A0R198 (A0R198_MYCS2) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
ATP-dependent Clp protease proteolytic subunit 2 HAMAP MF_00444
EC=3.4.21.92 HAMAP MF_00444

Alternative name(s):
Endopeptidase Clp 2 HAMAP MF_00444

Gene names

Name:	clpP EMBL ABK73665.1
Synonyms:	clpP2 HAMAP MF_00444
Ordered Locus Names:	MSMEG_4673

Organism

Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155) EMBL ABK73665.1

Taxonomic identifier

246196 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length	203 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins By similarity. HAMAP MF_00444
Catalytic activity	Hydrolysis of proteins to small peptides in the presence of ATP and magnesium. Alpha-casein is the usual test substrate. In the absence of ATP, only oligopeptides shorter than five residues are hydrolyzed (such as succinyl-Leu-Tyr-|-NHMec; and Leu-Tyr-Leu-|-Tyr-Trp, in which cleavage of the -Tyr-|-Leu- and -Tyr-|-Trp bonds also occurs). HAMAP MF_00444
Subcellular location	Cytoplasm By similarity HAMAP MF_00444.
Sequence similarities	Belongs to the peptidase S14 family. HAMAP MF_00444

Ontologies

Keywords
Cellular component	Cytoplasm HAMAP MF_00444
Ligand	ATP-binding HAMAP MF_00444 Nucleotide-binding
Molecular function	Hydrolase Protease Serine protease HAMAP MF_00444
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	proteolysis Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW serine-type endopeptidase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Active site	95	1	By similarity HAMAP MF_00444
	Active site	120	1	By similarity HAMAP MF_00444

Sequences

	Sequence		Length	Mass (Da)
	A0R198 [UniParc]. Last modified January 9, 2007. Version 1. Checksum: D0D361370452CEFE	FASTA	203	21,856
	10 20 30 40 50 60 MTDMRGTGQG LNLVDSVYER LLAERIIFLG SQVDDDIANR LCAQILLLSA EDPTKDIHLY 70 80 90 100 110 120 INSPGGSISA GMAIYDTMVL APCDIATYAM GMAASMGEFL LAAGTKGKRY ALPHARILMH 130 140 150 160 170 180 QPLGGVTGSA ADIAIQAEQF AVIKKEMFRL NAEFTGQPIE RIEADSDRDR WFTAQEALEY 190 200 GFVDHIITSA SVNGEGPGAG LDK

References

[1]	Fleischmann R.D., Dodson R.J., Haft D.H., Merkel J.S., Nelson W.C., Fraser C.M. Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700084 / mc(2)155.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000480 Genomic DNA. Translation: ABK73665.1.
RefSeq	YP_888936.1. NC_008596.1.
3D structure databases
ProteinModelPortal	A0R198.
SMR	A0R198. Positions 12-190.
ModBase	Search...
Protein-protein interaction databases
STRING	A0R198.
Protein family/group databases
MEROPS	S14.008.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBMYCT00000044178; EBMYCP00000042515; EBMYCG00000044173.
GeneID	4531883.
GenomeReviews	Gene locus MSMEG_4673 in contig CP000480_GR.
KEGG	msm:MSMEG_4673.
NMPDR	fig|246196.1.peg.4663.
PATRIC	18081655. VBIMycSme59918_4566.
TIGR	MSMEG_4673.
Phylogenomic databases
eggNOG	COG0740.
GeneTree	EBGT00050000015874.
HOGENOM	HBG558421.
OMA	NAICAQL.
ProtClustDB	PRK00277.
Family and domain databases
HAMAP	MF_00444. ClpP. [Tree]
InterPro	IPR023562. Pept_S14/S49. IPR001907. Pept_S14_ClpP. IPR018215. Pept_S14_ClpP_AS. [Graphical view]
KO	K01358.
PANTHER	PTHR10381. Pept_S14_ClpP. 1 hit.
Pfam	PF00574. CLP_protease. 1 hit. [Graphical view]
PRINTS	PR00127. CLPPROTEASEP.
PROSITE	PS00382. CLP_PROTEASE_HIS. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

A0R198_MYCS2

Accession

Primary (citable) accession number: A0R198

Entry history

Integrated into UniProtKB/TrEMBL:	January 9, 2007
Last sequence update:	January 9, 2007
Last modified:	December 14, 2011
This is version 40 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)