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Protein

Trigger factor

Gene

tig

Organism
Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase.UniRule annotation

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chaperone, Isomerase, Rotamase

Keywords - Biological processi

Cell cycle, Cell division

Enzyme and pathway databases

BioCyciMSME246196:GJ4Y-4673-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Trigger factorUniRule annotation (EC:5.2.1.8UniRule annotation)
Short name:
TFUniRule annotation
Alternative name(s):
PPIaseUniRule annotation
Gene namesi
Name:tigUniRule annotation
Ordered Locus Names:MSMEG_4674, MSMEI_4557
OrganismiMycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Taxonomic identifieri246196 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000006158 Componenti: Chromosome
  • UP000000757 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm

  • Note: About half TF is bound to the ribosome near the polypeptide exit tunnel while the other half is free in the cytoplasm.UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 469469Trigger factorPRO_1000022711Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi246196.MSMEG_4674.

Structurei

3D structure databases

ProteinModelPortaliA0R199.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini162 – 24382PPIase FKBP-typeUniRule annotationAdd
BLAST

Domaini

Consists of 3 domains; the N-terminus binds the ribosome, the middle domain has PPIase activity, while the C-terminus has intrinsic chaperone activity on its own.UniRule annotation

Sequence similaritiesi

Belongs to the FKBP-type PPIase family. Tig subfamily.UniRule annotation
Contains 1 PPIase FKBP-type domain.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DEA. Bacteria.
COG0544. LUCA.
HOGENOMiHOG000218240.
KOiK03545.
OMAiMLPEFEQ.
OrthoDBiPOG091H01T7.

Family and domain databases

Gene3Di1.10.3120.10. 1 hit.
3.30.70.1050. 1 hit.
HAMAPiMF_00303. Trigger_factor_Tig. 1 hit.
InterProiIPR001179. PPIase_FKBP_dom.
IPR005215. Trig_fac.
IPR008880. Trigger_fac_C.
IPR008881. Trigger_fac_ribosome-bd_bac.
IPR027304. Trigger_fact/SurA_dom.
[Graphical view]
PfamiPF00254. FKBP_C. 1 hit.
PF05698. Trigger_C. 1 hit.
PF05697. Trigger_N. 1 hit.
[Graphical view]
PIRSFiPIRSF003095. Trigger_factor. 1 hit.
SUPFAMiSSF102735. SSF102735. 1 hit.
SSF109998. SSF109998. 1 hit.
TIGRFAMsiTIGR00115. tig. 1 hit.
PROSITEiPS50059. FKBP_PPIASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A0R199-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKSTVEQLSP TRVRINVEVP FTELEPDFDR AFKELAKQVR LPGFRPGKAP
60 70 80 90 100
RKLLEARIGR GAVLEQVVND ALPSRYSEAV STSDLKPLGQ PEIEITKLED
110 120 130 140 150
NEELVFTAEV DIRPEITLPE LESLKITVDP IEVTDEEVDA ELQSLRARFG
160 170 180 190 200
TLKGVERGVQ EGDFVSIDLS ATVDGNEVPE AATEGLSHEV GSGQLIDGLD
210 220 230 240 250
EAIIGLKADE SKTFTTKLVA GEYAGQDAEV TVTVKSVKER ELPEPDDEFA
260 270 280 290 300
QLASEYDTIE ELRNSLVDQV RRLKSVQQAE QIRDKAIEAL LEQTEVPLPE
310 320 330 340 350
KIVQAQIDEV VHNAIHGLDH DEEKFAEQLA EQGSSREEFD AETRTEAEKA
360 370 380 390 400
VKTQLLMDAV ADKLEIQVSQ NDLTERLVLM SRQYGLEPQQ LIQILQQNNQ
410 420 430 440 450
LPAMFADVRR GLTIAAVVHA ATVTDTDGNV IDTMEFFGPS GEQAAEDSAE
460
ESTDAAEGEA AEDADDTDK
Length:469
Mass (Da):51,655
Last modified:January 9, 2007 - v1
Checksum:i08ABAEBE68968427
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000480 Genomic DNA. Translation: ABK73897.1.
CP001663 Genomic DNA. Translation: AFP41011.1.
RefSeqiWP_011730000.1. NZ_CP009494.1.
YP_888937.1. NC_008596.1.

Genome annotation databases

EnsemblBacteriaiABK73897; ABK73897; MSMEG_4674.
AFP41011; AFP41011; MSMEI_4557.
GeneIDi4536439.
KEGGimsb:LJ00_23115.
msg:MSMEI_4557.
msm:MSMEG_4674.
PATRICi18081657. VBIMycSme59918_4567.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000480 Genomic DNA. Translation: ABK73897.1.
CP001663 Genomic DNA. Translation: AFP41011.1.
RefSeqiWP_011730000.1. NZ_CP009494.1.
YP_888937.1. NC_008596.1.

3D structure databases

ProteinModelPortaliA0R199.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi246196.MSMEG_4674.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABK73897; ABK73897; MSMEG_4674.
AFP41011; AFP41011; MSMEI_4557.
GeneIDi4536439.
KEGGimsb:LJ00_23115.
msg:MSMEI_4557.
msm:MSMEG_4674.
PATRICi18081657. VBIMycSme59918_4567.

Phylogenomic databases

eggNOGiENOG4105DEA. Bacteria.
COG0544. LUCA.
HOGENOMiHOG000218240.
KOiK03545.
OMAiMLPEFEQ.
OrthoDBiPOG091H01T7.

Enzyme and pathway databases

BioCyciMSME246196:GJ4Y-4673-MONOMER.

Family and domain databases

Gene3Di1.10.3120.10. 1 hit.
3.30.70.1050. 1 hit.
HAMAPiMF_00303. Trigger_factor_Tig. 1 hit.
InterProiIPR001179. PPIase_FKBP_dom.
IPR005215. Trig_fac.
IPR008880. Trigger_fac_C.
IPR008881. Trigger_fac_ribosome-bd_bac.
IPR027304. Trigger_fact/SurA_dom.
[Graphical view]
PfamiPF00254. FKBP_C. 1 hit.
PF05698. Trigger_C. 1 hit.
PF05697. Trigger_N. 1 hit.
[Graphical view]
PIRSFiPIRSF003095. Trigger_factor. 1 hit.
SUPFAMiSSF102735. SSF102735. 1 hit.
SSF109998. SSF109998. 1 hit.
TIGRFAMsiTIGR00115. tig. 1 hit.
PROSITEiPS50059. FKBP_PPIASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTIG_MYCS2
AccessioniPrimary (citable) accession number: A0R199
Secondary accession number(s): I7GCP0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 9, 2007
Last modified: September 7, 2016
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.