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A0R1H7 (A0R1H7_MYCS2) Unreviewed, UniProtKB/TrEMBL

Last modified July 9, 2014. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein names
Gene names
Ordered Locus Names:MSMEG_4757 EMBL ABK70103.1, MSMEI_4637 EMBL AFP41086.1
OrganismMycobacterium smegmatis (strain ATCC 700084 / mc(2)155) [Reference proteome] [HAMAP] EMBL ABK70103.1
Taxonomic identifier246196 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium

Protein attributes

Sequence length3089 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding434 – 4363FMN PDB 4BJD PDB 4BJE PDB 4B3Y PDB 4BJF PDB 4BJG PDB 3ZEN

Sites

Binding site5231FMN PDB 4BJD PDB 4BJE PDB 4B3Y PDB 4BJF PDB 4BJG PDB 3ZEN
Binding site5501FMN PDB 4BJD PDB 4BJE PDB 4B3Y PDB 4BJF PDB 4BJG PDB 3ZEN
Binding site5771FMN PDB 4BJD PDB 4BJE PDB 4B3Y PDB 4BJF PDB 4BJG PDB 3ZEN
Binding site5821FMN PDB 4BJD PDB 4BJE PDB 4B3Y PDB 4BJF PDB 4BJG PDB 3ZEN
Binding site6141FMN; via amide nitrogen PDB 4BJD PDB 4BJE PDB 4B3Y PDB 4BJF PDB 4BJG PDB 3ZEN
Binding site6471FMN PDB 4BJD PDB 4BJE PDB 4B3Y PDB 4BJF PDB 4BJG PDB 3ZEN

Sequences

Sequence LengthMass (Da)Tools
A0R1H7 [UniParc].

Last modified January 9, 2007. Version 1.
Checksum: 251351CB2F8E7CF1

FASTA3,089329,538
        10         20         30         40         50         60 
MTIYEHDRVP AGWNDESGSD RTADGNAADT AHALVDRLSA GEPYAVAFGG QGSAWLETLE 

        70         80         90        100        110        120 
ELVSSAGIES ELATLAGEAE LLLEPVASEL VVVRPIGFEP LQWVRALAAE EPVPSDKQLT 

       130        140        150        160        170        180 
SAAVSVPGVL LTQIAAVRAL ARQGMDLTAT PPVAVAGHSQ GVLAVQALAA KGAKDVELLA 

       190        200        210        220        230        240 
LAQLIGAAGT LVARRRGITV LGDRPPMVSV TNADPERIYE LLEEFSSDVR TVLPPVLSIR 

       250        260        270        280        290        300 
NGRRSVVITG TPEQLSRFEL YCTQIAEKEE AERKNKLRGG AVFAPVFDPV QVEVGFHTPR 

       310        320        330        340        350        360 
LSDGIEIVGR WAETVGLDVE LAKELTESIL VRQVDWVDEI TELHEAGARW ILDLGPGDIL 

       370        380        390        400        410        420 
TRLTAPVIRG LGIGIVPAAT RGGQRNLFTV GAVPEVARPW SSYAPTVVKL PDGSVKLETK 

       430        440        450        460        470        480 
FTRLTGRSPI LLAGMTPTTV DAKIVAAAAN AGHWAELAGG GQVTEQIFND RIAELETLLE 

       490        500        510        520        530        540 
PGRAIQFNTL FLDPYLWKLQ VGGKRLVQRA RQSGAPIDGL VVSAGIPDLE EAVDIIDELN 

       550        560        570        580        590        600 
EVGISHVVFK PGTVEQIRSV IRIAAEVPTK PVIVHIEGGR AGGHHSWEDL DDLLLATYSE 

       610        620        630        640        650        660 
LRSRSNITIC VGGGIGTPER SAEYLSGRWA EVHGYPLMPI DGILVGTAAM ATLEATTSPQ 

       670        680        690        700        710        720 
VKQLLVETKG TEAWVGAGKA ANGMASGRSQ LGADIHEIDN AASRCGRLLD EVAGDADAVA 

       730        740        750        760        770        780 
ERRDEIIAAM AQTAKPYFGD VAEMTYLQWL RRYVELAIGD GNSTADTKRP DSPWLDITWR 

       790        800        810        820        830        840 
DRFEQMLKRA EARLHPQDFG PIETLFDADA DGERLLEDPE AAITALLQRY PDAETVVLHP 

       850        860        870        880        890        900 
ADVPFFVELC KTLGKPVNFV PVIDKDVRRW WRSDSLWQAH DARYEADQVC VIPGTAAVAG 

       910        920        930        940        950        960 
ITRVDEPVGE LLDRFEQAAV DEVLGAGAEP VEVLSRRQAR RDASGPLAVV LDAPDVLWAG 

       970        980        990       1000       1010       1020 
RMSVNPVHRI AAPTEWQVRE GSDNRSASHP STGARLEVAD DQHVVLSVPL SGTWIEIRFT 

      1030       1040       1050       1060       1070       1080 
LTDVVRSGGA PIVEVDDAAT AMRAVLAIAA GVEGPENLPK VVDNTATVTV DWDPERVADH 

      1090       1100       1110       1120       1130       1140 
TGVTATFGAP LAPTLTVVPD ALVGRCWPAV FAAIGSAATE AGFPVIEGLL SLVHLDHAAR 

      1150       1160       1170       1180       1190       1200 
LLAELPKEPA EFTVTAKASA ATDTEVGRVV PVSVEVRNAA DGALLATLEE RFAIRGRTGA 

      1210       1220       1230       1240       1250       1260 
AELTDPVRAG GAISDNATDT PRRRRRDVTV GAPVDMRPFA VVSGDHNPIH TDRAAALLAG 

      1270       1280       1290       1300       1310       1320 
LEGPIVHGMW LSAAAQHVVT ATDGKPVPPA KLIGWTARFL GMVKPGDQVD FRVDRVGIDV 

      1330       1340       1350       1360       1370       1380 
GAEVLEVSAR IGSELVMAAT ARLAAPKTVY AFPGQGIQHK GMGMEVRARS KAARKVWDSA 

      1390       1400       1410       1420       1430       1440 
DKFTRETLGF SVLHVVRDNP TSLIASGVHY HHPDGVLFLT QFTQVAMATV AAAQVAEMRE 

      1450       1460       1470       1480       1490       1500 
QGAFVEGAIA CGHSVGEYTA LACVSGVYEL EALLEVVFHR GSKMHDIVPR DELGRSNYRL 

      1510       1520       1530       1540       1550       1560 
AAIRPSQIDL DDADVKDFVA EISERTGEFL EIVNFNLRGS QYAIAGTVAG LEALEEEIER 

      1570       1580       1590       1600       1610       1620 
RRQITGGKRS FILVPGIDVP FHSSVLRVGV ADFRRSLERV MPRDKDPELI IGRYIPNLVP 

      1630       1640       1650       1660       1670       1680 
RPFTLDRDFI QEIRDLVPAE PLDEVLADYD TWRNEKPKEL CRKVVIELLA WQFASPVRWI 

      1690       1700       1710       1720       1730       1740 
ETQDLLFIEE AAGGLGVERF VEIGVKSAPT VAGLATNTLK LPEYSHSTVE VLNSERDAAV 

      1750       1760       1770       1780       1790       1800 
LFATDTDPEP EPEADEPTAD APAEAAPAAA AAPAPVAAPA APSGGPRPDD ITFDAADATV 

      1810       1820       1830       1840       1850       1860 
ALIALSAKMR IDQIEALDSI ESITDGASSR RNQLLVDLGS ELNLGAIDGA AEADLGALKG 

      1870       1880       1890       1900       1910       1920 
QVTKLARTYK PFGPVLSDAI NDQLRTVLGP SGKRPAYITE RVTKTWELGP GWAKHVTVEF 

      1930       1940       1950       1960       1970       1980 
ALGTREGSSV RGGDLGGLHA GALASAADVD KVIDGAVAAV AARRGISVSL PSAGGASGGV 

      1990       2000       2010       2020       2030       2040 
VDSAALGEFA EKVTGPDGVL ASAARLVLNQ LGLSDVVTTP EAATDAELID LVTAELGSDW 

      2050       2060       2070       2080       2090       2100 
PRLVAPTFDA RKAVVFDDRW ASAREDLVKL WLAEEGDIDA QWEQLSQRFE GTGHVVATQA 

      2110       2120       2130       2140       2150       2160 
NWWQGKALAA GRNVHASLFG RIAAGAENPG KGRYSDEVAV VTGASKGSIA ASVVGQLLDG 

      2170       2180       2190       2200       2210       2220 
GATVIATTSR LDDDRLAFYK QLYRDHARFD ATLWVVPANM ASYSDIDKLV EWVGTEQTES 

      2230       2240       2250       2260       2270       2280 
LGPQSIHLKD AQTPTLLFPF AAPRVAGDMS EVGSRAEMEM KVLLWAVQRL ISGLSKIGAE 

      2290       2300       2310       2320       2330       2340 
RDIASRLHVV LPGSPNRGMF GGDGAYGEAK SALDALENRW SAEKSWAERV SLAHALIGWT 

      2350       2360       2370       2380       2390       2400 
KGTGLMGQND AIVSAVEEAG VTTYTTDEMA AMLLDLCTVE TKVAAAGAPV KVDLTGGLGD 

      2410       2420       2430       2440       2450       2460 
IKIDMAELAA KAREEMSGAA DESDDEAPAG TIRALPSPPR GYNPAPAPEW DDLDVDPADL 

      2470       2480       2490       2500       2510       2520 
VVIVGGAELG PYGSSRTRFE MEVSGELSAA GVLELAWTTG MVKWEDDPKA GWYDTETGEL 

      2530       2540       2550       2560       2570       2580 
VPECEIVERY HDAVVERCGI REFVDDGAID PDHASPLLVS VFLDKDFTFV VSSEADARAF 

      2590       2600       2610       2620       2630       2640 
VQFDPEHTVA RPLPDSSDWE VTRKAGTEIR VPRKTKLSRT VGAQIPTGFD PTVWGISPDM 

      2650       2660       2670       2680       2690       2700 
ASSIDRVALW NIVATVDAFL SSGFTPTELM RWVHPSQVAS TQGTGMGGMT SMQTMYHGNL 

      2710       2720       2730       2740       2750       2760 
LGRAKPNDIL QEVLPNVVAA HVMQSYVGGY GAMVHPVGAC ATAAVSVEEG VDKIKLGKAD 

      2770       2780       2790       2800       2810       2820 
LVIAGGFDDL TLEAIIGFGD MAATADTEMM RAKGISDSKF SRANDRRRLG FLEAQGGGTI 

      2830       2840       2850       2860       2870       2880 
LLARGDLALK MGLPVLAVVG YAQSFADGVH TSIPAPGLGA LGAARGGRES TLARSLAQLG 

      2890       2900       2910       2920       2930       2940 
VGADDIAVIS KHDTSTLAND PNETELHERI ADSMGRAPGN PLFIVSQKTL TGHAKGGAAV 

      2950       2960       2970       2980       2990       3000 
FQMMGLCQIL RDGVIPPNRS LDCVDDELAT SGHFVWVREP LDLRGKFPLK AGLVTSLGFG 

      3010       3020       3030       3040       3050       3060 
HVSGLVALVH PEAFIAALDP SEREDYRTRA EQRMLAGQRR LVSAIAGGRP MYEKPADRRF 

      3070       3080 
DHDVPEKRQE AAMLLSTDAR LGENDQYVL 

« Hide

References

« Hide 'large scale' references
[1]"ICDS database: interrupted CoDing sequences in prokaryotic genomes."
Perrodou E., Deshayes C., Muller J., Schaeffer C., Van Dorsselaer A., Ripp R., Poch O., Reyrat J.M., Lecompte O.
Nucleic Acids Res. 34:D338-D343(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: MC2 155 EMBL AFP41086.1.
[2]Fleischmann R.D., Dodson R.J., Haft D.H., Merkel J.S., Nelson W.C., Fraser C.M.
Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 700084 / mc(2)155 and MC2 155 EMBL ABK70103.1.
[3]"Interrupted coding sequences in Mycobacterium smegmatis: authentic mutations or sequencing errors?"
Deshayes C., Perrodou E., Gallien S., Euphrasie D., Schaeffer C., Van-Dorsselaer A., Poch O., Lecompte O., Reyrat J.M.
Genome Biol. 8:R20.1-R20.9(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 700084 / mc(2)155 and MC2 155 EMBL AFP41086.1.
[4]"Ortho-proteogenomics: multiple proteomes investigation through orthology and a new MS-based protocol."
Gallien S., Perrodou E., Carapito C., Deshayes C., Reyrat J.M., Van Dorsselaer A., Poch O., Schaeffer C., Lecompte O.
Genome Res. 19:128-135(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 700084 / mc(2)155 and MC2 155.
[5]"7.5-A cryo-em structure of the mycobacterial fatty acid synthase."
Boehringer D., Ban N., Leibundgut M.
J. Mol. Biol. 425:841-849(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: STRUCTURE BY ELECTRON MICROSCOPY (7.50 ANGSTROMS) IN COMPLEX WITH FMN.
[6]"Structure and conformational variability of the mycobacterium tuberculosis fatty acid synthase multienzyme complex."
Ciccarelli L., Connell S.R., Enderle M., Mills D.J., Vonck J., Grininger M.
Structure 21:1251-1257(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: STRUCTURE BY ELECTRON MICROSCOPY (17.50 ANGSTROMS) IN COMPLEX WITH FMN.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000480 Genomic DNA. Translation: ABK70103.1.
CP001663 Genomic DNA. Translation: AFP41086.1.
RefSeqYP_006569381.1. NC_018289.1.
YP_889015.1. NC_008596.1.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
3ZENelectron microscopy7.50D/E/F1-3089[»]
4B3Yelectron microscopy7.50A/B/C1-3089[»]
4BJDelectron microscopy20.00A/B/C1-3089[»]
4BJEelectron microscopy20.00D/E/F1-3089[»]
4BJFelectron microscopy17.50D/E/F1-3089[»]
4BJGelectron microscopy17.50A/B/C1-3089[»]
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING246196.MSMEG_4757.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABK70103; ABK70103; MSMEG_4757.
AFP41086; AFP41086; MSMEI_4637.
GeneID4532653.
KEGGmsg:MSMEI_4637.
msm:MSMEG_4757.
PATRIC18081817. VBIMycSme59918_4642.

Phylogenomic databases

eggNOGCOG4982.
HOGENOMHOG000051526.
KOK11533.
OMAMFLDPYL.
OrthoDBEOG6WMHTT.

Enzyme and pathway databases

BioCycMSME246196:GJ4Y-4756-MONOMER.

Family and domain databases

Gene3D3.10.129.10. 1 hit.
3.20.20.70. 1 hit.
3.40.366.10. 5 hits.
3.40.47.10. 3 hits.
3.40.50.720. 1 hit.
InterProIPR001227. Ac_transferase_dom.
IPR014043. Acyl_transferase.
IPR016035. Acyl_Trfase/lysoPLipase.
IPR013785. Aldolase_TIM.
IPR013565. DUF1729.
IPR003965. Fatty_acid_synthase.
IPR029069. HotDog_dom.
IPR014031. Ketoacyl_synth_C.
IPR014030. Ketoacyl_synth_N.
IPR002539. MaoC_dom.
IPR016040. NAD(P)-bd_dom.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
PfamPF00698. Acyl_transf_1. 2 hits.
PF08354. DUF1729. 1 hit.
PF00109. ketoacyl-synt. 1 hit.
PF02801. Ketoacyl-synt_C. 1 hit.
PF01575. MaoC_dehydratas. 1 hit.
[Graphical view]
PRINTSPR01483. FASYNTHASE.
SUPFAMSSF52151. SSF52151. 5 hits.
SSF53901. SSF53901. 2 hits.
SSF54637. SSF54637. 1 hit.
ProtoNetSearch...

Entry information

Entry nameA0R1H7_MYCS2
AccessionPrimary (citable) accession number: A0R1H7
Entry history
Integrated into UniProtKB/TrEMBL: January 9, 2007
Last sequence update: January 9, 2007
Last modified: July 9, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)