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A0R0B2

- FABD_MYCS2

UniProt

A0R0B2 - FABD_MYCS2

Protein

Malonyl CoA-acyl carrier protein transacylase

Gene

fabD

Organism
Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 53 (01 Oct 2014)
      Sequence version 1 (09 Jan 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Malonyl-CoA + an [acyl-carrier-protein] = CoA + a malonyl-[acyl-carrier-protein].

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei75 – 751By similarity
    Active sitei178 – 1781By similarity

    GO - Molecular functioni

    1. [acyl-carrier-protein] S-malonyltransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. fatty acid biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Acyltransferase, Transferase

    Keywords - Biological processi

    Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

    Enzyme and pathway databases

    BioCyciMSME246196:GJ4Y-4324-MONOMER.
    UniPathwayiUPA00094.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Malonyl CoA-acyl carrier protein transacylase (EC:2.3.1.39)
    Short name:
    MCT
    Gene namesi
    Name:fabD
    Ordered Locus Names:MSMEG_4325, MSMEI_4225
    OrganismiMycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
    Taxonomic identifieri246196 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
    ProteomesiUP000000757: Chromosome, UP000006158: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 290290Malonyl CoA-acyl carrier protein transacylasePRO_0000396808Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Cross-linki157 – 157Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-Cter in protein Pup)1 Publication

    Keywords - PTMi

    Isopeptide bond, Ubl conjugation

    Interactioni

    Protein-protein interaction databases

    STRINGi246196.MSMEG_4325.

    Structurei

    3D structure databases

    ProteinModelPortaliA0R0B2.
    SMRiA0R0B2. Positions 1-290.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi190 – 1934Poly-Ala

    Sequence similaritiesi

    Belongs to the FabD family.Curated

    Phylogenomic databases

    eggNOGiCOG0331.
    HOGENOMiHOG000036505.
    KOiK00645.
    OMAiMVLVRER.
    OrthoDBiEOG6VB6T5.

    Family and domain databases

    Gene3Di3.40.366.10. 2 hits.
    InterProiIPR001227. Ac_transferase_dom.
    IPR014043. Acyl_transferase.
    IPR016035. Acyl_Trfase/lysoPLipase.
    IPR016036. Malonyl_transacylase_ACP-bd.
    [Graphical view]
    PfamiPF00698. Acyl_transf_1. 1 hit.
    [Graphical view]
    SUPFAMiSSF52151. SSF52151. 2 hits.
    SSF55048. SSF55048. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A0R0B2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLTPWLELPG AADRLAAWSQ ISGLDLTTLG TTATAEEITD TAVTQPLVVA    50
    ATLLAHEELT KRGHSAAETI VAGHSVGEIA AYAIAGVISA DDAVKLAATR 100
    GAEMAKACAV EPTGMAAVLG GDEAEVLARL EALDLVPANR NAAGQIVAAG 150
    AVAALDKLAE DPPAKARVRK LATAGAFHTH YMASALDGYA AAAQSVTTSE 200
    PTATLLSNAD GQPVASAADA MEKLVAQLTK PVRWDLCTAT LRDRFQNAES 250
    AGIVEFPPAG TLVGIAKREL KGTPTRAIKS PEDLDGLDQL 290
    Length:290
    Mass (Da):29,676
    Last modified:January 9, 2007 - v1
    Checksum:i06BFFF38EEDC5B69
    GO

    Sequence cautioni

    The sequence AFP40681.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000480 Genomic DNA. Translation: ABK74111.1.
    CP001663 Genomic DNA. Translation: AFP40681.1. Different initiation.
    RefSeqiYP_006568976.1. NC_018289.1.
    YP_888600.1. NC_008596.1.

    Genome annotation databases

    EnsemblBacteriaiABK74111; ABK74111; MSMEG_4325.
    AFP40681; AFP40681; MSMEI_4225.
    GeneIDi4536190.
    KEGGimsg:MSMEI_4225.
    msm:MSMEG_4325.
    PATRICi18081005. VBIMycSme59918_4243.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000480 Genomic DNA. Translation: ABK74111.1 .
    CP001663 Genomic DNA. Translation: AFP40681.1 . Different initiation.
    RefSeqi YP_006568976.1. NC_018289.1.
    YP_888600.1. NC_008596.1.

    3D structure databases

    ProteinModelPortali A0R0B2.
    SMRi A0R0B2. Positions 1-290.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 246196.MSMEG_4325.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABK74111 ; ABK74111 ; MSMEG_4325 .
    AFP40681 ; AFP40681 ; MSMEI_4225 .
    GeneIDi 4536190.
    KEGGi msg:MSMEI_4225.
    msm:MSMEG_4325.
    PATRICi 18081005. VBIMycSme59918_4243.

    Phylogenomic databases

    eggNOGi COG0331.
    HOGENOMi HOG000036505.
    KOi K00645.
    OMAi MVLVRER.
    OrthoDBi EOG6VB6T5.

    Enzyme and pathway databases

    UniPathwayi UPA00094 .
    BioCyci MSME246196:GJ4Y-4324-MONOMER.

    Family and domain databases

    Gene3Di 3.40.366.10. 2 hits.
    InterProi IPR001227. Ac_transferase_dom.
    IPR014043. Acyl_transferase.
    IPR016035. Acyl_Trfase/lysoPLipase.
    IPR016036. Malonyl_transacylase_ACP-bd.
    [Graphical view ]
    Pfami PF00698. Acyl_transf_1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52151. SSF52151. 2 hits.
    SSF55048. SSF55048. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Fleischmann R.D., Dodson R.J., Haft D.H., Merkel J.S., Nelson W.C., Fraser C.M.
      Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700084 / mc(2)155.
    2. "Interrupted coding sequences in Mycobacterium smegmatis: authentic mutations or sequencing errors?"
      Deshayes C., Perrodou E., Gallien S., Euphrasie D., Schaeffer C., Van-Dorsselaer A., Poch O., Lecompte O., Reyrat J.-M.
      Genome Biol. 8:R20.1-R20.9(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700084 / mc(2)155.
    3. "Ortho-proteogenomics: multiple proteomes investigation through orthology and a new MS-based protocol."
      Gallien S., Perrodou E., Carapito C., Deshayes C., Reyrat J.-M., Van Dorsselaer A., Poch O., Schaeffer C., Lecompte O.
      Genome Res. 19:128-135(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700084 / mc(2)155.
    4. Cited for: PUPYLATION AT LYS-157, IDENTIFICATION BY MASS SPECTROMETRY.

    Entry informationi

    Entry nameiFABD_MYCS2
    AccessioniPrimary (citable) accession number: A0R0B2
    Secondary accession number(s): I7GBV9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 10, 2010
    Last sequence update: January 9, 2007
    Last modified: October 1, 2014
    This is version 53 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3