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A0R1H7

- A0R1H7_MYCS2

UniProt

A0R1H7 - A0R1H7_MYCS2

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Protein
Submitted name:

Fatty acid synthase

Gene
MSMEG_4757, MSMEI_4637
Organism
Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Status
Unreviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei523 – 5231FMNImported
Binding sitei550 – 5501FMNImported
Binding sitei577 – 5771FMNImported
Binding sitei582 – 5821FMNImported
Binding sitei614 – 6141FMN; via amide nitrogenImported
Binding sitei647 – 6471FMNImported

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi434 – 4363FMNImported

GO - Molecular functioni

  1. enoyl-[acyl-carrier-protein] reductase (NADH) activity Source: InterPro
  2. nucleotide binding Source: UniProtKB-KW

GO - Biological processi

  1. fatty acid biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

TransferaseUniRule annotation

Keywords - Ligandi

Flavoprotein, FMNImported, Nucleotide-bindingImported

Enzyme and pathway databases

BioCyciMSME246196:GJ4Y-4756-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
Fatty acid synthaseImported
Gene namesi
Ordered Locus Names:MSMEG_4757Imported, MSMEI_4637Imported
OrganismiMycobacterium smegmatis (strain ATCC 700084 / mc(2)155)Imported
Taxonomic identifieri246196 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
ProteomesiUP000006158: Chromosome, UP000000757: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. fatty acid synthase complex Source: InterPro
Complete GO annotation...

Interactioni

Protein-protein interaction databases

STRINGi246196.MSMEG_4757.

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3ZENelectron microscopy7.50D/E/F1-3089[»]
4B3Yelectron microscopy7.50A/B/C1-3089[»]
4BJDelectron microscopy20.00A/B/C1-3089[»]
4BJEelectron microscopy20.00D/E/F1-3089[»]
4BJFelectron microscopy17.50D/E/F1-3089[»]
4BJGelectron microscopy17.50A/B/C1-3089[»]

Family & Domainsi

Phylogenomic databases

eggNOGiCOG4982.
HOGENOMiHOG000051526.
KOiK11533.
OMAiMFLDPYL.
OrthoDBiEOG6WMHTT.

Family and domain databases

Gene3Di3.10.129.10. 1 hit.
3.20.20.70. 1 hit.
3.40.366.10. 5 hits.
3.40.47.10. 3 hits.
3.40.50.720. 1 hit.
InterProiIPR001227. Ac_transferase_dom.
IPR014043. Acyl_transferase.
IPR016035. Acyl_Trfase/lysoPLipase.
IPR013785. Aldolase_TIM.
IPR013565. DUF1729.
IPR003965. Fatty_acid_synthase.
IPR029069. HotDog_dom.
IPR014031. Ketoacyl_synth_C.
IPR014030. Ketoacyl_synth_N.
IPR002539. MaoC_dom.
IPR016040. NAD(P)-bd_dom.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
PfamiPF00698. Acyl_transf_1. 2 hits.
PF08354. DUF1729. 1 hit.
PF00109. ketoacyl-synt. 1 hit.
PF02801. Ketoacyl-synt_C. 1 hit.
PF01575. MaoC_dehydratas. 1 hit.
[Graphical view]
PRINTSiPR01483. FASYNTHASE.
SUPFAMiSSF52151. SSF52151. 5 hits.
SSF53901. SSF53901. 2 hits.
SSF54637. SSF54637. 1 hit.

Sequencei

Sequence statusi: Complete.

A0R1H7-1 [UniParc]FASTAAdd to Basket

« Hide

MTIYEHDRVP AGWNDESGSD RTADGNAADT AHALVDRLSA GEPYAVAFGG     50
QGSAWLETLE ELVSSAGIES ELATLAGEAE LLLEPVASEL VVVRPIGFEP 100
LQWVRALAAE EPVPSDKQLT SAAVSVPGVL LTQIAAVRAL ARQGMDLTAT 150
PPVAVAGHSQ GVLAVQALAA KGAKDVELLA LAQLIGAAGT LVARRRGITV 200
LGDRPPMVSV TNADPERIYE LLEEFSSDVR TVLPPVLSIR NGRRSVVITG 250
TPEQLSRFEL YCTQIAEKEE AERKNKLRGG AVFAPVFDPV QVEVGFHTPR 300
LSDGIEIVGR WAETVGLDVE LAKELTESIL VRQVDWVDEI TELHEAGARW 350
ILDLGPGDIL TRLTAPVIRG LGIGIVPAAT RGGQRNLFTV GAVPEVARPW 400
SSYAPTVVKL PDGSVKLETK FTRLTGRSPI LLAGMTPTTV DAKIVAAAAN 450
AGHWAELAGG GQVTEQIFND RIAELETLLE PGRAIQFNTL FLDPYLWKLQ 500
VGGKRLVQRA RQSGAPIDGL VVSAGIPDLE EAVDIIDELN EVGISHVVFK 550
PGTVEQIRSV IRIAAEVPTK PVIVHIEGGR AGGHHSWEDL DDLLLATYSE 600
LRSRSNITIC VGGGIGTPER SAEYLSGRWA EVHGYPLMPI DGILVGTAAM 650
ATLEATTSPQ VKQLLVETKG TEAWVGAGKA ANGMASGRSQ LGADIHEIDN 700
AASRCGRLLD EVAGDADAVA ERRDEIIAAM AQTAKPYFGD VAEMTYLQWL 750
RRYVELAIGD GNSTADTKRP DSPWLDITWR DRFEQMLKRA EARLHPQDFG 800
PIETLFDADA DGERLLEDPE AAITALLQRY PDAETVVLHP ADVPFFVELC 850
KTLGKPVNFV PVIDKDVRRW WRSDSLWQAH DARYEADQVC VIPGTAAVAG 900
ITRVDEPVGE LLDRFEQAAV DEVLGAGAEP VEVLSRRQAR RDASGPLAVV 950
LDAPDVLWAG RMSVNPVHRI AAPTEWQVRE GSDNRSASHP STGARLEVAD 1000
DQHVVLSVPL SGTWIEIRFT LTDVVRSGGA PIVEVDDAAT AMRAVLAIAA 1050
GVEGPENLPK VVDNTATVTV DWDPERVADH TGVTATFGAP LAPTLTVVPD 1100
ALVGRCWPAV FAAIGSAATE AGFPVIEGLL SLVHLDHAAR LLAELPKEPA 1150
EFTVTAKASA ATDTEVGRVV PVSVEVRNAA DGALLATLEE RFAIRGRTGA 1200
AELTDPVRAG GAISDNATDT PRRRRRDVTV GAPVDMRPFA VVSGDHNPIH 1250
TDRAAALLAG LEGPIVHGMW LSAAAQHVVT ATDGKPVPPA KLIGWTARFL 1300
GMVKPGDQVD FRVDRVGIDV GAEVLEVSAR IGSELVMAAT ARLAAPKTVY 1350
AFPGQGIQHK GMGMEVRARS KAARKVWDSA DKFTRETLGF SVLHVVRDNP 1400
TSLIASGVHY HHPDGVLFLT QFTQVAMATV AAAQVAEMRE QGAFVEGAIA 1450
CGHSVGEYTA LACVSGVYEL EALLEVVFHR GSKMHDIVPR DELGRSNYRL 1500
AAIRPSQIDL DDADVKDFVA EISERTGEFL EIVNFNLRGS QYAIAGTVAG 1550
LEALEEEIER RRQITGGKRS FILVPGIDVP FHSSVLRVGV ADFRRSLERV 1600
MPRDKDPELI IGRYIPNLVP RPFTLDRDFI QEIRDLVPAE PLDEVLADYD 1650
TWRNEKPKEL CRKVVIELLA WQFASPVRWI ETQDLLFIEE AAGGLGVERF 1700
VEIGVKSAPT VAGLATNTLK LPEYSHSTVE VLNSERDAAV LFATDTDPEP 1750
EPEADEPTAD APAEAAPAAA AAPAPVAAPA APSGGPRPDD ITFDAADATV 1800
ALIALSAKMR IDQIEALDSI ESITDGASSR RNQLLVDLGS ELNLGAIDGA 1850
AEADLGALKG QVTKLARTYK PFGPVLSDAI NDQLRTVLGP SGKRPAYITE 1900
RVTKTWELGP GWAKHVTVEF ALGTREGSSV RGGDLGGLHA GALASAADVD 1950
KVIDGAVAAV AARRGISVSL PSAGGASGGV VDSAALGEFA EKVTGPDGVL 2000
ASAARLVLNQ LGLSDVVTTP EAATDAELID LVTAELGSDW PRLVAPTFDA 2050
RKAVVFDDRW ASAREDLVKL WLAEEGDIDA QWEQLSQRFE GTGHVVATQA 2100
NWWQGKALAA GRNVHASLFG RIAAGAENPG KGRYSDEVAV VTGASKGSIA 2150
ASVVGQLLDG GATVIATTSR LDDDRLAFYK QLYRDHARFD ATLWVVPANM 2200
ASYSDIDKLV EWVGTEQTES LGPQSIHLKD AQTPTLLFPF AAPRVAGDMS 2250
EVGSRAEMEM KVLLWAVQRL ISGLSKIGAE RDIASRLHVV LPGSPNRGMF 2300
GGDGAYGEAK SALDALENRW SAEKSWAERV SLAHALIGWT KGTGLMGQND 2350
AIVSAVEEAG VTTYTTDEMA AMLLDLCTVE TKVAAAGAPV KVDLTGGLGD 2400
IKIDMAELAA KAREEMSGAA DESDDEAPAG TIRALPSPPR GYNPAPAPEW 2450
DDLDVDPADL VVIVGGAELG PYGSSRTRFE MEVSGELSAA GVLELAWTTG 2500
MVKWEDDPKA GWYDTETGEL VPECEIVERY HDAVVERCGI REFVDDGAID 2550
PDHASPLLVS VFLDKDFTFV VSSEADARAF VQFDPEHTVA RPLPDSSDWE 2600
VTRKAGTEIR VPRKTKLSRT VGAQIPTGFD PTVWGISPDM ASSIDRVALW 2650
NIVATVDAFL SSGFTPTELM RWVHPSQVAS TQGTGMGGMT SMQTMYHGNL 2700
LGRAKPNDIL QEVLPNVVAA HVMQSYVGGY GAMVHPVGAC ATAAVSVEEG 2750
VDKIKLGKAD LVIAGGFDDL TLEAIIGFGD MAATADTEMM RAKGISDSKF 2800
SRANDRRRLG FLEAQGGGTI LLARGDLALK MGLPVLAVVG YAQSFADGVH 2850
TSIPAPGLGA LGAARGGRES TLARSLAQLG VGADDIAVIS KHDTSTLAND 2900
PNETELHERI ADSMGRAPGN PLFIVSQKTL TGHAKGGAAV FQMMGLCQIL 2950
RDGVIPPNRS LDCVDDELAT SGHFVWVREP LDLRGKFPLK AGLVTSLGFG 3000
HVSGLVALVH PEAFIAALDP SEREDYRTRA EQRMLAGQRR LVSAIAGGRP 3050
MYEKPADRRF DHDVPEKRQE AAMLLSTDAR LGENDQYVL 3089
Length:3,089
Mass (Da):329,538
Last modified:January 9, 2007 - v1
Checksum:i251351CB2F8E7CF1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000480 Genomic DNA. Translation: ABK70103.1.
CP001663 Genomic DNA. Translation: AFP41086.1.
RefSeqiYP_006569381.1. NC_018289.1.
YP_889015.1. NC_008596.1.

Genome annotation databases

EnsemblBacteriaiABK70103; ABK70103; MSMEG_4757.
AFP41086; AFP41086; MSMEI_4637.
GeneIDi4532653.
KEGGimsg:MSMEI_4637.
msm:MSMEG_4757.
PATRICi18081817. VBIMycSme59918_4642.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000480 Genomic DNA. Translation: ABK70103.1 .
CP001663 Genomic DNA. Translation: AFP41086.1 .
RefSeqi YP_006569381.1. NC_018289.1.
YP_889015.1. NC_008596.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3ZEN electron microscopy 7.50 D/E/F 1-3089 [» ]
4B3Y electron microscopy 7.50 A/B/C 1-3089 [» ]
4BJD electron microscopy 20.00 A/B/C 1-3089 [» ]
4BJE electron microscopy 20.00 D/E/F 1-3089 [» ]
4BJF electron microscopy 17.50 D/E/F 1-3089 [» ]
4BJG electron microscopy 17.50 A/B/C 1-3089 [» ]
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 246196.MSMEG_4757.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABK70103 ; ABK70103 ; MSMEG_4757 .
AFP41086 ; AFP41086 ; MSMEI_4637 .
GeneIDi 4532653.
KEGGi msg:MSMEI_4637.
msm:MSMEG_4757.
PATRICi 18081817. VBIMycSme59918_4642.

Phylogenomic databases

eggNOGi COG4982.
HOGENOMi HOG000051526.
KOi K11533.
OMAi MFLDPYL.
OrthoDBi EOG6WMHTT.

Enzyme and pathway databases

BioCyci MSME246196:GJ4Y-4756-MONOMER.

Family and domain databases

Gene3Di 3.10.129.10. 1 hit.
3.20.20.70. 1 hit.
3.40.366.10. 5 hits.
3.40.47.10. 3 hits.
3.40.50.720. 1 hit.
InterProi IPR001227. Ac_transferase_dom.
IPR014043. Acyl_transferase.
IPR016035. Acyl_Trfase/lysoPLipase.
IPR013785. Aldolase_TIM.
IPR013565. DUF1729.
IPR003965. Fatty_acid_synthase.
IPR029069. HotDog_dom.
IPR014031. Ketoacyl_synth_C.
IPR014030. Ketoacyl_synth_N.
IPR002539. MaoC_dom.
IPR016040. NAD(P)-bd_dom.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view ]
Pfami PF00698. Acyl_transf_1. 2 hits.
PF08354. DUF1729. 1 hit.
PF00109. ketoacyl-synt. 1 hit.
PF02801. Ketoacyl-synt_C. 1 hit.
PF01575. MaoC_dehydratas. 1 hit.
[Graphical view ]
PRINTSi PR01483. FASYNTHASE.
SUPFAMi SSF52151. SSF52151. 5 hits.
SSF53901. SSF53901. 2 hits.
SSF54637. SSF54637. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MC2 155Imported.
  2. Fleischmann R.D., Dodson R.J., Haft D.H., Merkel J.S., Nelson W.C., Fraser C.M.
    Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700084 / mc(2)155 and MC2 155Imported.
  3. "Interrupted coding sequences in Mycobacterium smegmatis: authentic mutations or sequencing errors?"
    Deshayes C., Perrodou E., Gallien S., Euphrasie D., Schaeffer C., Van-Dorsselaer A., Poch O., Lecompte O., Reyrat J.M.
    Genome Biol. 8:R20.1-R20.9(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700084 / mc(2)155 and MC2 155Imported.
  4. "Ortho-proteogenomics: multiple proteomes investigation through orthology and a new MS-based protocol."
    Gallien S., Perrodou E., Carapito C., Deshayes C., Reyrat J.M., Van Dorsselaer A., Poch O., Schaeffer C., Lecompte O.
    Genome Res. 19:128-135(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700084 / mc(2)155 and MC2 155.
  5. "7.5-A cryo-em structure of the mycobacterial fatty acid synthase."
    Boehringer D., Ban N., Leibundgut M.
    J. Mol. Biol. 425:841-849(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY ELECTRON MICROSCOPY (7.50 ANGSTROMS) IN COMPLEX WITH FMN.
  6. "Structure and conformational variability of the mycobacterium tuberculosis fatty acid synthase multienzyme complex."
    Ciccarelli L., Connell S.R., Enderle M., Mills D.J., Vonck J., Grininger M.
    Structure 21:1251-1257(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY ELECTRON MICROSCOPY (17.50 ANGSTROMS) IN COMPLEX WITH FMN.

Entry informationi

Entry nameiA0R1H7_MYCS2
AccessioniPrimary (citable) accession number: A0R1H7
Entry historyi
Integrated into UniProtKB/TrEMBL: January 9, 2007
Last sequence update: January 9, 2007
Last modified: July 9, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported, Complete proteome, Reference proteome

External Data

Dasty 3

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