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Protein

D-aminoacyl-tRNA deacylase

Gene

dtd

Organism
Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

D-aminoacyl-tRNA deacylase with broad substrate specificity. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo.UniRule annotation

Catalytic activityi

A D-aminoacyl-tRNA + H2O = a D-amino acid + tRNA.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei78 – 781NucleophileUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciMSME246196:GJ4Y-4290-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
D-aminoacyl-tRNA deacylaseUniRule annotation (EC:3.1.1.96UniRule annotation)
Alternative name(s):
D-tyrosyl-tRNA(Tyr) deacylase
Gene namesi
Name:dtdUniRule annotation
Ordered Locus Names:MSMEG_4291, MSMEI_4190
OrganismiMycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Taxonomic identifieri246196 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000006158 Componenti: Chromosome
  • UP000000757 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 143143D-aminoacyl-tRNA deacylasePRO_1000050856Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi246196.MSMEG_4291.

Structurei

3D structure databases

ProteinModelPortaliA0R080.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the DTD family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108YYA. Bacteria.
COG1490. LUCA.
HOGENOMiHOG000113982.
KOiK07560.
OMAiDGPVTIW.
OrthoDBiPOG091H02D0.

Family and domain databases

CDDicd00563. Dtyr_deacylase. 1 hit.
Gene3Di3.50.80.10. 1 hit.
HAMAPiMF_00518. Deacylase_Dtd. 1 hit.
InterProiIPR003732. Daa-tRNA_deacyls_DTD.
IPR023509. DTD-like_dom.
[Graphical view]
PANTHERiPTHR10472. PTHR10472. 1 hit.
PfamiPF02580. Tyr_Deacylase. 1 hit.
[Graphical view]
SUPFAMiSSF69500. SSF69500. 1 hit.
TIGRFAMsiTIGR00256. TIGR00256. 1 hit.

Sequencei

Sequence statusi: Complete.

A0R080-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRVLVQRVSR AQVTVDGEVV GAIDPQPQGL LALVGVTHDD DAAKAQRLAE
60 70 80 90 100
KLWKLRILDD ERSASDVAAP ILVISQFTLY ANTDKGRRPS WNAAAPGSVA
110 120 130 140
EPLVTEFTEA LRRLGATVET GVFGAHMEVE LVNDGPVTVL LEL
Length:143
Mass (Da):15,382
Last modified:January 9, 2007 - v1
Checksum:iA5F492118978D1D9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000480 Genomic DNA. Translation: ABK74712.1.
CP001663 Genomic DNA. Translation: AFP40647.1.
RefSeqiWP_011729707.1. NZ_CP009494.1.
YP_888568.1. NC_008596.1.

Genome annotation databases

EnsemblBacteriaiABK74712; ABK74712; MSMEG_4291.
AFP40647; AFP40647; MSMEI_4190.
GeneIDi4534728.
KEGGimsb:LJ00_21270.
msg:MSMEI_4190.
msm:MSMEG_4291.
PATRICi18080939. VBIMycSme59918_4211.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000480 Genomic DNA. Translation: ABK74712.1.
CP001663 Genomic DNA. Translation: AFP40647.1.
RefSeqiWP_011729707.1. NZ_CP009494.1.
YP_888568.1. NC_008596.1.

3D structure databases

ProteinModelPortaliA0R080.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi246196.MSMEG_4291.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABK74712; ABK74712; MSMEG_4291.
AFP40647; AFP40647; MSMEI_4190.
GeneIDi4534728.
KEGGimsb:LJ00_21270.
msg:MSMEI_4190.
msm:MSMEG_4291.
PATRICi18080939. VBIMycSme59918_4211.

Phylogenomic databases

eggNOGiENOG4108YYA. Bacteria.
COG1490. LUCA.
HOGENOMiHOG000113982.
KOiK07560.
OMAiDGPVTIW.
OrthoDBiPOG091H02D0.

Enzyme and pathway databases

BioCyciMSME246196:GJ4Y-4290-MONOMER.

Family and domain databases

CDDicd00563. Dtyr_deacylase. 1 hit.
Gene3Di3.50.80.10. 1 hit.
HAMAPiMF_00518. Deacylase_Dtd. 1 hit.
InterProiIPR003732. Daa-tRNA_deacyls_DTD.
IPR023509. DTD-like_dom.
[Graphical view]
PANTHERiPTHR10472. PTHR10472. 1 hit.
PfamiPF02580. Tyr_Deacylase. 1 hit.
[Graphical view]
SUPFAMiSSF69500. SSF69500. 1 hit.
TIGRFAMsiTIGR00256. TIGR00256. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiDTD_MYCS2
AccessioniPrimary (citable) accession number: A0R080
Secondary accession number(s): I7G4T9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 9, 2007
Last modified: September 7, 2016
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.