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A0R1H7

- A0R1H7_MYCS2

UniProt

A0R1H7 - A0R1H7_MYCS2

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Protein
Submitted name:

Fatty acid synthase

Gene

MSMEG_4757

Organism
Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei523 – 5231FMNImported
Binding sitei550 – 5501FMNImported
Binding sitei577 – 5771FMNImported
Binding sitei582 – 5821FMNImported
Binding sitei614 – 6141FMN; via amide nitrogenImported
Binding sitei647 – 6471FMNImported

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi434 – 4363FMNImported

GO - Molecular functioni

  1. enoyl-[acyl-carrier-protein] reductase (NADH) activity Source: InterPro
  2. nucleotide binding Source: UniProtKB-KW

GO - Biological processi

  1. fatty acid biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Ligandi

Flavoprotein, FMNImported, Nucleotide-bindingImported

Enzyme and pathway databases

BioCyciMSME246196:GJ4Y-4756-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
Fatty acid synthaseImported
Gene namesi
Ordered Locus Names:MSMEG_4757Imported, MSMEI_4637Imported
OrganismiMycobacterium smegmatis (strain ATCC 700084 / mc(2)155)Imported
Taxonomic identifieri246196 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
ProteomesiUP000000757: Chromosome, UP000006158: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. fatty acid synthase complex Source: InterPro
Complete GO annotation...

Interactioni

Protein-protein interaction databases

STRINGi246196.MSMEG_4757.

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3ZENelectron microscopy7.50D/E/F1-3089[»]
4B3Yelectron microscopy7.50A/B/C1-3089[»]
4BJDelectron microscopy20.00A/B/C1-3089[»]
4BJEelectron microscopy20.00D/E/F1-3089[»]
4BJFelectron microscopy17.50D/E/F1-3089[»]
4BJGelectron microscopy17.50A/B/C1-3089[»]
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiCOG4982.
HOGENOMiHOG000051526.
KOiK11533.
OMAiMFLDPYL.
OrthoDBiEOG6WMHTT.

Family and domain databases

Gene3Di3.10.129.10. 1 hit.
3.20.20.70. 1 hit.
3.40.366.10. 5 hits.
3.40.47.10. 3 hits.
3.40.50.720. 1 hit.
InterProiIPR001227. Ac_transferase_dom.
IPR014043. Acyl_transferase.
IPR016035. Acyl_Trfase/lysoPLipase.
IPR013785. Aldolase_TIM.
IPR013565. DUF1729.
IPR003965. Fatty_acid_synthase.
IPR029069. HotDog_dom.
IPR014031. Ketoacyl_synth_C.
IPR014030. Ketoacyl_synth_N.
IPR002539. MaoC_dom.
IPR016040. NAD(P)-bd_dom.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
PfamiPF00698. Acyl_transf_1. 2 hits.
PF08354. DUF1729. 1 hit.
PF00109. ketoacyl-synt. 1 hit.
PF02801. Ketoacyl-synt_C. 1 hit.
PF01575. MaoC_dehydratas. 1 hit.
[Graphical view]
PRINTSiPR01483. FASYNTHASE.
SUPFAMiSSF52151. SSF52151. 5 hits.
SSF53901. SSF53901. 2 hits.
SSF54637. SSF54637. 1 hit.

Sequencei

Sequence statusi: Complete.

A0R1H7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTIYEHDRVP AGWNDESGSD RTADGNAADT AHALVDRLSA GEPYAVAFGG
60 70 80 90 100
QGSAWLETLE ELVSSAGIES ELATLAGEAE LLLEPVASEL VVVRPIGFEP
110 120 130 140 150
LQWVRALAAE EPVPSDKQLT SAAVSVPGVL LTQIAAVRAL ARQGMDLTAT
160 170 180 190 200
PPVAVAGHSQ GVLAVQALAA KGAKDVELLA LAQLIGAAGT LVARRRGITV
210 220 230 240 250
LGDRPPMVSV TNADPERIYE LLEEFSSDVR TVLPPVLSIR NGRRSVVITG
260 270 280 290 300
TPEQLSRFEL YCTQIAEKEE AERKNKLRGG AVFAPVFDPV QVEVGFHTPR
310 320 330 340 350
LSDGIEIVGR WAETVGLDVE LAKELTESIL VRQVDWVDEI TELHEAGARW
360 370 380 390 400
ILDLGPGDIL TRLTAPVIRG LGIGIVPAAT RGGQRNLFTV GAVPEVARPW
410 420 430 440 450
SSYAPTVVKL PDGSVKLETK FTRLTGRSPI LLAGMTPTTV DAKIVAAAAN
460 470 480 490 500
AGHWAELAGG GQVTEQIFND RIAELETLLE PGRAIQFNTL FLDPYLWKLQ
510 520 530 540 550
VGGKRLVQRA RQSGAPIDGL VVSAGIPDLE EAVDIIDELN EVGISHVVFK
560 570 580 590 600
PGTVEQIRSV IRIAAEVPTK PVIVHIEGGR AGGHHSWEDL DDLLLATYSE
610 620 630 640 650
LRSRSNITIC VGGGIGTPER SAEYLSGRWA EVHGYPLMPI DGILVGTAAM
660 670 680 690 700
ATLEATTSPQ VKQLLVETKG TEAWVGAGKA ANGMASGRSQ LGADIHEIDN
710 720 730 740 750
AASRCGRLLD EVAGDADAVA ERRDEIIAAM AQTAKPYFGD VAEMTYLQWL
760 770 780 790 800
RRYVELAIGD GNSTADTKRP DSPWLDITWR DRFEQMLKRA EARLHPQDFG
810 820 830 840 850
PIETLFDADA DGERLLEDPE AAITALLQRY PDAETVVLHP ADVPFFVELC
860 870 880 890 900
KTLGKPVNFV PVIDKDVRRW WRSDSLWQAH DARYEADQVC VIPGTAAVAG
910 920 930 940 950
ITRVDEPVGE LLDRFEQAAV DEVLGAGAEP VEVLSRRQAR RDASGPLAVV
960 970 980 990 1000
LDAPDVLWAG RMSVNPVHRI AAPTEWQVRE GSDNRSASHP STGARLEVAD
1010 1020 1030 1040 1050
DQHVVLSVPL SGTWIEIRFT LTDVVRSGGA PIVEVDDAAT AMRAVLAIAA
1060 1070 1080 1090 1100
GVEGPENLPK VVDNTATVTV DWDPERVADH TGVTATFGAP LAPTLTVVPD
1110 1120 1130 1140 1150
ALVGRCWPAV FAAIGSAATE AGFPVIEGLL SLVHLDHAAR LLAELPKEPA
1160 1170 1180 1190 1200
EFTVTAKASA ATDTEVGRVV PVSVEVRNAA DGALLATLEE RFAIRGRTGA
1210 1220 1230 1240 1250
AELTDPVRAG GAISDNATDT PRRRRRDVTV GAPVDMRPFA VVSGDHNPIH
1260 1270 1280 1290 1300
TDRAAALLAG LEGPIVHGMW LSAAAQHVVT ATDGKPVPPA KLIGWTARFL
1310 1320 1330 1340 1350
GMVKPGDQVD FRVDRVGIDV GAEVLEVSAR IGSELVMAAT ARLAAPKTVY
1360 1370 1380 1390 1400
AFPGQGIQHK GMGMEVRARS KAARKVWDSA DKFTRETLGF SVLHVVRDNP
1410 1420 1430 1440 1450
TSLIASGVHY HHPDGVLFLT QFTQVAMATV AAAQVAEMRE QGAFVEGAIA
1460 1470 1480 1490 1500
CGHSVGEYTA LACVSGVYEL EALLEVVFHR GSKMHDIVPR DELGRSNYRL
1510 1520 1530 1540 1550
AAIRPSQIDL DDADVKDFVA EISERTGEFL EIVNFNLRGS QYAIAGTVAG
1560 1570 1580 1590 1600
LEALEEEIER RRQITGGKRS FILVPGIDVP FHSSVLRVGV ADFRRSLERV
1610 1620 1630 1640 1650
MPRDKDPELI IGRYIPNLVP RPFTLDRDFI QEIRDLVPAE PLDEVLADYD
1660 1670 1680 1690 1700
TWRNEKPKEL CRKVVIELLA WQFASPVRWI ETQDLLFIEE AAGGLGVERF
1710 1720 1730 1740 1750
VEIGVKSAPT VAGLATNTLK LPEYSHSTVE VLNSERDAAV LFATDTDPEP
1760 1770 1780 1790 1800
EPEADEPTAD APAEAAPAAA AAPAPVAAPA APSGGPRPDD ITFDAADATV
1810 1820 1830 1840 1850
ALIALSAKMR IDQIEALDSI ESITDGASSR RNQLLVDLGS ELNLGAIDGA
1860 1870 1880 1890 1900
AEADLGALKG QVTKLARTYK PFGPVLSDAI NDQLRTVLGP SGKRPAYITE
1910 1920 1930 1940 1950
RVTKTWELGP GWAKHVTVEF ALGTREGSSV RGGDLGGLHA GALASAADVD
1960 1970 1980 1990 2000
KVIDGAVAAV AARRGISVSL PSAGGASGGV VDSAALGEFA EKVTGPDGVL
2010 2020 2030 2040 2050
ASAARLVLNQ LGLSDVVTTP EAATDAELID LVTAELGSDW PRLVAPTFDA
2060 2070 2080 2090 2100
RKAVVFDDRW ASAREDLVKL WLAEEGDIDA QWEQLSQRFE GTGHVVATQA
2110 2120 2130 2140 2150
NWWQGKALAA GRNVHASLFG RIAAGAENPG KGRYSDEVAV VTGASKGSIA
2160 2170 2180 2190 2200
ASVVGQLLDG GATVIATTSR LDDDRLAFYK QLYRDHARFD ATLWVVPANM
2210 2220 2230 2240 2250
ASYSDIDKLV EWVGTEQTES LGPQSIHLKD AQTPTLLFPF AAPRVAGDMS
2260 2270 2280 2290 2300
EVGSRAEMEM KVLLWAVQRL ISGLSKIGAE RDIASRLHVV LPGSPNRGMF
2310 2320 2330 2340 2350
GGDGAYGEAK SALDALENRW SAEKSWAERV SLAHALIGWT KGTGLMGQND
2360 2370 2380 2390 2400
AIVSAVEEAG VTTYTTDEMA AMLLDLCTVE TKVAAAGAPV KVDLTGGLGD
2410 2420 2430 2440 2450
IKIDMAELAA KAREEMSGAA DESDDEAPAG TIRALPSPPR GYNPAPAPEW
2460 2470 2480 2490 2500
DDLDVDPADL VVIVGGAELG PYGSSRTRFE MEVSGELSAA GVLELAWTTG
2510 2520 2530 2540 2550
MVKWEDDPKA GWYDTETGEL VPECEIVERY HDAVVERCGI REFVDDGAID
2560 2570 2580 2590 2600
PDHASPLLVS VFLDKDFTFV VSSEADARAF VQFDPEHTVA RPLPDSSDWE
2610 2620 2630 2640 2650
VTRKAGTEIR VPRKTKLSRT VGAQIPTGFD PTVWGISPDM ASSIDRVALW
2660 2670 2680 2690 2700
NIVATVDAFL SSGFTPTELM RWVHPSQVAS TQGTGMGGMT SMQTMYHGNL
2710 2720 2730 2740 2750
LGRAKPNDIL QEVLPNVVAA HVMQSYVGGY GAMVHPVGAC ATAAVSVEEG
2760 2770 2780 2790 2800
VDKIKLGKAD LVIAGGFDDL TLEAIIGFGD MAATADTEMM RAKGISDSKF
2810 2820 2830 2840 2850
SRANDRRRLG FLEAQGGGTI LLARGDLALK MGLPVLAVVG YAQSFADGVH
2860 2870 2880 2890 2900
TSIPAPGLGA LGAARGGRES TLARSLAQLG VGADDIAVIS KHDTSTLAND
2910 2920 2930 2940 2950
PNETELHERI ADSMGRAPGN PLFIVSQKTL TGHAKGGAAV FQMMGLCQIL
2960 2970 2980 2990 3000
RDGVIPPNRS LDCVDDELAT SGHFVWVREP LDLRGKFPLK AGLVTSLGFG
3010 3020 3030 3040 3050
HVSGLVALVH PEAFIAALDP SEREDYRTRA EQRMLAGQRR LVSAIAGGRP
3060 3070 3080
MYEKPADRRF DHDVPEKRQE AAMLLSTDAR LGENDQYVL
Length:3,089
Mass (Da):329,538
Last modified:January 9, 2007 - v1
Checksum:i251351CB2F8E7CF1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000480 Genomic DNA. Translation: ABK70103.1.
CP001663 Genomic DNA. Translation: AFP41086.1.
RefSeqiYP_006569381.1. NC_018289.1.
YP_889015.1. NC_008596.1.

Genome annotation databases

EnsemblBacteriaiABK70103; ABK70103; MSMEG_4757.
AFP41086; AFP41086; MSMEI_4637.
GeneIDi4532653.
KEGGimsg:MSMEI_4637.
msm:MSMEG_4757.
PATRICi18081817. VBIMycSme59918_4642.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000480 Genomic DNA. Translation: ABK70103.1 .
CP001663 Genomic DNA. Translation: AFP41086.1 .
RefSeqi YP_006569381.1. NC_018289.1.
YP_889015.1. NC_008596.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3ZEN electron microscopy 7.50 D/E/F 1-3089 [» ]
4B3Y electron microscopy 7.50 A/B/C 1-3089 [» ]
4BJD electron microscopy 20.00 A/B/C 1-3089 [» ]
4BJE electron microscopy 20.00 D/E/F 1-3089 [» ]
4BJF electron microscopy 17.50 D/E/F 1-3089 [» ]
4BJG electron microscopy 17.50 A/B/C 1-3089 [» ]
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 246196.MSMEG_4757.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABK70103 ; ABK70103 ; MSMEG_4757 .
AFP41086 ; AFP41086 ; MSMEI_4637 .
GeneIDi 4532653.
KEGGi msg:MSMEI_4637.
msm:MSMEG_4757.
PATRICi 18081817. VBIMycSme59918_4642.

Phylogenomic databases

eggNOGi COG4982.
HOGENOMi HOG000051526.
KOi K11533.
OMAi MFLDPYL.
OrthoDBi EOG6WMHTT.

Enzyme and pathway databases

BioCyci MSME246196:GJ4Y-4756-MONOMER.

Family and domain databases

Gene3Di 3.10.129.10. 1 hit.
3.20.20.70. 1 hit.
3.40.366.10. 5 hits.
3.40.47.10. 3 hits.
3.40.50.720. 1 hit.
InterProi IPR001227. Ac_transferase_dom.
IPR014043. Acyl_transferase.
IPR016035. Acyl_Trfase/lysoPLipase.
IPR013785. Aldolase_TIM.
IPR013565. DUF1729.
IPR003965. Fatty_acid_synthase.
IPR029069. HotDog_dom.
IPR014031. Ketoacyl_synth_C.
IPR014030. Ketoacyl_synth_N.
IPR002539. MaoC_dom.
IPR016040. NAD(P)-bd_dom.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view ]
Pfami PF00698. Acyl_transf_1. 2 hits.
PF08354. DUF1729. 1 hit.
PF00109. ketoacyl-synt. 1 hit.
PF02801. Ketoacyl-synt_C. 1 hit.
PF01575. MaoC_dehydratas. 1 hit.
[Graphical view ]
PRINTSi PR01483. FASYNTHASE.
SUPFAMi SSF52151. SSF52151. 5 hits.
SSF53901. SSF53901. 2 hits.
SSF54637. SSF54637. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MC2 155Imported.
  2. Fleischmann R.D., Dodson R.J., Haft D.H., Merkel J.S., Nelson W.C., Fraser C.M.
    Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700084 / mc(2)155Imported and MC2 155Imported.
  3. "Interrupted coding sequences in Mycobacterium smegmatis: authentic mutations or sequencing errors?"
    Deshayes C., Perrodou E., Gallien S., Euphrasie D., Schaeffer C., Van-Dorsselaer A., Poch O., Lecompte O., Reyrat J.-M.
    Genome Biol. 8:R20.1-R20.9(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700084 / mc(2)155Imported and MC2 155Imported.
  4. "Ortho-proteogenomics: multiple proteomes investigation through orthology and a new MS-based protocol."
    Gallien S., Perrodou E., Carapito C., Deshayes C., Reyrat J.-M., Van Dorsselaer A., Poch O., Schaeffer C., Lecompte O.
    Genome Res. 19:128-135(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700084 / mc(2)155 and MC2 155.
  5. "7.5-A cryo-em structure of the mycobacterial fatty acid synthase."
    Boehringer D., Ban N., Leibundgut M.
    J. Mol. Biol. 425:841-849(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY ELECTRON MICROSCOPY (7.50 ANGSTROMS) IN COMPLEX WITH FMN.
  6. "Structure and conformational variability of the mycobacterium tuberculosis fatty acid synthase multienzyme complex."
    Ciccarelli L., Connell S.R., Enderle M., Mills D.J., Vonck J., Grininger M.
    Structure 21:1251-1257(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY ELECTRON MICROSCOPY (17.50 ANGSTROMS) IN COMPLEX WITH FMN.

Entry informationi

Entry nameiA0R1H7_MYCS2
AccessioniPrimary (citable) accession number: A0R1H7
Entry historyi
Integrated into UniProtKB/TrEMBL: January 9, 2007
Last sequence update: January 9, 2007
Last modified: October 29, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported, Complete proteome, Reference proteomeImported

External Data

Dasty 3