A0R191 (IOLG_MYCS2) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Inositol 2-dehydrogenase
EC=1.1.1.18

Alternative name(s):
Myo-inositol 2-dehydrogenase
Short name=MI 2-dehydrogenase

Gene names

Name:	iolG
Ordered Locus Names:	MSMEG_4666

Organism

Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)

Taxonomic identifier

246196 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length	345 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Involved in the oxidation of myo-inositol (MI) to 2-keto-myo-inositol (2KMI or 2-inosose) By similarity. HAMAP MF_01671
Catalytic activity	Myo-inositol + NAD+ = 2,4,6/3,5-pentahydroxycyclohexanone + NADH. HAMAP MF_01671
Subunit structure	Homotetramer By similarity. HAMAP MF_01671
Sequence similarities	Belongs to the gfo/idh/mocA family.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	inositol catabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	inositol 2-dehydrogenase activity Inferred from electronic annotation. Source: EC nucleotide binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 345	345	Inositol 2-dehydrogenase HAMAP MF_01671		PRO_0000352576

Sequences

	Sequence		Length	Mass (Da)
	A0R191 [UniParc]. Last modified January 9, 2007. Version 1. Checksum: A2137030D06F738D	FASTA	345	36,836
	10 20 30 40 50 60 MSDLRVAVLG VGVMGADHVE RLSTRIAGVK VAVVNDFIET RAEEIAAGVP GCRVVSDPLE 70 80 90 100 110 120 AIADPDVDAV VLATPGPTHD KQLLACLEQR KPVLCEKPLT TDVDSALDVV RREAELGVRL 130 140 150 160 170 180 IQVGFMRRFD PEYAELKTLI DAGEFGQPLV LHCVHRNAAV PPSFDSTMIV KDSLVHEVDV 190 200 210 220 230 240 TRFLFDEEIA SVHILRPTPN PGAPEGIQDP QIAIMKTPSG KHVDVELFVT TGVGYEVRTE 250 260 270 280 290 300 LVAEKGTAMI GLDVGLIRKG VPGTWGGAIA PDFRVRFGTA YDIEFQRWVA AVRHGIATGS 310 320 330 340 DDYTDGPTAW DGYAAAAVCA AGVESLAGGQ PVEVKMVERA SINGA

References

[1]	Fleischmann R.D., Dodson R.J., Haft D.H., Merkel J.S., Nelson W.C., Fraser C.M. Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700084 / mc(2)155.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000480 Genomic DNA. Translation: ABK74556.1.
RefSeq	YP_888929.1. NC_008596.1.
3D structure databases
ProteinModelPortal	A0R191.
ModBase	Search...
Protein-protein interaction databases
STRING	A0R191.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBMYCT00000041585; EBMYCP00000039922; EBMYCG00000041580.
GeneID	4534763.
GenomeReviews	Gene locus MSMEG_4666 in contig CP000480_GR.
KEGG	msm:MSMEG_4666.
NMPDR	fig|246196.1.peg.4656.
PATRIC	18081641. VBIMycSme59918_4559.
TIGR	MSMEG_4666.
Phylogenomic databases
eggNOG	COG0673.
GeneTree	EBGT00050000017284.
HOGENOM	HBG612336.
OMA	RTEVVGE.
ProtClustDB	CLSK956652.
Enzyme and pathway databases
BioCyc	MSME246196:MSMEG_4666-MONOMER.
Family and domain databases
HAMAP	MF_01671. IolG. [Tree]
InterPro	IPR023794. MI/DCI_dehydrogenase. IPR016040. NAD(P)-bd_dom. IPR000683. Oxidoreductase_N. IPR004104. OxRdtase_C. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K00010.
PANTHER	PTHR22604:SF7. PTHR22604:SF7. 1 hit.
Pfam	PF01408. GFO_IDH_MocA. 1 hit. PF02894. GFO_IDH_MocA_C. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

IOLG_MYCS2

Accession

Primary (citable) accession number: A0R191

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 14, 2008
Last sequence update:	January 9, 2007
Last modified:	December 14, 2011
This is version 39 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program