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Protein

Ribonuclease PH

Gene

rph

Organism
Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates.UniRule annotation

Catalytic activityi

tRNA(n+1) + phosphate = tRNA(n) + a nucleoside diphosphate.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Biological processi

tRNA processing

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonuclease PHUniRule annotation (EC:2.7.7.56UniRule annotation)
Short name:
RNase PHUniRule annotation
Alternative name(s):
tRNA nucleotidyltransferaseUniRule annotation
Gene namesi
Name:rphUniRule annotation
Ordered Locus Names:MSMEG_4901, MSMEI_4774
OrganismiMycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Taxonomic identifieri246196 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000006158 Componenti: Chromosome
  • UP000000757 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000248301 – 259Ribonuclease PHAdd BLAST259

Interactioni

Protein-protein interaction databases

STRINGi246196.MSMEG_4901.

Structurei

3D structure databases

ProteinModelPortaliA0R1W8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RNase PH family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105ED0. Bacteria.
COG0689. LUCA.
HOGENOMiHOG000229516.
KOiK00989.
OMAiKGKGQGW.
OrthoDBiPOG091H03ML.

Family and domain databases

CDDicd11362. RNase_PH_bact. 1 hit.
Gene3Di3.30.230.70. 1 hit.
HAMAPiMF_00564. RNase_PH. 1 hit.
InterProiIPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR027408. PNPase/RNase_PH_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR002381. RNase_PH_bac-type.
IPR018336. RNase_PH_CS.
[Graphical view]
PfamiPF01138. RNase_PH. 1 hit.
PF03725. RNase_PH_C. 1 hit.
[Graphical view]
SUPFAMiSSF54211. SSF54211. 1 hit.
SSF55666. SSF55666. 1 hit.
TIGRFAMsiTIGR01966. RNasePH. 1 hit.
PROSITEiPS01277. RIBONUCLEASE_PH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A0R1W8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRREDGRLD DELRPVVITR GFTSHPAGSV LVEFGQTRVM CTASVTEGVP
60 70 80 90 100
RWRKGSGQGW LTAEYAMLPA ATHDRSDRES VKGRIGGRTQ EISRLIGRSL
110 120 130 140 150
RACIDLAALG ENTIAIDCDV LQADGGTRTA AITGAYVALS DAVTWLAAAG
160 170 180 190 200
RLSDPRPLSC AIAAVSVGVV DGRVRVDLPY SEDSRAEVDM NVVATDTGTL
210 220 230 240 250
VEIQGTGEGA TFPRSTLDKM LDAALGATEQ LFVLQREALD APYPGVLPEG

PAPKKAFGS
Length:259
Mass (Da):27,384
Last modified:January 9, 2007 - v1
Checksum:i0B705F2B90061CD2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000480 Genomic DNA. Translation: ABK70048.1.
CP001663 Genomic DNA. Translation: AFP41222.1.
RefSeqiWP_011730177.1. NZ_CP009494.1.
YP_889156.1. NC_008596.1.

Genome annotation databases

EnsemblBacteriaiABK70048; ABK70048; MSMEG_4901.
AFP41222; AFP41222; MSMEI_4774.
GeneIDi4532887.
KEGGimsb:LJ00_24235.
msg:MSMEI_4774.
msm:MSMEG_4901.
PATRICi18082099. VBIMycSme59918_4782.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000480 Genomic DNA. Translation: ABK70048.1.
CP001663 Genomic DNA. Translation: AFP41222.1.
RefSeqiWP_011730177.1. NZ_CP009494.1.
YP_889156.1. NC_008596.1.

3D structure databases

ProteinModelPortaliA0R1W8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi246196.MSMEG_4901.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABK70048; ABK70048; MSMEG_4901.
AFP41222; AFP41222; MSMEI_4774.
GeneIDi4532887.
KEGGimsb:LJ00_24235.
msg:MSMEI_4774.
msm:MSMEG_4901.
PATRICi18082099. VBIMycSme59918_4782.

Phylogenomic databases

eggNOGiENOG4105ED0. Bacteria.
COG0689. LUCA.
HOGENOMiHOG000229516.
KOiK00989.
OMAiKGKGQGW.
OrthoDBiPOG091H03ML.

Family and domain databases

CDDicd11362. RNase_PH_bact. 1 hit.
Gene3Di3.30.230.70. 1 hit.
HAMAPiMF_00564. RNase_PH. 1 hit.
InterProiIPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR027408. PNPase/RNase_PH_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR002381. RNase_PH_bac-type.
IPR018336. RNase_PH_CS.
[Graphical view]
PfamiPF01138. RNase_PH. 1 hit.
PF03725. RNase_PH_C. 1 hit.
[Graphical view]
SUPFAMiSSF54211. SSF54211. 1 hit.
SSF55666. SSF55666. 1 hit.
TIGRFAMsiTIGR01966. RNasePH. 1 hit.
PROSITEiPS01277. RIBONUCLEASE_PH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRNPH_MYCS2
AccessioniPrimary (citable) accession number: A0R1W8
Secondary accession number(s): I7G6A0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 9, 2007
Last modified: November 2, 2016
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.