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Protein

Glutamate racemase

Gene

murI

Organism
Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Provides the (R)-glutamate required for cell wall biosynthesis.UniRule annotation

Catalytic activityi

L-glutamate = D-glutamate.UniRule annotation

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei75Proton donor/acceptorUniRule annotation1
Active sitei186Proton donor/acceptorUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processCell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

UniPathwayiUPA00219

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate racemaseUniRule annotation (EC:5.1.1.3UniRule annotation)
Gene namesi
Name:murIUniRule annotation
Ordered Locus Names:MSMEG_4903, MSMEI_4776
OrganismiMycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Taxonomic identifieri246196 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000006158 Componenti: Chromosome
  • UP000000757 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000475861 – 277Glutamate racemaseAdd BLAST277

Interactioni

Protein-protein interaction databases

STRINGi246196.MSMEG_4903

Structurei

Secondary structure

1277
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi8 – 15Combined sources8
Helixi18 – 27Combined sources10
Beta strandi33 – 37Combined sources5
Turni39 – 41Combined sources3
Helixi49 – 65Combined sources17
Beta strandi69 – 73Combined sources5
Helixi76 – 82Combined sources7
Turni83 – 85Combined sources3
Helixi86 – 90Combined sources5
Beta strandi95 – 99Combined sources5
Helixi100 – 109Combined sources10
Beta strandi111 – 119Combined sources9
Helixi121 – 125Combined sources5
Helixi128 – 132Combined sources5
Helixi133 – 135Combined sources3
Beta strandi140 – 145Combined sources6
Helixi149 – 154Combined sources6
Helixi161 – 176Combined sources16
Beta strandi180 – 186Combined sources7
Helixi189 – 192Combined sources4
Helixi193 – 200Combined sources8
Beta strandi205 – 208Combined sources4
Helixi209 – 223Combined sources15
Beta strandi240 – 246Combined sources7
Helixi248 – 259Combined sources12
Turni263 – 265Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5IJWX-ray1.76A/B1-277[»]
ProteinModelPortaliA0R1X0
SMRiA0R1X0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni12 – 13Substrate bindingUniRule annotation2
Regioni44 – 45Substrate bindingUniRule annotation2
Regioni76 – 77Substrate bindingUniRule annotation2
Regioni187 – 188Substrate bindingUniRule annotation2

Sequence similaritiesi

Belongs to the aspartate/glutamate racemases family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105F03 Bacteria
COG0796 LUCA
HOGENOMiHOG000262396
KOiK01776
OMAiVYGCTHY
OrthoDBiPOG091H00P1

Family and domain databases

HAMAPiMF_00258 Glu_racemase, 1 hit
InterProiView protein in InterPro
IPR015942 Asp/Glu/hydantoin_racemase
IPR001920 Asp/Glu_race
IPR018187 Asp/Glu_racemase_AS_1
IPR033134 Asp/Glu_racemase_AS_2
IPR004391 Glu_race
PANTHERiPTHR21198:SF2 PTHR21198:SF2, 1 hit
PfamiView protein in Pfam
PF01177 Asp_Glu_race, 1 hit
SUPFAMiSSF53681 SSF53681, 2 hits
TIGRFAMsiTIGR00067 glut_race, 1 hit
PROSITEiView protein in PROSITE
PS00923 ASP_GLU_RACEMASE_1, 1 hit
PS00924 ASP_GLU_RACEMASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

A0R1X0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDRLAPIGI FDSGVGGLTV ARAIIDQLPD EDIVYVGDTG NGPYGPLTIP
60 70 80 90 100
QIRAHSLAIG DDLVSRGVKA LVIACNTASS ACLRDARERY SPVPVVEVIL
110 120 130 140 150
PAVRRAVAAT RNGRIGVIGT QATIASGAYQ DAFAAARDTE VFTVACPRFV
160 170 180 190 200
DFVERGVTSG RQVLGLAEGY LEPLQLAEVD TLVLGCTHYP MLSGLIQLAM
210 220 230 240 250
GDNVTLVSSA EETAKDLLRV LTELDLLRPH PDDPSVTAVR RFEATGDPEA
260 270
FTALAARFLG PTLDGVRPVR RHAGAGR
Length:277
Mass (Da):29,283
Last modified:January 9, 2007 - v1
Checksum:i6E4BD345B82C8F62
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000480 Genomic DNA Translation: ABK72762.1
CP001663 Genomic DNA Translation: AFP41224.1
RefSeqiWP_011730179.1, NZ_CP009494.1
YP_889158.1, NC_008596.1

Genome annotation databases

EnsemblBacteriaiABK72762; ABK72762; MSMEG_4903
AFP41224; AFP41224; MSMEI_4776
GeneIDi4531366
KEGGimsb:LJ00_24245
msg:MSMEI_4776
msm:MSMEG_4903
PATRICifig|246196.19.peg.4784

Similar proteinsi

Entry informationi

Entry nameiMURI_MYCS2
AccessioniPrimary (citable) accession number: A0R1X0
Secondary accession number(s): I7GEC4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 9, 2007
Last modified: March 28, 2018
This is version 78 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome