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A0R0B2

- FABD_MYCS2

UniProt

A0R0B2 - FABD_MYCS2

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Protein

Malonyl CoA-acyl carrier protein transacylase

Gene

fabD

Organism
Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Catalytic activityi

Malonyl-CoA + an [acyl-carrier-protein] = CoA + a malonyl-[acyl-carrier-protein].

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei75 – 751By similarity
Active sitei178 – 1781By similarity

GO - Molecular functioni

  1. [acyl-carrier-protein] S-malonyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. fatty acid biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BioCyciMSME246196:GJ4Y-4324-MONOMER.
UniPathwayiUPA00094.

Names & Taxonomyi

Protein namesi
Recommended name:
Malonyl CoA-acyl carrier protein transacylase (EC:2.3.1.39)
Short name:
MCT
Gene namesi
Name:fabD
Ordered Locus Names:MSMEG_4325, MSMEI_4225
OrganismiMycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Taxonomic identifieri246196 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
ProteomesiUP000000757: Chromosome, UP000006158: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 290290Malonyl CoA-acyl carrier protein transacylasePRO_0000396808Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki157 – 157Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-Cter in protein Pup)1 Publication

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Interactioni

Protein-protein interaction databases

STRINGi246196.MSMEG_4325.

Structurei

3D structure databases

ProteinModelPortaliA0R0B2.
SMRiA0R0B2. Positions 1-290.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi190 – 1934Poly-Ala

Sequence similaritiesi

Belongs to the FabD family.Curated

Phylogenomic databases

eggNOGiCOG0331.
HOGENOMiHOG000036505.
KOiK00645.
OMAiMVLVRER.
OrthoDBiEOG6VB6T5.

Family and domain databases

Gene3Di3.40.366.10. 2 hits.
InterProiIPR001227. Ac_transferase_dom.
IPR014043. Acyl_transferase.
IPR016035. Acyl_Trfase/lysoPLipase.
IPR016036. Malonyl_transacylase_ACP-bd.
[Graphical view]
PfamiPF00698. Acyl_transf_1. 1 hit.
[Graphical view]
SUPFAMiSSF52151. SSF52151. 2 hits.
SSF55048. SSF55048. 1 hit.

Sequencei

Sequence statusi: Complete.

A0R0B2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLTPWLELPG AADRLAAWSQ ISGLDLTTLG TTATAEEITD TAVTQPLVVA
60 70 80 90 100
ATLLAHEELT KRGHSAAETI VAGHSVGEIA AYAIAGVISA DDAVKLAATR
110 120 130 140 150
GAEMAKACAV EPTGMAAVLG GDEAEVLARL EALDLVPANR NAAGQIVAAG
160 170 180 190 200
AVAALDKLAE DPPAKARVRK LATAGAFHTH YMASALDGYA AAAQSVTTSE
210 220 230 240 250
PTATLLSNAD GQPVASAADA MEKLVAQLTK PVRWDLCTAT LRDRFQNAES
260 270 280 290
AGIVEFPPAG TLVGIAKREL KGTPTRAIKS PEDLDGLDQL
Length:290
Mass (Da):29,676
Last modified:January 9, 2007 - v1
Checksum:i06BFFF38EEDC5B69
GO

Sequence cautioni

The sequence AFP40681.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000480 Genomic DNA. Translation: ABK74111.1.
CP001663 Genomic DNA. Translation: AFP40681.1. Different initiation.
RefSeqiYP_006568976.1. NC_018289.1.
YP_888600.1. NC_008596.1.

Genome annotation databases

EnsemblBacteriaiABK74111; ABK74111; MSMEG_4325.
AFP40681; AFP40681; MSMEI_4225.
GeneIDi4536190.
KEGGimsm:MSMEG_4325.
PATRICi18081005. VBIMycSme59918_4243.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000480 Genomic DNA. Translation: ABK74111.1 .
CP001663 Genomic DNA. Translation: AFP40681.1 . Different initiation.
RefSeqi YP_006568976.1. NC_018289.1.
YP_888600.1. NC_008596.1.

3D structure databases

ProteinModelPortali A0R0B2.
SMRi A0R0B2. Positions 1-290.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 246196.MSMEG_4325.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABK74111 ; ABK74111 ; MSMEG_4325 .
AFP40681 ; AFP40681 ; MSMEI_4225 .
GeneIDi 4536190.
KEGGi msm:MSMEG_4325.
PATRICi 18081005. VBIMycSme59918_4243.

Phylogenomic databases

eggNOGi COG0331.
HOGENOMi HOG000036505.
KOi K00645.
OMAi MVLVRER.
OrthoDBi EOG6VB6T5.

Enzyme and pathway databases

UniPathwayi UPA00094 .
BioCyci MSME246196:GJ4Y-4324-MONOMER.

Family and domain databases

Gene3Di 3.40.366.10. 2 hits.
InterProi IPR001227. Ac_transferase_dom.
IPR014043. Acyl_transferase.
IPR016035. Acyl_Trfase/lysoPLipase.
IPR016036. Malonyl_transacylase_ACP-bd.
[Graphical view ]
Pfami PF00698. Acyl_transf_1. 1 hit.
[Graphical view ]
SUPFAMi SSF52151. SSF52151. 2 hits.
SSF55048. SSF55048. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Fleischmann R.D., Dodson R.J., Haft D.H., Merkel J.S., Nelson W.C., Fraser C.M.
    Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700084 / mc(2)155.
  2. "Interrupted coding sequences in Mycobacterium smegmatis: authentic mutations or sequencing errors?"
    Deshayes C., Perrodou E., Gallien S., Euphrasie D., Schaeffer C., Van-Dorsselaer A., Poch O., Lecompte O., Reyrat J.-M.
    Genome Biol. 8:R20.1-R20.9(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700084 / mc(2)155.
  3. "Ortho-proteogenomics: multiple proteomes investigation through orthology and a new MS-based protocol."
    Gallien S., Perrodou E., Carapito C., Deshayes C., Reyrat J.-M., Van Dorsselaer A., Poch O., Schaeffer C., Lecompte O.
    Genome Res. 19:128-135(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700084 / mc(2)155.
  4. Cited for: PUPYLATION AT LYS-157, IDENTIFICATION BY MASS SPECTROMETRY.

Entry informationi

Entry nameiFABD_MYCS2
AccessioniPrimary (citable) accession number: A0R0B2
Secondary accession number(s): I7GBV9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 10, 2010
Last sequence update: January 9, 2007
Last modified: November 26, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3