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Protein

Glutamate-ammonia-ligase adenylyltransferase

Gene

glnE

Organism
Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Adenylation and deadenylation of glutamate--ammonia ligase.UniRule annotation

Catalytic activityi

ATP + [glutamine synthetase]-L-tyrosine = diphosphate + [glutamine synthetase]-O(4)-(5'-adenylyl)-L-tyrosine.UniRule annotation

Cofactori

Mg2+UniRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Ligandi

ATP-binding, Magnesium, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate-ammonia-ligase adenylyltransferaseUniRule annotation (EC:2.7.7.42UniRule annotation)
Alternative name(s):
Glutamine-synthetase adenylyltransferase
Short name:
ATaseUniRule annotation
[Glutamate--ammonia-ligase] adenylyltransferaseUniRule annotation
Gene namesi
Name:glnEUniRule annotation
Ordered Locus Names:MSMEG_4293, MSMEI_4192
OrganismiMycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Taxonomic identifieri246196 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000006158 Componenti: Chromosome
  • UP000000757 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000728471 – 999Glutamate-ammonia-ligase adenylyltransferaseAdd BLAST999

Interactioni

Protein-protein interaction databases

STRINGi246196.MSMEG_4293.

Structurei

3D structure databases

ProteinModelPortaliA0R082.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni149 – 347GlnE 1Add BLAST199
Regioni652 – 857GlnE 2Add BLAST206

Sequence similaritiesi

Belongs to the GlnE family.UniRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG4105CE6. Bacteria.
COG1391. LUCA.
HOGENOMiHOG000243040.
KOiK00982.
OMAiEFMVQYA.
OrthoDBiPOG091H0675.

Family and domain databases

HAMAPiMF_00802. GlnE. 1 hit.
InterProiIPR023057. GlnE.
IPR005190. GlnE_rpt_dom.
IPR013546. PII_UdlTrfase/GS_AdlTrfase.
[Graphical view]
PfamiPF08335. GlnD_UR_UTase. 2 hits.
PF03710. GlnE. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A0R082-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFVRKPATER PRLPSVGRLG LFDPHAPAHL DQLGWNTDDH VELLWSLSRA
60 70 80 90 100
PDADAALLAM VRLADELKDD WDELNRLLLT DRPLRGRLFA VLGSSLALGD
110 120 130 140 150
HLVAHPQSWR LLHGDVRLPS ARELRETFDD AARSVDIERG ASAAIPPLRD
160 170 180 190 200
LYRDRLLVLA ALDVASTVEN EPVLPFVTVS AHLSDLADAA LSAALIVATR
210 220 230 240 250
TVCGDLDPRL AVIAMGKCGA RELNYVSDVD VIFVGEDIEK DGRSDNLATA
260 270 280 290 300
TRVAGEMMRF AGDAFFEVDA ALRPEGKRGQ LVRTLDSHVA YYRRWAKTWE
310 320 330 340 350
FQALLKARPA AGDPELGQAY IDALMPMVWT ACEREDFVPE VQAMRRRVEE
360 370 380 390 400
LVPADVRSRE IKLGTGGLRD VEFAVQLLQL VHGRTDESLH VASTVDALAA
410 420 430 440 450
LGEGGYVGRD DAANMTASYE FLRLLEHRLQ LQRLKRTHML PDDNDDEAYR
460 470 480 490 500
WLARAAHIRP DGTHDAQGVL REELKRQSLR VSRLHAKLFY QPLLESVGHT
510 520 530 540 550
ALGIGEGMSA EAAERQLAAL GYERPQSALA HLAALTGATG RKGRIQQILL
560 570 580 590 600
PTLLDWLSDT PDPDAGLLAY RRLSDEHSDL RWFLGTLRDE GAVAKRLMRV
610 620 630 640 650
LGTSAYIPEL LMRAPEVIQM YADGPSGPKL LEDDRESRAR ALVASASRYA
660 670 680 690 700
DPVRAIAAAR TLRRRELARI ASADVLGMLD VIDVCKSLTA VWVAVLQAAL
710 720 730 740 750
DVVIRANTPD SGVPARIAVI GMGRLGGGEL GYGSDADVMF VCEPNSGVEE
760 770 780 790 800
SVAVRWSVGV AEQVRALLGT PSADPPLEVD TGLRPEGRSG PLVRTLASYD
810 820 830 840 850
AYYSQWAQPW EIQALLRAHR VAGDLELGER FLLMADKIRY PEGGVSASAV
860 870 880 890 900
QEIRRIKARV DAERLPRGAD PNTHTKLGRG GLADIEWTVQ LLQLRYAHKV
910 920 930 940 950
PALHNTSTLE ALNAIGAAEL VAEGDVELLR EAWLTATRAR NALVLVRGKP
960 970 980 990
TDQLPGPGRQ LNAVALAAGW GSDDGGEFLD NYLRVTRRAK AVVRKIFGG
Length:999
Mass (Da):109,400
Last modified:January 9, 2007 - v1
Checksum:iFA89762C1BCE383B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000480 Genomic DNA. Translation: ABK72782.1.
CP001663 Genomic DNA. Translation: AFP40649.1.
RefSeqiWP_011729708.1. NC_008596.1.
YP_888570.1. NC_008596.1.

Genome annotation databases

EnsemblBacteriaiABK72782; ABK72782; MSMEG_4293.
AFP40649; AFP40649; MSMEI_4192.
GeneIDi4532101.
KEGGimsg:MSMEI_4192.
msm:MSMEG_4293.
PATRICi18080943. VBIMycSme59918_4213.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000480 Genomic DNA. Translation: ABK72782.1.
CP001663 Genomic DNA. Translation: AFP40649.1.
RefSeqiWP_011729708.1. NC_008596.1.
YP_888570.1. NC_008596.1.

3D structure databases

ProteinModelPortaliA0R082.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi246196.MSMEG_4293.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABK72782; ABK72782; MSMEG_4293.
AFP40649; AFP40649; MSMEI_4192.
GeneIDi4532101.
KEGGimsg:MSMEI_4192.
msm:MSMEG_4293.
PATRICi18080943. VBIMycSme59918_4213.

Phylogenomic databases

eggNOGiENOG4105CE6. Bacteria.
COG1391. LUCA.
HOGENOMiHOG000243040.
KOiK00982.
OMAiEFMVQYA.
OrthoDBiPOG091H0675.

Family and domain databases

HAMAPiMF_00802. GlnE. 1 hit.
InterProiIPR023057. GlnE.
IPR005190. GlnE_rpt_dom.
IPR013546. PII_UdlTrfase/GS_AdlTrfase.
[Graphical view]
PfamiPF08335. GlnD_UR_UTase. 2 hits.
PF03710. GlnE. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGLNE_MYCS2
AccessioniPrimary (citable) accession number: A0R082
Secondary accession number(s): I7GD80
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: January 9, 2007
Last modified: November 2, 2016
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.