011
This is version 41 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program