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A0R0B2 (FABD_MYCS2) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 51. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Malonyl CoA-acyl carrier protein transacylase

Short name=MCT
EC=2.3.1.39
Gene names
Name:fabD
Ordered Locus Names:MSMEG_4325, MSMEI_4225
OrganismMycobacterium smegmatis (strain ATCC 700084 / mc(2)155) [Reference proteome] [HAMAP]
Taxonomic identifier246196 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium

Protein attributes

Sequence length290 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

Malonyl-CoA + [acyl-carrier-protein] = CoA + malonyl-[acyl-carrier-protein].

Pathway

Lipid metabolism; fatty acid biosynthesis.

Sequence similarities

Belongs to the FabD family.

Sequence caution

The sequence AFP40681.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 290290Malonyl CoA-acyl carrier protein transacylase
PRO_0000396808

Regions

Compositional bias190 – 1934Poly-Ala

Sites

Active site751 By similarity
Active site1781 By similarity

Amino acid modifications

Cross-link157Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-Cter in protein Pup)

Sequences

Sequence LengthMass (Da)Tools
A0R0B2 [UniParc].

Last modified January 9, 2007. Version 1.
Checksum: 06BFFF38EEDC5B69

FASTA29029,676
        10         20         30         40         50         60 
MLTPWLELPG AADRLAAWSQ ISGLDLTTLG TTATAEEITD TAVTQPLVVA ATLLAHEELT 

        70         80         90        100        110        120 
KRGHSAAETI VAGHSVGEIA AYAIAGVISA DDAVKLAATR GAEMAKACAV EPTGMAAVLG 

       130        140        150        160        170        180 
GDEAEVLARL EALDLVPANR NAAGQIVAAG AVAALDKLAE DPPAKARVRK LATAGAFHTH 

       190        200        210        220        230        240 
YMASALDGYA AAAQSVTTSE PTATLLSNAD GQPVASAADA MEKLVAQLTK PVRWDLCTAT 

       250        260        270        280        290 
LRDRFQNAES AGIVEFPPAG TLVGIAKREL KGTPTRAIKS PEDLDGLDQL 

« Hide

References

« Hide 'large scale' references
[1]Fleischmann R.D., Dodson R.J., Haft D.H., Merkel J.S., Nelson W.C., Fraser C.M.
Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 700084 / mc(2)155.
[2]"Interrupted coding sequences in Mycobacterium smegmatis: authentic mutations or sequencing errors?"
Deshayes C., Perrodou E., Gallien S., Euphrasie D., Schaeffer C., Van-Dorsselaer A., Poch O., Lecompte O., Reyrat J.-M.
Genome Biol. 8:R20.1-R20.9(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 700084 / mc(2)155.
[3]"Ortho-proteogenomics: multiple proteomes investigation through orthology and a new MS-based protocol."
Gallien S., Perrodou E., Carapito C., Deshayes C., Reyrat J.-M., Van Dorsselaer A., Poch O., Schaeffer C., Lecompte O.
Genome Res. 19:128-135(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 700084 / mc(2)155.
[4]"Expansion of the mycobacterial 'PUPylome'."
Watrous J., Burns K., Liu W.T., Patel A., Hook V., Bafna V., Barry C.E. III, Bark S., Dorrestein P.C.
Mol. Biosyst. 6:376-385(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: PUPYLATION AT LYS-157, IDENTIFICATION BY MASS SPECTROMETRY.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000480 Genomic DNA. Translation: ABK74111.1.
CP001663 Genomic DNA. Translation: AFP40681.1. Different initiation.
RefSeqYP_006568976.1. NC_018289.1.
YP_888600.1. NC_008596.1.

3D structure databases

ProteinModelPortalA0R0B2.
SMRA0R0B2. Positions 1-290.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING246196.MSMEG_4325.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABK74111; ABK74111; MSMEG_4325.
AFP40681; AFP40681; MSMEI_4225.
GeneID4536190.
KEGGmsg:MSMEI_4225.
msm:MSMEG_4325.
PATRIC18081005. VBIMycSme59918_4243.

Phylogenomic databases

eggNOGCOG0331.
HOGENOMHOG000036505.
KOK00645.
OMAMVLVRER.
OrthoDBEOG6VB6T5.

Enzyme and pathway databases

BioCycMSME246196:GJ4Y-4324-MONOMER.
UniPathwayUPA00094.

Family and domain databases

Gene3D3.40.366.10. 2 hits.
InterProIPR001227. Ac_transferase_dom.
IPR014043. Acyl_transferase.
IPR016035. Acyl_Trfase/lysoPLipase.
IPR016036. Malonyl_transacylase_ACP-bd.
[Graphical view]
PfamPF00698. Acyl_transf_1. 1 hit.
[Graphical view]
SUPFAMSSF52151. SSF52151. 2 hits.
SSF55048. SSF55048. 1 hit.
ProtoNetSearch...

Entry information

Entry nameFABD_MYCS2
AccessionPrimary (citable) accession number: A0R0B2
Secondary accession number(s): I7GBV9
Entry history
Integrated into UniProtKB/Swiss-Prot: August 10, 2010
Last sequence update: January 9, 2007
Last modified: July 9, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways