A0R197 (A0R197_MYCS2) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
ATP-dependent Clp protease proteolytic subunit 1 HAMAP MF_00444
EC=3.4.21.92 HAMAP MF_00444

Alternative name(s):
Endopeptidase Clp 1 HAMAP MF_00444

Gene names

Name:	clpP EMBL ABK75861.1
Synonyms:	clpP1 HAMAP MF_00444
Ordered Locus Names:	MSMEG_4672

Organism

Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155) EMBL ABK75861.1

Taxonomic identifier

246196 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length	218 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins By similarity. HAMAP MF_00444
Catalytic activity	Hydrolysis of proteins to small peptides in the presence of ATP and magnesium. Alpha-casein is the usual test substrate. In the absence of ATP, only oligopeptides shorter than five residues are hydrolyzed (such as succinyl-Leu-Tyr-|-NHMec; and Leu-Tyr-Leu-|-Tyr-Trp, in which cleavage of the -Tyr-|-Leu- and -Tyr-|-Trp bonds also occurs). HAMAP MF_00444
Subcellular location	Cytoplasm By similarity HAMAP MF_00444.
Sequence similarities	Belongs to the peptidase S14 family. HAMAP MF_00444

Ontologies

Keywords
Cellular component	Cytoplasm HAMAP MF_00444
Ligand	ATP-binding HAMAP MF_00444 Nucleotide-binding
Molecular function	Hydrolase Protease Serine protease HAMAP MF_00444
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	proteolysis Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW serine-type endopeptidase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Active site	114	1	By similarity HAMAP MF_00444
	Active site	139	1	By similarity HAMAP MF_00444

Sequences

	Sequence		Length	Mass (Da)
	A0R197 [UniParc]. Last modified January 9, 2007. Version 1. Checksum: B7E31A1578FB3F5A	FASTA	218	24,066
	10 20 30 40 50 60 MSNIHPSLDA RLQPQARYIL PSFIEHSSFG VKESNPYNKL FEERIIFLGV QVDDASANDI 70 80 90 100 110 120 MAQLLVLESL DPDRDITMYI NSPGGSFTSL MAIYDTMQYV RADIQTVCLG QAASAAAVLL 130 140 150 160 170 180 AAGTPGKRLA LPNARVLIHQ PALSGVIQGQ FSDLEIQAAE IERMRTLMET TLARHTGKDP 190 200 210 AQIRKDTDRD KILTAEEAKE YGIIDTVLQY RKLSAQTS

References

[1]	Fleischmann R.D., Dodson R.J., Haft D.H., Merkel J.S., Nelson W.C., Fraser C.M. Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700084 / mc(2)155.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000480 Genomic DNA. Translation: ABK75861.1.
RefSeq	YP_888935.1. NC_008596.1.
3D structure databases
ProteinModelPortal	A0R197.
ModBase	Search...
Protein-protein interaction databases
STRING	A0R197.
Protein family/group databases
MEROPS	S14.009.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBMYCT00000043166; EBMYCP00000041503; EBMYCG00000043161.
GeneID	4531075.
GenomeReviews	Gene locus MSMEG_4672 in contig CP000480_GR.
KEGG	msm:MSMEG_4672.
NMPDR	fig|246196.1.peg.4662.
PATRIC	18081653. VBIMycSme59918_4565.
TIGR	MSMEG_4672.
Phylogenomic databases
eggNOG	COG0740.
GeneTree	EBGT00050000015874.
HOGENOM	HBG558421.
OMA	QDPYTKL.
ProtClustDB	PRK12553.
Family and domain databases
HAMAP	MF_00444. ClpP. [Tree]
InterPro	IPR023562. Pept_S14/S49. IPR001907. Pept_S14_ClpP. IPR018215. Pept_S14_ClpP_AS. [Graphical view]
KO	K01358.
PANTHER	PTHR10381. Pept_S14_ClpP. 1 hit.
Pfam	PF00574. CLP_protease. 1 hit. [Graphical view]
PRINTS	PR00127. CLPPROTEASEP.
PROSITE	PS00382. CLP_PROTEASE_HIS. 1 hit. PS00381. CLP_PROTEASE_SER. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

A0R197_MYCS2

Accession

Primary (citable) accession number: A0R197

Entry history

Integrated into UniProtKB/TrEMBL:	January 9, 2007
Last sequence update:	January 9, 2007
Last modified:	December 14, 2011
This is version 42 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)