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Protein

Pyruvate dehydrogenase E1 component

Gene

aceE

Organism
Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. AceE has reductase activity with pyruvate but does not react with 2-oxoglutarate (By similarity).By similarity

Catalytic activityi

Pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO2.

Cofactori

Protein has several cofactor binding sites:

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processGlycolysis
LigandMagnesium, Pyruvate, Thiamine pyrophosphate

Names & Taxonomyi

Protein namesi
Recommended name:
Pyruvate dehydrogenase E1 component (EC:1.2.4.1)
Short name:
PDH E1 component
Gene namesi
Name:aceE
Ordered Locus Names:MSMEG_4323, MSMEI_4223
OrganismiMycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Taxonomic identifieri246196 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium fortuitum complex
Proteomesi
  • UP000006158 Componenti: Chromosome
  • UP000000757 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003968091 – 929Pyruvate dehydrogenase E1 componentAdd BLAST929

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki375Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-Cter in protein Pup)1 Publication

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Interactioni

Subunit structurei

Homodimer. Part of the PDH complex, consisting of multiple copies of AceE (E1), DlaT (E2) and Lpd (E3).By similarity

Protein-protein interaction databases

STRINGi246196.MSMEG_4323

Structurei

3D structure databases

ProteinModelPortaliA0R0B0
SMRiA0R0B0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG4105DAQ Bacteria
COG2609 LUCA
HOGENOMiHOG000115215
KOiK00163
OMAiREPWFPG
OrthoDBiPOG091H046S

Family and domain databases

CDDicd02017 TPP_E1_EcPDC_like, 1 hit
Gene3Di3.40.50.920, 1 hit
InterProiView protein in InterPro
IPR004660 2-oxoA_DH_E1
IPR035807 PDC_E1_N
IPR029061 THDP-binding
IPR009014 Transketo_C/PFOR_II
IPR005474 Transketolase_N
PANTHERiPTHR43825:SF3 PTHR43825:SF3, 1 hit
PfamiView protein in Pfam
PF00456 Transketolase_N, 1 hit
PIRSFiPIRSF000156 Pyruvate_dh_E1, 1 hit
SUPFAMiSSF52518 SSF52518, 2 hits
SSF52922 SSF52922, 1 hit
TIGRFAMsiTIGR00759 aceE, 1 hit

Sequencei

Sequence statusi: Complete.

A0R0B0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTEFVRQDL AQNSSTAAEP DRVRVIREGV ASYLPDIDTE ETAEWLESFD
60 70 80 90 100
ELLERSGPAR ARYLMLRLLE RAGEQRVAIP ALTSTDYVNT IPTELEPWFP
110 120 130 140 150
GDEDVERRYR AWIRWNAAIM VHRAQRPGVG VGGHISTYAS SATLYEVGFN
160 170 180 190 200
HFFRGKSHPG GGDHVFIQGH ASPGIYARAF LEGRLTTDQL DGFRQEHSHS
210 220 230 240 250
GGGLPSYPHP RLMPDFWEFP TVSMGLGPMN AIYQARFNHY LHDRGIKDTS
260 270 280 290 300
DQHVWAFLGD GEMDEPESRG LIQVAANEAL DNLTFVINCN LQRLDGPVRG
310 320 330 340 350
NGKIIQELES FFRGAGWNVI KVVWGREWDV LLHADRDGAL VNLMNSTPDG
360 370 380 390 400
DYQTYKANDG AYVRDHFFGR DPRTKALVAD MSDQEIWNLK RGGHDYRKVY
410 420 430 440 450
AAYRAAMEHK GQPTVILAKT IKGYTLGQHF EGRNATHQMK KLALEDLKNF
460 470 480 490 500
RDVTRVPVSD AQLEEDPYLP PYYHPGPEAP EIRYLLERRR ALGGFVPSRR
510 520 530 540 550
TKSKPLALPG SDTYKALKKG SGSQAVATTM ATVRTFKELL RDKNIGPRIV
560 570 580 590 600
PIIPDEARTF GMDSWFPSLK IYNRNGQLYT SVDSELMLAY KESEVGQILH
610 620 630 640 650
EGINEAGSTS SFTAVGTSYS THDEPMIPIY IFYSMFGFQR TGDGLWAAAD
660 670 680 690 700
QMARGFVLGA TAGRTTLTGE GLQHADGHSL LLASTNPAAV TYDPAFAYEI
710 720 730 740 750
AHIIESGLQR MYGEDPENVF FYLTIYNEPY QQPAEPENLD VEALLKGLYL
760 770 780 790 800
YRPAPEKRAK SAQILASGVA MPEALRAADL LASDWDVAAD VWSVTSWGEL
810 820 830 840 850
NREGVAIEKH RLRHPDEPAG TPHVTSALAD AAGPVIAVSD WMRAVPEQIR
860 870 880 890 900
PWVPGTYVTL GTDGFGFSDT RPAARRYFNT DAESVVVAVL QGLARDGEID
910 920
ASVAAQAAEQ YRIDDVSAAG VSYADTGSA
Length:929
Mass (Da):103,077
Last modified:January 9, 2007 - v1
Checksum:i5CB137A1D69BFB23
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000480 Genomic DNA Translation: ABK72760.1
CP001663 Genomic DNA Translation: AFP40679.1
RefSeqiWP_011729733.1, NZ_CP009494.1
YP_888598.1, NC_008596.1

Genome annotation databases

EnsemblBacteriaiABK72760; ABK72760; MSMEG_4323
AFP40679; AFP40679; MSMEI_4223
GeneIDi4531364
KEGGimsb:LJ00_21425
msg:MSMEI_4223
msm:MSMEG_4323
PATRICifig|246196.19.peg.4241

Similar proteinsi

Entry informationi

Entry nameiODP1_MYCS2
AccessioniPrimary (citable) accession number: A0R0B0
Secondary accession number(s): I7GD92
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 10, 2010
Last sequence update: January 9, 2007
Last modified: May 23, 2018
This is version 81 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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