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Protein

Glutamate racemase

Gene

murI

Organism
Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Provides the (R)-glutamate required for cell wall biosynthesis.UniRule annotation

Catalytic activityi

L-glutamate = D-glutamate.UniRule annotation

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei75Proton donor/acceptorUniRule annotation1
Active sitei186Proton donor/acceptorUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate racemaseUniRule annotation (EC:5.1.1.3UniRule annotation)
Gene namesi
Name:murIUniRule annotation
Ordered Locus Names:MSMEG_4903, MSMEI_4776
OrganismiMycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Taxonomic identifieri246196 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000006158 Componenti: Chromosome
  • UP000000757 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000475861 – 277Glutamate racemaseAdd BLAST277

Interactioni

Protein-protein interaction databases

STRINGi246196.MSMEG_4903.

Structurei

Secondary structure

1277
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi8 – 15Combined sources8
Helixi18 – 27Combined sources10
Beta strandi33 – 37Combined sources5
Turni39 – 41Combined sources3
Helixi49 – 65Combined sources17
Beta strandi69 – 73Combined sources5
Helixi76 – 82Combined sources7
Turni83 – 85Combined sources3
Helixi86 – 90Combined sources5
Beta strandi95 – 99Combined sources5
Helixi100 – 109Combined sources10
Beta strandi111 – 119Combined sources9
Helixi121 – 125Combined sources5
Helixi128 – 132Combined sources5
Helixi133 – 135Combined sources3
Beta strandi140 – 145Combined sources6
Helixi149 – 154Combined sources6
Helixi161 – 176Combined sources16
Beta strandi180 – 186Combined sources7
Helixi189 – 192Combined sources4
Helixi193 – 200Combined sources8
Beta strandi205 – 208Combined sources4
Helixi209 – 223Combined sources15
Beta strandi240 – 246Combined sources7
Helixi248 – 259Combined sources12
Turni263 – 265Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5IJWX-ray1.76A/B1-277[»]
ProteinModelPortaliA0R1X0.
SMRiA0R1X0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni12 – 13Substrate bindingUniRule annotation2
Regioni44 – 45Substrate bindingUniRule annotation2
Regioni76 – 77Substrate bindingUniRule annotation2
Regioni187 – 188Substrate bindingUniRule annotation2

Sequence similaritiesi

Belongs to the aspartate/glutamate racemases family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105F03. Bacteria.
COG0796. LUCA.
HOGENOMiHOG000262396.
KOiK01776.
OMAiVPYGSKS.
OrthoDBiPOG091H00P1.

Family and domain databases

Gene3Di3.40.50.1860. 1 hit.
HAMAPiMF_00258. Glu_racemase. 1 hit.
InterProiIPR015942. Asp/Glu/hydantoin_racemase.
IPR001920. Asp/Glu_race.
IPR018187. Asp/Glu_racemase_AS_1.
IPR033134. Asp/Glu_racemase_AS_2.
IPR004391. Glu_race.
[Graphical view]
PfamiPF01177. Asp_Glu_race. 1 hit.
[Graphical view]
SUPFAMiSSF53681. SSF53681. 2 hits.
TIGRFAMsiTIGR00067. glut_race. 1 hit.
PROSITEiPS00923. ASP_GLU_RACEMASE_1. 1 hit.
PS00924. ASP_GLU_RACEMASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A0R1X0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDRLAPIGI FDSGVGGLTV ARAIIDQLPD EDIVYVGDTG NGPYGPLTIP
60 70 80 90 100
QIRAHSLAIG DDLVSRGVKA LVIACNTASS ACLRDARERY SPVPVVEVIL
110 120 130 140 150
PAVRRAVAAT RNGRIGVIGT QATIASGAYQ DAFAAARDTE VFTVACPRFV
160 170 180 190 200
DFVERGVTSG RQVLGLAEGY LEPLQLAEVD TLVLGCTHYP MLSGLIQLAM
210 220 230 240 250
GDNVTLVSSA EETAKDLLRV LTELDLLRPH PDDPSVTAVR RFEATGDPEA
260 270
FTALAARFLG PTLDGVRPVR RHAGAGR
Length:277
Mass (Da):29,283
Last modified:January 9, 2007 - v1
Checksum:i6E4BD345B82C8F62
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000480 Genomic DNA. Translation: ABK72762.1.
CP001663 Genomic DNA. Translation: AFP41224.1.
RefSeqiWP_011730179.1. NZ_CP009494.1.
YP_889158.1. NC_008596.1.

Genome annotation databases

EnsemblBacteriaiABK72762; ABK72762; MSMEG_4903.
AFP41224; AFP41224; MSMEI_4776.
GeneIDi4531366.
KEGGimsb:LJ00_24245.
msg:MSMEI_4776.
msm:MSMEG_4903.
PATRICi18082103. VBIMycSme59918_4784.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000480 Genomic DNA. Translation: ABK72762.1.
CP001663 Genomic DNA. Translation: AFP41224.1.
RefSeqiWP_011730179.1. NZ_CP009494.1.
YP_889158.1. NC_008596.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5IJWX-ray1.76A/B1-277[»]
ProteinModelPortaliA0R1X0.
SMRiA0R1X0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi246196.MSMEG_4903.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABK72762; ABK72762; MSMEG_4903.
AFP41224; AFP41224; MSMEI_4776.
GeneIDi4531366.
KEGGimsb:LJ00_24245.
msg:MSMEI_4776.
msm:MSMEG_4903.
PATRICi18082103. VBIMycSme59918_4784.

Phylogenomic databases

eggNOGiENOG4105F03. Bacteria.
COG0796. LUCA.
HOGENOMiHOG000262396.
KOiK01776.
OMAiVPYGSKS.
OrthoDBiPOG091H00P1.

Enzyme and pathway databases

UniPathwayiUPA00219.

Family and domain databases

Gene3Di3.40.50.1860. 1 hit.
HAMAPiMF_00258. Glu_racemase. 1 hit.
InterProiIPR015942. Asp/Glu/hydantoin_racemase.
IPR001920. Asp/Glu_race.
IPR018187. Asp/Glu_racemase_AS_1.
IPR033134. Asp/Glu_racemase_AS_2.
IPR004391. Glu_race.
[Graphical view]
PfamiPF01177. Asp_Glu_race. 1 hit.
[Graphical view]
SUPFAMiSSF53681. SSF53681. 2 hits.
TIGRFAMsiTIGR00067. glut_race. 1 hit.
PROSITEiPS00923. ASP_GLU_RACEMASE_1. 1 hit.
PS00924. ASP_GLU_RACEMASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMURI_MYCS2
AccessioniPrimary (citable) accession number: A0R1X0
Secondary accession number(s): I7GEC4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 9, 2007
Last modified: November 2, 2016
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.