A0R1H7 (A0R1H7_MYCS2) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Fatty acid synthase EMBL ABK70103.1

Gene names

Ordered Locus Names:

MSMEG_4757 EMBL ABK70103.1, MSMEI_4637 EMBL AFP41086.1

Organism

Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155) [Reference proteome] [HAMAP] EMBL ABK70103.1

Taxonomic identifier

246196 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Actinobacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium smegmatis

Protein attributes

Sequence length	3089 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

Ontologies

Keywords
Molecular function	Transferase RuleBase RU000693
Technical term	3D-structure PDB 4B3Y PDB 3ZEN Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	fatty acid biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular_component	fatty acid synthase complex Inferred from electronic annotation. Source: InterPro
Molecular_function	enoyl-[acyl-carrier-protein] reductase (NADH) activity Inferred from electronic annotation. Source: InterPro nucleotide binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	A0R1H7 [UniParc]. Last modified January 9, 2007. Version 1. Checksum: 251351CB2F8E7CF1	FASTA	3,089	329,538
	10 20 30 40 50 60 MTIYEHDRVP AGWNDESGSD RTADGNAADT AHALVDRLSA GEPYAVAFGG QGSAWLETLE 70 80 90 100 110 120 ELVSSAGIES ELATLAGEAE LLLEPVASEL VVVRPIGFEP LQWVRALAAE EPVPSDKQLT 130 140 150 160 170 180 SAAVSVPGVL LTQIAAVRAL ARQGMDLTAT PPVAVAGHSQ GVLAVQALAA KGAKDVELLA 190 200 210 220 230 240 LAQLIGAAGT LVARRRGITV LGDRPPMVSV TNADPERIYE LLEEFSSDVR TVLPPVLSIR 250 260 270 280 290 300 NGRRSVVITG TPEQLSRFEL YCTQIAEKEE AERKNKLRGG AVFAPVFDPV QVEVGFHTPR 310 320 330 340 350 360 LSDGIEIVGR WAETVGLDVE LAKELTESIL VRQVDWVDEI TELHEAGARW ILDLGPGDIL 370 380 390 400 410 420 TRLTAPVIRG LGIGIVPAAT RGGQRNLFTV GAVPEVARPW SSYAPTVVKL PDGSVKLETK 430 440 450 460 470 480 FTRLTGRSPI LLAGMTPTTV DAKIVAAAAN AGHWAELAGG GQVTEQIFND RIAELETLLE 490 500 510 520 530 540 PGRAIQFNTL FLDPYLWKLQ VGGKRLVQRA RQSGAPIDGL VVSAGIPDLE EAVDIIDELN 550 560 570 580 590 600 EVGISHVVFK PGTVEQIRSV IRIAAEVPTK PVIVHIEGGR AGGHHSWEDL DDLLLATYSE 610 620 630 640 650 660 LRSRSNITIC VGGGIGTPER SAEYLSGRWA EVHGYPLMPI DGILVGTAAM ATLEATTSPQ 670 680 690 700 710 720 VKQLLVETKG TEAWVGAGKA ANGMASGRSQ LGADIHEIDN AASRCGRLLD EVAGDADAVA 730 740 750 760 770 780 ERRDEIIAAM AQTAKPYFGD VAEMTYLQWL RRYVELAIGD GNSTADTKRP DSPWLDITWR 790 800 810 820 830 840 DRFEQMLKRA EARLHPQDFG PIETLFDADA DGERLLEDPE AAITALLQRY PDAETVVLHP 850 860 870 880 890 900 ADVPFFVELC KTLGKPVNFV PVIDKDVRRW WRSDSLWQAH DARYEADQVC VIPGTAAVAG 910 920 930 940 950 960 ITRVDEPVGE LLDRFEQAAV DEVLGAGAEP VEVLSRRQAR RDASGPLAVV LDAPDVLWAG 970 980 990 1000 1010 1020 RMSVNPVHRI AAPTEWQVRE GSDNRSASHP STGARLEVAD DQHVVLSVPL SGTWIEIRFT 1030 1040 1050 1060 1070 1080 LTDVVRSGGA PIVEVDDAAT AMRAVLAIAA GVEGPENLPK VVDNTATVTV DWDPERVADH 1090 1100 1110 1120 1130 1140 TGVTATFGAP LAPTLTVVPD ALVGRCWPAV FAAIGSAATE AGFPVIEGLL SLVHLDHAAR 1150 1160 1170 1180 1190 1200 LLAELPKEPA EFTVTAKASA ATDTEVGRVV PVSVEVRNAA DGALLATLEE RFAIRGRTGA 1210 1220 1230 1240 1250 1260 AELTDPVRAG GAISDNATDT PRRRRRDVTV GAPVDMRPFA VVSGDHNPIH TDRAAALLAG 1270 1280 1290 1300 1310 1320 LEGPIVHGMW LSAAAQHVVT ATDGKPVPPA KLIGWTARFL GMVKPGDQVD FRVDRVGIDV 1330 1340 1350 1360 1370 1380 GAEVLEVSAR IGSELVMAAT ARLAAPKTVY AFPGQGIQHK GMGMEVRARS KAARKVWDSA 1390 1400 1410 1420 1430 1440 DKFTRETLGF SVLHVVRDNP TSLIASGVHY HHPDGVLFLT QFTQVAMATV AAAQVAEMRE 1450 1460 1470 1480 1490 1500 QGAFVEGAIA CGHSVGEYTA LACVSGVYEL EALLEVVFHR GSKMHDIVPR DELGRSNYRL 1510 1520 1530 1540 1550 1560 AAIRPSQIDL DDADVKDFVA EISERTGEFL EIVNFNLRGS QYAIAGTVAG LEALEEEIER 1570 1580 1590 1600 1610 1620 RRQITGGKRS FILVPGIDVP FHSSVLRVGV ADFRRSLERV MPRDKDPELI IGRYIPNLVP 1630 1640 1650 1660 1670 1680 RPFTLDRDFI QEIRDLVPAE PLDEVLADYD TWRNEKPKEL CRKVVIELLA WQFASPVRWI 1690 1700 1710 1720 1730 1740 ETQDLLFIEE AAGGLGVERF VEIGVKSAPT VAGLATNTLK LPEYSHSTVE VLNSERDAAV 1750 1760 1770 1780 1790 1800 LFATDTDPEP EPEADEPTAD APAEAAPAAA AAPAPVAAPA APSGGPRPDD ITFDAADATV 1810 1820 1830 1840 1850 1860 ALIALSAKMR IDQIEALDSI ESITDGASSR RNQLLVDLGS ELNLGAIDGA AEADLGALKG 1870 1880 1890 1900 1910 1920 QVTKLARTYK PFGPVLSDAI NDQLRTVLGP SGKRPAYITE RVTKTWELGP GWAKHVTVEF 1930 1940 1950 1960 1970 1980 ALGTREGSSV RGGDLGGLHA GALASAADVD KVIDGAVAAV AARRGISVSL PSAGGASGGV 1990 2000 2010 2020 2030 2040 VDSAALGEFA EKVTGPDGVL ASAARLVLNQ LGLSDVVTTP EAATDAELID LVTAELGSDW 2050 2060 2070 2080 2090 2100 PRLVAPTFDA RKAVVFDDRW ASAREDLVKL WLAEEGDIDA QWEQLSQRFE GTGHVVATQA 2110 2120 2130 2140 2150 2160 NWWQGKALAA GRNVHASLFG RIAAGAENPG KGRYSDEVAV VTGASKGSIA ASVVGQLLDG 2170 2180 2190 2200 2210 2220 GATVIATTSR LDDDRLAFYK QLYRDHARFD ATLWVVPANM ASYSDIDKLV EWVGTEQTES 2230 2240 2250 2260 2270 2280 LGPQSIHLKD AQTPTLLFPF AAPRVAGDMS EVGSRAEMEM KVLLWAVQRL ISGLSKIGAE 2290 2300 2310 2320 2330 2340 RDIASRLHVV LPGSPNRGMF GGDGAYGEAK SALDALENRW SAEKSWAERV SLAHALIGWT 2350 2360 2370 2380 2390 2400 KGTGLMGQND AIVSAVEEAG VTTYTTDEMA AMLLDLCTVE TKVAAAGAPV KVDLTGGLGD 2410 2420 2430 2440 2450 2460 IKIDMAELAA KAREEMSGAA DESDDEAPAG TIRALPSPPR GYNPAPAPEW DDLDVDPADL 2470 2480 2490 2500 2510 2520 VVIVGGAELG PYGSSRTRFE MEVSGELSAA GVLELAWTTG MVKWEDDPKA GWYDTETGEL 2530 2540 2550 2560 2570 2580 VPECEIVERY HDAVVERCGI REFVDDGAID PDHASPLLVS VFLDKDFTFV VSSEADARAF 2590 2600 2610 2620 2630 2640 VQFDPEHTVA RPLPDSSDWE VTRKAGTEIR VPRKTKLSRT VGAQIPTGFD PTVWGISPDM 2650 2660 2670 2680 2690 2700 ASSIDRVALW NIVATVDAFL SSGFTPTELM RWVHPSQVAS TQGTGMGGMT SMQTMYHGNL 2710 2720 2730 2740 2750 2760 LGRAKPNDIL QEVLPNVVAA HVMQSYVGGY GAMVHPVGAC ATAAVSVEEG VDKIKLGKAD 2770 2780 2790 2800 2810 2820 LVIAGGFDDL TLEAIIGFGD MAATADTEMM RAKGISDSKF SRANDRRRLG FLEAQGGGTI 2830 2840 2850 2860 2870 2880 LLARGDLALK MGLPVLAVVG YAQSFADGVH TSIPAPGLGA LGAARGGRES TLARSLAQLG 2890 2900 2910 2920 2930 2940 VGADDIAVIS KHDTSTLAND PNETELHERI ADSMGRAPGN PLFIVSQKTL TGHAKGGAAV 2950 2960 2970 2980 2990 3000 FQMMGLCQIL RDGVIPPNRS LDCVDDELAT SGHFVWVREP LDLRGKFPLK AGLVTSLGFG 3010 3020 3030 3040 3050 3060 HVSGLVALVH PEAFIAALDP SEREDYRTRA EQRMLAGQRR LVSAIAGGRP MYEKPADRRF 3070 3080 DHDVPEKRQE AAMLLSTDAR LGENDQYVL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"ICDS database: interrupted CoDing sequences in prokaryotic genomes." Perrodou E., Deshayes C., Muller J., Schaeffer C., Van Dorsselaer A., Ripp R., Poch O., Reyrat J.M., Lecompte O. Nucleic Acids Res. 34:D338-D343(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: MC2 155 EMBL AFP41086.1.
[2]	Fleischmann R.D., Dodson R.J., Haft D.H., Merkel J.S., Nelson W.C., Fraser C.M. Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700084 / mc(2)155 and MC2 155 EMBL ABK70103.1.
[3]	"Interrupted coding sequences in Mycobacterium smegmatis: authentic mutations or sequencing errors?" Deshayes C., Perrodou E., Gallien S., Euphrasie D., Schaeffer C., Van-Dorsselaer A., Poch O., Lecompte O., Reyrat J.M. Genome Biol. 8:R20-R20(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700084 / mc(2)155 and MC2 155 EMBL AFP41086.1.
[4]	"Ortho-proteogenomics: multiple proteomes investigation through orthology and a new MS-based protocol." Gallien S., Perrodou E., Carapito C., Deshayes C., Reyrat J.M., Van Dorsselaer A., Poch O., Schaeffer C., Lecompte O. Genome Res. 19:128-135(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700084 / mc(2)155 and MC2 155 EMBL AFP41086.1.
[5]	"7.5-A Cryo-EM Structure of the Mycobacterial Fatty Acid Synthase." Boehringer D., Ban N., Leibundgut M. J. Mol. Biol. 425:841-849(2013) [PubMed] [Europe PMC] [Abstract] Cited for: STRUCTURE BY ELECTRON MICROSCOPY (7.50 ANGSTROMS).

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

CP000480 Genomic DNA. Translation: ABK70103.1.
CP001663 Genomic DNA. Translation: AFP41086.1.

RefSeq

YP_006569381.1. NC_018289.1.
YP_889015.1. NC_008596.1.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
3ZEN	electron microscopy	7.50	D/E/F	1-3089	[»]
4B3Y	electron microscopy	7.50	A/B/C	1-3089	[»]

ModBase

Search...

Protein-protein interaction databases

STRING

246196.MSMEG_4757.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

EnsemblBacteria

ABK70103; ABK70103; MSMEG_4757.
AFP41086; AFP41086; MSMEI_4637.

GeneID

13429857.
4532653.

KEGG

msg:MSMEI_4637.
msm:MSMEG_4757.

PATRIC

18081817. VBIMycSme59918_4642.

Phylogenomic databases

eggNOG

COG4982.

HOGENOM

HOG000051526.

KO

K11533.

OMA

SVGEYNA.

ProtClustDB

CLSK791903.

Enzyme and pathway databases

BioCyc

MSME246196:GJ4Y-4756-MONOMER.

Family and domain databases

Gene3D

3.20.20.70. 1 hit.
3.40.366.10. 5 hits.
3.40.47.10. 3 hits.
3.40.50.720. 1 hit.

InterPro

IPR001227. Ac_transferase_dom.
IPR014043. Acyl_transferase.
IPR016035. Acyl_Trfase/lysoPLipase.
IPR013785. Aldolase_TIM.
IPR013565. DUF1729.
IPR003965. Fatty_acid_synthase.
IPR014031. Ketoacyl_synth_C.
IPR014030. Ketoacyl_synth_N.
IPR002539. MaoC_dom.
IPR016040. NAD(P)-bd_dom.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]

Pfam

PF00698. Acyl_transf_1. 2 hits.
PF08354. DUF1729. 1 hit.
PF00109. ketoacyl-synt. 1 hit.
PF02801. Ketoacyl-synt_C. 1 hit.
PF01575. MaoC_dehydratas. 1 hit.
[Graphical view]

PRINTS

PR01483. FASYNTHASE.

SUPFAM

SSF52151. Acyl_Trfase/lysoPlipase. 2 hits.
SSF53901. Thiolase-like. 2 hits.

ProtoNet

Search...

Entry information

Entry name

A0R1H7_MYCS2

Accession

Primary (citable) accession number: A0R1H7

Entry history

Integrated into UniProtKB/TrEMBL:	January 9, 2007
Last sequence update:	January 9, 2007
Last modified:	May 1, 2013
This is version 56 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)